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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Reye syndrome
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Accession:DOID:14525 term browser browse the term
Definition:A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
Synonyms:exact_synonym: Adult Reye Syndrome;   Adult Reye's Syndrome;   Fatty Liver with Encephalopathy;   Reye Johnson Syndrome;   Reye Like Syndrome;   Reye's Like Syndrome;   Reye's Syndrome
 primary_id: MESH:D012202;   RDO:0006486
 xref: GARD:7570;   ICD10CM:G93.7;   ICD9CM:331.81;   NCI:C34983
For additional species annotation, visit the Alliance of Genome Resources.


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Reye syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin treatment IEP RGD PMID:25162205 RGD:14694843 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Txnip thioredoxin interacting protein ISS MouseDO NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16103
    syndrome 6989
      Reye syndrome 2
Path 2
Term Annotations click to browse term
  disease 16103
    Developmental Diseases 9506
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 8364
        genetic disease 7847
          inherited metabolic disorder 2223
            lipid metabolism disorder 900
              lipid storage disease 467
                fatty liver disease 287
                  Reye syndrome 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.