Term:periventricular leukomalacia
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Accession:DOID:13088 term browser browse the term
Definition:Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
Synonyms:exact_synonym: Cystic Periventricular Leukomalacia;   Cystic Periventricular Leukomalacias;   Neonatal Cerebral Leukomalacia;   Neonatal Cerebral Leukomalacias;   Periventricular Encephalomalacia;   Periventricular Encephalomalacias;   Periventricular Leucomalacia;   Periventricular Leucomalacias;   Periventricular Leukomalacias
 primary_id: MESH:D007969;   RDO:0006000
 xref: GARD:10285
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periventricular leukomalacia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnah11 dynein, axonemal, heavy chain 11 JBrowse link 6 145,784,893 146,099,212 RGD:8554872
G Mbp myelin basic protein JBrowse link 18 79,326,738 79,437,310 RGD:7327203
G Mcoln1 mucolipin 1 JBrowse link 12 2,054,629 2,068,682 RGD:8554872
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:5683904
G Rps6kc1 ribosomal protein S6 kinase C1 JBrowse link 13 109,338,761 109,589,209 RGD:8554872
G Tmco1 transmembrane and coiled-coil domains 1 JBrowse link 13 85,465,015 85,559,113 RGD:8554872
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580604

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14823
    disease of anatomical entity 13997
      cardiovascular system disease 4055
        vascular disease 3038
          cerebrovascular disease 788
            periventricular leukomalacia 7
Path 2
Term Annotations click to browse term
  disease 14823
    disease of anatomical entity 13997
      nervous system disease 9111
        central nervous system disease 6908
          brain disease 6412
            cerebrovascular disease 788
              periventricular leukomalacia 7
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