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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:colon carcinoma
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Accession:DOID:1520 term browser browse the term
Definition:A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. (DO)
Synonyms:exact_synonym: carcinoma of colon;   colonic carcinoma
 primary_id: RDO:9002019
 xref: NCI:C4910
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
colon carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:17611497, PMID:18256540, PMID:18392055, PMID:18504432, PMID:18611285, PMID:19418217, PMID:19487299, PMID:19853286, PMID:20233444, PMID:20453058, PMID:21464312, PMID:21512767, PMID:21793738, PMID:22538770, PMID:22610119, PMID:22722201, PMID:22722839, PMID:22980975, PMID:23237847, PMID:23348505, PMID:23700467, PMID:23728071, PMID:23934607, PMID:24190505, PMID:24657128, PMID:25157968, PMID:26619011, PMID:28492532 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:1338904, PMID:1528264, PMID:8187091, PMID:8381579, PMID:8940262, PMID:9288102, PMID:9585599, PMID:9724771, PMID:9731522, PMID:9731533, PMID:9751605, PMID:9831355, PMID:9869602, PMID:9869603, PMID:9869620, PMID:9950360, PMID:9973276, PMID:10439961, PMID:10679643, PMID:10737795, PMID:10938175, PMID:11001924, PMID:11159880, PMID:11207040, PMID:11354631, PMID:12173321, PMID:12533824, PMID:14624392, PMID:14633595, PMID:15712637, PMID:15929773, PMID:16140997, PMID:16228836, PMID:16569251, PMID:16875934, PMID:17854661, PMID:18343606, PMID:19047896, PMID:19768578, PMID:20223039, PMID:20685668, PMID:22703879, PMID:22810696, PMID:23204322, PMID:23576677, PMID:23896379, PMID:24033266, PMID:24310308, PMID:24416237, PMID:24599579, PMID:24728327, PMID:24861525, PMID:25157968, PMID:25604157, PMID:25741868, PMID:25980754, PMID:25981591, PMID:26187149, PMID:26300997, PMID:26314409, PMID:26332594, PMID:26394139, PMID:26421687, PMID:26467025, PMID:26625971, PMID:26845104, PMID:27146957, PMID:27153395, PMID:27978560, PMID:28050010, PMID:28135136, PMID:28135145, PMID:28492532, PMID:28749474, PMID:29478780, PMID:29506128, PMID:29961768, PMID:30152102, PMID:30426508, PMID:30487145 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Axin2 axin 2 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:11017067, PMID:28492532 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bard1 BRCA1 associated RING domain 1 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:25741868, PMID:26350354, PMID:28135145, PMID:28492532, PMID:31371347 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9020077 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl10 BCL10, immune signaling adaptor ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9989495 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase treatment ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:12068308, PMID:12198537, PMID:12447372, PMID:12460918, PMID:12460919, PMID:12619120, PMID:12644542, PMID:12670889, PMID:12692057, PMID:12794760, PMID:12960123, PMID:14513361, PMID:14602780, PMID:14679157, PMID:15001635, PMID:15035987, PMID:15126572, PMID:15181070, PMID:15342696, PMID:15356022, PMID:15386408, PMID:15687339, PMID:15998781, PMID:16015629, PMID:16174717, PMID:16187918, PMID:16772349, PMID:17374713, PMID:17488796, PMID:17704260, PMID:17785355, PMID:18039235, PMID:18060073, PMID:18398503, PMID:18413255, PMID:19001320, PMID:19010912, PMID:19018267, PMID:19238210, PMID:19404918, PMID:19537845, PMID:19561230, PMID:20008640, PMID:20350999, PMID:20413299, PMID:20619739, PMID:20630094, PMID:20818844, PMID:20823850, PMID:20857202, PMID:21107320, PMID:21107323, PMID:21129611, PMID:21156289, PMID:21163703, PMID:21426297, PMID:21483012, PMID:21502544, PMID:21639808, PMID:21641636, PMID:21683865, PMID:21975775, PMID:22038996, PMID:22048237, PMID:22113612, PMID:22180495, PMID:22281684, PMID:22351686, PMID:22356324, PMID:22389471, PMID:22448344, PMID:22536370, PMID:22586120, PMID:22608338, PMID:22649091, PMID:22663011, PMID:22735384, PMID:22743296, PMID:22773810, PMID:22805292, PMID:22972589, PMID:22997239, PMID:23020132, PMID:23031422, PMID:23251002, PMID:23302800, PMID:23325582, PMID:23470635, PMID:23524406, PMID:23549875, PMID:23614898, PMID:23680146, PMID:23685455, PMID:23812671, PMID:23833300, PMID:23845441, PMID:23918947, PMID:24033266, PMID:24107445, PMID:24112392, PMID:24163374, PMID:24388723, PMID:24508103, PMID:24512911, PMID:24576830, PMID:24583796, PMID:24586605, PMID:24594804, PMID:24670642, PMID:24717435, PMID:25024077, PMID:25037139, PMID:25079330, PMID:25155755, PMID:25157968, PMID:25265492, PMID:25265494, PMID:25370471, PMID:25399551, PMID:25741868, PMID:25950823, PMID:25989278, PMID:26619011, PMID:26678033, PMID:27404270, PMID:27480103, PMID:28492532, PMID:28854169, PMID:28891408, PMID:29925953, PMID:31779674, PMID:31891627, PMID:22319199 