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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatic disease
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Accession:DOID:1575 term browser browse the term
Definition:Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
Synonyms:exact_synonym: rheumatic diseases;   rheumatism
 primary_id: MESH:D012216
For additional species annotation, visit the Alliance of Genome Resources.


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adult-onset Still's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hgf hepatocyte growth factor ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
Beukes hip dysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700029J07Rik RIKEN cDNA 1700029J07 gene ISO ClinVar Annotator: match by term: Hip dysplasia, beukes type ClinVar PMID:2389793, PMID:21228277, PMID:26428751 NCBI chr 8:45,939,196...45,975,488
Ensembl chr 8:45,953,606...45,975,440
Ensembl chr 8:45,953,606...45,975,440
JBrowse link
G Ufsp2 UFM1-specific peptidase 2 ISO ClinVar Annotator: match by term: OSTEOARTHROPATHY, PREMATURE DEGENERATIVE, OF HIP
ClinVar Annotator: match by term: Hip dysplasia, beukes type
OMIM
ClinVar
PMID:2389793, PMID:21228277, PMID:25741868, PMID:26428751, PMID:28892125 NCBI chr 8:45,975,515...45,996,958
Ensembl chr 8:45,975,528...45,996,958
JBrowse link
CREST syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpc1 centromere protein C1 ISO associated with Anticentromere antibody positivity RGD PMID:25220385 RGD:27372886 NCBI chr 5:86,012,018...86,065,962
Ensembl chr 5:86,012,024...86,065,583
JBrowse link
G Fbn1 fibrillin 1 ISO RGD PMID:10395706 RGD:12910471 NCBI chr 2:125,300,594...125,506,485
Ensembl chr 2:125,300,594...125,507,993
JBrowse link
diffuse scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing severity ISO protein:decreased expression:serum RGD PMID:21615510 RGD:8694418 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO protein:increased expression:serum RGD PMID:14730619 RGD:8548886 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Bank1 B cell scaffold protein with ankyrin repeats 1 susceptibility ISO DNA:SNPs: :rs10516487,rs17266594,rs3733197(human) RGD PMID:19815934 RGD:9684975 NCBI chr 3:136,053,363...136,326,141
Ensembl chr 3:136,053,363...136,326,066
JBrowse link
G Cav1 caveolin 1, caveolae protein susceptibility
no_association
ISO DNA:SNPs:intron, 3' utr: (rs729949, rs3815412, rs9920) (human)
DNA:SNPs:enhancer, intron:multiple
RGD PMID:22402147, PMID:22402147 RGD:8661768, RGD:8661768 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 ISO RGD PMID:18432520 RGD:5135258 NCBI chr 5:90,759,298...90,761,625
Ensembl chr 5:90,759,360...90,761,624
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO RGD PMID:8254199 RGD:5147984 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO DNA:polymorphism::HLA-DQA1*0501; RGD PMID:11014350 RGD:8547725 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G Il10 interleukin 10 ISO protein:increased expression:serum RGD PMID:9034992 RGD:5684371 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13 interleukin 13 ISO DNA:SNPs:5' utr, enhancer: (rs1800925, rs2243204) (human) RGD PMID:16832637 RGD:5684369 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:20338043 RGD:12792275 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 susceptibility ISO DNA:missense mutation:cds:p.F196S (rs1059702) (human) RGD PMID:21898345 RGD:7495782 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Kdr kinase insert domain protein receptor ISO protein:increased expression:serum: RGD PMID:19886888 RGD:8551850 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Stat4 signal transducer and activator of transcription 4 susceptibility
no_association
ISO DNA:SNP:introns: (rs7574865, rs10168266) (human)
DNA:SNP:intron: (rs7574865) (human)
DNA:SNP:intron: (rs3821236) (human)
RGD PMID:23755762, PMID:19286670, PMID:23755762 RGD:8661701, RGD:8661714, RGD:8661701 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189
JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO RGD PMID:16112028 RGD:1578361 NCBI chr17:34,187,556...34,197,225
Ensembl chr17:34,187,553...34,197,225
JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO RGD PMID:16112028 RGD:1578361 NCBI chr17:34,204,479...34,216,321
Ensembl chr17:34,203,527...34,216,321
JBrowse link
G Tlr2 toll-like receptor 2 disease_progression ISO DNA:polymorphism:cds:p.P631H(rs5743704)(human) RGD PMID:21905008 RGD:8553044 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Wrn Werner syndrome RecQ like helicase ISO RGD PMID:16906373 RGD:10042980 NCBI chr 8:33,234,372...33,385,543
Ensembl chr 8:33,234,384...33,385,527
JBrowse link
Digital Arthropathy-Brachydactyly, Familial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO ClinVar Annotator: match by term: Digital arthropathy-brachydactyly, familial
ClinVar Annotator: match by OMIM:606835
OMIM
ClinVar
PMID:956253, PMID:1520078, PMID:4056805, PMID:8179305, PMID:11891693, PMID:14755468, PMID:18587396, PMID:19232556, PMID:20037586, PMID:20037587, PMID:20037588, PMID:20104247, PMID:20425821, PMID:20460441, PMID:20503319, PMID:20577006, PMID:21115951, PMID:21288981, PMID:21336783, PMID:21454511, PMID:21964574, PMID:22702953, PMID:22791502, PMID:22851605, PMID:24575025, PMID:24677493, PMID:24789864, PMID:25256292, PMID:25741868, PMID:25900305, PMID:26110311, PMID:26249260, PMID:26467025, PMID:27330106, PMID:28492532, PMID:28898540 NCBI chr 5:114,622,152...114,658,435
Ensembl chr 5:114,622,152...114,658,421
JBrowse link
erythema nodosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 ISO associated with Leprosy RGD PMID:2783924 RGD:7421527 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G Cfb complement factor B ISO associated with Leprosy RGD PMID:2783924 RGD:7421527 NCBI chr17:34,856,374...34,862,514
Ensembl chr17:34,856,374...34,862,518
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 susceptibility ISO associated with Behcet Syndrome;DNA:deletion:: (human) RGD PMID:22766250 RGD:7794848 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 ISO associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human) RGD PMID:12198697 RGD:7364926 NCBI chr17:37,480,851...37,483,554
Ensembl chr17:37,480,851...37,483,552
JBrowse link
G H2-Q4 histocompatibility 2, Q region locus 4 ISO associated with Inflammatory Bowel Diseases; DNA:polymorphisms:cds:multiple (human) RGD PMID:12198697 RGD:7364926 NCBI chr17:35,379,617...35,384,674
Ensembl chr17:35,379,617...35,385,290
JBrowse link
G Lta lymphotoxin A ISO associated with Sarcoidosis;DNA:polymorphism:intron RGD PMID:19225544 RGD:8548773 NCBI chr17:35,203,165...35,205,578
Ensembl chr17:35,203,165...35,205,351
JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human) RGD PMID:12198697 RGD:7364926 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor susceptibility ISO associated with Behcet Syndrome;DNA:polymorphism: : rs7975232(human) RGD PMID:24880677 RGD:13217417 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
Familial Osteochondritis Dissecans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan ISO OMIM NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
fibromyalgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase ISO protein:decreased activity:mononuclear cell: RGD PMID:22532869 RGD:9479066 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 ISO protein:decreased expression:plasma RGD PMID:19924498 RGD:14995946 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Comt catechol-O-methyltransferase severity ISO DNA:polymorphism:cds:p.V158M(human) RGD PMID:24762091 RGD:13450944 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Il1rn interleukin 1 receptor antagonist severity ISO protein:increased expression:serum (human) RGD PMID:10341365 RGD:8549787 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
Hand Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 (alpha) no_association ISO DNA:SNPs:exons: (rs2077647, rs1801132) (human) RGD PMID:19884274 RGD:10045830 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) no_association ISO DNA:SNPs:introns: (rs1256034, rs1256059, rs944460) (human) RGD PMID:19884274 RGD:10045830 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Il4 interleukin 4 no_association ISO DNA:SNPs:promoter, 5' utr, intron:multiple RGD PMID:20219689 RGD:10402786 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il4ra interleukin 4 receptor, alpha no_association ISO DNA:SNPs:promoter, exons:multiple RGD PMID:20219689 RGD:10402786 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Matn3 matrilin 3 ISO ClinVar Annotator: match by term: HAND OSTEOARTHRITIS ClinVar PMID:12736871 NCBI chr12:8,947,929...8,972,028
Ensembl chr12:8,947,929...8,972,028
JBrowse link
Juvenile Pauciarticular Chronic Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism: :HLA-DRB1*1104, HLA-DRB1*080(human) RGD PMID:7955632 RGD:7365102 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
juvenile rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700019D03Rik RIKEN cDNA 1700019D03 gene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:52,922,324...52,992,657
Ensembl chr 1:52,922,324...53,020,179
JBrowse link
G Acpp acid phosphatase, prostate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:104,288,240...104,337,722
Ensembl chr 9:104,288,251...104,337,748
JBrowse link
G Acrbp proacrosin binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:125,049,927...125,063,265
Ensembl chr 6:125,049,689...125,063,267
JBrowse link
G Adcy7 adenylate cyclase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:88,272,190...88,329,965
Ensembl chr 8:88,272,403...88,329,962
JBrowse link
G Alox12 arachidonate 12-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:70,241,457...70,255,380
Ensembl chr11:70,241,457...70,255,353
JBrowse link
G Ankrd9 ankyrin repeat domain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:110,976,420...110,979,082
Ensembl chr12:110,975,353...110,979,040
JBrowse link
G Aopep aminopeptidase O ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:62,964,893...63,326,096
Ensembl chr13:62,964,893...63,326,096
JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:71,110,659...71,167,849
Ensembl chr 9:71,110,659...71,168,682
JBrowse link
G Areg amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:91,139,599...91,148,432
Ensembl chr 5:91,139,599...91,148,432
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:64,086,840...64,382,941
Ensembl chr15:64,086,857...64,382,919
JBrowse link
G Avl9 AVL9 cell migration associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:56,714,839...56,761,912
Ensembl chr 6:56,714,899...56,761,912
JBrowse link
G B4galt5 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:167,298,444...167,349,178
Ensembl chr 2:167,298,444...167,349,183
JBrowse link
G Btg1 BTG anti-proliferation factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:96,617,001...96,622,813
Ensembl chr10:96,617,006...96,622,809
JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:78,359,860...78,377,181
Ensembl chr16:78,332,637...78,377,192
JBrowse link
G C8b complement component 8, beta polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:7980680 NCBI chr 4:104,766,317...104,804,548
Ensembl chr 4:104,766,317...104,804,548
JBrowse link
G C9orf72 C9orf72, member of C9orf72-SMCR8 complex ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:35,191,285...35,226,153
Ensembl chr 4:35,191,285...35,226,175
JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Camsap1 calmodulin regulated spectrin-associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:25,926,838...25,983,562
Ensembl chr 2:25,926,838...25,983,282
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 no_association ISO DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
DNA:polymorphisms: :multiple (human)
RGD PMID:17565662, PMID:16775617 RGD:1626283, RGD:1626284 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Cd14 CD14 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd83 CD83 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:43,785,112...43,803,133
