Term:eosinophilic esophagitis
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Accession:DOID:13922 term browser browse the term
Definition:Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.
Synonyms:exact_synonym: EE;   EOE1;   EOE2;   ESOPHAGITIS, EOSINOPHILIC, 1;   ESOPHAGITIS, EOSINOPHILIC, 2;   Eosinophilic Chronic Esophagitides;   Eosinophilic Chronic Esophagitis;   Eosinophilic Esophagitides;   esophageal eosinophilia
 narrow_synonym: pediatric eosinophilic esophagitis
 primary_id: MESH:D057765;   RDO:0007790
 alt_id: OMIM:610247;   OMIM:613412
 xref: ORDO:73247
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eosinophilic esophagitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:6771318
G Ccl26 C-C motif chemokine ligand 26 JBrowse link 12 24,157,182 24,161,870 RGD:11081156
G Ccr3 C-C motif chemokine receptor 3 JBrowse link 8 133,026,539 133,040,999 RGD:6893390
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:5490306
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:11352743
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:11354947
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6771318
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11073602
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14823
    disease of anatomical entity 13997
      gastrointestinal system disease 4247
        gastroenteritis 378
          esophagitis 26
            eosinophilic esophagitis 9
Path 2
Term Annotations click to browse term
  disease 14823
    disease of anatomical entity 13997
      Immune & Inflammatory Diseases 3007
        immune system disease 2440
          hypersensitivity reaction disease 1488
            allergic hypersensitivity disease 546
              Immediate Hypersensitivity 418
                eosinophilic esophagitis 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.