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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:colon carcinoma
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Accession:DOID:1520 term browser browse the term
Definition:A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. (DO)
Synonyms:exact_synonym: carcinoma of colon;   colonic carcinoma
 primary_id: RDO:9002019
 xref: NCI:C4910
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
colon carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:17611497, PMID:18256540, PMID:18392055, PMID:18504432, PMID:18611285, PMID:19418217, PMID:19487299, PMID:19853286, PMID:20233444, PMID:20453058, PMID:21464312, PMID:21512767, PMID:21793738, PMID:22538770, PMID:22610119, PMID:22722201, PMID:22722839, PMID:22980975, PMID:23237847, PMID:23348505, PMID:23700467, PMID:23728071, PMID:23934607, PMID:24190505, PMID:24657128, PMID:25157968, PMID:26619011, PMID:28492532
G AMCF-II alveolar macrophage-derived chemotactic factor-II disease_progression ISO RGD PMID:18413816 RGD:5135268 NCBI chr 8:70,008,225...70,010,360
Ensembl chr 8:70,008,162...70,010,358
JBrowse link
G APC APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Carcinoma of colon
ClinVar Annotator: match by term: Colonic carcinoma
ClinVar PMID:1338904, PMID:1528264, PMID:8187091, PMID:8381579, PMID:8940262, PMID:9288102, PMID:9585599, PMID:9724771, PMID:9731522, PMID:9731533, PMID:9751605, PMID:9831355, PMID:9869602, PMID:9869603, PMID:9869620, PMID:9950360, PMID:9973276, PMID:10439961, PMID:10679643, PMID:10737795, PMID:10938175, PMID:11001924, PMID:11159880, PMID:11207040, PMID:11354631, PMID:12173321, PMID:12533824, PMID:14624392, PMID:14633595, PMID:15712637, PMID:15929773, PMID:16140997, PMID:16228836, PMID:16569251, PMID:16875934, PMID:17854661, PMID:18343606, PMID:19047896, PMID:19768578, PMID:20223039, PMID:20685668, PMID:22703879, PMID:22810696, PMID:23204322, PMID:23576677, PMID:23896379, PMID:24033266, PMID:24310308, PMID:24416237, PMID:24599579, PMID:24728327, PMID:24861525, PMID:25157968, PMID:25604157, PMID:25741868, PMID:25980754, PMID:25981591, PMID:26187149, PMID:26300997, PMID:26314409, PMID:26332594, PMID:26394139, PMID:26421687, PMID:26467025, PMID:26625971, PMID:26845104, PMID:27146957, PMID:27153395, PMID:27978560, PMID:28050010, PMID:28135136, PMID:28135145, PMID:28492532, PMID:28749474, PMID:29478780, PMID:29506128, PMID:29961768, PMID:30152102, PMID:30426508, PMID:30487145 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,912
JBrowse link
G AXIN2 axin 2 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:11017067, PMID:28492532 NCBI chr12:12,311,293...12,343,207
Ensembl chr12:12,311,293...12,343,200
JBrowse link
G BARD1 BRCA1 associated RING domain 1 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:25741868, PMID:26350354, PMID:28135145, PMID:28492532, PMID:31371347 NCBI chr15:117,049,483...117,135,889
Ensembl chr15:117,047,839...117,175,851
JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9020077 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL10 BCL10 immune signaling adaptor ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9989495 NCBI chr 4:130,645,427...130,653,317
Ensembl chr 4:130,645,174...130,657,995
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase treatment ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
RGD
ClinVar
PMID:12068308, PMID:12198537, PMID:12447372, PMID:12460918, PMID:12460919, PMID:12619120, PMID:12644542, PMID:12670889, PMID:12692057, PMID:12794760, PMID:12960123, PMID:14513361, PMID:14602780, PMID:14679157, PMID:15001635, PMID:15035987, PMID:15126572, PMID:15181070, PMID:15342696, PMID:15356022, PMID:15386408, PMID:15687339, PMID:15998781, PMID:16015629, PMID:16174717, PMID:16187918, PMID:16772349, PMID:17374713, PMID:17488796, PMID:17704260, PMID:17785355, PMID:18039235, PMID:18060073, PMID:18398503, PMID:18413255, PMID:19001320, PMID:19010912, PMID:19018267, PMID:19238210, PMID:19404918, PMID:19537845, PMID:19561230, PMID:20008640, PMID:20350999, PMID:20413299, PMID:20619739, PMID:20630094, PMID:20818844, PMID:20823850, PMID:20857202, PMID:21107320, PMID:21107323, PMID