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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatic disease
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Accession:DOID:1575 term browser browse the term
Definition:Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
Synonyms:exact_synonym: rheumatic diseases;   rheumatism
 primary_id: MESH:D012216
For additional species annotation, visit the Alliance of Genome Resources.


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adult-onset Still's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hgf hepatocyte growth factor ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chrNW_004936734:354,798...428,356 JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
Beukes hip dysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUNH4orf47 chromosome unknown C4orf47 homolog ISO ClinVar Annotator: match by term: Hip dysplasia, beukes type ClinVar PMID:2389793, PMID:21228277, PMID:26428751 NCBI chrNW_004936554:3,908,570...3,925,957 JBrowse link
G Ufsp2 UFM1 specific peptidase 2 ISO OMIM NCBI chrNW_004936554:3,926,046...3,945,575 JBrowse link
CREST syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpc centromere protein C ISO associated with Anticentromere antibody positivity RGD PMID:25220385 RGD:27372886 NCBI chrNW_004936582:920,852...978,167 JBrowse link
G Fbn1 fibrillin 1 ISO RGD PMID:10395706 RGD:12910471 NCBI chrNW_004936471:10,747,030...10,969,223 JBrowse link
diffuse scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing severity ISO protein:decreased expression:serum RGD PMID:21615510 RGD:8694418 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Agt angiotensinogen ISO protein:increased expression:serum RGD PMID:14730619 RGD:8548886 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Bank1 B cell scaffold protein with ankyrin repeats 1 susceptibility ISO DNA:SNPs: :rs10516487,rs17266594,rs3733197(human) RGD PMID:19815934 RGD:9684975 NCBI chrNW_004936520:1,207,078...1,284,679 JBrowse link
G Cav1 caveolin 1 no_association
susceptibility
ISO DNA:SNPs:enhancer, intron:multiple
DNA:SNPs:intron, 3' utr: (rs729949, rs3815412, rs9920) (human)
RGD PMID:22402147 RGD:8661768 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Il10 interleukin 10 ISO protein:increased expression:serum RGD PMID:9034992 RGD:5684371 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il13 interleukin 13 ISO DNA:SNPs:5' utr, enhancer: (rs1800925, rs2243204) (human) RGD PMID:16832637 RGD:5684369 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 susceptibility ISO DNA:missense mutation:cds:p.F196S (rs1059702) (human) RGD PMID:21898345 RGD:7495782 NCBI chrNW_004936809:891,407...900,311 JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:serum: RGD PMID:19886888 RGD:8551850 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Stat4 signal transducer and activator of transcription 4 no_association
susceptibility
ISO DNA:SNP:intron: (rs3821236) (human)
DNA:SNP:intron: (rs7574865) (human)
DNA:SNP:introns: (rs7574865, rs10168266) (human)
RGD PMID:19286670, PMID:23755762 RGD:8661701, RGD:8661714 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member susceptibility ISO RGD PMID:16112028 RGD:1578361 NCBI chrNW_004936476:25,899,514...25,907,690 JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO RGD PMID:16112028 RGD:1578361 NCBI chrNW_004936476:25,913,699...25,923,419 JBrowse link
G Tlr2 toll like receptor 2 disease_progression ISO DNA:polymorphism:cds:p.P631H(rs5743704)(human) RGD PMID:21905008 RGD:8553044 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Wrn WRN RecQ like helicase ISO RGD PMID:16906373 RGD:10042980 NCBI chrNW_004936792:862,659...1,005,065 JBrowse link
Digital Arthropathy-Brachydactyly, Familial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO OMIM NCBI chrNW_004936769:1,424,526...1,447,547 JBrowse link
erythema nodosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 ISO associated with Leprosy RGD PMID:2783924 RGD:7421527 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cfb complement factor B ISO associated with Leprosy RGD PMID:2783924 RGD:7421527 NCBI chrNW_004936727:1,595,872...1,602,274 JBrowse link
G Lta lymphotoxin alpha ISO associated with Sarcoidosis;DNA:polymorphism:intron RGD PMID:19225544 RGD:8548773 NCBI chrNW_004936727:1,940,081...1,941,022 JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human) RGD PMID:12198697 RGD:7364926 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vdr vitamin D receptor susceptibility ISO associated with Behcet Syndrome;DNA:polymorphism: : rs7975232(human) RGD PMID:24880677 RGD:13217417 NCBI chrNW_004936512:5,741,836...5,800,999 JBrowse link
Familial Osteochondritis Dissecans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan ISO OMIM NCBI chrNW_004936483:14,811,152...14,846,305 JBrowse link
fibromyalgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase ISO protein:decreased activity:mononuclear cell: RGD PMID:22532869 RGD:9479066 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Comt catechol-O-methyltransferase severity ISO DNA:polymorphism:cds:p.V158M(human) RGD PMID:24762091 RGD:13450944 NCBI chrNW_004936619:3,847,059...3,883,866 JBrowse link
G Il1rn interleukin 1 receptor antagonist severity ISO protein:increased expression:serum (human) RGD PMID:10341365 RGD:8549787 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
Hand Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 no_association ISO DNA:SNPs:exons: (rs2077647, rs1801132) (human) RGD PMID:19884274 RGD:10045830 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Esr2 estrogen receptor 2 no_association ISO DNA:SNPs:introns: (rs1256034, rs1256059, rs944460) (human) RGD PMID:19884274 RGD:10045830 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G Il4 interleukin 4 no_association ISO DNA:SNPs:promoter, 5' utr, intron:multiple RGD PMID:20219689 RGD:10402786 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
G Il4r interleukin 4 receptor no_association ISO DNA:SNPs:promoter, exons:multiple RGD PMID:20219689 RGD:10402786 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Matn3 matrilin 3 ISO ClinVar Annotator: match by term: HAND OSTEOARTHRITIS ClinVar PMID:12736871 NCBI chrNW_004936493:11,352,206...11,371,596 JBrowse link
juvenile rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936529:5,661,772...5,723,108 JBrowse link
G Acrbp acrosin binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936709:1,148,454...1,158,069 JBrowse link
G Adcy7 adenylate cyclase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936475:3,368,069...3,393,306 JBrowse link
G Ankrd9 ankyrin repeat domain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936835:608,461...613,157 JBrowse link
G Aopep aminopeptidase O (putative) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936626:3,704,474...3,973,913 JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:19,321,366...19,361,227 JBrowse link
G Areg amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936470:18,340,120...18,640,396 JBrowse link
G Avl9 AVL9 cell migration associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936478:8,545,240...8,606,875 JBrowse link
G B4galt5 beta-1,4-galactosyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936514:4,719,198...4,736,638 JBrowse link
G Bend2 BEN domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936470:7,379,946...7,441,955 JBrowse link
G Btg1 BTG anti-proliferation factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936507:8,789,952...8,797,247 JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936505:10,032,333...10,046,008 JBrowse link
G C8b complement C8 beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:7980680 NCBI chrNW_004936522:4,638,111...4,673,388 JBrowse link
G C9orf72 C9orf72-SMCR8 complex subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936611:2,074,655...2,101,846 JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936579:868,681...1,046,198 JBrowse link
G Camsap1 calmodulin regulated spectrin associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936669:1,785,229...1,831,876 JBrowse link
G Cd14 CD14 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936531:9,572,392...9,575,771 JBrowse link
G Cd83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936552:637,471...654,422 JBrowse link
G Cd8b CD8b molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936712:828,073...841,889 JBrowse link
G Ciita class II major histocompatibility complex transactivator no_association
susceptibility
ISO DNA:polymorphism:promoter:rs3087456, no association in a German cohort
DNA:polymorphism:exon:1614G>C (human)
RGD PMID:16426246, PMID:17661914 RGD:5491187, RGD:5491189 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Cmtm2 CKLF like MARVEL transmembrane domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936475:16,916,568...16,921,196 JBrowse link