Ensembl chr13:43,784,775...43,803,132
JBrowse link
G Cd8b1 CD8 antigen, beta chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:71,322,788...71,337,492
Ensembl chr 6:71,322,788...71,337,494
JBrowse link
G Ciita class II transactivator susceptibility
no_association
ISO DNA:polymorphism:exon:1614G>C (human)
DNA:polymorphism:promoter:rs3087456, no association in a German cohort (Human)
RGD PMID:17661914, PMID:16426246 RGD:5491187, RGD:5491189 NCBI chr16:10,480,014...10,531,064
Ensembl chr16:10,480,059...10,528,418
JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:104,281,042...104,293,181
Ensembl chr 8:104,281,042...104,293,181
JBrowse link
G Crem cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum RGD PMID:22885951 RGD:6906884 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Cttn cortactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:144,435,724...144,471,560
Ensembl chr 7:144,435,733...144,471,009
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504, PMID:26387944 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:60,601,723...60,763,191
Ensembl chr13:60,601,947...60,763,191
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G Dusp2 dual specificity phosphatase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:127,336,159...127,338,377
Ensembl chr 2:127,336,159...127,338,376
JBrowse link
G Dusp4 dual specificity phosphatase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:34,807,610...34,819,894
Ensembl chr 8:34,807,297...34,819,894
JBrowse link
G Dysf dysferlin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:84,008,361...84,211,060
Ensembl chr 6:84,008,590...84,211,060
JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egr1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Elf2 E74-like factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:51,252,720...51,340,683
Ensembl chr 3:51,252,720...51,340,663
JBrowse link
G Etnk1 ethanolamine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:143,166,866...143,208,546
Ensembl chr 6:143,167,221...143,232,307
JBrowse link
G Etv6 ets variant 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:134,035,700...134,270,158
Ensembl chr 6:134,035,700...134,270,158
JBrowse link
G Fam20a FAM20A, golgi associated secretory pathway pseudokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:109,669,746...109,723,163
Ensembl chr11:109,669,749...109,722,279
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:96,282,909...96,293,969
Ensembl chr 3:96,282,909...96,293,969
JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:101,108,499...101,284,405
Ensembl chr 7:101,092,863...101,284,405
JBrowse link
G Fos FBJ osteosarcoma oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosb FBJ osteosarcoma oncogene B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:19,302,696...19,310,118
Ensembl chr 7:19,302,696...19,310,051
JBrowse link
G Fosl2 fos-like antigen 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:32,136,472...32,157,840
Ensembl chr 5:32,135,801...32,157,842
JBrowse link
G Foxp1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:98,925,342...99,522,746
Ensembl chr 6:98,925,338...99,522,721
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gm12248 predicted gene 12248 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:58,063,682...58,093,196
Ensembl chr11:58,063,552...58,093,134
JBrowse link
G Gm15262 predicted gene 15262 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:161,297,856...161,334,722
Ensembl chr  X:161,287,456...161,366,252
JBrowse link
G Gmpr guanosine monophosphate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:45,507,428...45,546,386
Ensembl chr13:45,507,444...45,553,800
JBrowse link
G Gng11 guanine nucleotide binding protein (G protein), gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:4,003,987...4,008,445
Ensembl chr 6:4,003,904...4,008,445
JBrowse link
G Gp1bb glycoprotein Ib, beta polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:18,620,319...18,622,403
Ensembl chr16:18,620,317...18,622,403
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 susceptibility ISO DNA:deletion: : RGD PMID:18328165 RGD:5490992 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphism (human) RGD PMID:19811310, PMID:10457895 RGD:5147815, RGD:5147863 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphism (human) RGD PMID:10457895 RGD:5147863 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta ISO DNA:polymorphism (human) RGD PMID:19908388, PMID:10457895 RGD:5147587, RGD:5147863 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G H2ac8 H2A clustered histone 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:23,570,663...23,571,220
Ensembl chr13:23,570,517...23,571,220
JBrowse link
G Hbegf heparin-binding EGF-like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:36,504,927...36,515,805
Ensembl chr18:36,504,927...36,515,805
JBrowse link
G Herpud2 HERPUD family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:25,108,126...25,151,813
Ensembl chr 9:25,108,132...25,151,820
JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:16047841 RGD:8694357 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO protein:increased expression:serum,synovial fluid: RGD PMID:8255671 RGD:12910480 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Igf1r insulin-like growth factor I receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Il1a interleukin 1 alpha ISO DNA:SNP:promoter:-889C>T (human) RGD PMID:8162643 RGD:7794716 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:mononuclear cell RGD PMID:21859687 RGD:5147870 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 ISO
ISS
protein:increased expression:serum:
OMIM:604302
MouseDO PMID:9489833 RGD:7829742 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga2b integrin alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:102,453,297...102,469,883
Ensembl chr11:102,453,297...102,470,122
JBrowse link
G Itgb5 integrin beta 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:33,829,665...33,949,338
Ensembl chr16:33,829,665...33,949,338
JBrowse link
G Jmjd1c jumonji domain containing 1C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:67,096,351...67,256,326
Ensembl chr10:67,096,125...67,256,326
JBrowse link
G Jun jun proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kat6b K(lysine) acetyltransferase 6B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:21,499,216...21,672,478
Ensembl chr14:21,481,434...21,672,478
JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:95,257,558...95,300,260
Ensembl chr16:95,257,558...95,300,260
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:145,216,699...145,250,420
Ensembl chr 6:145,216,699...145,250,239
JBrowse link
G Lacc1 laccase domain containing 1 ISO ClinVar Annotator: match by term: JUVENILE ARTHRITIS OMIM
ClinVar
PMID:25147203, PMID:25220867, PMID:27881174, PMID:29717096, PMID:30872671 NCBI chr14:77,021,739...77,036,929
Ensembl chr14:77,024,200...77,036,904
JBrowse link
G Lilra5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:4,237,643...4,243,690
Ensembl chr 7:4,237,754...4,243,463
JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:24,393,350...24,992,578
Ensembl chr16:24,393,507...24,992,578
JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:140,008,689...140,321,608
Ensembl chr 5:140,008,689...140,321,552
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Maml2 mastermind like transcriptional coactivator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:13,296,561...13,709,533
Ensembl chr 9:13,297,957...13,709,388
JBrowse link
G Map2 microtubule-associated protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 ISO RGD PMID:18334024 RGD:12910845 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Mex3c mex3 RNA binding family member C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:73,572,637...73,592,578
Ensembl chr18:73,573,044...73,592,575
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISS OMIM:604302 MouseDO NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mir22hg Mir22 host gene (non-protein coding) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:75,461,539...75,466,690
Ensembl chr11:75,461,539...75,466,676
JBrowse link
G Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:11,404,717...11,427,246
Ensembl chr19:11,404,770...11,427,246
JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:96,096,045...96,168,553
Ensembl chr  X:96,096,042...96,168,552
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:58,941,234...59,083,956
Ensembl chr15:58,941,234...59,082,005
JBrowse link
G Myzap myocardial zonula adherens protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:71,504,347...71,592,360
Ensembl chr 9:71,504,347...71,592,360
JBrowse link
G Ndel1 nudE neurodevelopment protein 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:68,821,434...68,853,146
Ensembl chr11:68,821,434...68,871,858
JBrowse link
G Neat1 nuclear paraspeckle assembly transcript 1 (non-protein coding) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:5,824,708...5,845,480
Ensembl chr19:5,824,708...5,845,478
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:48,045,078...48,086,447
Ensembl chr 4:48,045,153...48,086,447
JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:31,807,452...32,891,609
Ensembl chr 8:31,814,551...32,884,797
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:129,479,150...129,507,350
Ensembl chr 6:129,485,244...129,507,165
JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:4,236,785...4,241,026
Ensembl chr11:4,236,420...4,241,026
JBrowse link
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:83,375,607...83,464,610
Ensembl chr15:83,375,607...83,464,606
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta isoform ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:93,654,863...93,749,951
Ensembl chr  X:93,654,863...93,749,951
JBrowse link
G Per1 period circadian clock 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:69,095,108...69,109,965
Ensembl chr11:69,095,217...69,109,960
JBrowse link
G Pgm5 phosphoglucomutase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:24,678,261...24,861,842
Ensembl chr19:24,683,016...24,861,855
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Plk2 polo like kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:110,395,044...110,400,844
Ensembl chr13:110,395,046...110,400,844
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:92,539,636...92,608,428
Ensembl chr 9:92,542,223...92,608,428
JBrowse link
G Pros1 protein S (alpha) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:62,854,307...62,929,346
Ensembl chr16:62,854,307...62,929,346
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ISO DNA: snp : cds : rs2476601 RGD PMID:15934099 RGD:6484550 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G R3hdm2 R3H domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:127,380,332...127,499,384
Ensembl chr10:127,380,327...127,499,384
JBrowse link
G Rasgef1b RasGEF domain family, member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:99,217,420...99,252,927
Ensembl chr 5:99,217,426...99,729,065
JBrowse link
G Rbm47 RNA binding motif protein 47 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:66,016,549...66,151,954
Ensembl chr 5:66,016,549...66,173,118
JBrowse link
G Rere arginine glutamic acid dipeptide (RE) repeats ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:150,281,511...150,621,966
Ensembl chr 4:150,281,646...150,621,966
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:69,151,058...69,291,791
Ensembl chr10:69,151,434...69,291,791
JBrowse link
G Rnf103 ring finger protein 103 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:71,493,844...71,510,880
Ensembl chr 6:71,493,894...71,510,881
JBrowse link
G Selp selectin, platelet severity ISO protein:increased expression:plasma RGD PMID:21124648 RGD:6219006 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Sh2d2a SH2 domain containing 2A ISO RGD PMID:15129233 RGD:2298870 NCBI chr 3:87,846,755...87,855,722
Ensembl chr 3:87,846,755...87,855,722
JBrowse link