:21129611, PMID:21156289, PMID:21163703, PMID:21426297, PMID:21483012, PMID:21502544, PMID:21639808, PMID:21641636, PMID:21683865, PMID:21975775, PMID:22038996, PMID:22048237, PMID:22113612, PMID:22180495, PMID:22281684, PMID:22319199, PMID:22351686, PMID:22356324, PMID:22389471, PMID:22448344, PMID:22536370, PMID:22586120, PMID:22608338, PMID:22649091, PMID:22663011, PMID:22735384, PMID:22743296, PMID:22773810, PMID:22805292, PMID:22972589, PMID:22997239, PMID:23020132, PMID:23031422, PMID:23251002, PMID:23302800, PMID:23325582, PMID:23470635, PMID:23524406, PMID:23549875, PMID:23614898, PMID:23680146, PMID:23685455, PMID:23812671, PMID:23833300, PMID:23845441, PMID:23918947, PMID:24033266, PMID:24107445, PMID:24112392, PMID:24163374, PMID:24388723, PMID:24508103, PMID:24512911, PMID:24576830, PMID:24583796, PMID:24586605, PMID:24594804, PMID:24670642, PMID:24717435, PMID:25024077, PMID:25037139, PMID:25079330, PMID:25155755, PMID:25157968, PMID:25265492, PMID:25265494, PMID:25370471, PMID:25399551, PMID:25741868, PMID:25950823, PMID:25989278, PMID:26619011, PMID:26678033, PMID:27404270, PMID:27480103, PMID:28492532, PMID:28854169, PMID:28891408, PMID:29925953, PMID:31779674, PMID:31891627 RGD:11567267 NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,959...9,132,553
JBrowse link
G BRCA2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Carcinoma of colon
ClinVar Annotator: match by term: Colonic carcinoma
ClinVar PMID:15937982, PMID:16758124, PMID:20167696, PMID:21520333, PMID:24814045, PMID:25058500, PMID:25348012, PMID:25741868, PMID:27165003, PMID:28223274, PMID:28492532, PMID:29394989, PMID:29849630, PMID:29881398, PMID:29884841, PMID:30254663 NCBI chr11:8,805,950...8,858,128 JBrowse link
G BRIP1 BRCA1 interacting protein C-terminal helicase 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:21964575, PMID:25058500, PMID:25741868, PMID:27165003, PMID:28492532 NCBI chr12:36,498,138...36,639,847
Ensembl chr12:36,443,697...36,634,088
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9521327 NCBI chr 3:45,585,188...45,623,240
Ensembl chr 3:45,585,226...45,624,543
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9521327, PMID:24728327, PMID:28492532 NCBI chr 1:131,093,026...131,143,840 JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein ISO RGD PMID:16391854 RGD:7488899 NCBI chr14:50,528,950...50,558,664
Ensembl chr14:50,528,954...50,558,663
JBrowse link
G CTNNB1 catenin beta 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9065402, PMID:9294210, PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 treatment ISO RGD PMID:30381616 RGD:27095891 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
JBrowse link
G DCC DCC netrin 1 receptor ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:8188295 NCBI chr 1:101,518,629...103,087,021
Ensembl chr 1:102,080,200...103,087,249
JBrowse link
G DLC1 DLC1 Rho GTPase activating protein ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10649492 NCBI chr17:1,169,709...1,637,171
Ensembl chr17:1,170,195...1,637,162
JBrowse link
G EP300 E1A binding protein p300 ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:10700188, PMID:28492532 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760
JBrowse link
G FANCC FA complementation group C ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003 NCBI chr10:26,796,546...27,055,271 JBrowse link
G FGFR3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:1908846, PMID:7773297, PMID:8589699, PMID:8858131, PMID:9677066, PMID:10073901, PMID:10471491, PMID:10696568, PMID:11038465, PMID:11241532, PMID:11529856, PMID:11879084, PMID:11906172, PMID:12833394, PMID:15772091, PMID:16841094, PMID:17384684, PMID:18642369, PMID:19381019, PMID:19749790, PMID:25157968, PMID:25606676, PMID:25741868, PMID:26619011, PMID:28492532, PMID:30311386 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,151...895,912
JBrowse link
G FLCN folliculin ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:12843323, PMID:15805188, PMID:15852235, PMID:18234728, PMID:19457309, PMID:19802896, PMID:20618353, PMID:21937013, PMID:22703879, PMID:23050938, PMID:24033266, PMID:24393238, PMID:24728327, PMID:25594584, PMID:25741868, PMID:28492532, PMID:28558743 NCBI chr12:61,029,186...61,045,400 JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,620,700...5,795,264
JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:11807987, PMID:25741868, PMID:28492532 NCBI chr 2:78,076,008...78,115,137
Ensembl chr 2:78,076,080...78,115,137
JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase ISO DNA:::adenoviral delivery of human gene in mouse model of colon cancer RGD PMID:19494278 RGD:5688759 NCBI chr14:15,718,261...15,773,534
Ensembl chr14:15,718,266...15,763,710
JBrowse link
G IGF2R insulin like growth factor 2 receptor ISO protein:increased expression:serum: RGD PMID:29940770 RGD:14985218 NCBI chr 1:7,369,485...7,472,480
Ensembl chr 1:7,368,103...7,472,548
JBrowse link
G KDR kinase insert domain receptor ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,116...41,856,339
JBrowse link
G MCC MCC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:1848370 NCBI chr 2:116,286,353...116,748,620
Ensembl chr 2:116,287,198...116,741,955
JBrowse link
G MLH1 mutL homolog 1 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:10495924, PMID:11555625, PMID:11781295, PMID:11948175, PMID:12386821, PMID:12547705, PMID:12658575, PMID:14699485, PMID:15713769, PMID:15731775, PMID:15849733, PMID:15926618, PMID:16995940, PMID:17054581, PMID:17135187, PMID:17210669, PMID:17312306, PMID:17510385, PMID:18205192, PMID:18561205, PMID:19419416, PMID:19698169, PMID:20020535, PMID:20587412, PMID:20682701, PMID:20864636, PMID:21404117, PMID:21952876, PMID:22703879, PMID:22736432, PMID:22753075, PMID:22949379, PMID:24033266, PMID:24344984, PMID:24362816, PMID:25741868, PMID:26247049, PMID:28445943, PMID:28492532 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:8062247, PMID:8261515, PMID:9288790, PMID:9718327, PMID:10793088, PMID:12362047, PMID:14970868, PMID:15713769, PMID:15731775, PMID:15849733, PMID:17312306, PMID:17414604, PMID:19459153, PMID:19698169, PMID:20223024, PMID:20591884, PMID:21239990, PMID:21590452, PMID:24278394, PMID:24710284, PMID:25741868, PMID:26467025, PMID:27016151, PMID:28492532, PMID:29238914, PMID:30376427 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:9299504, PMID:9806551, PMID:10519336, PMID:10521313, PMID:13298683, PMID:15972314 NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876
JBrowse link
G MUTYH mutY DNA glycosylase ISO ClinVar Annotator: match by term: Carcinoma of colon
ClinVar Annotator: match by term: Colonic carcinoma
ClinVar PMID:11818965, PMID:12606733, PMID:14579148, PMID:14991577, PMID:15188161, PMID:15236166, PMID:15366000, PMID:15635083, PMID:15931596, PMID:15987719, PMID:16134147, PMID:16140997, PMID:16338133, PMID:16492921, PMID:16557584, PMID:16616356, PMID:16941501, PMID:17122612, PMID:17219385, PMID:17368238, PMID:17489848, PMID:17524638, PMID:17581577, PMID:17674103, PMID:17949294, PMID:17956577, PMID:18271935, PMID:18414213, PMID:18506705, PMID:18534194, PMID:19032956, PMID:19245865, PMID:19394335, PMID:19527492, PMID:19531215, PMID:19725997, PMID:19732775, PMID:19793053, PMID:19836313, PMID:19953527, PMID:19998059, PMID:20191381, PMID:20418187, PMID:20618354, PMID:20663686, PMID:20687945, PMID:20725929, PMID:20848659, PMID:21063410, PMID:21167187, PMID:21171015, PMID:21178863, PMID:21443744, PMID:21520333, PMID:21777424, PMID:21815886, PMID:21952991, PMID:22158503, PMID:22266422, PMID:22297469, PMID:22402879, PMID:22473953, PMID:22641385, PMID:22703879, PMID:22722201, PMID:22744763, PMID:22865608, PMID:22922830, PMID:22926731, PMID:22976915, PMID:23007840, PMID:23035301, PMID:23108399, PMID:23322991, PMID:23361220, PMID:23561487, PMID:23605219, PMID:23625202, PMID:23805267, PMID:24033266, PMID:24039736, PMID:24082139, PMID:24278394, PMID:24444654, PMID:24470512, PMID:24691292, PMID:24728327, PMID:24799981, PMID:24953332, PMID:25525159, PMID:25569433, PMID:25741868, PMID:25820570, PMID:25937855, PMID:25980754, PMID:26377631, PMID:26467025, PMID:26681312, PMID:26822237, PMID:26845104, PMID:26976419, PMID:27145315, PMID:27153395, PMID:27600092, PMID:27621404, PMID:27829682, PMID:28135145, PMID:28492532, PMID:28634180, PMID:28944238, PMID:30151275, PMID:30256826, PMID:30564557 NCBI chr 6:166,002,853...166,012,191 JBrowse link