G Crem cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936574:3,478,969...3,546,738 JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:22885951 RGD:6906884 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Cttn cortactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936599:481,234...503,857 JBrowse link
G CUNH2orf88 chromosome unknown C2orf88 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936506:7,883,823...7,903,949 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504, PMID:26387944 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936680:2,842,930...3,020,757 JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936609:2,688,170...2,691,057 JBrowse link
G Dusp2 dual specificity phosphatase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936744:271,619...273,272 JBrowse link
G Dusp4 dual specificity phosphatase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936573:765,954...778,524 JBrowse link
G Dysf dysferlin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936491:15,412,606...15,618,519 JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936563:1,058,803...1,181,393 JBrowse link
G Egr1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Elf2 E74 like ETS transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936535:8,426,550...8,496,129 JBrowse link
G Etnk1 ethanolamine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936548:4,340,632...4,405,880 JBrowse link
G Etv6 ETS variant transcription factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936587:5,328,467...5,457,260 JBrowse link
G Fam20a FAM20A golgi associated secretory pathway pseudokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936541:7,867,856...7,916,145 JBrowse link
G Faxdc2 fatty acid hydroxylase domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936515:8,004,569...8,038,794 JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936498:2,089,069...2,344,007 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936488:4,384,710...4,388,118 JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936706:1,900,954...1,907,567 JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936493:4,308,683...4,327,102 JBrowse link
G Foxp1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936603:2,631,781...3,146,104 JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936591:3,998,359...4,001,491 JBrowse link
G Gmpr guanosine monophosphate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936552:2,458,728...2,496,145 JBrowse link
G Gng11 G protein subunit gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936803:57,659...62,005 JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936619:3,627,649...3,629,129 JBrowse link
G Hbegf heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936531:9,332,939...9,345,039 JBrowse link
G Herpud2 HERPUD family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936478:11,294,193...11,335,241 JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:16047841 RGD:8694357 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Hspa6 heat shock protein family A (Hsp70) member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004937131:25,603...28,458 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO protein:increased expression:serum,synovial fluid: RGD PMID:8255671 RGD:12910480 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Il1a interleukin 1 alpha ISO DNA:SNP:promoter:-889C>T (human) RGD PMID:8162643 RGD:7794716 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:mononuclear cell RGD PMID:21859687 RGD:5147870 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Itga2b integrin subunit alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936541:813,815...828,826 JBrowse link
G Itgb5 integrin subunit beta 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936725:417,824...530,993 JBrowse link
G Jmjd1c jumonji domain containing 1C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936753:1,413,935...1,645,974 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936522:3,034,364...3,037,632 JBrowse link
G Kat6b lysine acetyltransferase 6B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936521:4,309,699...4,497,755 JBrowse link
G Kcnj15 potassium inwardly rectifying channel subfamily J member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936500:4,685,832...4,690,338 JBrowse link
G Klf4 Kruppel like factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936559:5,105,456...5,109,970 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936548:2,078,568...2,113,877 JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936578:1,362,041...2,009,031 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Maff MAF bZIP transcription factor F ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936492:2,983,322...2,988,900 JBrowse link
G Map2 microtubule associated protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936845:475,406...752,600 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936619:1,889,841...1,932,646 JBrowse link
G Mex3c mex-3 RNA binding family member C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936497:12,178,350...12,201,795 JBrowse link
G Ms4a4a membrane spanning 4-domains A4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936581:2,550,229...2,572,638 JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936635:2,390,390...2,461,870 JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936470:22,963,498...23,117,923 JBrowse link
G Myzap myocardial zonula adherens protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:18,853,797...18,940,362 JBrowse link
G Ndel1 nudE neurodevelopment protein 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936595:1,656,956...1,692,775 JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936469:21,912,118...21,920,486 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936524:8,252,321...8,290,747 JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936766:1,104,841...1,306,368 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936902:405,536...416,393 JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936904:390,089...394,195 JBrowse link
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936718:739,133...850,775 JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936624:31,678...125,318 JBrowse link
G Per1 period circadian regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936595:1,366,883...1,382,138 JBrowse link
G Pgm5 phosphoglucomutase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936503:4,696,473...4,858,561 JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Plk2 polo like kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936480:9,680,461...9,686,593 JBrowse link
G Plod2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936519:9,053,192...9,139,221 JBrowse link
G Pros1 protein S ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936666:18,303...110,357 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO DNA: snp : cds : rs2476601 RGD PMID:15934099 RGD:6484550 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G R3hdm2 R3H domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936646:1,447,704...1,571,363 JBrowse link
G Rasgef1b RasGEF domain family member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936749:177,737...723,269 JBrowse link
G Rbm47 RNA binding motif protein 47 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936482:7,852,346...8,016,612 JBrowse link
G Rere arginine-glutamic acid dipeptide repeats ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936623:2,678,627...2,942,387 JBrowse link
G Rhobtb1 Rho related BTB domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936614:2,101,175...2,230,441 JBrowse link
G Rnf103 ring finger protein 103 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936712:977,650...997,623 JBrowse link
G Selp selectin P severity ISO protein:increased expression:plasma RGD PMID:21124648 RGD:6219006 NCBI chrNW_004936481:17,076,660...17,112,501 JBrowse link
G Sh2d2a SH2 domain containing 2A ISO DNA:polymorphism:promoter RGD PMID:15129233 RGD:2298870 NCBI chrNW_004936580:5,959,971...5,967,250 JBrowse link
G Sh3bgrl2 SH3 domain binding glutamate rich protein like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936510:10,488,055...10,516,114 JBrowse link
G Sik1 salt inducible kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936500:774,749...784,326 JBrowse link
G Sipa1l1 signal induced proliferation associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936488:819,503...1,175,043 JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10857800, PMID:16597321 RGD:5684977 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Slc22a16 solute carrier family 22 member 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936564:6,311,934...6,352,759 JBrowse link