G Sh3bgrl2 SH3 domain binding glutamic acid-rich protein like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:83,548,338...83,600,292
Ensembl chr 9:83,548,327...83,638,801
JBrowse link
G Sik1 salt inducible kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:31,844,248...31,855,804
Ensembl chr17:31,844,250...31,855,804
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:82,169,377...82,451,786
Ensembl chr12:82,169,320...82,451,786
JBrowse link
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 ISO DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:16597321, PMID:10857800 RGD:5684977 NCBI chr 1:74,375,014...74,386,057
Ensembl chr 1:74,375,195...74,386,062
JBrowse link
G Slc22a16 solute carrier family 22 (organic cation transporter), member 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:40,570,321...40,604,132
Ensembl chr10:40,570,336...40,604,132
JBrowse link
G Slc26a2 solute carrier family 26 (sulfate transporter), member 2 susceptibility ISO DNA:SNPs: : RGD PMID:17393463 RGD:13208931 NCBI chr18:61,196,854...61,211,596
Ensembl chr18:61,192,919...61,211,612
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Stab1 stabilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:31,139,017...31,168,651
Ensembl chr14:31,139,013...31,168,641
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Stim1 stromal interaction molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:102,261,514...102,437,319
Ensembl chr 7:102,267,806...102,437,319
JBrowse link
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:55,741,797...55,933,659
Ensembl chr19:55,741,820...55,933,654
JBrowse link
G Tfdp1 transcription factor Dp 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:13,338,725...13,378,448
Ensembl chr 8:13,338,751...13,378,448
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:84,432,855...84,476,775
Ensembl chr 2:84,432,855...84,476,775
JBrowse link
G Thbd thrombomodulin ISO protein:increased expression:serum RGD PMID:15209962 RGD:5685023 NCBI chr 2:148,404,471...148,408,188
Ensembl chr 2:148,404,466...148,408,188
JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:52,038,113...52,056,681
Ensembl chr 2:52,038,009...52,056,686
JBrowse link
G Tnfaip8 tumor necrosis factor, alpha-induced protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:49,979,427...50,093,229
Ensembl chr18:49,979,427...50,107,173
JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:28,261,901...28,670,585
Ensembl chr 3:28,263,214...28,675,858
JBrowse link
G Treml1 triggering receptor expressed on myeloid cells-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:48,359,916...48,367,176
Ensembl chr17:48,359,916...48,367,176
JBrowse link
G Ttll5 tubulin tyrosine ligase-like family, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:85,824,693...86,053,760
Ensembl chr12:85,824,659...86,061,893
JBrowse link
G Tubb2a tubulin, beta 2A class IIA ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:34,074,278...34,078,008
Ensembl chr13:34,074,274...34,078,007
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:18,282,726...18,332,004
Ensembl chr14:18,282,722...18,331,859
JBrowse link
G Ube3c ubiquitin protein ligase E3C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:29,569,242...29,676,077
Ensembl chr 5:29,569,242...29,676,092
JBrowse link
G Uhrf1bp1l UHRF1 (ICBP90) binding protein 1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:89,744,968...89,819,891
Ensembl chr10:89,744,991...89,819,871
JBrowse link
G Wasf3 WASP family, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:146,385,006...146,473,615
Ensembl chr 5:146,384,985...146,473,615
JBrowse link
G Wwox WW domain-containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:114,439,635...115,352,712
Ensembl chr 8:114,439,655...115,352,708
JBrowse link
G Zfand3 zinc finger, AN1-type domain 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:30,005,039...30,210,823
Ensembl chr17:30,004,733...30,210,828
JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:115,384,799...115,432,772
Ensembl chr10:115,384,959...115,432,772
JBrowse link
Knee Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 disease_progression ISO protein:increased expression:chondrocyte: RGD PMID:10903884 RGD:10053727 NCBI chr 9:69,453,683...69,491,792
Ensembl chr 9:69,453,620...69,491,795
JBrowse link
G Anxa5 annexin A5 disease_progression ISO protein:increased expression:chondrocyte: RGD PMID:10903884 RGD:10053727 NCBI chr 3:36,448,923...36,475,887
Ensembl chr 3:36,448,923...36,475,894
JBrowse link
G Ar androgen receptor ISO DNA:repeat:exon:c.172(CAG)8-34 (human) RGD PMID:16098017 RGD:10043199 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Aspn asporin severity ISO mRNA:increased expression:cartilage:
DNA:repeats:exon:
RGD PMID:15640800, PMID:15640800 RGD:9684965, RGD:9684965 NCBI chr13:49,544,443...49,567,565
Ensembl chr13:49,544,443...49,567,565
JBrowse link
G B2m beta-2 microglobulin ISO protein:increased expression:serum RGD PMID:18795399 RGD:6482710 NCBI chr 2:122,147,687...122,153,082
Ensembl chr 2:122,147,686...122,153,083
JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:20131282 RGD:6907382 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:20131282 RGD:6907382 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bglap bone gamma carboxyglutamate protein ISO RGD PMID:22294259, PMID:21387139 RGD:6483563, RGD:6483595 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 IMP mRNA,protein:increased expression:dorsal root ganglion: RGD PMID:23185004 RGD:8661785 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Cd36 CD36 molecule disease_progression ISO RGD PMID:21765106, PMID:19342682 RGD:6893494, RGD:6893565 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 ISO protein:increased expression:cartilage: RGD PMID:22702043 RGD:10395278 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISO DNA:SNP:intron, 5' utr: (rs1062033) (human) RGD PMID:20417295 RGD:10045662 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 severity ISO mRNA,protein:increased expression:fat pad: RGD PMID:21765106 RGD:6893494 NCBI chr 7:99,153,663...99,182,713
Ensembl chr 7:99,153,658...99,182,719
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO RGD PMID:20131282 RGD:6907382 NCBI chr19:30,545,876...30,549,496
Ensembl chr19:30,545,863...30,549,665
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:25435813 RGD:13506963 NCBI chr 9:78,478,453...78,481,724
Ensembl chr 9:78,478,449...78,489,151
JBrowse link
G Efemp1 epidermal growth factor-containing fibulin-like extracellular matrix protein 1 ISO protein:increased expression:serum: RGD PMID:22275171 RGD:10401792 NCBI chr11:28,853,154...28,926,743
Ensembl chr11:28,853,204...28,926,743
JBrowse link
G Epas1 endothelial PAS domain protein 1 no_association ISO DNA:SNP:5' utr: (rs17039192) (human) RGD PMID:22247019, PMID:20495570 RGD:10395367, RGD:10395368 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:25422652 RGD:10400892 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Esr1 estrogen receptor 1 (alpha) ISO DNA:repeat:promoter:-1174(TA)9-25 (human)
DNA:polymorphisms, haplotype:intron, exon
DNA:SNP:cds:c.1782G>A (rs2228480) (human)
DNA:SNPs:intron: (rs2234693, rs9340799) (human)
RGD PMID:16098017, PMID:15380041, PMID:20128071, PMID:24772413 RGD:10043199, RGD:10045840, RGD:10045835, RGD:10045829 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO DNA:repeat:intron:c.1092+3607(CA)13-27 (human) RGD PMID:16098017 RGD:10043199 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G F2 coagulation factor II ISO RGD PMID:21041276 RGD:5147774 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 treatment IMP RGD PMID:27159076 RGD:11568056 NCBI chr 5:33,721,724...33,737,068
Ensembl chr 5:33,721,674...33,737,068
JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367
JBrowse link
G Gsr glutathione reductase ISO protein:increased expression:synovial fluid RGD PMID:16289733 RGD:10401830 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmgb1 high mobility group box 1 severity ISO protein:increased expression:synovial fluid
mRNA:decreased expression:articular cartilage
RGD PMID:21968272, PMID:19139395 RGD:10402061, RGD:10402184 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmgb2 high mobility group box 2 severity ISO
IMP
mRNA:decreased expression:articular cartilage RGD PMID:19139395, PMID:19139395 RGD:10402184, RGD:10402184 NCBI chr 8:57,511,843...57,515,999
Ensembl chr 8:57,511,907...57,515,999
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 IEP
ISO
mRNA:increased expression:tibial plateaux (mouse)
mRNA:decreased expression:blood (human)
RGD PMID:9497939, PMID:16139532 RGD:10412655, RGD:10429075 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Igf1 insulin-like growth factor 1 disease_progression
severity
ISO
IEP
protein:decreased expression:plasma (rat)
mRNA:increased expression:meniscus:
RGD PMID:8461919, PMID:17133593, PMID:9497937, PMID:20633672 RGD:10045862, RGD:10003130, RGD:10046057, RGD:10045868 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor ISO RGD PMID:8948288 RGD:10045874 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Il1a interleukin 1 alpha ISO
IEP
protein:increased expression:cartilage cell: RGD PMID:24534736, PMID:9497937, PMID:9034998 RGD:10045944, RGD:10046057, RGD:10045946 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il2 interleukin 2 severity ISO protein:increased expression:synovial fluid: RGD PMID:22035391 RGD:5687147 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il4 interleukin 4 susceptibility ISO DNA:repeat:intron: (rs8179190) (human) RGD PMID:18182309, PMID:24406619 RGD:2317291, RGD:10402787 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Kl klotho susceptibility ISO DNA:SNPs:promoter,exon:395G>A,2998C>T(human) RGD PMID:18465812 RGD:10403041 NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
JBrowse link
G Lep leptin ISO protein:decreased expression:serum: RGD PMID:23575542 RGD:10411887 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor susceptibility ISO protein:increased expression:serum:
DNA:SNP:cds:668A>G(human)
RGD PMID:23575542, PMID:23575542 RGD:10411887, RGD:10411887 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 susceptibility ISO DNA:snp:promoter:g.-2820G>A (rs10980705) (human) RGD PMID:18325907 RGD:10054291 NCBI chr 4:58,435,252...58,554,027
Ensembl chr 4:58,435,255...58,553,898
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr17:75,005,480...75,392,512
Ensembl chr17:75,005,568...75,392,512
JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:synovial membrane RGD PMID:30106113 RGD:25824950 NCBI chr  X:96,242,817...96,242,926
Ensembl chr  X:96,242,817...96,242,926
JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) treatment ISO RGD PMID:21167838 RGD:8549737 NCBI chr 9:7,464,141...7,476,869
Ensembl chr 9:7,464,141...7,476,869
JBrowse link
G Mmp3 matrix metallopeptidase 3 treatment ISO RGD PMID:22114772 RGD:8694098 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Penk preproenkephalin treatment ISO RGD PMID:21928671 RGD:10003115 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Ptges prostaglandin E synthase ISO RGD PMID:17530714 RGD:2300093 NCBI chr 2:30,889,471...30,931,020
Ensembl chr 2:30,889,471...30,929,863
JBrowse link
G Sbno1 strawberry notch 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 5:124,368,702...124,426,007
Ensembl chr 5:124,368,702...124,426,001
JBrowse link
G Slc26a2 solute carrier family 26 (sulfate transporter), member 2 susceptibility ISO DNA:deletion:promoter:-716_-713del4A(human) RGD PMID:11558903 RGD:13208866 NCBI chr18:61,196,854...61,211,596
Ensembl chr18:61,192,919...61,211,612
JBrowse link
G Tgfa transforming growth factor alpha ISO mRNA, protein:increased expression:cartilage RGD PMID:17968906 RGD:2317486 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor ISO GAD PMID:15118671 RGD:1331525 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 8:107,436,334...107,559,290
Ensembl chr 8:107,436,365...107,558,595
JBrowse link
limited scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1, caveolae protein susceptibility
