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ONTOLOGY REPORT - ANNOTATIONS


Term:intracranial arteriosclerosis
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Accession:DOID:13097 term browser browse the term
Definition:Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Synonyms:exact_synonym: Cerebral Arterioscleroses;   Cerebral Arteriosclerosis;   Intracranial Arterioscleroses;   intracranial atheroscleroses;   intracranial atherosclerosis
 primary_id: MESH:D002537
 alt_id: RDO:0005160
For additional species annotation, visit the Alliance of Genome Resources.


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CADASIL term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htra1 HtrA serine peptidase 1 JBrowse link 1 201,499,067 201,548,508 RGD:11554173
G Notch3 notch receptor 3 JBrowse link 7 14,138,495 14,189,688 RGD:8554872
RGD:11554173
CADASIL 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Notch3 notch receptor 3 JBrowse link 7 14,138,495 14,189,688 RGD:7240710
RGD:8554872
CADASIL 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htra1 HtrA serine peptidase 1 JBrowse link 1 201,499,067 201,548,508 RGD:8554872
RGD:7240710
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htra1 HtrA serine peptidase 1 JBrowse link 1 201,499,067 201,548,508 RGD:7240710
RGD:8554872
Multi-Infarct Dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:10054257
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:10054050
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:10054050
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:10449132
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:10047081
vascular dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:14696801
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:2303174
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:10059369
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:13792766
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:10401142
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10400891
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:10402076
G Flt1 Fms related receptor tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:10402076
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:10402374
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:11352822
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:13792687
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:13792687
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:13792687
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:13792766
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:10402403
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1598446
RGD:10045864
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:10045873
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1626633
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:13792766
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:1582624
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:10401142
G Pon2 paraoxonase 2 JBrowse link 4 30,344,705 30,380,119 RGD:1580219
G Rpgrip1l Rpgrip1-like JBrowse link 19 17,115,266 17,208,055 RGD:13204815
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:11041644
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 JBrowse link 1 88,779,476 88,780,425 RGD:11554173
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6478792
G Sncg synuclein, gamma JBrowse link 16 10,722,110 10,726,648 RGD:6478792
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1581412
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:2303174
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:13825254
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:2290557

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15610
    disease of anatomical entity 14968
      cardiovascular system disease 4275
        vascular disease 3304
          cerebrovascular disease 799
            intracranial arterial disease 241
              intracranial arteriosclerosis 40
                vascular dementia + 40
Path 2
Term Annotations click to browse term
  disease 15610
    disease of anatomical entity 14968
      nervous system disease 10400
        central nervous system disease 8547
          brain disease 7903
            cerebrovascular disease 799
              intracranial arterial disease 241
                intracranial arteriosclerosis 40
                  vascular dementia + 40
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.