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Term:Sjogren's syndrome
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Accession:DOID:12894 term browser browse the term
Definition:Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
Synonyms:exact_synonym: Sicca Syndrome;   Sjogren Syndrome;   Sjogrens Syndrome;   xerodermosteosis
 primary_id: MESH:D012859;   RDO:0006582
 alt_id: OMIM:270150
 xref: GARD:10252
For additional species annotation, visit the Alliance of Genome Resources.


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Sjogren's syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aire autoimmune regulator JBrowse link 20 11,365,630 11,380,636 RGD:13592920
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:7495765
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:8657019
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:7401265
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:5683622
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:8551796
RGD:8551818
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:13592920
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11520791
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:9491774
RGD:9491835
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:7421506
RGD:7421519
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:13592920
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:5147747
G Dgkq diacylglycerol kinase, theta JBrowse link 14 2,069,409 2,083,370 RGD:11554173
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:13592920
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:8662410
RGD:13592920
RGD:8662451
RGD:8662436
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:11554173
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6218983
G Gtf2i general transcription factor II I JBrowse link 12 25,410,804 25,487,970 RGD:11554173
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10450595
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 JBrowse link 10 35,872,619 35,879,911 RGD:10054311
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:8158122
RGD:8547705
RGD:8547696
G Id3 inhibitor of DNA binding 3, HLH protein JBrowse link 5 154,489,603 154,491,172 RGD:13592920
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:8142390
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1580479
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:11554173
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:8549582
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:8696035
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655918
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:8549786
RGD:8549807
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:13592920
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:8549566
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:13592920
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:13592920
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:7829718
G Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 JBrowse link 8 90,343,307 90,360,085 RGD:11554173
G Itsn2 intersectin 2 JBrowse link 6 30,098,378 30,208,694 RGD:11554173
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:8548776
RGD:8548787
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:13592920
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:8693671
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:8547814
RGD:8547858
G Muc16 mucin 16, cell surface associated JBrowse link 8 18,438,838 18,639,777 RGD:7364772
G Muc19 mucin 19, oligomeric JBrowse link 7 133,048,727 133,166,551 RGD:7364736
RGD:13592920
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:7364736
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:11554173
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:13592920
G Phip pleckstrin homology domain interacting protein JBrowse link 8 90,387,339 90,483,964 RGD:11554173
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:8547550
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:11554173
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:11534998
RGD:11534999
G Pttg1 pituitary tumor-transforming 1 JBrowse link 10 29,014,332 29,026,088 RGD:11554173
G Reg1a regenerating family member 1 alpha JBrowse link 4 109,497,962 109,500,626 RGD:9850137
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:13592920
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:5147809
RGD:7421543
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:7421543
RGD:7483566
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147809
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6478702
G St14 suppression of tumorigenicity 14 JBrowse link 8 32,240,113 32,280,813 RGD:13592920
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:8661690
RGD:11554173
RGD:8661709
RGD:8661708
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:7394829
RGD:13592920
RGD:7394845
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:13592920
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7394766
RGD:10450595
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:11554173
G Tnfsf13b TNF superfamily member 13b JBrowse link 16 85,275,690 85,306,419 RGD:13592920
G Tnip1 TNFAIP3 interacting protein 1 JBrowse link 10 40,255,776 40,303,092 RGD:11554173
G Traf3ip2 Traf3 interacting protein 2 JBrowse link 20 44,679,861 44,722,874 RGD:13592920
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480477
G Vip vasoactive intestinal peptide JBrowse link 1 42,169,307 42,177,582 RGD:5685375

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14759
    syndrome 4210
      Sjogren's syndrome 68
        Pancreatitis, Sclerosing Cholangitis, and Sicca Complex 0
Path 2
Term Annotations click to browse term
  disease 14759
    disease of anatomical entity 13978
      Immune & Inflammatory Diseases 2999
        immune system disease 2432
          Autoimmune Diseases 1474
            autoimmune hypersensitivity disease 1195
              autoimmune disease of musculoskeletal system 812
                rheumatic disease 799
                  rheumatoid arthritis 488
                    Sjogren's syndrome 68
                      Pancreatitis, Sclerosing Cholangitis, and Sicca Complex 0
paths to the root