RGD:11567267 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca2 BRCA2, DNA repair associated ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:15937982, PMID:16758124, PMID:20167696, PMID:21520333, PMID:24814045, PMID:25058500, PMID:25348012, PMID:25741868, PMID:27165003, PMID:28223274, PMID:28492532, PMID:29394989, PMID:29849630, PMID:29881398, PMID:29884841, PMID:30254663 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:21964575, PMID:25058500, PMID:25741868, PMID:27165003, PMID:28492532 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9521327 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9521327, PMID:24728327, PMID:28492532 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO RGD PMID:16391854 RGD:7488899 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:9065402, PMID:9294210, PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment ISO RGD PMID:30381616 RGD:27095891 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 disease_progression IMP RGD PMID:18413816 RGD:5135268 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Dcc DCC netrin 1 receptor ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:8188295 NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10649492 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Ep300 E1A binding protein p300 ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:10700188, PMID:28492532 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fancc FA complementation group C ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003 NCBI chr17:826,512...955,703
Ensembl chr17:833,509...955,615
JBrowse link
G Fance FA complementation group E ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003, PMID:28492532 NCBI chr20:7,888,927...7,906,142
Ensembl chr20:7,895,083...7,906,142
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:1908846, PMID:7773297, PMID:8589699, PMID:8858131, PMID:9677066, PMID:10073901, PMID:10471491, PMID:10696568, PMID:11038465, PMID:11241532, PMID:11529856, PMID:11879084, PMID:11906172, PMID:12833394, PMID:15772091, PMID:16841094, PMID:17384684, PMID:18642369, PMID:19381019, PMID:19749790, PMID:25157968, PMID:25606676, PMID:25741868, PMID:26619011, PMID:28492532, PMID:30311386 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Flcn folliculin ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:12843323, PMID:15805188, PMID:15852235, PMID:18234728, PMID:19457309, PMID:19802896, PMID:20618353, PMID:21937013, PMID:22703879, PMID:23050938, PMID:24033266, PMID:24393238, PMID:24728327, PMID:25594584, PMID:25741868, PMID:28492532, PMID:28558743 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand treatment ISO RGD PMID:10842197 RGD:11049504 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:11807987, PMID:25741868, PMID:28492532 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO DNA:::adenoviral delivery of human gene in mouse model of colon cancer RGD PMID:19494278 RGD:5688759 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO protein:increased expression:serum: RGD PMID:29940770 RGD:14985218 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Kdr kinase insert domain receptor ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mcc MCC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:1848370 NCBI chr18:35,683,185...35,817,117
NCBI chr 1:12,006,663...12,128,849
Ensembl chr 1:12,006,660...12,128,845
Ensembl chr18:12,006,660...12,128,845
JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:10495924, PMID:11555625, PMID:11781295, PMID:11948175, PMID:12386821, PMID:12547705, PMID:12658575, PMID:14699485, PMID:15713769, PMID:15731775, PMID:15849733, PMID:15926618, PMID:16995940, PMID:17054581, PMID:17135187, PMID:17210669, PMID:17312306, PMID:17510385, PMID:18205192, PMID:18561205, PMID:19419416, PMID:19698169, PMID:20020535, PMID:20587412, PMID:20682701, PMID:20864636, PMID:21404117, PMID:21952876, PMID:22703879, PMID:22736432, PMID:22753075, PMID:22949379, PMID:24033266, PMID:24344984, PMID:24362816, PMID:25741868, PMID:26247049, PMID:28445943, PMID:28492532 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mlh3 mutL homolog 3 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:11317354 NCBI chr 6:109,059,386...109,095,876
