Term:temporal arteritis
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Accession:DOID:13375 term browser browse the term
Definition:A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)
Synonyms:exact_synonym: Cranial Arteritides;   Cranial Arteritis;   Giant Cell Aortic Arteritis;   Giant Cell Aortitides;   Giant Cell Aortitis;   Giant Cell Aortitis, Horton's;   Giant Cell Arteritides;   Giant Cell Arteritis;   Horton Disease;   Horton Giant Cell Arteritis;   Horton's Disease;   Horton's Giant Cell Arteritis;   Hortons Disease;   Juvenile Temporal Arteritides;   Juvenile Temporal Arteritis;   Temporal Arteritides
 primary_id: MESH:D013700
 alt_id: OMIM:187360;   RDO:0004477
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temporal arteritis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1581162
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:5024918
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:1581301
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:9491785
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:11059502
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:6482238
G Eln elastin JBrowse link 12 24,978,478 25,021,864 RGD:9585754
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:5147974
G Fcgr3a Fc fragment of IgG receptor IIIa JBrowse link 13 89,385,775 89,396,047 RGD:5147974
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:8157621
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:8698666
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655865
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:6892962
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:7829811
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:6482238
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:8693752
G Mfge8 milk fat globule-EGF factor 8 protein JBrowse link 1 140,845,478 140,860,882 RGD:1582497
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:8657040
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:1580575
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:7829739
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147583
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7777158

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14920
    sensory system disease 4265
      skin disease 2268
        vascular skin disease 136
          temporal arteritis 22
            Juvenile Giant Cell Arteritis 0
Path 2
Term Annotations click to browse term
  disease 14920
    disease of anatomical entity 14086
      Immune & Inflammatory Diseases 3003
        immune system disease 2425
          hypersensitivity reaction disease 1465
            autoimmune hypersensitivity disease 1169
              autoimmune disease of the nervous system 402
                central nervous system vasculitis 24
                  temporal arteritis 22
                    Juvenile Giant Cell Arteritis 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.