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ONTOLOGY REPORT - ANNOTATIONS


Term:hypersensitivity reaction type III disease
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Accession:DOID:1557 term browser browse the term
Definition:Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.
Synonyms:exact_synonym: Immune Complex Disease;   Immune Complex Diseases;   Type III Hypersensitivities;   Type III Hypersensitivity
 primary_id: MESH:D007105;   RDO:0004916
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hypersensitivity reaction type III disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:11554173
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:11554173
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:11554173
allergic cutaneous vasculitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:11039037
arthus reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:11040701
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:1624328
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:9068463
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:9588604
Henoch-Schoenlein purpura term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:11038920
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:11039045
RGD:11039055
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:11554173
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:11522500
RGD:11528567
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:11354986
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10755701
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:10755701
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6909151
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:11354946
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:11059888
G Mefv MEFV innate immuity regulator, pyrin JBrowse link 10 12,045,813 12,056,229 RGD:7349346
RGD:11531116
RGD:7349347
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11541055
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:11554173
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11552576
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:5147830
Serum Sickness term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11554173
type I complement component 8 deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C8a complement C8 alpha chain JBrowse link 5 124,348,536 124,403,117 RGD:7240710
RGD:8554872
type II complement component 8 deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C8b complement C8 beta chain JBrowse link 5 124,298,269 124,338,055 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      immune system disease 2517
        hypersensitivity reaction disease 1489
          hypersensitivity reaction type III disease 26
            Henoch-Schoenlein purpura + 15
            Serum Sickness 1
            arthus reaction 4
            hypersensitivity vasculitis + 16
            type I complement component 8 deficiency 1
            type II complement component 8 deficiency 1
Path 2
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      Immune & Inflammatory Diseases 3089
        immune system disease 2517
          hypersensitivity reaction disease 1489
            allergic hypersensitivity disease 554
              hypersensitivity reaction type III disease 26
                Henoch-Schoenlein purpura + 15
                Serum Sickness 1
                arthus reaction 4
                hypersensitivity vasculitis + 16
                type I complement component 8 deficiency 1
                type II complement component 8 deficiency 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.