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ONTOLOGY REPORT - ANNOTATIONS


Term:polyneuropathy
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Accession:DOID:1389 term browser browse the term
Definition:Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Synonyms:exact_synonym: Acquired Polyneuropathy;   Critical Illness Polyneuropathies;   Critical Illness Polyneuropathy;   Familial Polyneuropathies;   Familial Polyneuropathy;   Inherited Polyneuropathies;   Inherited Polyneuropathy;   Motor Polyneuropathies;   acquired polyneuropathies;   motor polyneuropathy;   multifocal motor neuropathy;   polyneuropathies
 primary_id: MESH:D011115
 alt_id: OMIA:001292
 xref: ICD10CM:G62.9;   NCI:C26951
For additional species annotation, visit the Alliance of Genome Resources.


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polyneuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:5685648
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:5686395
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 JBrowse link 6 134,958,854 135,085,769 RGD:8554872
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:11554173
G Fcgr3a Fc fragment of IgG receptor IIIa JBrowse link 13 89,385,775 89,396,047 RGD:11352254
G Gdap1 ganglioside-induced differentiation-associated-protein 1 JBrowse link 5 1,328,963 1,347,946 RGD:8554872
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:13792836
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:2307274
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:8554872
G Med25 mediator complex subunit 25 JBrowse link 1 100,872,240 100,887,864 RGD:8554872
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:1358786
G Pnpla6 patatin-like phospholipase domain containing 6 JBrowse link 12 2,068,749 2,098,139 RGD:11554173
G Polg DNA polymerase gamma, catalytic subunit JBrowse link 1 141,172,117 141,188,893 RGD:8554872
G Reep1 receptor accessory protein 1 JBrowse link 4 99,618,622 99,735,329 RGD:8554872
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147579
G Scp2 sterol carrier protein 2 JBrowse link 5 127,647,934 127,735,703 RGD:11554173
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:8547710
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1581254
G Sod3 superoxide dismutase 3 JBrowse link 14 60,958,583 60,971,143 RGD:1581254
G Tgm6 transglutaminase 6 JBrowse link 3 122,644,183 122,680,054 RGD:8554872
46,XY Partial Gonadal Dysgenesis, with Minifascicular Neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dhh desert hedgehog signaling molecule JBrowse link 7 140,575,288 140,580,783 RGD:7240710
RGD:8554872
adult-onset ataxia and polyneuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 JBrowse link MT 7,919 8,599 RGD:8554872
alcoholic neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:10402569
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:10402569
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:10402569
CATARACTS, GROWTH HORMONE DEFICIENCY, SENSORY NEUROPATHY, SENSORINEURAL HEARING LOSS, AND SKELETAL DYSPLASIA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Iars2 isoleucyl-tRNA synthetase 2, mitochondrial JBrowse link 13 103,229,868 103,265,019 RGD:7240710
RGD:8554872
chronic inflammatory demyelinating polyradiculoneuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl28 C-C motif chemokine ligand 28 JBrowse link 2 52,379,341 52,403,979 RGD:4890012
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:4890012
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:13204856
demyelinating polyneuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:8554872
Guillain-Barre syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aire autoimmune regulator JBrowse link 20 11,365,630 11,380,636 RGD:13592920
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:5685658
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549645
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:13592920
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:5686395
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:5686395
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6218983
G Hcrt hypocretin neuropeptide precursor JBrowse link 10 88,669,216 88,670,430 RGD:1600925
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:7240710
RGD:8554872
hereditary sensory and autonomic neuropathy type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:8554872
hereditary sensory and autonomic neuropathy type 1A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:7240710
hereditary sensory and autonomic neuropathy type 1C term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahsa1 activator of Hsp90 ATPase activity 1 JBrowse link 6 111,296,168 111,304,224 RGD:8554872
G Gstz1 glutathione S-transferase zeta 1 JBrowse link 6 111,176,798 111,187,246 RGD:8554872
G Ism2 isthmin 2 JBrowse link 6 111,309,054 111,329,967 RGD:8554872
G Noxred1 NADP-dependent oxidoreductase domain containing 1 JBrowse link 6 111,243,232 111,271,107 RGD:8554872
G Pomt2 protein-O-mannosyltransferase 2 JBrowse link 6 111,137,329 111,176,991 RGD:8554872
G Samd15 sterile alpha motif domain containing 15 JBrowse link 6 111,223,026 111,241,326 RGD:8554872
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:7240710
RGD:8554872
G Tmed8 transmembrane p24 trafficking protein family member 8 JBrowse link 6 111,188,938 111,222,866 RGD:8554872
G Vipas39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog JBrowse link 6 111,271,283 111,296,013 RGD:8554872
hereditary sensory and autonomic neuropathy type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif1a kinesin family member 1A JBrowse link 9 100,171,851 100,253,626 RGD:8554872
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:8554872
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:8554872
RGD:11554173
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:8554872
hereditary sensory and autonomic neuropathy type 2A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif1a kinesin family member 1A JBrowse link 9 100,171,851 100,253,626 RGD:8554872
RGD:11554173
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:8554872
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:8554872
RGD:11554173
G Scn9a sodium voltage-gated channel alpha subunit 9 JBrowse link 3 52,583,953 52,664,209 RGD:11554173
RGD:8554872
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:7240710
RGD:8554872
hereditary sensory and autonomic neuropathy type 2B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:7240710
RGD:8554872
hereditary sensory and autonomic neuropathy type 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:8554872
RGD:7240710
G Scn11a sodium voltage-gated channel alpha subunit 11 JBrowse link 8 128,450,793 128,527,510 RGD:8554872
hereditary sensory and autonomic neuropathy type 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dst dystonin JBrowse link 9 37,902,336 38,296,961 RGD:7240710
RGD:8554872
hereditary sensory and autonomic neuropathy type 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn11a sodium voltage-gated channel alpha subunit 11 JBrowse link 8 128,450,793 128,527,510 RGD:7240710
RGD:8554872
hereditary sensory and autonomic neuropathy type 8 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prdm12 PR/SET domain 12 JBrowse link 3 10,181,104 10,199,185 RGD:7240710
RGD:8554872
hereditary sensory neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cct4 chaperonin containing TCP1 subunit 4 JBrowse link 14 107,767,392 107,780,270 RGD:1299607
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:9588627
RGD:11554173
G Dst dystonin JBrowse link 9 37,902,336 38,296,961 RGD:13592920
G Kif1a kinesin family member 1A JBrowse link 9 100,171,851 100,253,626 RGD:12911225
RGD:8554872
RGD:12911226
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:11554173
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:5684543
RGD:8554872
RGD:11554173
RGD:5684770
RGD:5684769
RGD:5684767
RGD:5684544
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:8554872
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:11554173
G Scn11a sodium voltage-gated channel alpha subunit 11 JBrowse link 8 128,450,793 128,527,510 RGD:13592920
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:8554872
hereditary sensory neuropathy type 1D term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atl1 atlastin GTPase 1 JBrowse link 6 92,229,764 92,370,428 RGD:7240710
RGD:8554872
hereditary sensory neuropathy type 1E term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:7240710
RGD:8554872
hereditary sensory neuropathy type 1F term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atl3 atlastin GTPase 3 JBrowse link 1 222,746,023 222,788,439 RGD:7240710
RGD:8554872
hereditary sensory neuropathy type 2C term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif1a kinesin family member 1A JBrowse link 9 100,171,851 100,253,626 RGD:7240710
RGD:8554872
hereditary sensory neuropathy type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:8554872
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:7240710
RGD:8554872
Leukoencephalopathy with Dystonia and Motor Neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scp2 sterol carrier protein 2 JBrowse link 5 127,647,934 127,735,703 RGD:7240710
RGD:8554872
PCWH syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:13592920
G Polr2f RNA polymerase II, I and III subunit F JBrowse link 7 120,380,543 120,392,214 RGD:8554872
G Sox10 SRY-box transcription factor 10 JBrowse link 7 120,393,238 120,403,523 RGD:7240710
RGD:8554872
RGD:12802339
PHARC syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd12 abhydrolase domain containing 12, lysophospholipase JBrowse link 3 146,630,298 146,690,375 RGD:7240710
RGD:8554872
Polyendocrine-Polyneuropathy Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmxl2 Dmx-like 2 JBrowse link 8 58,932,575 59,077,788 RGD:7240710
RGD:8554872
Ribose 5-Phosphate Isomerase Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpia ribose 5-phosphate isomerase A JBrowse link 4 98,568,028 98,593,664 RGD:7240710
RGD:8554872
Riley-Day syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elp1 elongator complex protein 1 JBrowse link 5 73,503,406 73,552,798 RGD:5129156
RGD:8554872
RGD:5129155
RGD:7240710
sensory peripheral neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bace1 beta-secretase 1 JBrowse link 8 50,140,092 50,162,388 RGD:13782150
G Gdap1 ganglioside-induced differentiation-associated-protein 1 JBrowse link 5 1,328,963 1,347,946 RGD:8554872
G Gjb1 gap junction protein, beta 1 JBrowse link X 71,272,030 71,279,973 RGD:8554872
G Mir15b microRNA 15b JBrowse link 2 165,605,923 165,606,020 RGD:13782150
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:8554872
G Scn11a sodium voltage-gated channel alpha subunit 11 JBrowse link 8 128,450,793 128,527,510 RGD:8554872
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 JBrowse link 3 132,560,437 132,689,313 RGD:8554872
Tangier disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1600951
RGD:8554872
RGD:19165130
RGD:11554173
RGD:7240710
RGD:1298571
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:8554872
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration and Progressive Polyneuropathy Type) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc25a19 solute carrier family 25 member 19 JBrowse link 10 104,166,594 104,179,523 RGD:8554872
RGD:7240710