G Slc26a2 solute carrier family 26 member 2 susceptibility ISO DNA:SNPs: : RGD PMID:17393463 RGD:13208931 NCBI chrNW_004936504:4,990,996...5,005,658 JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
G Stab1 stabilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936473:3,333,988...3,363,256 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Stim1 stromal interaction molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936498:849,775...1,063,552 JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
G Tfdp1 transcription factor Dp-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936472:184,808...214,628 JBrowse link
G Tfpi tissue factor pathway inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936506:10,103,120...10,172,800 JBrowse link
G Thbd thrombomodulin ISO protein:increased expression:serum RGD PMID:15209962 RGD:5685023 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:3,064,466...3,081,125 JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936469:26,129,339...26,145,464 JBrowse link
G Tnfaip8 TNF alpha induced protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936715:2,205,977...2,322,835 JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936593:1,166,995...1,546,253 JBrowse link
G Treml1 triggering receptor expressed on myeloid cells like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936476:18,668,809...18,673,183 JBrowse link
G Ttll5 tubulin tyrosine ligase like 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936488:4,723,314...4,983,926 JBrowse link
G Ube2e1 ubiquitin conjugating enzyme E2 E1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936473:15,487,341...15,557,516 JBrowse link
G Ube3c ubiquitin protein ligase E3C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936797:452,597...529,631 JBrowse link
G Uhrf1bp1l UHRF1 binding protein 1 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936492:13,622,582...13,703,033 JBrowse link
G Wasf3 WASP family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936948:345,942...465,323 JBrowse link
G Wwox WW domain containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936475:26,342,245...27,209,563 JBrowse link
G Zfand3 zinc finger AN1-type containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936476:21,365,287...21,591,031 JBrowse link
G Zfc3h1 zinc finger C3H1-type containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936568:681,802...730,918 JBrowse link
Knee Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 disease_progression ISO protein:increased expression:chondrocyte: RGD PMID:10903884 RGD:10053727 NCBI chrNW_004936471:21,274,112...21,329,286 JBrowse link
G Anxa5 annexin A5 disease_progression ISO protein:increased expression:chondrocyte: RGD PMID:10903884 RGD:10053727 NCBI chrNW_004936662:926,302...959,964 JBrowse link
G Ar androgen receptor ISO DNA:repeat:exon:c.172(CAG)8-34 (human) RGD PMID:16098017 RGD:10043199 NCBI chrNW_004936635:485,903...647,820 JBrowse link
G Aspn asporin severity ISO DNA:repeats:exon:
mRNA:increased expression:cartilage:
RGD PMID:15640800 RGD:9684965 NCBI chrNW_004936487:2,080,014...2,104,534 JBrowse link
G B2m beta-2-microglobulin ISO protein:increased expression:serum RGD PMID:18795399 RGD:6482710 NCBI chrNW_004936471:7,646,504...7,655,656 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:20131282 RGD:6907382 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:20131282 RGD:6907382 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO RGD PMID:21387139, PMID:22294259 RGD:6483563, RGD:6483595 NCBI chrNW_004936580:5,480,023...5,482,288 JBrowse link
G Cd36 CD36 molecule disease_progression ISO RGD PMID:19342682, PMID:21765106 RGD:6893494, RGD:6893565 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Ctnnb1 catenin beta 1 ISO protein:increased expression:cartilage: RGD PMID:22702043 RGD:10395278 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 severity ISO mRNA,protein:increased expression:fat pad: RGD PMID:21765106 RGD:6893494 NCBI chrNW_004936498:4,514,212...4,544,523 JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO RGD PMID:20131282 RGD:6907382 NCBI chrNW_004936787:307,290...309,963 JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:25435813 RGD:13506963 NCBI chrNW_004936859:740,620...744,534 JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 ISO protein:increased expression:serum: RGD PMID:22275171 RGD:10401792 NCBI chrNW_004936491:2,159,654...2,214,480 JBrowse link
G Epas1 endothelial PAS domain protein 1 no_association ISO DNA:SNP:5' utr: (rs17039192) (human) RGD PMID:20495570, PMID:22247019 RGD:10395367, RGD:10395368 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:25422652 RGD:10400892 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:polymorphisms, haplotype:intron, exon
DNA:SNPs:intron: (rs2234693, rs9340799) (human)
DNA:repeat:promoter:-1174(TA)9-25 (human)
DNA:SNP:cds:c.1782G>A (rs2228480) (human)
RGD PMID:15380041, PMID:16098017, PMID:20128071, PMID:24772413 RGD:10043199, RGD:10045829, RGD:10045835, RGD:10045840 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Esr2 estrogen receptor 2 ISO DNA:repeat:intron:c.1092+3607(CA)13-27 (human) RGD PMID:16098017 RGD:10043199 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:21041276 RGD:5147774 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 treatment ISO RGD PMID:27159076 RGD:11568056 NCBI chrNW_004936477:21,591,772...21,606,289 JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936561:5,343,038...5,347,721 JBrowse link
G Gsr glutathione-disulfide reductase ISO protein:increased expression:synovial fluid RGD PMID:16289733 RGD:10401830 NCBI chrNW_004936792:531,076...579,083 JBrowse link
G Hmgb1 high mobility group box 1 severity ISO protein:increased expression:synovial fluid
mRNA:decreased expression:articular cartilage
RGD PMID:19139395, PMID:21968272 RGD:10402061, RGD:10402184 NCBI chrNW_004936472:25,236,728...25,246,585 JBrowse link
G Hmgb2 high mobility group box 2 severity ISO mRNA:decreased expression:articular cartilage RGD PMID:19139395 RGD:10402184 NCBI chrNW_004936516:4,536,664...4,539,331 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO mRNA:decreased expression:blood (human)
mRNA:increased expression:tibial plateaux (mouse)
RGD PMID:9497939, PMID:16139532 RGD:10412655, RGD:10429075 NCBI chrNW_004936835:316,767...321,999 JBrowse link
G Igf1 insulin like growth factor 1 disease_progression
severity
ISO mRNA:increased expression:meniscus:
protein:decreased expression:plasma (rat)
RGD PMID:8461919, PMID:9497937, PMID:17133593, PMID:20633672 RGD:10003130, RGD:10045862, RGD:10045868, RGD:10046057 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO RGD PMID:8948288 RGD:10045874 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:cartilage cell: RGD PMID:9034998, PMID:9497937, PMID:24534736 RGD:10045944, RGD:10045946, RGD:10046057 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il2 interleukin 2 severity ISO protein:increased expression:synovial fluid: RGD PMID:22035391 RGD:5687147 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il4 interleukin 4 susceptibility ISO DNA:repeat:intron: (rs8179190) (human) RGD PMID:18182309, PMID:24406619 RGD:10402787, RGD:2317291 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
G Kl klotho susceptibility ISO DNA:SNPs:promoter,exon:395G>A,2998C>T(human) RGD PMID:18465812 RGD:10403041 NCBI chrNW_004936472:27,604,681...27,649,613 JBrowse link
G Lep leptin ISO protein:decreased expression:serum: RGD PMID:23575542 RGD:10411887 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G Lepr leptin receptor susceptibility ISO protein:increased expression:serum:
DNA:SNP:cds:668A>G(human)
RGD PMID:23575542 RGD:10411887 NCBI chrNW_004936591:5,771,371...5,846,177 JBrowse link
G LOC101954950 aromatase ISO DNA:SNP:intron, 5' utr: (rs1062033) (human) RGD PMID:20417295 RGD:10045662 NCBI chrNW_004936471:13,107,603...13,136,910 JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 susceptibility ISO DNA:snp:promoter:g.-2820G>A (rs10980705) (human) RGD PMID:18325907 RGD:10054291 NCBI chrNW_004936559:2,187,791...2,331,587 JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936493:253,390...640,140 JBrowse link
G Mmp1 matrix metallopeptidase 1 treatment ISO RGD PMID:21167838 RGD:8549737 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Penk proenkephalin treatment ISO RGD PMID:21928671 RGD:10003115 NCBI chrNW_004936496:3,016,247...3,021,726 JBrowse link
G Ptges prostaglandin E synthase ISO RGD PMID:17530714 RGD:2300093 NCBI chrNW_004936487:16,959,263...16,968,909 JBrowse link
G Sbno1 strawberry notch homolog 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936558:1,383,652...1,442,298 JBrowse link
G Slc26a2 solute carrier family 26 member 2 susceptibility ISO DNA:deletion:promoter:-716_-713del4A(human) RGD PMID:11558903 RGD:13208866 NCBI chrNW_004936504:4,990,996...5,005,658 JBrowse link