Ensembl chr 6:109,059,341...109,095,557
JBrowse link
G Msh2 mutS homolog 2 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:8062247, PMID:8261515, PMID:9288790, PMID:9718327, PMID:10793088, PMID:12362047, PMID:14970868, PMID:15713769, PMID:15731775, PMID:15849733, PMID:17312306, PMID:17414604, PMID:19459153, PMID:19698169, PMID:20223024, PMID:20591884, PMID:21239990, PMID:21590452, PMID:24278394, PMID:24710284, PMID:25741868, PMID:26467025, PMID:27016151, PMID:28492532, PMID:29238914, PMID:30376427 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:9299504, PMID:9806551, PMID:10519336, PMID:10521313, PMID:13298683, PMID:15972314 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mutyh mutY DNA glycosylase ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:11818965, PMID:12606733, PMID:14579148, PMID:14991577, PMID:15188161, PMID:15236166, PMID:15366000, PMID:15635083, PMID:15931596, PMID:15987719, PMID:16134147, PMID:16140997, PMID:16338133, PMID:16492921, PMID:16557584, PMID:16616356, PMID:16941501, PMID:17122612, PMID:17219385, PMID:17368238, PMID:17489848, PMID:17524638, PMID:17581577, PMID:17674103, PMID:17949294, PMID:17956577, PMID:18271935, PMID:18414213, PMID:18506705, PMID:18534194, PMID:19032956, PMID:19245865, PMID:19394335, PMID:19527492, PMID:19531215, PMID:19725997, PMID:19732775, PMID:19793053, PMID:19836313, PMID:19953527, PMID:19998059, PMID:20191381, PMID:20418187, PMID:20618354, PMID:20663686, PMID:20687945, PMID:20725929, PMID:20848659, PMID:21063410, PMID:21167187, PMID:21171015, PMID:21178863, PMID:21443744, PMID:21520333, PMID:21777424, PMID:21815886, PMID:21952991, PMID:22158503, PMID:22266422, PMID:22297469, PMID:22402879, PMID:22473953, PMID:22641385, PMID:22703879, PMID:22722201, PMID:22744763, PMID:22865608, PMID:22922830, PMID:22926731, PMID:22976915, PMID:23007840, PMID:23035301, PMID:23108399, PMID:23322991, PMID:23361220, PMID:23561487, PMID:23605219, PMID:23625202, PMID:23805267, PMID:24033266, PMID:24039736, PMID:24082139, PMID:24278394, PMID:24444654, PMID:24470512, PMID:24691292, PMID:24728327, PMID:24799981, PMID:24953332, PMID:25525159, PMID:25569433, PMID:25741868, PMID:25820570, PMID:25937855, PMID:25980754, PMID:26377631, PMID:26467025, PMID:26681312, PMID:26822237, PMID:26845104, PMID:26976419, PMID:27145315, PMID:27153395, PMID:27600092, PMID:27621404, PMID:27829682, PMID:28135145, PMID:28492532, PMID:28634180, PMID:28944238, PMID:30151275, PMID:30256826, PMID:30564557 NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:2674680, PMID:3102434, PMID:8120410, PMID:16291983, PMID:18390968, PMID:18633438, PMID:20130576, PMID:20179705, PMID:22962325, PMID:23414587, PMID:25157968, PMID:26619011 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Carcinoma of colon ClinVar PMID:18053174, PMID:25741868, PMID:26283626, PMID:26315354, PMID:26467025, PMID:26580448, PMID:26689913, PMID:28135145, PMID:28492532, PMID:28944238 NCBI chr 1:192,064,586...192,088,547
Ensembl chr 1:192,064,589...192,088,520
JBrowse link
G Pdgfrl platelet-derived growth factor receptor-like ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:7898930 NCBI chr16:54,386,269...54,450,426
Ensembl chr16:54,386,288...54,450,426
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:15016963, PMID:15254419, PMID:15520168, PMID:15608678, PMID:15647370, PMID:15805248, PMID:16906227, PMID:16930767, PMID:17376864, PMID:17673550, PMID:18676830, PMID:18725974, PMID:19029981, PMID:19223544, PMID:19366826, PMID:19513541, PMID:19903786, PMID:20453058, PMID:20619739, PMID:21430269, PMID:21558396, PMID:21824802, PMID:22162582, PMID:22162589, PMID:22271473, PMID:22658544, PMID:22729222, PMID:22729223, PMID:22729224, PMID:23066039, PMID:23100325, PMID:23888070, PMID:24033266, PMID:24265155, PMID:24782230, PMID:25157968, PMID:25741868, PMID:26266975, PMID:26266985, PMID:26619011, PMID:26822237, PMID:27626068, PMID:27631024, PMID:28492532 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25637381, PMID:25741868, PMID:26467025, PMID:28492532 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10394368 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prf1 perforin 1 IDA RGD PMID:22420317 RGD:6482822 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:7509295 NCBI chr 4:10,631,129...10,702,390
Ensembl chr 4:10,631,073...10,702,386