G NRAS NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:2674680, PMID:3102434, PMID:8120410, PMID:16291983, PMID:18390968, PMID:18633438, PMID:20130576, PMID:20179705, PMID:22962325, PMID:23414587, PMID:25157968, PMID:26619011 NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227
JBrowse link
G PALB2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:18053174, PMID:25741868, PMID:26283626, PMID:26315354, PMID:26467025, PMID:26580448, PMID:26689913, PMID:28135145, PMID:28492532, PMID:28944238 NCBI chr 3:22,586,881...22,612,837
Ensembl chr 3:22,586,856...22,612,835
JBrowse link
G PDGFRL platelet derived growth factor receptor like ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:7898930 NCBI chr17:5,278,872...5,328,859
Ensembl chr17:5,279,004...5,329,511
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:15016963, PMID:15254419, PMID:15520168, PMID:15608678, PMID:15647370, PMID:15805248, PMID:16906227, PMID:16930767, PMID:17376864, PMID:17673550, PMID:18676830, PMID:18725974, PMID:19029981, PMID:19223544, PMID:19366826, PMID:19513541, PMID:19903786, PMID:20453058, PMID:20619739, PMID:21430269, PMID:21558396, PMID:21824802, PMID:22162582, PMID:22162589, PMID:22271473, PMID:22658544, PMID:22729222, PMID:22729223, PMID:22729224, PMID:23066039, PMID:23100325, PMID:23888070, PMID:24033266, PMID:24265155, PMID:24782230, PMID:25157968, PMID:25741868, PMID:26266975, PMID:26266985, PMID:26619011, PMID:26822237, PMID:27626068, PMID:27631024, PMID:28492532 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G POLD1 DNA polymerase delta 1, catalytic subunit ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25637381, PMID:25741868, PMID:26467025, PMID:28492532 NCBI chr 6:55,247,799...55,272,087
Ensembl chr 6:55,247,861...55,272,166
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10394368 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PRF1 perforin 1 ISO RGD PMID:22420317 RGD:6482822 NCBI chr14:73,515,306...73,520,256
Ensembl chr14:73,512,769...73,520,202
JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:7509295 NCBI chr 9:102,480,914...102,563,969
Ensembl chr 9:102,480,922...102,563,905
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:12089527 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,425...14,726,715
JBrowse link
G RAD54B RAD54 homolog B ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10362364 NCBI chr 4:42,249,482...42,369,408
Ensembl chr 4:42,249,512...42,369,447
JBrowse link
G REV3L REV3 like, DNA directed polymerase zeta catalytic subunit ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003 NCBI chr 1:77,196,592...77,400,551
Ensembl chr 1:77,197,409...77,400,137
JBrowse link
G TGFB1 transforming growth factor beta 1 disease_progression ISO RGD PMID:11166150 RGD:13432074 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TGFB2 transforming growth factor beta 2 disease_progression ISO RGD PMID:10416598, PMID:11166150 RGD:13432074, RGD:13432084 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
G TLR3 toll like receptor 3 ISO protein:increased expression:colon RGD PMID:23467704 RGD:21079438 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,966,040...47,058,734
JBrowse link
G TNFRSF17 TNF receptor superfamily member 17 ISO RGD PMID:11104810 RGD:2317311 NCBI chr 3:31,137,672...31,141,862
Ensembl chr 3:31,137,682...31,141,868
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:serum (human) RGD PMID:1655258 RGD:5131434 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,073...64,331,909
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:serum (human) RGD PMID:1655258 RGD:5131434 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,149
JBrowse link