no_association
ISO DNA:SNPs:enhancer, intron:multiple
DNA:SNPs:3' utr, intron: (rs9920, rs729949, rs3815412) (human)
RGD PMID:22402147, PMID:22402147 RGD:8661768, RGD:8661768 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 IMP
IEP
mRNA,protein:increased expression:skin: RGD PMID:12925209, PMID:12925209 RGD:8661733, RGD:8661733 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 IEP mRNA,protein:increased expression:skin: RGD PMID:12925209 RGD:8661733 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) IMP RGD PMID:17102953 RGD:12903974 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) IMP RGD PMID:17102953 RGD:12903974 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Il2 interleukin 2 susceptibility ISO DNA:polymorphism::-384T>G(human) RGD PMID:17444587 RGD:4142872 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:20808962 RGD:4892610 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Kdr kinase insert domain protein receptor ISO protein:increased expression:serum: RGD PMID:19886888 RGD:8551850 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Pgf placental growth factor ISO protein:increased expression:plasma RGD PMID:22461185 RGD:6483571 NCBI chr12:85,166,637...85,177,785
Ensembl chr12:85,166,635...85,177,790
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 IEP mRNA,protein:increased expression:skin: RGD PMID:15730388 RGD:13208597 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Stat4 signal transducer and activator of transcription 4 no_association
susceptibility
ISO DNA:SNPs:introns: (rs10168266, rs3821236) (human)
DNA:SNP:intron: (rs7574865) (human)
RGD PMID:23755762, PMID:23755762, PMID:19286670 RGD:8661701, RGD:8661701, RGD:8661714 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189
JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO RGD PMID:16112028 RGD:1578361 NCBI chr17:34,204,479...34,216,321
Ensembl chr17:34,203,527...34,216,321
JBrowse link
Lipodermatosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen, type I, alpha 1 ISO mRNA:increased expression:dermis RGD PMID:15727634 RGD:5688298 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
localized scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) IEP mRNA,protein:increased expression:skin: RGD PMID:15803328 RGD:8662838 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) ISO CTD Direct Evidence: therapeutic CTD PMID:15863969 NCBI chr11:98,700,183...98,703,631
Ensembl chr11:98,701,263...98,703,629
JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:14712301 RGD:8548627 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:7916356 RGD:8158116 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12920362 RGD:8549537 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Lmna lamin A ISO CTD Direct Evidence: marker/mechanism CTD PMID:15726408 NCBI chr 3:88,481,148...88,509,932
Ensembl chr 3:88,480,147...88,509,956
JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) ISO RGD PMID:9804345 RGD:1582543 NCBI chr 9:7,464,141...7,476,869
Ensembl chr 9:7,464,141...7,476,869
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:7510487 RGD:7394847 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9843018 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr18:74,779,212...74,806,207
Ensembl chr18:74,779,197...74,806,208
JBrowse link
G Acan aggrecan treatment IDA
ISO
RGD PMID:22833446, PMID:21853458 RGD:11570535, RGD:11570544 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Aco1 aconitase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Actb actin, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 5:142,903,115...142,907,976
Ensembl chr 5:142,903,115...142,906,754
JBrowse link
G Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chr 7:133,883,199...134,225,097
Ensembl chr 7:133,883,199...134,232,146
JBrowse link
G Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) IMP RGD PMID:15818704 RGD:1559176 NCBI chr 3:89,339,640...89,350,028
Ensembl chr 3:89,338,542...89,349,996
JBrowse link
G Adamts14 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 ISO DNA:missense mutation:cds: (rs4747096) (human) RGD PMID:18790654 RGD:6771189 NCBI chr10:61,197,112...61,273,419
Ensembl chr10:61,197,112...61,273,438
JBrowse link
G Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 treatment IEP associated with Bone Diseases, Metabolic RGD PMID:22432033 RGD:10043110 NCBI chr 1:171,250,129...171,262,267
Ensembl chr 1:171,250,421...171,260,637
JBrowse link
G Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) treatment
disease_progression
no_association
IMP
IEP
ISO
IDA
associated with Bone Diseases, Metabolic
mRNA:increased expression:cartilage
protein:alternative form:synovium
DNA:missense mutations:exon: (rs226794, rs2830585) (human)
DNA:missense mutation:exon:p.R614H (human)
RGD PMID:23982761, PMID:22432033, PMID:17530714, PMID:22084394, PMID:23954517, PMID:11801682, PMID:18240210, PMID:23546441, PMID:22961118 RGD:10043101, RGD:10043110, RGD:2300093, RGD:10003165, RGD:10043107, RGD:10043106, RGD:10043105, RGD:10043103, RGD:10043102 NCBI chr16:85,858,157...85,901,125
Ensembl chr16:85,856,173...85,901,828
JBrowse link
G Adgrg2 adhesion G protein-coupled receptor G2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr  X:160,390,318...160,498,076
Ensembl chr  X:160,390,690...160,498,070
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO CTD Direct Evidence: marker/mechanism CTD PMID:16948116, PMID:23894457 RGD:8695985 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ak4 adenylate kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 4:101,416,478...101,467,771
Ensembl chr 4:101,419,277...101,466,995
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24728293 NCBI chr 9:71,215,789...71,296,243
Ensembl chr 9:71,215,789...71,296,243
JBrowse link
G Aspn asporin no_association
susceptibility
ISO DNA:repeats:exon:
CTD Direct Evidence: marker/mechanism
CTD
OMIM
PMID:16542493 RGD:9684966 NCBI chr13:49,544,443...49,567,565
Ensembl chr13:49,544,443...49,567,565
JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:24,978,167...25,006,077
Ensembl chr 7:24,978,167...25,005,958
JBrowse link
G Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 8:69,088,736...69,113,718
Ensembl chr 8:69,088,646...69,113,711
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:612400 MouseDO NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Bad BCL2-associated agonist of cell death ISO RGD PMID:19217321 RGD:10053643 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bag6 BCL2-associated athanogene 6 susceptibility ISO DNA:SNP: :rs3117582(human) RGD PMID:25231575 RGD:14390133 NCBI chr17:35,135,156...35,147,321
Ensembl chr17:35,135,178...35,147,322
JBrowse link
G Bax BCL2-associated X protein ISO protein:increased expression:chondrocyte RGD PMID:19217321, PMID:16864079 RGD:10053643, RGD:10054095 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO protein:increased expression:chondrocyte RGD PMID:19217321, PMID:16864079 RGD:10053643, RGD:10054095 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related IEP
ISO
protein:decreased expression:cartilage RGD PMID:20187128, PMID:20187128 RGD:6483317, RGD:6483317 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bglap bone gamma carboxyglutamate protein disease_progression ISO RGD PMID:20157712 RGD:6483599 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bmp2 bone morphogenetic protein 2 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Bmp7 bone morphogenetic protein 7 IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr 2:172,868,012...172,940,321
Ensembl chr 2:172,868,012...172,940,321
JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr14:34,411,061...34,503,336
Ensembl chr14:34,410,734...34,503,341
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16690336 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29138829 RGD:13782343 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:29138829 RGD:13782343 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cav1 caveolin 1, caveolae protein ISO RGD PMID:16508959 RGD:10043354 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Ccl22 chemokine (C-C motif) ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chr 8:94,745,684...94,751,388
Ensembl chr 8:94,745,590...94,751,699
JBrowse link
G Ccr4 chemokine (C-C motif) receptor 4 ISO protein:increased expression:synovial membrane: RGD PMID:19942450 RGD:10054497 NCBI chr 9:114,490,316...114,505,476
Ensembl chr 9:114,490,316...114,504,916
JBrowse link
G Cd36 CD36 molecule susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A treatment ISO RGD PMID:24009074 RGD:10043190 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta susceptibility IMP RGD PMID:22095691 RGD:10401214 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Chil1 chitinase-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 1:134,182,156...134,190,031
Ensembl chr 1:134,182,176...134,190,181
JBrowse link
G Cilp cartilage intermediate layer protein, nucleotide pyrophosphohydrolase disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chr 9:65,265,180...65,280,614
Ensembl chr 9:65,265,180...65,280,605
JBrowse link
G Clec3b C-type lectin domain family 3, member b disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chr 9:123,150,946...123,157,432
Ensembl chr 9:123,150,946...123,157,432
JBrowse link
G Clic1 chloride intracellular channel 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr17:35,050,243...35,058,719
Ensembl chr17:35,049,966...35,058,749
JBrowse link
G Clic4 chloride intracellular channel 4 (mitochondrial) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 4:135,213,969...135,272,760
Ensembl chr 4:135,213,969...135,272,814
JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789, PMID:18784066 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Col11a1 collagen, type XI, alpha 1 IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr 3:114,030,479...114,220,756
Ensembl chr 3:114,030,540...114,220,718
JBrowse link
G Col1a1 collagen, type I, alpha 1 no_association ISO DNA:SNP:intron:IVS1 RGD PMID:10743824 RGD:5688331 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col2a1 collagen, type II, alpha 1 onset
treatment
ISO DNA:missense mutation:exon:p.R75C (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:9061443, PMID:16189708, PMID:16755660, PMID:19216861 RGD:8657384, RGD:8661226 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Col6a2 collagen, type VI, alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr10:76,595,756...76,623,630
Ensembl chr10:76,595,762...76,623,630
JBrowse link
G Col9a1 collagen, type IX, alpha 1 IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr 1:24,177,589...24,252,738
Ensembl chr 1:24,177,610...24,252,684
JBrowse link
G Comp cartilage oligomeric matrix protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:7670472 NCBI chr 8:70,373,548...70,382,066
Ensembl chr 8:70,373,558...70,382,066
JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctsk cathepsin K ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr 3:95,499,210...95,509,387
Ensembl chr 3:95,499,256...95,509,362
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 5:90,759,298...90,761,625
Ensembl chr 5:90,759,360...90,761,624
JBrowse link
G Dapp1 dual adaptor for phosphotyrosine and 3-phosphoinositides 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 3:137,931,007...137,981,549
Ensembl chr 3:137,931,007...137,981,545
JBrowse link
G Ddx3x DEAD box helicase 3, X-linked ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr  X:13,280,496...13,293,988
Ensembl chr  X:13,280,970...13,294,052
JBrowse link
G Dpep1 dipeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr 8:123,186,235...123,201,812
Ensembl chr 8:123,186,242...123,201,812
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr14:66,802,864...66,911,041
Ensembl chr14:66,802,864...66,868,688
JBrowse link
G Edil3 EGF-like repeats and discoidin I-like domains 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr13:88,821,472...89,323,225
Ensembl chr13:88,821,472...89,323,223