G Tgfa transforming growth factor alpha ISO mRNA:increased expression:cartilage
protein:increased expression:cartilage
RGD PMID:17968906 RGD:2317486 NCBI chrNW_004936491:14,659,089...14,758,614 JBrowse link
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936475:19,835,909...19,944,426 JBrowse link
limited scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 susceptibility
no_association
ISO DNA:SNPs:enhancer, intron:multiple
DNA:SNPs:3' utr, intron: (rs9920, rs729949, rs3815412) (human)
RGD PMID:22402147 RGD:8661768 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:17102953 RGD:12903974 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO RGD PMID:17102953 RGD:12903974 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Il2 interleukin 2 susceptibility ISO DNA:polymorphism::-384T>G(human) RGD PMID:17444587 RGD:4142872 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:20808962 RGD:4892610 NCBI chrNW_004936503:111,722...243,627 JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:serum: RGD PMID:19886888 RGD:8551850 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Pgf placental growth factor ISO protein:increased expression:plasma RGD PMID:22461185 RGD:6483571 NCBI chrNW_004936488:4,098,187...4,111,108 JBrowse link
G Serpine1 serpin family E member 1 ISO mRNA,protein:increased expression:skin: RGD PMID:15730388 RGD:13208597 NCBI chrNW_004936543:1,032,543...1,040,956 JBrowse link
G Stat4 signal transducer and activator of transcription 4 susceptibility
no_association
ISO DNA:SNP:intron: (rs7574865) (human)
DNA:SNPs:introns: (rs10168266, rs3821236) (human)
RGD PMID:19286670, PMID:23755762 RGD:8661701, RGD:8661714 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO RGD PMID:16112028 RGD:1578361 NCBI chrNW_004936476:25,913,699...25,923,419 JBrowse link
Lipodermatosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO mRNA:increased expression:dermis RGD PMID:15727634 RGD:5688298 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
localized scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO mRNA,protein:increased expression:skin: RGD PMID:15803328 RGD:8662838 NCBI chrNW_004936476:22,717,308...22,725,127 JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:15863969 NCBI chrNW_004936490:15,142,526...15,146,375 JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:14712301 RGD:8548627 NCBI chrNW_004936734:354,798...428,356 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:7916356 RGD:8158116 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12920362 RGD:8549537 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Lmna lamin A/C ISO CTD Direct Evidence: marker/mechanism CTD PMID:15726408 NCBI chrNW_004936580:5,374,208...5,395,442 JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO RGD PMID:9804345 RGD:1582543 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO RGD PMID:7510487 RGD:7394847 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9843018 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936497:13,242,644...13,269,007 JBrowse link
G Acan aggrecan treatment ISO RGD PMID:21853458, PMID:22833446 RGD:11570535, RGD:11570544 NCBI chrNW_004936483:14,811,152...14,846,305 JBrowse link
G Aco1 aconitase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936524:1,081,672...1,134,971 JBrowse link
G Actb actin beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936765:667,107...670,627 JBrowse link
G Adam12 ADAM metallopeptidase domain 12 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936486:13,963,000...14,189,948 JBrowse link
G Adam15 ADAM metallopeptidase domain 15 ISO RGD PMID:15818704 RGD:1559176 NCBI chrNW_004936580:4,588,182...4,598,659 JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif 14 ISO DNA:missense mutation:cds: (rs4747096) (human) RGD PMID:18790654 RGD:6771189 NCBI chrNW_004936521:7,951,176...8,025,666 JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 treatment ISO associated with Bone Diseases, Metabolic RGD PMID:22432033 RGD:10043110 NCBI chrNW_004936903:490,718...500,443 JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 treatment
disease_progression
no_association
ISO protein:alternative form:synovium
associated with Bone Diseases, Metabolic
mRNA:increased expression:cartilage
DNA:missense mutations:exon: (rs226794, rs2830585) (human)
DNA:missense mutation:exon:p.R614H (human)
RGD PMID:11801682, PMID:17530714, PMID:18240210, PMID:22084394, PMID:22432033, PMID:22961118, PMID:23546441, PMID:23954517, PMID:23982761 RGD:10003165, RGD:10043101, RGD:10043102, RGD:10043103, RGD:10043105, RGD:10043106, RGD:10043107, RGD:10043110, RGD:2300093 NCBI chrNW_004936640:857,565...899,355 JBrowse link
G Adgrg2 adhesion G protein-coupled receptor G2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936844:552,729...619,429 JBrowse link
G Ager advanced glycosylation end-product specific receptor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:16948116, PMID:23894457 RGD:8695985 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Ak4 adenylate kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936692:2,593,409...2,654,583 JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24728293 NCBI chrNW_004936471:19,175,997...19,263,335 JBrowse link
G Aspn asporin susceptibility
no_association
ISO CTD Direct Evidence: marker/mechanism
DNA:repeats:exon:
OMIM
CTD
RGD
PMID:16542493 RGD:9684966 NCBI chrNW_004936487:2,080,014...2,104,534 JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936706:476,473...494,659 JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936555:4,285,269...4,307,715 JBrowse link
G Bad BCL2 associated agonist of cell death ISO RGD PMID:19217321 RGD:10053643 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Bag6 BAG cochaperone 6 susceptibility ISO DNA:SNP: :rs3117582(human) RGD PMID:25231575 RGD:14390133 NCBI chrNW_004936727:1,866,235...1,885,266 JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO protein:increased expression:chondrocyte RGD PMID:16864079, PMID:19217321 RGD:10053643, RGD:10054095 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO protein:increased expression:chondrocyte RGD PMID:16864079, PMID:19217321 RGD:10053643, RGD:10054095 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Becn1 beclin 1 ISO protein:decreased expression:cartilage RGD PMID:20187128 RGD:6483317 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Bglap bone gamma-carboxyglutamate protein disease_progression ISO RGD PMID:20157712 RGD:6483599 NCBI chrNW_004936580:5,480,023...5,482,288 JBrowse link
G Bmp2 bone morphogenetic protein 2 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936485:12,428,765...12,439,570 JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936534:4,707,658...4,871,865 JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29138829 RGD:13782343 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:29138829 RGD:13782343 NCBI chrNW_004936474:3,178,097...3,196,130 JBrowse link
G Cav1 caveolin 1 ISO RGD PMID:16508959 RGD:10043354 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chrNW_004936475:9,432,505...9,436,240 JBrowse link
G Ccr4 C-C motif chemokine receptor 4 ISO protein:increased expression:synovial membrane: RGD PMID:19942450 RGD:10054497 NCBI chrNW_004936473:23,321,167...23,323,075 JBrowse link
G Cd36 CD36 molecule susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Chi3l1 chitinase 3 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936567:1,411,080...1,418,332 JBrowse link
G Cilp cartilage intermediate layer protein disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936471:25,501,538...25,517,033 JBrowse link
G Clec3b C-type lectin domain family 3 member B disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936695:731,184...738,752 JBrowse link
G Clic1 chloride intracellular channel 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936727:1,797,966...1,803,401 JBrowse link
G Clic4 chloride intracellular channel 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936474:9,664,872...9,711,036 JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789, PMID:18784066 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Col1a1 collagen type I alpha 1 chain no_association ISO DNA:SNP:intron:IVS1 RGD PMID:10743824 RGD:5688331 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936585:5,650,322...5,686,393 JBrowse link
G Col2a1 collagen type II alpha 1 chain onset
treatment
ISO DNA:missense mutation:exon:p.R75C (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9061443, PMID:16189708, PMID:16755660, PMID:19216861 RGD:8657384, RGD:8661226 NCBI chrNW_004936512:5,861,933...5,894,898 JBrowse link
G Col6a2 collagen type VI alpha 2 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936778:394,985...430,070 JBrowse link
