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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:colon carcinoma
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Accession:DOID:1520 term browser browse the term
Definition:A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. (DO)
Synonyms:exact_synonym: carcinoma of colon;   colonic carcinoma
 primary_id: RDO:9002019
 xref: NCI:C4910
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
colon carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:17611497, PMID:18256540, PMID:18392055, PMID:18504432, PMID:18611285, PMID:19418217, PMID:19487299, PMID:19853286, PMID:20233444, PMID:20453058, PMID:21464312, PMID:21512767, PMID:21793738, PMID:22538770, PMID:22610119, PMID:22722201, PMID:22722839, PMID:22980975, PMID:23237847, PMID:23348505, PMID:23700467, PMID:23728071, PMID:23934607, PMID:24190505, PMID:24657128, PMID:25157968, PMID:26619011, PMID:28492532 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G APC APC regulator of WNT signaling pathway IAGP ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:1338904, PMID:1528264, PMID:8187091, PMID:8381579, PMID:8940262, PMID:9288102, PMID:9585599, PMID:9724771, PMID:9731522, PMID:9731533, PMID:9751605, PMID:9831355, PMID:9869602, PMID:9869603, PMID:9869620, PMID:9950360, PMID:9973276, PMID:10439961, PMID:10679643, PMID:10737795, PMID:10938175, PMID:11001924, PMID:11159880, PMID:11207040, PMID:11354631, PMID:12173321, PMID:12533824, PMID:14624392, PMID:14633595, PMID:15712637, PMID:15929773, PMID:16140997, PMID:16228836, PMID:16569251, PMID:16875934, PMID:17854661, PMID:18343606, PMID:19047896, PMID:19768578, PMID:20223039, PMID:20685668, PMID:22703879, PMID:22810696, PMID:23204322, PMID:23576677, PMID:23896379, PMID:24033266, PMID:24310308, PMID:24416237, PMID:24599579, PMID:24728327, PMID:24861525, PMID:25157968, PMID:25604157, PMID:25741868, PMID:25980754, PMID:25981591, PMID:26187149, PMID:26300997, PMID:26314409, PMID:26332594, PMID:26394139, PMID:26421687, PMID:26467025, PMID:26625971, PMID:26845104, PMID:27146957, PMID:27153395, PMID:27978560, PMID:28050010, PMID:28135136, PMID:28135145, PMID:28492532, PMID:28749474, PMID:29478780, PMID:29506128, PMID:29961768, PMID:30152102, PMID:30426508, PMID:30487145 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G AXIN2 axin 2 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:11017067, PMID:28492532 NCBI chr17:65,528,563...65,561,648
Ensembl chr17:65,528,563...65,561,648
JBrowse link
G BARD1 BRCA1 associated RING domain 1 IAGP ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:25741868, PMID:26350354, PMID:28135145, PMID:28492532, PMID:31371347 NCBI chr 2:214,725,645...214,809,683
Ensembl chr 2:214,725,646...214,809,683
JBrowse link
G BAX BCL2 associated X, apoptosis regulator IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9020077 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL10 BCL10 immune signaling adaptor IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9989495 NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase treatment IMP
IAGP
ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:12068308, PMID:12198537, PMID:12447372, PMID:12460918, PMID:12460919, PMID:12619120, PMID:12644542, PMID:12670889, PMID:12692057, PMID:12794760, PMID:12960123, PMID:14513361, PMID:14602780, PMID:14679157, PMID:15001635, PMID:15035987, PMID:15126572, PMID:15181070, PMID:15342696, PMID:15356022, PMID:15386408, PMID:15687339, PMID:15998781, PMID:16015629, PMID:16174717, PMID:16187918, PMID:16772349, PMID:17374713, PMID:17488796, PMID:17704260, PMID:17785355, PMID:18039235, PMID:18060073, PMID:18398503, PMID:18413255, PMID:19001320, PMID:19010912, PMID:19018267, PMID:19238210, PMID:19404918, PMID:19537845, PMID:19561230, PMID:20008640, PMID:20350999, PMID:20413299, PMID:20619739, PMID:20630094, PMID:20818844, PMID:20823850, PMID:20857202, PMID:21107320, PMID:21107323, PMID:21129611, PMID:21156289, PMID:21163703, PMID:21426297, PMID:21483012, PMID:21502544, PMID:21639808, PMID:21641636, PMID:21683865, PMID:21975775, PMID:22038996, PMID:22048237, PMID:22113612, PMID:22180495, PMID:22281684, PMID:22351686, PMID:22356324, PMID:22389471, PMID:22448344, PMID:22536370, PMID:22586120, PMID:22608338, PMID:22649091, PMID:22663011, PMID:22735384, PMID:22743296, PMID:22773810, PMID:22805292, PMID:22972589, PMID:22997239, PMID:23020132, PMID:23031422, PMID:23251002, PMID:23302800, PMID:23325582, PMID:23470635, PMID:23524406, PMID:23549875, PMID:23614898, PMID:23680146, PMID:23685455, PMID:23812671, PMID:23833300, PMID:23845441, PMID:23918947, PMID:24033266, PMID:24107445, PMID:24112392, PMID:24163374, PMID:24388723, PMID:24508103, PMID:24512911, PMID:24576830, PMID:24583796, PMID:24586605, PMID:24594804, PMID:24670642, PMID:24717435, PMID:25024077, PMID:25037139, PMID:25079330, PMID:25155755, PMID:25157968, PMID:25265492, PMID:25265494, PMID:25370471, PMID:25399551, PMID:25741868, PMID:25950823, PMID:25989278, PMID:26619011, PMID:26678033, PMID:27404270, PMID:27480103, PMID:28492532, PMID:28854169, PMID:28891408, PMID:29925953, PMID:31779674, PMID:31891627, PMID:22319199 RGD:11567267 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
Ensembl chr 7:140,719,327...140,924,929
JBrowse link
G BRCA2 BRCA2 DNA repair associated IAGP ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:15937982, PMID:16758124, PMID:20167696, PMID:21520333, PMID:24814045, PMID:25058500, PMID:25348012, PMID:25741868, PMID:27165003, PMID:28223274, PMID:28492532, PMID:29394989, PMID:29849630, PMID:29881398, PMID:29884841, PMID:30254663 NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
Ensembl chr13:32,315,086...32,400,268
JBrowse link
G BRIP1 BRCA1 interacting protein C-terminal helicase 1 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:21964575, PMID:25058500, PMID:25741868, PMID:27165003, PMID:28492532 NCBI chr17:61,679,139...61,864,120
Ensembl chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,528
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9521327 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9521327, PMID:24728327, PMID:28492532 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,136
Ensembl chr15:40,161,023...40,221,136
JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein IEP RGD PMID:16391854 RGD:7488899 NCBI chr22:20,917,407...20,953,747
Ensembl chr22:20,917,407...20,953,747
JBrowse link
G CTNNB1 catenin beta 1 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9065402, PMID:9294210, PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 treatment ISO RGD PMID:30381616 RGD:27095891 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 disease_progression ISO RGD PMID:18413816 RGD:5135268 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
JBrowse link
G DCC DCC netrin 1 receptor IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:8188295 NCBI chr18:52,340,172...53,535,899
Ensembl chr18:52,340,197...53,535,903
JBrowse link
G DLC1 DLC1 Rho GTPase activating protein IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10649492 NCBI chr 8:13,083,361...13,604,620
Ensembl chr 8:13,083,361...13,604,610
JBrowse link
G EP300 E1A binding protein p300 IAGP ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:10700188, PMID:28492532 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G FANCC FA complementation group C IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003 NCBI chr 9:95,099,054...95,317,730