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr10:81,176,631...81,182,509
Ensembl chr10:81,176,631...81,182,498
JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:10806043 RGD:1626498 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eno1 enolase 1, alpha non-neuron ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr10:24,637,914...24,712,159
Ensembl chr10:24,637,914...24,712,159
JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP
ISO
protein:increased expression:layer of synovial tissue, stromal cell
mRNA:increased expression:cartilage
RGD PMID:21869830, PMID:12823854, PMID:20495569, PMID:20495569 RGD:10395364, RGD:10395366, RGD:10395365, RGD:10395365 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 IEP mRNA:decreased expression:knee, articular cartilage of joint RGD PMID:24964749 RGD:10045611 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524
JBrowse link
G Erg ETS transcription factor IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr16:95,359,169...95,586,600
Ensembl chr16:95,359,169...95,586,593
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chr 4:150,853,796...150,868,889
Ensembl chr 4:150,853,919...150,868,892
JBrowse link
G Esd esterase D/formylglutathione hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr14:74,732,151...74,750,765
Ensembl chr14:74,732,297...74,750,765
JBrowse link
G Esr1 estrogen receptor 1 (alpha) ISO DNA:SNP:intron: (rs2234693) (human)
DNA:SNPs:introns: (rs2234693, rs9340799) (human)
RGD PMID:20417295, PMID:19884274 RGD:10045662, RGD:10045830 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO DNA:SNP:intron: (rs1256031) (human) RGD PMID:19884274 RGD:10045830 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Etfa electron transferring flavoprotein, alpha polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 9:55,454,436...55,512,243
Ensembl chr 9:55,454,508...55,512,243
JBrowse link
G Ezr ezrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO RGD PMID:8254199 RGD:5147984 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Fgf18 fibroblast growth factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr11:33,116,970...33,147,400
Ensembl chr11:33,117,430...33,147,400
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:22393163 RGD:10402075 NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO mRNA:increased expression:trabecular bone: RGD PMID:15781004 RGD:10402109 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fn1 fibronectin 1 ISO protein:increased expression:cartilage: RGD PMID:8646429 RGD:10402156 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Frzb frizzled-related protein susceptibility ISO ClinVar Annotator: match by OMIM:165720
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Osteoarthritis
ClinVar
CTD
OMIM
PMID:15210948, PMID:25741868 NCBI chr 2:80,411,970...80,447,396
Ensembl chr 2:80,411,970...80,447,625
JBrowse link
G Ftl1 ferritin light polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gdf5 growth differentiation factor 5 ISO
IEA
CTD Direct Evidence: marker/mechanism
OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401
OMIM
CTD
MouseDO
PMID:18830904, PMID:30664745 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367
JBrowse link
G Gh growth hormone ISO protein:increased expression:plasma RGD PMID:7152485 RGD:10003140 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865
JBrowse link
G Ghr growth hormone receptor ISO DNA:deletion:exon: RGD PMID:23740230 RGD:10003113 NCBI chr15:3,317,755...3,583,352
Ensembl chr15:3,317,760...3,583,492
JBrowse link
G Gls glutaminase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 1:52,163,449...52,235,009
Ensembl chr 1:52,163,448...52,233,232
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 5:30,119,423...30,154,980
Ensembl chr 5:30,118,304...30,155,162
JBrowse link
G Hbp1 high mobility group box transcription factor 1 ISO RGD PMID:22586168 RGD:10402054 NCBI chr12:31,926,452...31,950,530
Ensembl chr12:31,926,254...31,950,535
JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 1:52,845,038...52,920,986
Ensembl chr 1:52,844,929...52,920,986
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO
IMP
protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854, PMID:18789153 RGD:10395366, RGD:10402406 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmgb1 high mobility group box 1 IEP RGD PMID:22330250 RGD:10401949 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 9:54,586,511...54,604,662
Ensembl chr 9:54,586,334...54,604,661
JBrowse link
G Ifna16 interferon alpha 16 treatment ISO RGD PMID:30456844 RGD:36174218 NCBI chr 4:88,676,287...88,676,856
Ensembl chr 4:88,675,915...88,676,924
JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:blood: RGD PMID:2290165 RGD:10045857 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor severity ISO mRNA:increased expression:articular cartilage of joint: RGD PMID:8609369 RGD:10045889 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Igf2 insulin-like growth factor 2 ISO mRNA:increased expression:cartilage RGD PMID:22527881 RGD:10402552 NCBI chr 7:142,650,768...142,666,816
Ensembl chr 7:142,650,766...142,666,816
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO RGD PMID:18775662 RGD:10402575 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Ihh Indian hedgehog ISO
IEP
protein:increased expression:cartilage RGD PMID:24786088, PMID:24786088 RGD:12910979, RGD:12910979 NCBI chr 1:74,945,315...74,951,672
Ensembl chr 1:74,945,315...74,951,672
JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:chonodrocyte: RGD PMID:9497936 RGD:10047053 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta treatment ISO CTD Direct Evidence: marker/mechanism CTD PMID:21954917, PMID:22890185 RGD:7207218 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4ra interleukin 4 receptor, alpha ISO protein:increased expression:serum RGD PMID:16647277 RGD:10402785 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22035391 RGD:5687147 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Immt inner membrane protein, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 6:71,831,091...71,875,266
Ensembl chr 6:71,831,331...71,877,388
JBrowse link
G Ins2 insulin II ISO protein:increased expression:blood: RGD PMID:2290165 RGD:10045857 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Isoc2a isochorismatase domain containing 2a ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:4,877,053...4,895,717
Ensembl chr 7:4,877,153...4,896,973
JBrowse link
G Jag1 jagged 1 ISO RGD PMID:18354251 RGD:6482239 NCBI chr 2:137,081,451...137,116,520
Ensembl chr 2:137,081,456...137,116,644
JBrowse link
G Lep leptin severity ISO protein:increased expression:tibia, cartilage, chondrocyte (human) RGD PMID:14613274 RGD:10053634 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11790802, PMID:12379497 NCBI chr19:5,740,900...5,758,536
Ensembl chr19:5,740,904...5,758,532
JBrowse link
G Matn3 matrilin 3 susceptibility IEA
ISO
OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401
ClinVar Annotator: match by term: OSTEOARTHRITIS OF DISTAL INTERPHALANGEAL JOINTS
CTD Direct Evidence: marker/mechanism
MouseDO
ClinVar
CTD
OMIM
PMID:12736871 NCBI chr12:8,947,929...8,972,028
Ensembl chr12:8,947,929...8,972,028
JBrowse link
G Mmp13 matrix metallopeptidase 13 treatment ISO
IMP
mRNA, protein:increased expression:cartilage RGD PMID:16128596, PMID:11134178, PMID:17530714, PMID:23982761, PMID:22890185 RGD:7207089, RGD:10043117, RGD:2300093, RGD:10043101, RGD:7207218 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) ISO protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chr 9:7,464,141...7,476,869
Ensembl chr 9:7,464,141...7,476,869
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:synovial fluid (human) RGD PMID:15194590 RGD:7207131 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO protein:increased expression:synovial fluid (human) RGD PMID:16128596, PMID:15194590 RGD:7207089, RGD:7207131 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chr 9:7,558,429...7,568,486
Ensembl chr 9:7,558,456...7,568,485
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr  X:96,096,045...96,168,553
Ensembl chr  X:96,096,042...96,168,552
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IMP RGD PMID:24651621, PMID:22084394 RGD:10003163, RGD:10003165 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Mvp major vault protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:126,986,860...127,014,594
Ensembl chr 7:126,986,860...127,014,621
JBrowse link
G Myh13 myosin, heavy polypeptide 13, skeletal muscle ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr11:67,327,103...67,371,587
Ensembl chr11:67,321,658...67,371,586
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D ISO protein:increased expression:spinal cord RGD PMID:20722027 RGD:10412653 NCBI chr 5:21,662,901...21,701,622
Ensembl chr 5:21,662,901...21,701,396
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chr 5:125,017,153...125,179,238
Ensembl chr 5:125,017,153...125,179,219
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr19:3,908,863...3,912,774
Ensembl chr19:3,908,863...3,912,774
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr19:4,007,499...4,012,755
Ensembl chr19:4,007,384...4,012,806
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr11:93,949,814...93,956,256
Ensembl chr11:93,949,814...93,956,259
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr16:29,579,281...29,663,127
Ensembl chr16:29,579,334...29,654,884
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 6:124,841,089...124,857,746
Ensembl chr 6:124,841,089...124,857,752
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 9:113,651,744...113,708,279
Ensembl chr 9:113,651,744...113,708,259
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr  X:160,122,219...160,138,430
Ensembl chr  X:160,122,209...160,138,413
JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO mRNA:increased expression:tibia (rat) RGD PMID:21864409 RGD:6771362 NCBI chr11:106,654,213...106,715,281
Ensembl chr11:106,654,217...106,750,628
JBrowse link
G Plcd1 phospholipase C, delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 9:119,071,527...119,093,502
Ensembl chr 9:119,071,527...119,093,502
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 9:92,539,636...92,608,428
Ensembl chr 9:92,542,223...92,608,428
JBrowse link
G Pls3 plastin 3 (T-isoform) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr  X:75,785,653...75,875,182
Ensembl chr  X:75,785,654...75,875,182
JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO RGD PMID:21378032 RGD:5508809 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Pou3f3 POU domain, class 3, transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 1:42,695,768...42,700,210
Ensembl chr 1:42,694,925...42,703,176
Ensembl chr 1:42,694,925...42,703,176
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr17:20,945,454...20,965,905
Ensembl chr17:20,945,311...20,965,916
JBrowse link
G Psmb1 proteasome (prosome, macropain) subunit, beta type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr17:15,475,721...15,498,276
Ensembl chr17:15,475,021...15,499,751
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 susceptibility ISO DNA:SNP (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:32004530, PMID:15334463 RGD:1625347 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ran RAN, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 5:129,020,156...129,024,322
Ensembl chr 5:129,020,069...129,024,323
JBrowse link
G Rcn3 reticulocalbin 3, EF-hand calcium binding domain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 7:45,082,914...45,092,322
Ensembl chr 7:45,082,913...45,092,221
JBrowse link
G Runx2 runt related transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G S100a4 S100 calcium binding protein A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16948116 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G Scrn1 secernin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 6:54,474,794...54,566,517
Ensembl chr 6:54,501,173...54,566,489
JBrowse link