G Comp cartilage oligomeric matrix protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:7670472 NCBI chrNW_004936596:2,544,389...2,551,155 JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936816:680,798...690,959 JBrowse link
G Ctsk cathepsin K ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936580:1,022,762...1,038,020 JBrowse link
G Dapp1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936520:3,138,213...3,188,498 JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936502:7,770,896...7,820,555 JBrowse link
G Dpep1 dipeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936641:379,112...384,711 JBrowse link
G Dpysl2 dihydropyrimidinase like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936757:311,317...422,870 JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936469:2,998,424...3,391,386 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936588:2,259,236...2,267,692 JBrowse link
G Egr1 early growth response 1 ISO mRNA, protein: decreased expression RGD PMID:10806043 RGD:1626498 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936623:3,115,357...3,130,289 JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO mRNA:increased expression:cartilage
protein:increased expression:layer of synovial tissue, stromal cell
RGD PMID:12823854, PMID:20495569, PMID:21869830 RGD:10395364, RGD:10395365, RGD:10395366 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO mRNA:decreased expression:knee, articular cartilage of joint RGD PMID:24964749 RGD:10045611 NCBI chrNW_004936706:1,854,938...1,867,521 JBrowse link
G Esd esterase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936565:285,789...309,390 JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:SNPs:introns: (rs2234693, rs9340799) (human)
DNA:SNP:intron: (rs2234693) (human)
RGD PMID:19884274, PMID:20417295 RGD:10045662, RGD:10045830 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Esr2 estrogen receptor 2 ISO DNA:SNP:intron: (rs1256031) (human) RGD PMID:19884274 RGD:10045830 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G Etfa electron transfer flavoprotein subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936471:35,868,851...35,942,662 JBrowse link
G Ezr ezrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936489:10,413,374...10,457,771 JBrowse link
G Fgf18 fibroblast growth factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936609:3,677,661...3,706,511 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:22393163 RGD:10402075 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO mRNA:increased expression:trabecular bone: RGD PMID:15781004 RGD:10402109 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Fn1 fibronectin 1 ISO protein:increased expression:cartilage: RGD PMID:8646429 RGD:10402156 NCBI chrNW_004936586:1,708,803...1,773,372 JBrowse link
G Frzb frizzled related protein susceptibility ISO ClinVar Annotator: match by term: Osteoarthritis susceptibility 1
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:15210948, PMID:25741868 NCBI chrNW_004936509:11,440,414...11,471,042 JBrowse link
G Ftl ferritin light chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936664:2,976,325...2,977,878 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Gdf5 growth differentiation factor 5 ISO OMIM NCBI chrNW_004936561:5,343,038...5,347,721 JBrowse link
G Ghr growth hormone receptor ISO DNA:deletion:exon: RGD PMID:23740230 RGD:10003113 NCBI chrNW_004936518:235,996...380,225 JBrowse link
G Gls glutaminase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936506:7,237,099...7,314,011 JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936527:722,548...727,169 JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936493:6,182,786...6,224,601 JBrowse link
G Hbp1 HMG-box transcription factor 1 ISO RGD PMID:22586168 RGD:10402054 NCBI chrNW_004936479:16,855,368...16,886,210 JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936506:7,811,624...7,882,861 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854, PMID:18789153 RGD:10395366, RGD:10402406 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:22330250 RGD:10401949 NCBI chrNW_004936472:25,236,728...25,246,585 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936483:15,845,777...15,864,341 JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936471:36,823,003...36,842,576 JBrowse link
G Igf1 insulin like growth factor 1 ISO protein:decreased expression:blood: RGD PMID:2290165 RGD:10045857 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Igf1r insulin like growth factor 1 receptor severity ISO mRNA:increased expression:articular cartilage of joint: RGD PMID:8609369 RGD:10045889 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Igf2 insulin like growth factor 2 ISO mRNA:increased expression:cartilage RGD PMID:22527881 RGD:10402552 NCBI chrNW_004936816:972,902...981,232 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:18775662 RGD:10402575 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Ihh Indian hedgehog signaling molecule ISO protein:increased expression:cartilage RGD PMID:24786088 RGD:12910979 NCBI chrNW_004936569:1,474,693...1,480,562 JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:chonodrocyte: RGD PMID:9497936 RGD:10047053 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:21954917, PMID:22890185 RGD:7207218 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il4r interleukin 4 receptor ISO protein:increased expression:serum RGD PMID:16647277 RGD:10402785 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22035391 RGD:5687147 NCBI chrNW_004936647:2,647,982...2,651,477 JBrowse link
G Immt inner membrane mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936712:1,257,427...1,301,045 JBrowse link
G Ins insulin ISO protein:increased expression:blood: RGD PMID:2290165 RGD:10045857 NCBI chrNW_004936816:1,002,137...1,003,357 JBrowse link
G Isoc2 isochorismatase domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936886:681,325...686,142 JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO RGD PMID:18354251 RGD:6482239 NCBI chrNW_004936485:8,857,688...8,894,270 JBrowse link
G Lep leptin severity ISO protein:increased expression:tibia, cartilage, chondrocyte (human) RGD PMID:14613274 RGD:10053634 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G LOC101969021 somatotropin ISO protein:increased expression:plasma RGD PMID:7152485 RGD:10003140 NCBI chrNW_004936541:4,524,397...4,528,234 JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11790802, PMID:12379497 NCBI chrNW_004936599:3,902,903...3,918,471 JBrowse link
G Matn3 matrilin 3 susceptibility ISO ClinVar Annotator: match by term: OSTEOARTHRITIS OF DISTAL INTERPHALANGEAL JOINTS
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:12736871 NCBI chrNW_004936493:11,352,206...11,371,596 JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Mmp13 matrix metallopeptidase 13 treatment ISO mRNA, protein:increased expression:cartilage RGD PMID:11134178, PMID:16128596, PMID:17530714, PMID:22890185, PMID:23982761 RGD:10043101, RGD:10043117, RGD:2300093, RGD:7207089, RGD:7207218 NCBI chrNW_004936551:5,040,084...5,050,384 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:synovial fluid (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004936551:5,228,950...5,238,948 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936635:2,390,390...2,461,870 JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:22084394, PMID:24651621 RGD:10003163, RGD:10003165 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Mvp major vault protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936501:12,598,907...12,610,306 JBrowse link
G Myh13 myosin heavy chain 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936595:3,204,487...3,262,459 JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D ISO protein:increased expression:spinal cord RGD PMID:20722027 RGD:10412653 NCBI chrNW_004936479:20,259,260...20,293,116 JBrowse link
G Ncor2 nuclear receptor corepressor 2 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936558:658,723...775,263 JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936599:2,081,493...2,085,635 JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936599:2,169,434...2,173,090 JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936490:10,634,788...10,640,182 JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936711:1,027,531...1,113,796 JBrowse link
G P3h3 prolyl 3-hydroxylase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936709:977,851...989,949 JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936473:24,010,942...24,086,836 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936844:889,720...906,631 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO mRNA:increased expression:tibia (rat) RGD PMID:21864409 RGD:6771362 NCBI chrNW_004936541:4,873,459...4,919,787 JBrowse link