Term paths to the root
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Term Annotations click to browse term
  disease 16022
    disease of anatomical entity 15275
      nervous system disease 10770
        peripheral nervous system disease 2367
          polyneuropathy 82
            46,XY Partial Gonadal Dysgenesis, with Minifascicular Neuropathy 1
            Laryngeal Abductor Paralysis with Cerebellar Ataxia and Motor Neuropathy 0
            Leukoencephalopathy with Dystonia and Motor Neuropathy 1
            PCWH syndrome 3
            PHARC syndrome 1
            POEMS syndrome 0
            Polyendocrine-Polyneuropathy Syndrome 1
            Ribose 5-Phosphate Isomerase Deficiency 1
            Sensorineural Deafness with Peripheral Neuropathy and Arterial Disease 0
            Severe Infantile Axonal Neuropathy 0
            Tangier disease 2
            Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration and Progressive Polyneuropathy Type) 1
            Unilateral Aplasia of Extensor Muscles of Fingers, with Generalized Polyneuropathy 0
            adult-onset ataxia and polyneuropathy 1
            alcoholic neuropathy 3
            chronic polyneuropathy + 0
            demyelinating polyneuropathy + 4
            hereditary sensory neuropathy + 27
            idiopathic progressive polyneuropathy 0
            paraneoplastic polyneuropathy 0
            polyneuropathy in collagen vascular disease 0
            polyradiculoneuropathy + 19
            sensory peripheral neuropathy 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.