G TP53 tumor protein p53 ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:1565143, PMID:1565144, PMID:1683921, PMID:1978757, PMID:7732013, PMID:7887414, PMID:8164043, PMID:8198984, PMID:8203469, PMID:8423216, PMID:8825920, PMID:9047394, PMID:9242456, PMID:9290701, PMID:9569050, PMID:9865903, PMID:10064694, PMID:10411893, PMID:10797439, PMID:10864200, PMID:11040944, PMID:11101847, PMID:11139324, PMID:11180592, PMID:11391594, PMID:11479205, PMID:11782540, PMID:11920959, PMID:12007217, PMID:12619118, PMID:12672316, PMID:12826609, PMID:15004724, PMID:15173255, PMID:15381368, PMID:15390294, PMID:15580553, PMID:15607980, PMID:15607981, PMID:15825182, PMID:15925506, PMID:15951970, PMID:15977174, PMID:16401470, PMID:16489069, PMID:16682957, PMID:16818505, PMID:17224268, PMID:17289876, PMID:17540308, PMID:17606709, PMID:17636407, PMID:17727479, PMID:18391940, PMID:18511570, PMID:18555592, PMID:19127115, PMID:19367569, PMID:19556618, PMID:19881536, PMID:20113312, PMID:20128691, PMID:20407015, PMID:20516128, PMID:20689556, PMID:20693561, PMID:21187651, PMID:21232794, PMID:21305319, PMID:21343334, PMID:21484931, PMID:21512767, PMID:21519010, PMID:21552135, PMID:21601526, PMID:21761402, PMID:22006311, PMID:22110706, PMID:22186996, PMID:22233476, PMID:22652532, PMID:22698404, PMID:22710932, PMID:22811390, PMID:22899716, PMID:22915647, PMID:22919068, PMID:23161690, PMID:23246812, PMID:23263379, PMID:23484829, PMID:23538418, PMID:23792586, PMID:23894400, PMID:24033266, PMID:24381225, PMID:24487413, PMID:24501221, PMID:24573247, PMID:24641375, PMID:24651012, PMID:24677579, PMID:24728327, PMID:24810334, PMID:24868540, PMID:25157968, PMID:25525159, PMID:25527155, PMID:25584008, PMID:25741868, PMID:25787918, PMID:25952993, PMID:26086041, PMID:26230955, PMID:26467025, PMID:26585234, PMID:26619011, PMID:26681312, PMID:26822237, PMID:26845104, PMID:27153395, PMID:27276561, PMID:27374712, PMID:27463065, PMID:27493922, PMID:27516001, PMID:27680515, PMID:27683180, PMID:27895058, PMID:27959731, PMID:28125078, PMID:28349240, PMID:28369373, PMID:28453743, PMID:28492532, PMID:28772286, PMID:28861920, PMID:29478780, PMID:29489754, PMID:29945567, PMID:30076369, PMID:30224644, PMID:30287823, PMID:30327374, PMID:30374176, PMID:30883245, PMID:31016814, PMID:31159747 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G TYMS thymidylate synthetase ISO human tumor in mouse model RGD PMID:17848948 RGD:5133430 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,640,031...105,660,601
JBrowse link
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 ISO mRNA:increased expression:colonic mucosa (human) RGD PMID:8541345 RGD:11352739 NCBI chr 2:59,238,802...59,241,512 JBrowse link
G VEGFA vascular endothelial growth factor A treatment ISO RGD PMID:18657413 RGD:15003195 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
colon adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA7 annexin A7 ISO protein:decreased expression:colon RGD PMID:17708571 RGD:2292654 NCBI chr14:76,205,238...76,234,646
Ensembl chr14:76,205,224...76,234,631
JBrowse link
G APC APC regulator of WNT signaling pathway ISO associated with Adenomatous Polyposis Coli;DNA:point mutation:CDS:p.K1137X (3409A>T) (rat)
ClinVar Annotator: match by term: Adenocarcinoma of the colon
RGD
ClinVar
PMID:17360473, PMID:24033266, PMID:24728327, PMID:25741868, PMID:27978560, PMID:28492532 RGD:1601201 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,912
JBrowse link
G BAX BCL2 associated X, apoptosis regulator susceptibility ISO DNA:frameshift mutation: ; RGD PMID:9020077 RGD:734633 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G CSF2 colony stimulating factor 2 treatment ISO RGD PMID:10830715 RGD:10450245 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G CTNNB1 catenin beta 1 ISO DNA:mutation RGD PMID:16886601 RGD:1599637 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G DAXX death domain associated protein ISO protein:decreased expression:colon: RGD PMID:16569639 RGD:9587838 NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,854...29,681,110
JBrowse link
G FECH ferrochelatase ISO mRNA:decreased expression:colon RGD PMID:28075030 RGD:14700888 NCBI chr 1:106,861,628...106,898,407
Ensembl chr 1:106,854,002...106,898,418
JBrowse link
G HMGB1 high mobility group box 1 ISO RGD PMID:20616616 RGD:10402080 NCBI chr11:7,195,556...7,321,071 JBrowse link