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:12089527 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Rad54b RAD54 homolog B ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:10362364 NCBI chr 5:25,140,531...25,214,469
Ensembl chr 5:25,146,949...25,214,376
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit ISO ClinVar Annotator: match by term: Colonic carcinoma ClinVar PMID:25058500, PMID:27165003 NCBI chr20:44,803,664...44,961,362
Ensembl chr20:44,803,666...44,961,382
JBrowse link
G Tgfb1 transforming growth factor, beta 1 disease_progression ISO RGD PMID:11166150 RGD:13432074 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 disease_progression ISO RGD PMID:11166150, PMID:10416598 RGD:13432074, RGD:13432084 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tlr3 toll-like receptor 3 ISO protein:increased expression:colon RGD PMID:23467704 RGD:21079438 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 ISO RGD PMID:11104810 RGD:2317311 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:serum (human) RGD PMID:1655258 RGD:5131434 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:serum (human) RGD PMID:1655258 RGD:5131434 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Colonic carcinoma
ClinVar Annotator: match by term: Carcinoma of colon
ClinVar PMID:1565143, PMID:1565144, PMID:1683921, PMID:1978757, PMID:7732013, PMID:7887414, PMID:8164043, PMID:8198984, PMID:8203469, PMID:8423216, PMID:8825920, PMID:9047394, PMID:9242456, PMID:9290701, PMID:9569050, PMID:9865903, PMID:10064694, PMID:10411893, PMID:10797439, PMID:10864200, PMID:11040944, PMID:11101847, PMID:11139324, PMID:11180592, PMID:11391594, PMID:11479205, PMID:11782540, PMID:11920959, PMID:12007217, PMID:12619118, PMID:12672316, PMID:12826609, PMID:15004724, PMID:15173255, PMID:15381368, PMID:15390294, PMID:15580553, PMID:15607980, PMID:15607981, PMID:15825182, PMID:15925506, PMID:15951970, PMID:15977174, PMID:16401470, PMID:16489069, PMID:16682957, PMID:16818505, PMID:17224268, PMID:17289876, PMID:17540308, PMID:17606709, PMID:17636407, PMID:17727479, PMID:18391940, PMID:18511570, PMID:18555592, PMID:19127115, PMID:19367569, PMID:19556618, PMID:19881536, PMID:20113312, PMID:20128691, PMID:20407015, PMID:20516128, PMID:20689556, PMID:20693561, PMID:21187651, PMID:21232794, PMID:21305319, PMID:21343334, PMID:21484931, PMID:21512767, PMID:21519010, PMID:21552135, PMID:21601526, PMID:21761402, PMID:22006311, PMID:22110706, PMID:22186996, PMID:22233476, PMID:22652532, PMID:22698404, PMID:22710932, PMID:22811390, PMID:22899716, PMID:22915647, PMID:22919068, PMID:23161690, PMID:23246812, PMID:23263379, PMID:23484829, PMID:23538418, PMID:23792586, PMID:23894400, PMID:24033266, PMID:24381225, PMID:24487413, PMID:24501221, PMID:24573247, PMID:24641375, PMID:24651012, PMID:24677579, PMID:24728327, PMID:24810334, PMID:24868540, PMID:25157968, PMID:25525159, PMID:25527155, PMID:25584008, PMID:25741868, PMID:25787918, PMID:25952993, PMID:26086041, PMID:26230955, PMID:26467025, PMID:26585234, PMID:26619011, PMID:26681312, PMID:26822237, PMID:26845104, PMID:27153395, PMID:27276561, PMID:27374712, PMID:27463065, PMID:27493922, PMID:27516001, PMID:27680515, PMID:27683180, PMID:27895058, PMID:27959731, PMID:28125078, PMID:28349240, PMID:28369373, PMID:28453743, PMID:28492532, PMID:28772286, PMID:28861920, PMID:29478780, PMID:29489754, PMID:29945567, PMID:30076369, PMID:30224644, PMID:30287823, PMID:30327374, PMID:30374176, PMID:30883245, PMID:31016814, PMID:31159747 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tyms thymidylate synthetase ISO human tumor in mouse model RGD PMID:17848948 RGD:5133430 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 ISO mRNA:increased expression:colonic mucosa (human) RGD PMID:8541345 RGD:11352739 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO RGD PMID:18657413 RGD:15003195 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
colon adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa7 annexin A7 ISO protein:decreased expression:colon RGD PMID:17708571 RGD:2292654 NCBI chr15:4,254,470...4,281,296
Ensembl chr15:4,254,499...4,281,287
JBrowse link
G Apc APC regulator of WNT signaling pathway IMP
ISO
associated with Adenomatous Polyposis Coli;DNA:point mutation:CDS:p.K1137X (3409A>T) (rat)
ClinVar Annotator: match by term: Adenocarcinoma of the colon