G Plcd1 phospholipase C delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936473:27,364,404...27,387,337 JBrowse link
G Plod2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936519:9,053,192...9,139,221 JBrowse link
G Pls3 plastin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936499:246,042...335,440 JBrowse link
G Pomc proopiomelanocortin ISO RGD PMID:21378032 RGD:5508809 NCBI chrNW_004936493:7,060,747...7,065,276 JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936602:1,230,907...1,368,588 JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit Aalpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936901:622,893...653,044 JBrowse link
G Psmb1 proteasome 20S subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004937098:67,298...80,019 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 susceptibility ISO DNA:SNP (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15334463, PMID:32004530 RGD:1625347 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ran RAN, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936660:1,669,352...1,673,972 JBrowse link
G Rcn3 reticulocalbin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936664:3,382,467...3,396,111 JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936476:14,695,965...14,818,246 JBrowse link
G S100a4 S100 calcium binding protein A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16948116 NCBI chrNW_004936580:3,355,751...3,358,030 JBrowse link
G Scrn1 secernin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936478:6,222,498...6,281,162 JBrowse link
G Sdcbp syndecan binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936496:14,331,971...14,347,123 JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936815:1,148,963...1,167,585 JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936494:12,643,790...12,702,390 JBrowse link
G Sgcg sarcoglycan gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936688:2,083,930...2,191,206 JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18973239 NCBI chrNW_004936474:24,205,878...24,236,611 JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21217753, PMID:22772368 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:18784066, PMID:22108257 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Tent5a terminal nucleotidyltransferase 5A susceptibility ISO DNA:repeats: : RGD PMID:25231575 RGD:14390133 NCBI chrNW_004936510:8,813,977...8,820,909 JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chrNW_004936803:69,296...90,270 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tgm2 transglutaminase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936561:3,178,244...3,207,551 JBrowse link
G Tlr8 toll like receptor 8 ISO ClinVar Annotator: match by term: Osteoarthritis ClinVar NCBI chrNW_004936470:2,638,020...2,642,201 JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004936470:27,571,263...27,598,725 JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO RGD PMID:14872496 RGD:2290500 NCBI chrNW_004936593:212,642...230,645 JBrowse link
G Tnfsf15 TNF superfamily member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936487:3,959,224...3,975,959 JBrowse link
G Trap1 TNF receptor associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936694:667,687...704,994 JBrowse link
G Trim2 tripartite motif containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936576:88,163...202,944 JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21964574 NCBI chrNW_004936769:1,424,526...1,447,547 JBrowse link
G Txnrd1 thioredoxin reductase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936492:10,185,096...10,244,466 JBrowse link
G Vdac2 voltage dependent anion channel 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936521:4,122,447...4,136,228 JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16876394, PMID:18784066 NCBI chrNW_004936520:10,051,692...10,059,324 JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004936532:5,931,677...5,938,569 JBrowse link
Osteoarthritis with Mild Chondrodysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain ISO OMIM NCBI chrNW_004936512:5,861,933...5,894,898 JBrowse link
Osteoarthritis, Experimental term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19404941 RGD:9068434 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp6 caspase 6 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004936563:912,502...920,025 JBrowse link
G Casp7 caspase 7 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004936486:4,082,664...4,114,942 JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004936726:554,627...596,334 JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment ISO RGD PMID:25128628 RGD:11041187 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:22833219 RGD:10402072 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO RGD PMID:23041435 RGD:10402106 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A treatment ISO RGD PMID:16394269 RGD:10402538 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO mRNA:decreased expression:knee RGD PMID:24754147 RGD:10412054 NCBI chrNW_004936477:20,234,582...20,250,756 JBrowse link
G Map1lc3a microtubule associated protein 1 light chain 3 alpha treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chrNW_004936561:6,104,748...6,106,348 JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO RGD PMID:29364174 RGD:13800565 NCBI chrNW_004936501:12,342,670...12,390,650 JBrowse link
G Serpinf1 serpin family F member 1 severity ISO RGD PMID:28122611 RGD:27226703 NCBI chrNW_004936538:7,885,816...7,898,308 JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chrNW_004936660:2,160,394...2,188,848 JBrowse link
Osteoarthritis, Hip term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO mRNA:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chrNW_004936640:857,565...899,355 JBrowse link
G Aspn asporin ISO DNA:repeats:exon: RGD PMID:15640800 RGD:9684965 NCBI chrNW_004936487:2,080,014...2,104,534 JBrowse link
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936487:5,409,413...5,854,418 JBrowse link
G Chadl chondroadherin like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28319091, PMID:30374069 NCBI chrNW_004936492:633,443...643,550 JBrowse link
G Col10a1 collagen type X alpha 1 chain ISO mRNA, protein:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chrNW_004936824:734,499...741,674 JBrowse link
G Col11a1 collagen type XI alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936730:466,912...680,823 JBrowse link
G Col1a1 collagen type I alpha 1 chain no_association
susceptibility
ISO DNA:SNP:intron:g.2046G>T (human) RGD PMID:9811048, PMID:15880349, PMID:17187661 RGD:5688305, RGD:5688306, RGD:5688330 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
G Comp cartilage oligomeric matrix protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28319091 NCBI chrNW_004936596:2,544,389...2,551,155 JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936541:2,288,847...2,333,129 JBrowse link
G Diablo diablo IAP-binding mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936558:2,260,459...2,268,941 JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:SNP:intron:g.-397T>C (human) RGD PMID:17419075 RGD:10045661 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Filip1 filamin A interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936788:737,375...900,912 JBrowse link
G Gdf5 growth differentiation factor 5 ISO ClinVar Annotator: match by term: Osteoarthritis of hip ClinVar PMID:17384641 NCBI chrNW_004936561:5,343,038...5,347,721 JBrowse link
G Ghr growth hormone receptor ISO associated with Acromegaly;DNA:deletion:exon: RGD PMID:19864451 RGD:10003142 NCBI chrNW_004936518:235,996...380,225 JBrowse link
G Hdac9 histone deacetylase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936546:4,398,003...5,247,649 JBrowse link
G Hfe homeostatic iron regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069, PMID:30664745 NCBI chrNW_004936886:617,531...620,661 JBrowse link
G Il4r interleukin 4 receptor susceptibility
no_association
ISO DNA:SNPs:multiple
DNA:missense mutations:cds:p.S411L, p.S727A (rs1805013, rs1805016) (human)
RGD PMID:14745651, PMID:19036616 RGD:10402782, RGD:10402784 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Itih1 inter-alpha-trypsin inhibitor heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936473:3,534,071...3,548,554 JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936487:14,513,303...14,587,771 JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936599:3,902,903...3,918,471 JBrowse link
G Mapt microtubule associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO mRNA, protein:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chrNW_004936551:5,040,084...5,050,384 JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936476:14,695,965...14,818,246 JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