G LOC100511937 phosphatidylinositol 3-kinase regulatory subunit gamma treatment ISO RGD PMID:24632606 RGD:13432053 NCBI chr 6:165,268,260...165,402,668 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO RGD PMID:24691442 RGD:13210775 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO RGD PMID:24691442 RGD:13210775 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase ISO mRNA:decreased expression:colon (rat) RGD PMID:16886601 RGD:1599637 NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,161...138,779,938
JBrowse link
G MIR155 microRNA mir-155 treatment ISO RGD PMID:29535520 RGD:21409754 NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902
JBrowse link
G MSH2 mutS homolog 2 ISO ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:8261515, PMID:10978353, PMID:14580774, PMID:15365996, PMID:15655560, PMID:16614121, PMID:17374836, PMID:18325052, PMID:18561205, PMID:22977643, PMID:24033266, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MSH6 mutS homolog 6 ISO ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:25741868 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,128
JBrowse link
G PCSK5 proprotein convertase subtilisin/kexin type 5 ISO mRNA:decreased expression:colon: RGD PMID:19737405 RGD:11556207 NCBI chr 1:228,854,587...229,308,054
Ensembl chr 1:228,854,595...229,308,906
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO DNA:mutation RGD PMID:17575153 RGD:5685670 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D ISO ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:30311386 NCBI chr12:37,485,601...37,536,159
Ensembl chr12:37,485,586...37,536,146
JBrowse link
G RAC1 Rac family small GTPase 1 treatment ISO mRNA:alternative form RGD PMID:10597294, PMID:19561401 RGD:13432049, RGD:13432051 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,771...4,803,687
JBrowse link
G RAD54L RAD54 like ISO ClinVar Annotator: match by term: Colonic adenocarcinoma ClinVar PMID:10362365 NCBI chr 6:165,156,833...165,184,641
Ensembl chr 6:165,152,978...165,184,776
JBrowse link
G SRSF4 serine and arginine rich splicing factor 4 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 6:86,064,776...86,092,769
Ensembl chr 6:85,891,364...86,131,682
JBrowse link
G SRSF5 serine and arginine rich splicing factor 5 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 7:93,393,379...93,398,510
Ensembl chr 7:93,393,426...93,403,015
JBrowse link
G SRSF6 serine and arginine rich splicing factor 6 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr17:46,119,612...46,122,540
Ensembl chr17:46,119,409...46,173,944
JBrowse link
G TERT telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421
JBrowse link
G TGFB1 transforming growth factor beta 1 disease_progression ISO RGD PMID:9019169 RGD:13432089 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G VEGFC vascular endothelial growth factor C ISO mRNA:increased expression:colon RGD PMID:18424890 RGD:2315488 NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,037,893...39,133,041
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12615
    disease of cellular proliferation 5453
      cancer 3978
        cell type cancer 2960
          carcinoma 1973
            colon carcinoma 72
              adenosquamous colon carcinoma 0
              colon adenocarcinoma + 26
              colon carcinoma in situ 0
              colon small cell carcinoma 0
              colon squamous cell carcinoma 0
              medullary colon carcinoma 0
Path 2
Term Annotations click to browse term
  disease 12615
    disease of anatomical entity 12148
      gastrointestinal system disease 4070
        Gastrointestinal Diseases 2407
          Gastrointestinal Neoplasms 1663
            Intestinal Neoplasms 648
              intestinal cancer 234
                large intestine cancer 230
                  colorectal cancer 230
                    colon cancer 124
                      colon carcinoma 72
                        adenosquamous colon carcinoma 0
                        colon adenocarcinoma + 26
                        colon carcinoma in situ 0
                        colon small cell carcinoma 0
                        colon squamous cell carcinoma 0
                        medullary colon carcinoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.