ClinVar PMID:24033266, PMID:24728327, PMID:25741868, PMID:27978560, PMID:28492532, PMID:17360473 RGD:1601201 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G ApcPirc APC, WNT signaling pathway regulator; polyposis in the rat colon IMP associated with Adenomatous Polyposis Coli RGD PMID:17360473 RGD:1601201
G Bax BCL2 associated X, apoptosis regulator susceptibility ISO DNA:frameshift mutation: ; RGD PMID:9020077 RGD:734633 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Csf2 colony stimulating factor 2 treatment ISO RGD PMID:10830715 RGD:10450245 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 IAGP DNA:mutation RGD PMID:16886601 RGD:1599637 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Daxx death-domain associated protein ISO protein:decreased expression:colon: RGD PMID:16569639 RGD:9587838 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Fech ferrochelatase ISO mRNA:decreased expression:colon RGD PMID:28075030 RGD:14700888 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hmgb1 high mobility group box 1 IEP RGD PMID:20616616 RGD:10402080 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO RGD PMID:24691442 RGD:13210775 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO RGD PMID:24691442 RGD:13210775 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase IEP mRNA:decreased expression:colon (rat) RGD PMID:16886601 RGD:1599637 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir155 microRNA 155 treatment ISO RGD PMID:29535520 RGD:21409754 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Msh2 mutS homolog 2 ISO ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:8261515, PMID:10978353, PMID:14580774, PMID:15365996, PMID:15655560, PMID:16614121, PMID:17374836, PMID:18325052, PMID:18561205, PMID:22977643, PMID:24033266, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msh6 mutS homolog 6 ISO ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:25741868 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO mRNA:decreased expression:colon: RGD PMID:19737405 RGD:11556207 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO DNA:mutation RGD PMID:17575153 RGD:5685670 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 treatment ISO RGD PMID:24632606 RGD:13432053 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D ISO ClinVar Annotator: match by term: Adenocarcinoma of the colon ClinVar PMID:30311386 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Rac1 Rac family small GTPase 1 treatment ISO mRNA:alternative form RGD PMID:10597294, PMID:19561401 RGD:13432049, RGD:13432051 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rad54l RAD54 like ISO ClinVar Annotator: match by synonym: Colonic adenocarcinoma ClinVar PMID:10362365 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 5:150,032,999...150,060,769
Ensembl chr 5:150,032,999...150,060,765
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 6:104,611,026...104,640,033
Ensembl chr 6:104,611,026...104,615,302
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 3:159,305,345...159,310,668
Ensembl chr 3:159,305,345...159,310,668
JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 disease_progression ISO RGD PMID:9019169 RGD:13432089 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Vegfc vascular endothelial growth factor C IEP mRNA:increased expression:colon RGD PMID:18424890 RGD:2315488 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    disease of cellular proliferation 5913
      cancer 4236
        cell type cancer 3105
          carcinoma 2109
            colon carcinoma 76
              adenosquamous colon carcinoma 0
              colon adenocarcinoma + 27
              colon carcinoma in situ 0
              colon small cell carcinoma 0
              colon squamous cell carcinoma 0
              medullary colon carcinoma 0
Path 2
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      gastrointestinal system disease 4673
        Gastrointestinal Diseases 2599
          Gastrointestinal Neoplasms 1768
            Intestinal Neoplasms 690
              intestinal cancer 249
                large intestine cancer 245
                  colorectal cancer 245
                    colon cancer 132
                      colon carcinoma 76
                        adenosquamous colon carcinoma 0
                        colon adenocarcinoma + 27
                        colon carcinoma in situ 0
                        colon small cell carcinoma 0
                        colon squamous cell carcinoma 0
                        medullary colon carcinoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.