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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:migraine without aura
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Accession:DOID:12783 term browser browse the term
Definition:Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Synonyms:exact_synonym: Common Migraine;   Common Migraines;   MGOA;   MGR4;   MIGRAINE WITHOUT AURA, SUSCEPTIBILITY TO, 4
 primary_id: MESH:D020326;   RDO:0007393
 alt_id: OMIM:607501
 xref: ICD10CM:G43.0;   ICD9CM:346.1;   NCI:C117004
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
migraine without aura term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chr 5:81,179,614...82,168,528
Ensembl chr 5:81,179,605...82,168,427
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:11304026, PMID:14659530 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Eno2 enolase 2 ISO protein:increased expression:serum RGD PMID:21293918 RGD:5508769 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Ldlr low density lipoprotein receptor ISO DNA:repeat:exon (human) RGD PMID:12873747 RGD:5490245 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Mef2d myocyte enhancer factor 2D ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chr 2:187,511,775...187,541,285
Ensembl chr 2:187,512,164...187,538,026
JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Migraine without aura ClinVar PMID:8878478, PMID:9388399, PMID:12754354, PMID:15229130, PMID:15287509, PMID:15857853, PMID:20071773, PMID:21940951, PMID:24425116, PMID:24886907, PMID:25412914, PMID:25741868, PMID:26467025, PMID:28334938, PMID:32581362 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Phactr1 phosphatase and actin regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chr17:23,245,423...23,761,207 JBrowse link
G S100b S100 calcium binding protein B ISO protein:increased expression:serum RGD PMID:21293918 RGD:5508769 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11304026 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:14718719 RGD:1580316 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16045
    disease of anatomical entity 15292
      nervous system disease 10879
        central nervous system disease 9020
          brain disease 8346
            Headache Disorders 52
              Primary Headache Disorders 52
                migraine 52
                  migraine without aura 12
                    Familial Hemiplegic Migraine 4 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.