G Sdcbp syndecan binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 4:6,365,680...6,396,122
Ensembl chr 4:6,365,650...6,408,423
JBrowse link
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr13:74,322,255...74,350,240
Ensembl chr13:74,322,254...74,350,280
JBrowse link
G Sec23a SEC23 homolog A, COPII coat complex component ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr12:58,958,384...59,012,017
Ensembl chr12:58,958,383...59,012,017
JBrowse link
G Serpina1e serine (or cysteine) peptidase inhibitor, clade A, member 1E ISO RGD PMID:20434574 RGD:2324964 NCBI chr12:103,946,931...103,956,897
Ensembl chr12:103,946,931...103,958,975
JBrowse link
G Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr14:61,219,106...61,275,062
Ensembl chr14:61,219,115...61,258,490
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18973239 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983
JBrowse link
G Smad3 SMAD family member 3 ISO
IEA
CTD Direct Evidence: marker/mechanism
OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401
CTD
MouseDO
PMID:21217753, PMID:22772368 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:18784066, PMID:22108257 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A susceptibility ISO DNA:repeats: : RGD PMID:25231575 RGD:14390133 NCBI chr 9:85,320,439...85,327,150
Ensembl chr 9:85,320,439...85,327,348
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 6:3,962,589...3,988,978
Ensembl chr 6:3,962,595...3,988,919
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I IEA OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:612400 MouseDO NCBI chr 4:47,353,222...47,414,926
Ensembl chr 4:47,353,222...47,414,931
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr 2:158,116,405...158,146,392
Ensembl chr 2:158,116,402...158,146,436
JBrowse link
G Tlr8 toll-like receptor 8 ISO ClinVar Annotator: match by term: Osteoarthritis ClinVar NCBI chr  X:167,241,123...167,264,329
Ensembl chr  X:167,242,696...167,264,329
JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b ISO RGD PMID:14872496 RGD:2290500 NCBI chr14:69,767,472...69,784,411
Ensembl chr14:69,767,472...69,784,411
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 ISO RGD PMID:14872496 RGD:2290500 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr 4:63,724,600...63,745,059
Ensembl chr 4:63,727,084...63,745,113
Ensembl chr 4:63,727,084...63,745,113
JBrowse link
G Trap1 TNF receptor-associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr16:4,039,971...4,077,840
Ensembl chr16:4,039,971...4,077,827
JBrowse link
G Trim2 tripartite motif-containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 3:84,160,439...84,308,352
Ensembl chr 3:84,160,439...84,306,877
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21964574 NCBI chr 5:114,622,152...114,658,435
Ensembl chr 5:114,622,152...114,658,421
JBrowse link
G Txnrd1 thioredoxin reductase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Vdac2 voltage-dependent anion channel 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr14:21,831,561...21,845,879
Ensembl chr14:21,825,238...21,845,879
JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16876394, PMID:18784066 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chr12:21,390,329...21,417,436
Ensembl chr12:21,390,071...21,417,637
JBrowse link
Osteoarthritis with Mild Chondrodysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen, type II, alpha 1 ISO ClinVar Annotator: match by term: Osteoarthritis with mild chondrodysplasia
ClinVar Annotator: match by term: NAMAQUALAND HIP DYSPLASIA
OMIM
ClinVar
PMID:1975693, PMID:1985108, PMID:7752132, PMID:7757086, PMID:8325895, PMID:8507190, PMID:9101290, PMID:9711874, PMID:25741868, PMID:28492532 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
Osteoarthritis, Experimental term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1, autophagy related treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19404941 RGD:9068434 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Col1a1 collagen, type I, alpha 1 treatment ISO RGD PMID:25128628 RGD:11041187 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IMP RGD PMID:22833219 RGD:10402072 NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO RGD PMID:23041435 RGD:10402106 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Hspa1a heat shock protein 1A treatment ISO RGD PMID:16394269 RGD:10402538 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 ISO mRNA:decreased expression:knee RGD PMID:24754147 RGD:10412054 NCBI chr 5:35,091,490...35,105,699
Ensembl chr 5:35,091,501...35,105,766
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chr 2:155,276,364...155,278,073
Ensembl chr 2:155,276,297...155,278,073
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO RGD PMID:29364174 RGD:13800565 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 severity IMP RGD PMID:28122611 RGD:27226703 NCBI chr11:75,410,029...75,422,623
Ensembl chr11:75,409,769...75,422,701
JBrowse link
G Ulk1 unc-51 like kinase 1 treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chr 5:110,784,489...110,810,120
Ensembl chr 5:110,784,488...110,810,097
JBrowse link
Osteoarthritis, Hip term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) ISO mRNA:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chr16:85,858,157...85,901,125
Ensembl chr16:85,856,173...85,901,828
JBrowse link
G Aspn asporin ISO mRNA:increased expression:cartilage: RGD PMID:15640800 RGD:9684965 NCBI chr13:49,544,443...49,567,565
Ensembl chr13:49,544,443...49,567,565
JBrowse link
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 4:65,380,803...66,404,537
Ensembl chr 4:65,380,803...66,404,611
JBrowse link
G Chadl chondroadherin-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28319091, PMID:30374069 NCBI chr15:81,686,166...81,697,373
Ensembl chr15:81,678,296...81,697,287
JBrowse link
G Col10a1 collagen, type X, alpha 1 ISO mRNA, protein:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chr10:34,389,981...34,397,085
Ensembl chr10:34,389,981...34,397,085
JBrowse link
G Col11a1 collagen, type XI, alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 3:114,030,479...114,220,756
Ensembl chr 3:114,030,540...114,220,718
JBrowse link
G Col1a1 collagen, type I, alpha 1 no_association
susceptibility
ISO DNA:SNP:intron:g.2046G>T (human) RGD PMID:17187661, PMID:9811048, PMID:15880349 RGD:5688305, RGD:5688330, RGD:5688306 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Comp cartilage oligomeric matrix protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28319091 NCBI chr 8:70,373,548...70,382,066
Ensembl chr 8:70,373,558...70,382,066
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr11:104,130,463...104,175,523
Ensembl chr11:104,132,855...104,175,523
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr 5:123,511,330...123,524,164
Ensembl chr 5:123,509,765...123,524,176
JBrowse link
G Esr1 estrogen receptor 1 (alpha) ISO DNA:SNP:intron:g.-397T>C (human) RGD PMID:17419075 RGD:10045661 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Filip1 filamin A interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 9:79,805,018...80,012,851
Ensembl chr 9:79,805,094...80,012,851
JBrowse link
G Gdf5 growth differentiation factor 5 ISO ClinVar Annotator: match by term: Osteoarthritis of hip ClinVar PMID:17384641 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367
JBrowse link
G Ghr growth hormone receptor ISO associated with Acromegaly;DNA:deletion:exon: RGD PMID:19864451 RGD:10003142 NCBI chr15:3,317,755...3,583,352
Ensembl chr15:3,317,760...3,583,492
JBrowse link
G Hdac9 histone deacetylase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr12:34,047,580...34,917,095
Ensembl chr12:34,047,580...34,917,095
JBrowse link
G Hfe homeostatic iron regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069, PMID:30664745 NCBI chr 7:4,772,373...4,782,907
Ensembl chr 7:4,772,373...4,782,859
JBrowse link
G Il4ra interleukin 4 receptor, alpha susceptibility
no_association
ISO DNA:SNPs:multiple
DNA:missense mutations:cds:p.S411L, p.S727A (rs1805013, rs1805016) (human)
RGD PMID:14745651, PMID:19036616 RGD:10402782, RGD:10402784 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr14:30,929,180...30,943,289
Ensembl chr14:30,929,180...30,943,289
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 2:33,560,965...33,641,208
Ensembl chr 2:33,560,965...33,640,511
Ensembl chr 2:33,560,965...33,640,511
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr19:5,740,900...5,758,536
Ensembl chr19:5,740,904...5,758,532
JBrowse link
G Mapt microtubule-associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO mRNA, protein:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Runx2 runt related transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Smo smoothened, frizzled class receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 6:29,735,497...29,761,366
Ensembl chr 6:29,735,503...29,761,365
JBrowse link
G Tnc tenascin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chr 4:63,959,785...64,047,015
Ensembl chr 4:63,959,785...64,047,015
JBrowse link
Osteoarthritis, Temporomandibular Joint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Becn1 beclin 1, autophagy related ISO RGD PMID:31007149 RGD:34888237 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Casp12 caspase 12 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 ISO RGD PMID:31007149 RGD:34888237 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) ISO mRNA:increased expression:mandibular condyle, cartilage (rat) RGD PMID:23934157 RGD:8663479 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Hspa5 heat shock protein 5 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta ISO RGD PMID:31007149 RGD:34888237 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Rps6 ribosomal protein S6 ISO RGD PMID:31007149 RGD:34888237 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412
JBrowse link
otulipenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otulin OTU deubiquitinase with linear linkage specificity ISO ClinVar Annotator: match by term: AUTOINFLAMMATION, PANNICULITIS, AND DERMATOSIS SYNDROME ClinVar
OMIM
PMID:27523608, PMID:27559085 NCBI chr15:27,597,055...27,630,977
Ensembl chr15:27,542,635...27,630,693
JBrowse link
polymyalgia rheumatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone no_association ISO DNA:polymorphism:promoter RGD PMID:12051390 RGD:1581301 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Crp C-reactive protein, pentraxin-related treatment ISO RGD PMID:2859021 RGD:9495925 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30657865 RGD:14746966 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 ISO DNA:polymorphism:cds: RGD PMID:12375325 RGD:8693752 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:11796404 RGD:7241254 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO protein:increased expression:plasma, endothelial microparticle (human) RGD PMID:22211720 RGD:6771319 NCBI chr11:106,654,213...106,715,281
Ensembl chr11:106,654,217...106,750,628
JBrowse link
Reynolds Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lbr lamin B receptor ISO ClinVar Annotator: match by term: Reynolds syndrome OMIM
ClinVar
PMID:20522425, PMID:25741868 NCBI chr 1:181,815,315...181,842,401
Ensembl chr 1:181,815,335...181,843,046
JBrowse link
rheumatic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gc vitamin D binding protein ISO RGD PMID:2737695 RGD:5509933 NCBI chr 5:89,417,511...89,457,898
Ensembl chr 5:89,417,522...89,457,898
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:14567831 RGD:13702910 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
rheumatic heart disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule ISO mRNA:decreased expression:blood, mononuclear cell RGD PMID:16741676 RGD:6893529 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:26823728 RGD:13792679 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphisms, haplotypes:multiple RGD PMID:17559688 RGD:5147792 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphisms:cds:HLA-DQB1*08 (human) RGD PMID:17578051 RGD:5147630 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism (human)