Ensembl chr 9:95,099,054...95,426,796
JBrowse link
G FANCE FA complementation group E IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003, PMID:28492532 NCBI chr 6:35,452,338...35,467,106
Ensembl chr 6:35,452,338...35,467,102
Ensembl chr 6:35,452,338...35,467,102
JBrowse link
G FGFR3 fibroblast growth factor receptor 3 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:1908846, PMID:7773297, PMID:8589699, PMID:8858131, PMID:9677066, PMID:10073901, PMID:10471491, PMID:10696568, PMID:11038465, PMID:11241532, PMID:11529856, PMID:11879084, PMID:11906172, PMID:12833394, PMID:15772091, PMID:16841094, PMID:17384684, PMID:18642369, PMID:19381019, PMID:19749790, PMID:25157968, PMID:25606676, PMID:25741868, PMID:26619011, PMID:28492532, PMID:30311386 NCBI chr 4:1,793,293...1,808,872
Ensembl chr 4:1,793,293...1,808,872
JBrowse link
G FLCN folliculin IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:12843323, PMID:15805188, PMID:15852235, PMID:18234728, PMID:19457309, PMID:19802896, PMID:20618353, PMID:21937013, PMID:22703879, PMID:23050938, PMID:24033266, PMID:24393238, PMID:24728327, PMID:25594584, PMID:25741868, PMID:28492532, PMID:28558743 NCBI chr17:17,206,946...17,237,188
Ensembl chr17:17,212,212...17,237,188
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand treatment IMP RGD PMID:10842197 RGD:11049504 NCBI chr19:49,474,172...49,487,037
Ensembl chr19:49,474,207...49,486,231
JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 IAGP ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:11807987, PMID:25741868, PMID:28492532 NCBI chr 5:180,601,506...180,650,298
Ensembl chr 5:180,601,506...180,649,624
JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase IMP DNA:::adenoviral delivery of human gene in mouse model of colon cancer RGD PMID:19494278 RGD:5688759 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154
JBrowse link
G IGF2R insulin like growth factor 2 receptor IEP protein:increased expression:serum: RGD PMID:29940770 RGD:14985218 NCBI chr 6:159,969,082...160,111,504
Ensembl chr 6:159,969,082...160,113,507
Ensembl chr 6:159,969,082...160,113,507
JBrowse link
G KDR kinase insert domain receptor IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G MCC MCC regulator of WNT signaling pathway IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:1848370 NCBI chr 5:113,022,101...113,488,453
Ensembl chr 5:113,022,099...113,488,823
JBrowse link
G MLH1 mutL homolog 1 IAGP ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:10495924, PMID:11555625, PMID:11781295, PMID:11948175, PMID:12386821, PMID:12547705, PMID:12658575, PMID:14699485, PMID:15713769, PMID:15731775, PMID:15849733, PMID:15926618, PMID:16995940, PMID:17054581, PMID:17135187, PMID:17210669, PMID:17312306, PMID:17510385, PMID:18205192, PMID:18561205, PMID:19419416, PMID:19698169, PMID:20020535, PMID:20587412, PMID:20682701, PMID:20864636, PMID:21404117, PMID:21952876, PMID:22703879, PMID:22736432, PMID:22753075, PMID:22949379, PMID:24033266, PMID:24344984, PMID:24362816, PMID:25741868, PMID:26247049, PMID:28445943, PMID:28492532 NCBI chr 3:36,993,487...37,050,846
Ensembl chr 3:36,993,350...37,050,846
Ensembl chr 3:36,993,350...37,050,846
JBrowse link
G MLH3 mutL homolog 3 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:11317354 NCBI chr14:75,013,764...75,051,479
Ensembl chr14:75,013,769...75,051,532
Ensembl chr14:75,013,769...75,051,532
JBrowse link
