ONTOLOGY REPORT - ANNOTATIONS


Term:sick sinus syndrome
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Accession:DOID:13884 term browser browse the term
Definition:A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Synonyms:exact_synonym: Dysfunctions, Sinus Node;   SICK SINUS SYNDROME 3, SUSCEPTIBILITY TO;   SSS3;   Sick Sinus Node Syndrome;   Sinus Node Disease;   Sinus Node Diseases;   Sinus Node Dysfunction;   sinus node infection
 primary_id: MESH:D012804
 alt_id: OMIM:614090;   RDO:0006573
 xref: OMIM:PS608567;   ORDO:166282
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sick sinus syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:8548870
G Ank2 ankyrin 2 JBrowse link 2 231,224,643 231,522,655 RGD:1599114
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:11554173
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 JBrowse link 2 50,099,576 50,499,799 RGD:13592920
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:13592920
RGD:8554872
G Kcnj5 potassium voltage-gated channel subfamily J member 5 JBrowse link 8 33,435,493 33,463,410 RGD:11554173
G Myh6 myosin heavy chain 6 JBrowse link 15 33,605,653 33,629,730 RGD:11554173
RGD:8554872
RGD:7240710
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:11554173
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:8554872
RGD:13592920
G Snta1 syntrophin, alpha 1 JBrowse link 3 149,874,023 149,905,980 RGD:8554872
Sick Sinus Syndrome 1, Autosomal Recessive term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:7240710
RGD:8554872
Sick Sinus Syndrome 2, Autosomal Dominant term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14875
    syndrome 4220
      sick sinus syndrome 10
        Sick Sinus Syndrome 1, Autosomal Recessive 1
        Sick Sinus Syndrome 2, Autosomal Dominant 1
        Sinus Node Disease and Myopia 0
Path 2
Term Annotations click to browse term
  disease 14875
    disease of anatomical entity 14051
      nervous system disease 9116
        peripheral nervous system disease 2009
          neuropathy 1830
            neuromuscular disease 1411
              muscular disease 908
                muscle tissue disease 636
                  sinoatrial node disease 10
                    sick sinus syndrome 10
                      Sick Sinus Syndrome 1, Autosomal Recessive 1
                      Sick Sinus Syndrome 2, Autosomal Dominant 1
                      Sinus Node Disease and Myopia 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.