G Smo smoothened, frizzled class receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936579:5,893,064...5,917,021 JBrowse link
G Tnc tenascin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004936487:4,172,263...4,256,780 JBrowse link
Osteoarthritis, Temporomandibular Joint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004936712:413,602...454,443 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004936541:4,613,197...4,705,911 JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:mandibular condyle, cartilage (rat) RGD PMID:23934157 RGD:8663479 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004936487:13,348,465...13,352,717 JBrowse link
G Rps6 ribosomal protein S6 ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004936652:1,252,986...1,255,987 JBrowse link
otulipenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otulin OTU deubiquitinase with linear linkage specificity ISO OMIM NCBI chrNW_004936665:1,654,045...1,690,955 JBrowse link
polymyalgia rheumatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone no_association ISO DNA:polymorphism:promoter RGD PMID:12051390 RGD:1581301 NCBI chrNW_004936496:7,759,656...7,761,555 JBrowse link
G Crp C-reactive protein treatment ISO RGD PMID:2859021 RGD:9495925 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30657865 RGD:14746966 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:plasma, endothelial microparticle (human) RGD PMID:22211720 RGD:6771319 NCBI chrNW_004936541:4,873,459...4,919,787 JBrowse link
Reynolds Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lbr lamin B receptor ISO OMIM NCBI chrNW_004936526:2,254,463...2,282,785 JBrowse link
rheumatic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gc GC vitamin D binding protein ISO RGD PMID:2737695 RGD:5509933 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:14567831 RGD:13702910 NCBI chrNW_004936659:616,570...627,172 JBrowse link
rheumatic heart disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule ISO mRNA:decreased expression:blood, mononuclear cell RGD PMID:16741676 RGD:6893529 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:26823728 RGD:13792679 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Igf1 insulin like growth factor 1 ISO RGD PMID:16406300 RGD:1582623 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Il10 interleukin 10 no_association ISO RGD PMID:16043936 RGD:1598626 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
rheumatic myocarditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Sele selectin E severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chrNW_004936481:16,915,203...16,921,840 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:22987107 RGD:13702907 NCBI chrNW_004936748:785,491...802,791 JBrowse link
rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20080907, PMID:22104130 NCBI chrNW_004936763:1,225,355...1,308,257 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936636:292,631...341,999 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936490:11,039,968...11,086,670 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936472:14,396,986...14,624,597 JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936578:5,838,044...5,916,287 JBrowse link
G Acan aggrecan disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased degradation:cartilage
CTD
RGD
PMID:15292528, PMID:16507130 RGD:11570537 NCBI chrNW_004936483:14,811,152...14,846,305 JBrowse link
G Ackr3 atypical chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936525:1,559,575...1,570,679 JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 ISO mRNA:increased expression:synovium RGD PMID:11801682 RGD:10043106 NCBI chrNW_004936903:490,718...500,443 JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO protein:alternative form:synovium RGD PMID:11801682 RGD:10043106 NCBI chrNW_004936640:857,565...899,355 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:12833524, PMID:21789720 RGD:5686424 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936619:597,970...618,564 JBrowse link
G Adrb3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:12739037 RGD:5684893 NCBI chrNW_004936710:1,410,589...1,413,279 JBrowse link
G Aff3 AF4/FMR2 family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936661:771,265...1,264,456 JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO protein:decreased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16385501, PMID:20541603 RGD:7244141 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18617548 NCBI chrNW_004936546:3,737,908...3,783,492 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Ang angiogenin ISO RGD PMID:12653852 RGD:6892721 NCBI chrNW_004936880:39,372...40,070 JBrowse link
G Ankrd55 ankyrin repeat domain 55 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936480:11,672,300...11,769,183 JBrowse link
G Anxa3 annexin A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936676:2,153,752...2,216,498 JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:20367977 RGD:5685646 NCBI chrNW_004936542:2,098,683...2,101,127 JBrowse link
G Arid5b AT-rich interaction domain 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963, PMID:23143596 NCBI chrNW_004936614:1,072,263...1,252,573 JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19193698 NCBI chrNW_004936586:1,782,581...1,809,458 JBrowse link
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936491:7,482,226...7,511,419 JBrowse link
G B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936475:17,624,327...17,627,944 JBrowse link
G Baiap2l1 BAR/IMD domain containing adaptor protein 2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936750:829,188...918,316 JBrowse link
G Bcl2a1 BCL2 related protein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936471:37,981,851...37,993,097 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936604:548,844...551,031 JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:3488088, PMID:22447331 RGD:6483593, RGD:6483600 NCBI chrNW_004936580:5,480,023...5,482,288 JBrowse link
G Bgn biglycan ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chrNW_004936809:375,589...389,718 JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936675:3,228,982...3,246,617 JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936534:4,707,658...4,871,865 JBrowse link
G Btnl2 butyrophilin like 2 susceptibility ISO DNA:SNPs: : RGD PMID:23364395 RGD:9685033 NCBI chrNW_004936727:567,656...587,784 JBrowse link
G C3 complement C3 ISO RGD PMID:7561187 RGD:11040775 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chrNW_004936579:868,681...1,046,198 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:18785314 RGD:5684540 NCBI chrNW_004936486:4,082,664...4,114,942 JBrowse link
G Cast calpastatin ISO RGD PMID:7706496 RGD:5683620 NCBI chrNW_004936523:6,688,153...6,798,184 JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Cav2 caveolin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936589:2,553,932...2,561,186 JBrowse link
G Ccl21 C-C motif chemokine ligand 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chrNW_004936524:2,787,963...2,789,116 JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chrNW_004936475:9,432,505...9,436,240 JBrowse link
G Ccl8 C-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936538:805,273...806,715 JBrowse link
G Ccn1 cellular communication network factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936608:152,174...155,123 JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936560:42,561...45,748 JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chrNW_004936596:223,660...224,739 JBrowse link
G Ccr4 C-C motif chemokine receptor 4 ISO mRNA:increased expression:synovium:
protein:increased expression:synovial membrane:
RGD PMID:19942450, PMID:25430645 RGD:10054497, RGD:10054499 NCBI chrNW_004936473:23,321,167...23,323,075 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453841, PMID:20453842, PMID:23143596 NCBI chrNW_004936489:16,669,297...16,689,451 JBrowse link
G Cd2 CD2 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936627:1,902,120...1,915,257 JBrowse link
G Cd244 CD244 molecule susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:18794858 NCBI chrNW_004936903:146,108...162,410 JBrowse link
G Cd28 CD28 molecule ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:19075187, PMID:19898481, PMID:20453842, PMID:23143596 RGD:5131619 NCBI chrNW_004936631:335,411...363,407 JBrowse link
G Cd3e CD3e molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936542:3,379,361...3,390,677 JBrowse link
G Cd40 CD40 molecule ISO DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:18794853, PMID:20453842, PMID:20498205, PMID:23143596 RGD:5490972 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Cd5 CD5 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936581:1,854,166...1,866,843 JBrowse link