G MSH2 mutS homolog 2 IAGP ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:8062247, PMID:8261515, PMID:9288790, PMID:9718327, PMID:10793088, PMID:12362047, PMID:14970868, PMID:15713769, PMID:15731775, PMID:15849733, PMID:17312306, PMID:17414604, PMID:19459153, PMID:19698169, PMID:20223024, PMID:20591884, PMID:21239990, PMID:21590452, PMID:24278394, PMID:24710284, PMID:25741868, PMID:26467025, PMID:27016151, PMID:28492532, PMID:29238914, PMID:30376427 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 IAGP ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:9299504, PMID:9806551, PMID:10519336, PMID:10521313, PMID:13298683, PMID:15972314 NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262
JBrowse link
G MUTYH mutY DNA glycosylase IAGP ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:11818965, PMID:12606733, PMID:14579148, PMID:14991577, PMID:15188161, PMID:15236166, PMID:15366000, PMID:15635083, PMID:15931596, PMID:15987719, PMID:16134147, PMID:16140997, PMID:16338133, PMID:16492921, PMID:16557584, PMID:16616356, PMID:16941501, PMID:17122612, PMID:17219385, PMID:17368238, PMID:17489848, PMID:17524638, PMID:17581577, PMID:17674103, PMID:17949294, PMID:17956577, PMID:18271935, PMID:18414213, PMID:18506705, PMID:18534194, PMID:19032956, PMID:19245865, PMID:19394335, PMID:19527492, PMID:19531215, PMID:19725997, PMID:19732775, PMID:19793053, PMID:19836313, PMID:19953527, PMID:19998059, PMID:20191381, PMID:20418187, PMID:20618354, PMID:20663686, PMID:20687945, PMID:20725929, PMID:20848659, PMID:21063410, PMID:21167187, PMID:21171015, PMID:21178863, PMID:21443744, PMID:21520333, PMID:21777424, PMID:21815886, PMID:21952991, PMID:22158503, PMID:22266422, PMID:22297469, PMID:22402879, PMID:22473953, PMID:22641385, PMID:22703879, PMID:22722201, PMID:22744763, PMID:22865608, PMID:22922830, PMID:22926731, PMID:22976915, PMID:23007840, PMID:23035301, PMID:23108399, PMID:23322991, PMID:23361220, PMID:23561487, PMID:23605219, PMID:23625202, PMID:23805267, PMID:24033266, PMID:24039736, PMID:24082139, PMID:24278394, PMID:24444654, PMID:24470512, PMID:24691292, PMID:24728327, PMID:24799981, PMID:24953332, PMID:25525159, PMID:25569433, PMID:25741868, PMID:25820570, PMID:25937855, PMID:25980754, PMID:26377631, PMID:26467025, PMID:26681312, PMID:26822237, PMID:26845104, PMID:26976419, PMID:27145315, PMID:27153395, PMID:27600092, PMID:27621404, PMID:27829682, PMID:28135145, PMID:28492532, PMID:28634180, PMID:28944238, PMID:30151275, PMID:30256826, PMID:30564557 NCBI chr 1:45,329,242...45,340,447
Ensembl chr 1:45,329,163...45,340,893
JBrowse link
G NRAS NRAS proto-oncogene, GTPase IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:2674680, PMID:3102434, PMID:8120410, PMID:16291983, PMID:18390968, PMID:18633438, PMID:20130576, PMID:20179705, PMID:22962325, PMID:23414587, PMID:25157968, PMID:26619011 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
JBrowse link
G PALB2 partner and localizer of BRCA2 IAGP ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:18053174, PMID:25741868, PMID:26283626, PMID:26315354, PMID:26467025, PMID:26580448, PMID:26689913, PMID:28135145, PMID:28492532, PMID:28944238 NCBI chr16:23,603,162...23,641,337
Ensembl chr16:23,603,160...23,641,310
JBrowse link
G PDGFRL platelet derived growth factor receptor like IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:7898930 NCBI chr 8:17,576,433...17,643,144
Ensembl chr 8:17,576,433...17,644,071