DNA:polymorphism:cds:HLA-DRB1*13 (human)
RGD PMID:17578051, PMID:16426242 RGD:5147630, RGD:5147643 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:16406300 RGD:1582623 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Il10 interleukin 10 no_association ISO RGD PMID:16043936 RGD:1598626 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
rheumatic myocarditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Sele selectin, endothelial cell severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO GAD PMID:15118671 RGD:1331525 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:20080907, PMID:22104130 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Acan aggrecan disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased degradation:cartilage
CTD PMID:15292528, PMID:16507130 RGD:11570537 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Ackr3 atypical chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:90,203,980...90,215,724
Ensembl chr 1:90,203,980...90,216,751
JBrowse link
G Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 ISO mRNA:increased expression:synovium RGD PMID:11801682 RGD:10043106 NCBI chr 1:171,250,129...171,262,267
Ensembl chr 1:171,250,421...171,260,637
JBrowse link
G Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) ISO protein:alternative form:synovium RGD PMID:11801682 RGD:10043106 NCBI chr16:85,858,157...85,901,125
Ensembl chr16:85,856,173...85,901,828
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12833524, PMID:21789720 RGD:5686424 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adrb3 adrenergic receptor, beta 3 ISO DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:12739037 RGD:5684893 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Aff3 AF4/FMR2 family, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:38,175,393...38,630,178
Ensembl chr 1:38,177,326...38,664,955
JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO protein:decreased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:16385501, PMID:20541603 RGD:7244141 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ahr aryl-hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18617548 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 ISO RGD PMID:12653852 RGD:6892721 NCBI chr14:51,091,077...51,102,009
Ensembl chr14:51,091,150...51,102,009
JBrowse link
G Ankrd55 ankyrin repeat domain 55 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr13:112,288,451...112,384,005
Ensembl chr13:112,288,451...112,384,002
JBrowse link
G Anxa3 annexin A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 5:96,793,385...96,845,968
Ensembl chr 5:96,793,339...96,845,966
JBrowse link
G Apoa4 apolipoprotein A-IV ISO protein:increased expression:blood serum (human) RGD PMID:20367977 RGD:5685646 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Arid5b AT rich interactive domain 5B (MRF1-like) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963, PMID:23143596 NCBI chr10:68,092,523...68,279,355
Ensembl chr10:68,092,520...68,278,740
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19193698 NCBI chr 1:71,557,156...71,579,403
Ensembl chr 1:71,557,150...71,579,631
JBrowse link
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr11:22,834,739...22,860,336
Ensembl chr11:22,759,738...22,860,961
JBrowse link
G B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 8:105,252,638...105,255,250
Ensembl chr 8:105,252,638...105,255,153
JBrowse link
G Baiap2l1 BAI1-associated protein 2-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 5:144,264,525...144,358,112
Ensembl chr 5:144,264,526...144,358,112
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Bglap bone gamma carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:22447331, PMID:3488088 RGD:6483593, RGD:6483600 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bgn biglycan ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr  X:73,483,601...73,495,936
Ensembl chr  X:73,483,602...73,495,933
JBrowse link
G Blk B lymphoid kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr14:63,372,837...63,417,187
Ensembl chr14:63,372,836...63,417,037
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Btnl2 butyrophilin-like 2 susceptibility ISO DNA:SNPs: : RGD PMID:23364395 RGD:9685033 NCBI chr17:34,354,789...34,369,492
Ensembl chr17:34,354,822...34,369,495
JBrowse link
G C3 complement component 3 ISO RGD PMID:7561187 RGD:11040775 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G C4b complement component 4B (Chido blood group) ISO RGD PMID:22076784 RGD:5688263 NCBI chr17:34,728,139...34,743,902
Ensembl chr17:34,728,380...34,743,882
JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Casp7 caspase 7 ISO RGD PMID:18785314 RGD:5684540 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Cast calpastatin ISO RGD PMID:7706496 RGD:5683620 NCBI chr13:74,692,366...74,808,874
Ensembl chr13:74,692,368...74,808,810
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav2 caveolin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 6:17,281,185...17,289,130
Ensembl chr 6:17,281,185...17,289,115
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 ISO protein:increased expression:serum RGD PMID:20056091 RGD:4891442 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl21a chemokine (C-C motif) ligand 21A (serine) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
JBrowse link
G Ccl22 chemokine (C-C motif) ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chr 8:94,745,684...94,751,388
Ensembl chr 8:94,745,590...94,751,699
JBrowse link
G Ccl8 chemokine (C-C motif) ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr11:82,115,185...82,116,799
Ensembl chr11:82,115,185...82,116,799
JBrowse link
G Ccn1 cellular communication network factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 3:145,646,971...145,649,985
Ensembl chr 3:145,646,976...145,649,981
JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccr1 chemokine (C-C motif) receptor 1 ISO RGD PMID:12860725 RGD:5688170 NCBI chr 9:123,962,126...123,968,692
Ensembl chr 9:123,962,124...123,968,692
JBrowse link
G Ccr3 chemokine (C-C motif) receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr 9:124,017,825...124,031,692
Ensembl chr 9:124,021,972...124,031,689
JBrowse link
G Ccr4 chemokine (C-C motif) receptor 4 ISO protein:increased expression:synovial membrane:
mRNA:increased expression:synovium:
RGD PMID:19942450, PMID:25430645 RGD:10054497, RGD:10054499 NCBI chr 9:114,490,316...114,505,476
Ensembl chr 9:114,490,316...114,504,916
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 resistance
no_association
ISO DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD PMID:16541097, PMID:17565662 RGD:1626290, RGD:1626283 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Ccr6 chemokine (C-C motif) receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453841, PMID:20453842, PMID:23143596 NCBI chr17:8,236,041...8,258,519
Ensembl chr17:8,236,043...8,257,141
JBrowse link
G Cd2 CD2 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 3:101,275,908...101,287,939
Ensembl chr 3:101,275,899...101,287,939
JBrowse link
G Cd244a CD244 molecule A susceptibility ISO ClinVar Annotator: match by OMIM:180300
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:18794858 NCBI chr 1:171,558,718...171,585,316
Ensembl chr 1:171,559,193...171,609,746
JBrowse link
G Cd28 CD28 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596, PMID:19075187 RGD:5131619 NCBI chr 1:60,746,388...60,773,359
Ensembl chr 1:60,716,800...60,773,359
JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 9:44,998,735...45,009,663
Ensembl chr 9:44,998,740...45,009,627
JBrowse link
G Cd40 CD40 antigen ISO DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:18794853, PMID:20453842, PMID:23143596, PMID:20498205 RGD:5490972 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd5 CD5 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr19:10,718,107...10,739,026
Ensembl chr19:10,717,116...10,739,002
JBrowse link
G Cd80 CD80 antigen ISO protein:increased expression:serum RGD PMID:22917707 RGD:6893647 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd83 CD83 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr13:43,785,112...43,803,133
Ensembl chr13:43,784,775...43,803,132
JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta ISO protein:increased expression:knee, articular cartilage (human) RGD PMID:19248099 RGD:10401213 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Chil1 chitinase-like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:10461474 RGD:4892605 NCBI chr 1:134,182,156...134,190,031
Ensembl chr 1:134,182,176...134,190,181
JBrowse link
G Ciita class II transactivator susceptibility
no_association
ISO DNA:haplotype:promoter/CDS:rs3087456G/rs4774C (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by OMIM:180300
DNA:polymorphism:promoter:-168A>G (human)
DNA:polymorphism:promoter:rs3087456, no association in a German cohort (Human)
CTD
OMIM
ClinVar
PMID:15821736, PMID:16849401, PMID:19221398, PMID:15821736, PMID:16426246 RGD:5491176, RGD:1358146, RGD:5491189 NCBI chr16:10,480,014...10,531,064
Ensembl chr16:10,480,059...10,528,418
JBrowse link
G Clec12a C-type lectin domain family 12, member a ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 6:129,349,783...129,365,303
Ensembl chr 6:129,342,691...129,365,303
JBrowse link
G Clec16a C-type lectin domain family 16, member A ISO DNA:polymorphism:intron:rs6498169G (human) RGD PMID:19221398 RGD:5491176 NCBI chr16:10,545,309...10,744,878
Ensembl chr16:10,545,339...10,744,878
JBrowse link
G Col2a1 collagen, type II, alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27028940, PMID:29935983 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:1568518, PMID:22173958, PMID:22173958 RGD:6904209, RGD:6904209 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Cx3cl1 chemokine (C-X3-C motif) ligand 1 ISO RGD PMID:11465708 RGD:4892002 NCBI chr 8:94,772,180...94,782,427
Ensembl chr 8:94,772,009...94,782,427
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:19192274 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 5:90,759,298...90,761,625
Ensembl chr 5:90,759,360...90,761,624
JBrowse link
G Cxcr3 chemokine (C-X-C motif) receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr  X:101,731,535...101,734,147
Ensembl chr  X:101,731,535...101,734,269
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 9:44,602,983...44,640,731
Ensembl chr 9:44,604,892...44,640,731
JBrowse link
G Dhfr dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr13:92,354,783...92,389,053
Ensembl chr13:92,354,726...92,389,053
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr14:7,965,187...7,994,760
Ensembl chr14:7,964,533...7,994,573
JBrowse link
G Dnase2a deoxyribonuclease II alpha IEA OMIM:180300 MouseDO NCBI chr 8:84,908,755...84,911,703
Ensembl chr 8:84,908,560...84,922,915
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 severity ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3b DNA methyltransferase 3B disease_progression ISO DNA:polymorphism:promoter:-283C>T(human) RGD PMID:19777235 RGD:9589110 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Edn1 endothelin 1 treatment ISO RGD PMID:22249931 RGD:8661695 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Eln elastin ISO RGD PMID:12643515 RGD:9585739 NCBI chr 5:134,702,595...134,747,368
Ensembl chr 5:134,702,593...134,747,323
JBrowse link
G Eno1 enolase 1, alpha non-neuron ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898480 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Esr2 estrogen receptor 2 (beta) severity ISO DNA:SNP:exon:rs1256049(human) RGD PMID:21523342 RGD:5508794 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) susceptibility ISO DNA:snp:promoter:g.-670A>G (human)
protein:increased expression:serum (human)
RGD PMID:23053964, PMID:20875116, PMID:12148596 RGD:8662433, RGD:12903969, RGD:8662455 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I ISO protein:increased expression:synovial joint: RGD PMID:16670289 RGD:9685708 NCBI chr 3:96,282,909...96,293,969
Ensembl chr 3:96,282,909...96,293,969
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Fcgr4 Fc receptor, IgG, low affinity IV susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human)
DNA:CNVs
protein:decreased expression:NK cell
RGD PMID:19019892, PMID:25154742, PMID:15334114 RGD:5508391, RGD:11344974, RGD:5508467 NCBI chr 1:171,018,926...171,029,761
Ensembl chr 1:171,018,920...171,029,761
JBrowse link
G Fkbp5 FK506 binding protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr17:28,398,753...28,486,149
Ensembl chr17:28,399,094...28,517,527
JBrowse link
G Foxo3 forkhead box O3 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell,synovium: RGD PMID:19435720 RGD:10402186 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Foxp3 forkhead box P3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20476861 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Fpgs folylpolyglutamyl synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 2:32,682,609...32,704,196
Ensembl chr 2:32,682,609...32,704,145
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr16:91,621,395...91,646,972
Ensembl chr16:91,621,186...91,646,952
JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 2:9,857,078...9,887,953
Ensembl chr 2:9,857,078...9,890,034
JBrowse link
G Gc vitamin D binding protein ISO protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD PMID:3874814, PMID:9548303 RGD:5509931 NCBI chr 5:89,417,511...89,457,898
Ensembl chr 5:89,417,522...89,457,898
JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18830904 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367
JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 4:20,041,997...20,066,111
Ensembl chr 4:20,042,052...20,066,750
JBrowse link
G Gin1 gypsy retrotransposon integrase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:97,770,172...97,793,710
Ensembl chr 1:97,770,172...97,793,709
JBrowse link
G Gprc5a G protein-coupled receptor, family C, group 5, member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 6:135,065,662...135,084,709
Ensembl chr 6:135,065,651...135,084,709
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IAGP
ISO
DNA: deletion: : heterozygous
CTD Direct Evidence: marker/mechanism
protein: decreased expression: mononuclear cells
CTD PMID:10094932, PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 no_association IAGP
ISO
DNA: deletion::GRK2 and GRK6 deletions resulted in more severe arthritis
protein: decreased expression: mononuclear leukocytes
RGD PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr19:60,889,560...61,095,968
Ensembl chr19:60,889,749...61,095,968
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IAGP
ISO
DNA: deletion: : homozygous
CTD Direct Evidence: marker/mechanism
protein: decreased expression: mononuclear cells
CTD PMID:10094932, PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr13:55,445,072...55,460,927
Ensembl chr13:55,445,072...55,460,927
JBrowse link
G Gsdme gasdermin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 6:50,207,401...50,263,857
Ensembl chr 6:50,188,888...50,263,862
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 susceptibility ISO DNA:deletion: :
DNA:deletion: :
RGD PMID:16887863, PMID:15940757, PMID:16870093 RGD:5490993, RGD:5490998, RGD:5490994 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 severity
susceptibility
ISO DNA:deletion: : RGD PMID:19473562, PMID:20401725, PMID:20597111 RGD:5490553, RGD:5490983, RGD:5490982 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphisms
DNA:polymorphism (human)
RGD PMID:11482129, PMID:11454644 RGD:5147859, RGD:5147860 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphism (human) RGD PMID:11454644 RGD:5147860 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphisms: :multiple (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human)
DNA:polymorphisms (human)
CTD PMID:19898480, PMID:20453842, PMID:22286218, PMID:21246357, PMID:11454644, PMID:19117368 RGD:5147567, RGD:5147860, RGD:5147616 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr13:89,540,529...89,611,832
Ensembl chr13:89,539,796...89,611,652
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr16:36,934,983...36,963,214
Ensembl chr16:36,934,983...36,963,212
JBrowse link
G Hdac1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289289 NCBI chr 4:129,516,104...129,542,646
Ensembl chr 4:129,516,104...129,542,713
JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hgf hepatocyte growth factor disease_progression ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 severity ISO RGD PMID:18025202 RGD:9685481 NCBI chr 6:51,460,434...51,470,048
Ensembl chr 6:51,460,932...51,469,894
JBrowse link
G Hoxd10 homeobox D10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:74,684,273...74,695,106
Ensembl chr 2:74,691,924...74,695,105
JBrowse link
G Hoxd11 homeobox D11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:74,679,558...74,687,016
Ensembl chr 2:74,679,557...74,687,016
JBrowse link
G Hoxd13 homeobox D13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:74,668,225...74,671,603
Ensembl chr 2:74,668,310...74,671,599
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:193,221,640...193,264,045
Ensembl chr 1:193,221,634...193,264,075
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hspa4 heat shock protein 4 ISO protein:increased expression:peripheral blood lymphocyte (human) RGD PMID:22047640 RGD:5688784 NCBI chr11:53,259,814...53,300,479
Ensembl chr11:53,259,814...53,300,457
JBrowse link
G Hspa5 heat shock protein 5 ISO protein:increased expression:synovial joint RGD PMID:11315915 RGD:5685639 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa9 heat shock protein 9 ISO protein:increased expression:synovial cell: RGD PMID:23739258 RGD:10402561 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb1 heat shock protein 1 ISO protein:increased expression:serum: RGD PMID:21417552 RGD:10402843 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Ifng interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:1417133 RGD:8157623 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf2 insulin-like growth factor 2 ISO DNA:loss of imprinting:synovial cell
protein:decreased expression:plasma
RGD PMID:19556211, PMID:11247331 RGD:5510001, RGD:5510014 NCBI chr 7:142,650,768...142,666,816
Ensembl chr 7:142,650,766...142,666,816
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Ikzf3 IKAROS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr11:98,464,610...98,546,031
Ensembl chr11:98,464,902...98,546,031
JBrowse link
G Il10 interleukin 10 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:12847677, PMID:22450443 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:20926833 RGD:9068415 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16368150 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of ClinVar PMID:12847677 NCBI chr 1:130,932,656...130,945,457
Ensembl chr 1:130,932,656...130,940,115
JBrowse link
G Il1a interleukin 1 alpha severity ISO associated with lung disease, interstitial
protein:increased expression:plasma, synovial fluid
RGD PMID:11192540, PMID:8162643 RGD:4142818, RGD:7794716 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12566094, PMID:17379860, PMID:22450443, PMID:22414257 RGD:6482656 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO
IMP
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:7706905, PMID:19192274, PMID:19447938, PMID:10637275 RGD:7174696, RGD:8549810 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 ISO RGD PMID:6421522 RGD:8662948 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il20 interleukin 20 ISO RGD PMID:16947773 RGD:5147395 NCBI chr 1:130,906,985...130,911,296
Ensembl chr 1:130,906,985...130,911,451
JBrowse link
G Il21r interleukin 21 receptor IMP RGD PMID:19342640 RGD:6892964 NCBI chr 7:125,603,252...125,634,397
Ensembl chr 7:125,603,429...125,633,570
JBrowse link
G Il23a interleukin 23, alpha subunit p19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752
JBrowse link
G Il23r interleukin 23 receptor susceptibility ISO DNA:SNP::rs1343151(human) RGD PMID:18647855 RGD:8549596 NCBI chr 6:67,422,932...67,491,855
Ensembl chr 6:67,422,932...67,491,855
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:20476861, PMID:23143596 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Il2rb interleukin 2 receptor, beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr15:78,479,256...78,511,621
Ensembl chr15:78,479,256...78,495,271
JBrowse link
G Il3 interleukin 3 ISO DNA: SNPs: Multiple: gene-gene interaction RGD PMID:20018070 RGD:5686905 NCBI chr11:54,265,085...54,267,279
Ensembl chr11:54,265,303...54,267,277
JBrowse link
G Il4ra interleukin 4 receptor, alpha severity ISO DNA:SNP: :rs1805010 (human) RGD PMID:24782180 RGD:10402783 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22293286 RGD:5687156 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274, PMID:22450443 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il6ra interleukin 6 receptor, alpha ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16729287, PMID:23143596 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Il6st interleukin 6 signal transducer ISO
IEA
CTD Direct Evidence: marker/mechanism
OMIM:180300
CTD
MouseDO
PMID:20453842 NCBI chr13:112,464,070...112,506,860
Ensembl chr13:112,464,070...112,510,086
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Irf5 interferon regulatory factor 5 ISO ClinVar Annotator: match by synonym: RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:15657875, PMID:16642019, PMID:17599733, PMID:18063667, PMID:20453842, PMID:23143596 NCBI chr 6:29,526,130...29,541,869
Ensembl chr 6:29,526,625...29,541,871
JBrowse link
G Irf8 interferon regulatory factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 8:120,736,358...120,756,694
Ensembl chr 8:120,736,358...120,756,694
JBrowse link
G Itga6 integrin alpha 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 2:71,786,886...71,858,427
Ensembl chr 2:71,745,616...71,858,416
JBrowse link
G Itgb2 integrin beta 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Itpa inosine triphosphatase (nucleoside triphosphate pyrophosphatase) treatment ISO DNA:SNP: :94C>A(human) RGD PMID:29441893 RGD:14975307 NCBI chr 2:130,664,692...130,681,614
Ensembl chr 2:130,667,610...130,681,614
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:21510883 RGD:6483024 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Kif5a kinesin family member 5A susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:snps:intron, 3' utr:c.2756-43A>C, c.*776C>T (rs775246, rs775251) (human)
DNA:snp:intron:c.1717-152C>G (rs1678542) (human)
CTD PMID:23143596, PMID:21784728, PMID:23378462 RGD:12793073, RGD:12793072 NCBI chr10:127,225,695...127,266,348
Ensembl chr10:127,225,696...127,263,348
JBrowse link
G Lcn2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7554268 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Lhx2 LIM homeobox protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:38,339,271...38,369,737
Ensembl chr 2:38,339,281...38,369,733
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO RGD PMID:17082220 RGD:5508419 NCBI chr15:91,672,791...91,816,124
Ensembl chr15:91,673,175...91,816,120
JBrowse link
G Ly96 lymphocyte antigen 96 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 1:16,688,456...16,709,605
Ensembl chr 1:16,688,051...16,709,611
JBrowse link
G Mab21l2 mab-21-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 3:86,546,050...86,548,283
Ensembl chr 3:86,545,581...86,548,629
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:37,133,243...37,138,926
Ensembl chr10:37,133,375...37,138,920
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr18:70,568,225...70,629,134
Ensembl chr18:70,568,189...70,626,131
JBrowse link
G Mbd4 methyl-CpG binding domain protein 4 susceptibility
no_association
ISO DNA:snps:introns:IVS5-140A>G (rs3138355), IVS6-218C>T (rs2005618) (human)
DNA:snps:cds, intron:p.E346K, IVS6-218C>T (rs140693, rs2005618) (human)