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:15016963, PMID:15254419, PMID:15520168, PMID:15608678, PMID:15647370, PMID:15805248, PMID:16906227, PMID:16930767, PMID:17376864, PMID:17673550, PMID:18676830, PMID:18725974, PMID:19029981, PMID:19223544, PMID:19366826, PMID:19513541, PMID:19903786, PMID:20453058, PMID:20619739, PMID:21430269, PMID:21558396, PMID:21824802, PMID:22162582, PMID:22162589, PMID:22271473, PMID:22658544, PMID:22729222, PMID:22729223, PMID:22729224, PMID:23066039, PMID:23100325, PMID:23888070, PMID:24033266, PMID:24265155, PMID:24782230, PMID:25157968, PMID:25741868, PMID:26266975, PMID:26266985, PMID:26619011, PMID:26822237, PMID:27626068, PMID:27631024, PMID:28492532 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G POLD1 DNA polymerase delta 1, catalytic subunit IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25637381, PMID:25741868, PMID:26467025, PMID:28492532 NCBI chr19:50,384,291...50,418,018
Ensembl chr19:50,384,204...50,418,018
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10394368 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRF1 perforin 1 ISO RGD PMID:22420317 RGD:6482822 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:7509295 NCBI chr 7:77,537,190...77,640,069
Ensembl chr 7:77,537,295...77,640,069
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:12089527 NCBI chr11:47,980,504...48,170,839
Ensembl chr11:47,980,558...48,170,841
JBrowse link
G RAD54B RAD54 homolog B IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10362364 NCBI chr 8:94,371,960...94,475,115
Ensembl chr 8:94,371,960...94,475,115
Ensembl chr 8:94,371,960...94,475,115
JBrowse link
G REV3L REV3 like, DNA directed polymerase zeta catalytic subunit IAGP ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003 NCBI chr 6:111,299,033...111,483,711
Ensembl chr 6:111,299,028...111,483,715
JBrowse link
G TGFB1 transforming growth factor beta 1 disease_progression IEP RGD PMID:11166150 RGD:13432074 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB2 transforming growth factor beta 2 disease_progression IEP
ISO
RGD PMID:11166150, PMID:10416598 RGD:13432074, RGD:13432084 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TLR3 toll like receptor 3 IEP protein:increased expression:colon RGD PMID:23467704 RGD:21079438 NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,069,152...186,088,069
Ensembl chr 4:186,069,152...186,088,069
JBrowse link
G TNFRSF17 TNF receptor superfamily member 17 IDA RGD PMID:11104810 RGD:2317311 NCBI chr16:11,965,210...11,968,068
Ensembl chr16:11,965,210...11,968,068
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A IEP protein:increased expression:serum (human) RGD PMID:1655258 RGD:5131434 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B IEP protein:increased expression:serum (human) RGD PMID:1655258 RGD:5131434 NCBI chr 1:12,166,948...12,209,222
Ensembl chr 1:12,166,991...12,209,228
JBrowse link
G TP53 tumor protein p53 IAGP ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:1565143, PMID:1565144, PMID:1683921, PMID:1978757, PMID:7732013, PMID:7887414, PMID:8164043, PMID:8198984, PMID:8203469, PMID:8423216, PMID:8825920, PMID:9047394, PMID:9242456, PMID:9290701, PMID:9569050, PMID:9865903, PMID:10064694, PMID:10411893, PMID:10797439, PMID:10864200, PMID:11040944, PMID:11101847, PMID:11139324, PMID:11180592, PMID:11391594, PMID:11479205, PMID:11782540, PMID:11920959, PMID:12007217, PMID:12619118, PMID:12672316, PMID:12826609, PMID:15004724, PMID:15173255, PMID:15381368, PMID:15390294, PMID:15580553, PMID:15607980, PMID:15607981, PMID:15825182, PMID:15925506, PMID:15951970, PMID:15977174, PMID:16401470, PMID:16489069, PMID:16682957, PMID:16818505, PMID:17224268, PMID:17289876, PMID:17540308, PMID:17606709, PMID:17636407, PMID:17727479, PMID:18391940, PMID:18511570, PMID:18555592, PMID:19127115, PMID:19367569, PMID:19556618, PMID:19881536, PMID:20113312, PMID:20128691, PMID:20407015, PMID:20516128, PMID:20689556, PMID:20693561, PMID:21187651, PMID:21232794, PMID:21305319, PMID:21343334, PMID:21484931, PMID:21512767, PMID:21519010, PMID:21552135, PMID:21601526, PMID:21761402, PMID:22006311, PMID:22110706, PMID:22186996, PMID:22233476, PMID:22652532, PMID:22698404, PMID:22710932, PMID:22811390, PMID:22899716, PMID:22915647, PMID:22919068, PMID:23161690, PMID:23246812, PMID:23263379, PMID:23484829, PMID:23538418, PMID:23792586, PMID:23894400, PMID:24033266, PMID:24381225, PMID:24487413, PMID:24501221, PMID:24573247, PMID:24641375, PMID:24651012, PMID:24677579, PMID:24728327, PMID:24810334, PMID:24868540, PMID:25157968, PMID:25525159, PMID:25527155, PMID:25584008, PMID:25741868, PMID:25787918, PMID:25952993, PMID:26086041, PMID:26230955, PMID:26467025, PMID:26585234, PMID:26619011, PMID:26681312, PMID:26822237, PMID:26845104, PMID:27153395, PMID:27276561, PMID:27374712, PMID:27463065, PMID:27493922, PMID:27516001, PMID:27680515, PMID:27683180, PMID:27895058, PMID:27959731, PMID:28125078, PMID:28349240, PMID:28369373, PMID:28453743, PMID:28492532, PMID:28772286, PMID:28861920, PMID:29478780, PMID:29489754, PMID:29945567, PMID:30076369, PMID:30224644, PMID:30287823, PMID:30327374, PMID:30374176, PMID:30883245, PMID:31016814, PMID:31159747 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TYMS thymidylate synthetase IMP human tumor in mouse model RGD PMID:17848948 RGD:5133430 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 IEP mRNA:increased expression:colonic mucosa (human) RGD PMID:8541345 RGD:11352739 NCBI chr19:18,563,766...18,577,550
Ensembl chr19:18,571,730...18,577,550
JBrowse link
G VEGFA vascular endothelial growth factor A treatment IDA RGD PMID:18657413 RGD:15003195 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
colon adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA7 annexin A7 IEP protein:decreased expression:colon RGD PMID:17708571 RGD:2292654 NCBI chr10:73,375,101...73,414,058
Ensembl chr10:73,375,101...73,414,076
JBrowse link
G APC APC regulator of WNT signaling pathway ISO
IAGP
associated with Adenomatous Polyposis Coli;DNA:point mutation:CDS:p.K1137X (3409A>T) (rat)
ClinVar Annotator: match by term: Adenocarcinoma of the colon
ClinVar PMID:24033266, PMID:24728327, PMID:25741868, PMID:27978560, PMID:28492532, PMID:17360473 RGD:1601201 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G BAX BCL2 associated X, apoptosis regulator susceptibility IAGP DNA:frameshift mutation: ; RGD PMID:9020077 RGD:734633 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CSF2 colony stimulating factor 2 treatment ISO RGD PMID:10830715 RGD:10450245 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CTNNB1 catenin beta 1 ISO DNA:mutation RGD PMID:16886601 RGD:1599637 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G DAXX death domain associated protein IEP protein:decreased expression:colon: RGD PMID:16569639 RGD:9587838 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016
JBrowse link
G FECH ferrochelatase IEP mRNA:decreased expression:colon RGD PMID:28075030 RGD:14700888 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
G HMGB1 high mobility group box 1 ISO RGD PMID:20616616 RGD:10402080 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 IDA RGD PMID:24691442 RGD:13210775 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 IDA RGD PMID:24691442 RGD:13210775 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase ISO mRNA:decreased expression:colon (rat) RGD PMID:16886601 RGD:1599637 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MIR155 microRNA 155 treatment IMP RGD PMID:29535520 RGD:21409754 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044
JBrowse link
G MSH2 mutS homolog 2 IAGP ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:8261515, PMID:10978353, PMID:14580774, PMID:15365996, PMID:15655560, PMID:16614121, PMID:17374836, PMID:18325052, PMID:18561205, PMID:22977643, PMID:24033266, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSH6 mutS homolog 6 IAGP ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:25741868 NCBI chr 2:47,783,145...47,806,954
Ensembl chr 2:47,695,530...47,810,101
Ensembl chr 2:47,695,530...47,810,101
JBrowse link
G PCSK5 proprotein convertase subtilisin/kexin type 5 IEP mRNA:decreased expression:colon: RGD PMID:19737405 RGD:11556207 NCBI chr 9:75,890,646...76,362,975
Ensembl chr 9:75,890,644...76,362,975
Ensembl chr 9:75,890,644...76,362,975
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IAGP DNA:mutation RGD PMID:17575153 RGD:5685670 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 treatment IDA RGD PMID:24632606 RGD:13432053 NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036
JBrowse link
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D IAGP ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:30311386 NCBI chr17:60,600,187...60,666,280
Ensembl chr17:60,600,183...60,666,280
JBrowse link
G RAC1 Rac family small GTPase 1 treatment IEP
IMP
mRNA:alternative form RGD PMID:10597294, PMID:19561401 RGD:13432049, RGD:13432051 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RAD54L RAD54 like IAGP ClinVar Annotator: match by term: Colonic adenocarcinoma ClinVar PMID:10362365 NCBI chr 1:46,247,688...46,278,477
Ensembl chr 1:46,246,461...46,278,480
JBrowse link
G SRSF4 serine and arginine rich splicing factor 4 IEP mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 1:29,147,743...29,181,900
Ensembl chr 1:29,147,743...29,181,900
JBrowse link
G SRSF5 serine and arginine rich splicing factor 5 IEP mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr14:69,767,112...69,772,005
Ensembl chr14:69,726,900...69,772,005
JBrowse link
G SRSF6 serine and arginine rich splicing factor 6 IEP mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr20:43,457,893...43,464,243
Ensembl chr20:43,457,893...43,466,046
JBrowse link
G TERT telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TGFB1 transforming growth factor beta 1 disease_progression IMP RGD PMID:9019169 RGD:13432089 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G VEGFC vascular endothelial growth factor C ISO mRNA:increased expression:colon RGD PMID:18424890 RGD:2315488 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17777
    disease of cellular proliferation 6722
      cancer 4550
        cell type cancer 3378
          carcinoma 2183
            colon carcinoma 75
              adenosquamous colon carcinoma 0
              colon adenocarcinoma + 26
              colon carcinoma in situ 0
              colon small cell carcinoma 0
              colon squamous cell carcinoma 0
              medullary colon carcinoma 0
Path 2
Term Annotations click to browse term
  disease 17777
    disease of anatomical entity 16339
      gastrointestinal system disease 4566
        Gastrointestinal Diseases 2654
          Gastrointestinal Neoplasms 1799
            Intestinal Neoplasms 693
              intestinal cancer 250
                large intestine cancer 246
                  colorectal cancer 246
                    colon cancer 130
                      colon carcinoma 75
                        adenosquamous colon carcinoma 0
                        colon adenocarcinoma + 26
                        colon carcinoma in situ 0
                        colon small cell carcinoma 0
                        colon squamous cell carcinoma 0
                        medullary colon carcinoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.