G Cd80 CD80 molecule ISO protein:increased expression:serum RGD PMID:22917707 RGD:6893647 NCBI chrNW_004936536:6,462,080...6,483,450 JBrowse link
G Cd83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936552:637,471...654,422 JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853 NCBI chrNW_004936803:1,025,047...1,229,396 JBrowse link
G Chi3l1 chitinase 3 like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:10461474 RGD:4892605 NCBI chrNW_004936567:1,411,080...1,418,332 JBrowse link
G Ciita class II major histocompatibility complex transactivator susceptibility
no_association
ISO ClinVar Annotator: match by term: Rheumatoid arthritis
DNA:haplotype:promoter/CDS:rs3087456G/rs4774C
DNA:polymorphism:promoter:rs3087456, no association in a German cohort
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
RGD
CTD
PMID:15821736, PMID:16426246, PMID:16849401, PMID:19221398 RGD:5491176, RGD:5491189 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Clec12a C-type lectin domain family 12 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936902:542,981...556,142 JBrowse link
G Clec16a C-type lectin domain containing 16A ISO DNA:polymorphism:intron:rs6498169G RGD PMID:19221398 RGD:5491176 NCBI chrNW_004936530:9,089,478...9,264,563 JBrowse link
G Col2a1 collagen type II alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:27028940, PMID:29935983 NCBI chrNW_004936512:5,861,933...5,894,898 JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chrNW_004936519:6,431,156...6,473,183 JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:1568518, PMID:22173958 RGD:6904209 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Csf2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936647:3,081,896...3,083,864 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936816:680,798...690,959 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:11465708 RGD:4892002 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:19192274 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chrNW_004936762:66,636...69,694 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Ddit4 DNA damage inducible transcript 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936521:6,646,864...6,648,982 JBrowse link
G Ddx6 DEAD-box helicase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936542:3,748,599...3,781,405 JBrowse link
G Dhfr dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Dnase1l3 deoxyribonuclease 1 like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chrNW_004936473:8,430,235...8,495,170 JBrowse link
G Dnmt1 DNA methyltransferase 1 severity ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chrNW_004936659:520,181...565,496 JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO DNA:polymorphism:promoter:-283C>T(human) RGD PMID:19777235 RGD:9589110 NCBI chrNW_004936485:19,547,836...19,570,716 JBrowse link
G Edn1 endothelin 1 treatment ISO RGD PMID:22249931 RGD:8661695 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Eln elastin ISO RGD PMID:12643515 RGD:9585739 NCBI chrNW_004936543:3,135,169...3,165,023 JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898480 NCBI chrNW_004936623:3,115,357...3,130,289 JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Esr2 estrogen receptor 2 severity ISO DNA:SNP:exon:rs1256049(human) RGD PMID:21523342 RGD:5508794 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO DNA:snp:promoter:g.-670A>G (human)
protein:increased expression:serum (human)
RGD PMID:12148596, PMID:20875116, PMID:23053964 RGD:12903969, RGD:8662433, RGD:8662455 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human)
DNA:CNVs
protein:decreased expression:NK cell
RGD PMID:15334114, PMID:19019892, PMID:25154742 RGD:11344974, RGD:5508391, RGD:5508467 NCBI chrNW_004937131:42,523...49,533 JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936476:23,611,166...23,702,283 JBrowse link
G Foxo3 forkhead box O3 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell,synovium: RGD PMID:19435720 RGD:10402186 NCBI chrNW_004936564:4,788,036...4,907,600 JBrowse link
G Foxp3 forkhead box P3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20476861 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
G Fpgs folylpolyglutamate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936487:15,453,010...15,466,591 JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936500:8,750,928...8,782,303 JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936484:6,780,692...6,800,883 JBrowse link
G Gc GC vitamin D binding protein ISO protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:3874814, PMID:9548303 RGD:5509931 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18830904 NCBI chrNW_004936561:5,343,038...5,347,721 JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936496:10,485,528...10,505,506 JBrowse link
G Gin1 gypsy retrotransposon integrase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936523:1,418,387...1,443,322 JBrowse link
G Gprc5a G protein-coupled receptor class C group 5 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936587:4,427,208...4,443,302 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO CTD Direct Evidence: marker/mechanism
DNA: deletion: : heterozygous
protein: decreased expression: mononuclear leukocytes
CTD
RGD
PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 no_association ISO protein: : mononuclear blood cells
DNA: deletion::GRK2 and GRK6 deletions resulted in more severe arthritis
RGD PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO DNA: deletion: : homozygous
protein: decreased expression: mononuclear leukocytes
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chrNW_004936597:1,706,671...1,722,370 JBrowse link
G Gsdme gasdermin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936478:1,655,487...1,720,996 JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936469:2,745,568...2,772,789 JBrowse link
G Hcls1 hematopoietic cell-specific Lyn substrate 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936536:8,065,489...8,084,777 JBrowse link
G Hdac1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289289 NCBI chrNW_004936474:15,320,635...15,351,418 JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Hgf hepatocyte growth factor disease_progression ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chrNW_004936734:354,798...428,356 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 severity ISO RGD PMID:18025202 RGD:9685481 NCBI chrNW_004936478:2,970,261...2,980,277 JBrowse link
G Hoxd10 homeobox D10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936509:5,603,661...5,606,850 JBrowse link
G Hoxd13 homeobox D13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936509:5,579,846...5,581,651 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936557:3,358,809...3,403,461 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chrNW_004936835:316,767...321,999 JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:peripheral blood lymphocyte (human) RGD PMID:22047640 RGD:5688784 NCBI chrNW_004936647:2,087,650...2,133,343 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO protein:increased expression:synovial joint RGD PMID:11315915 RGD:5685639 NCBI chrNW_004936487:13,348,465...13,352,717 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO protein:increased expression:synovial cell: RGD PMID:23739258 RGD:10402561 NCBI chrNW_004936531:7,702,186...7,716,428 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO protein:increased expression:serum: RGD PMID:21417552 RGD:10402843 NCBI chrNW_004936543:2,110,351...2,111,896 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Ifng interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:1417133, PMID:22450443 RGD:8157623 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Igf2 insulin like growth factor 2 ISO DNA:loss of imprinting:synovial cell
protein:decreased expression:plasma
RGD PMID:11247331, PMID:19556211 RGD:5510001, RGD:5510014 NCBI chrNW_004936816:972,902...981,232 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Ikzf3 IKAROS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936490:14,939,693...15,025,728 JBrowse link
G Il10 interleukin 10 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:12847677, PMID:22450443 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:20926833 RGD:9068415 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16368150 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of ClinVar PMID:12847677 NCBI chrNW_004936557:5,765,093...5,769,853 JBrowse link
G Il1a interleukin 1 alpha severity ISO protein:increased expression:plasma, synovial fluid
associated with lung disease, interstitial
RGD PMID:8162643, PMID:11192540 RGD:4142818, RGD:7794716 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum
CTD
RGD
PMID:12566094, PMID:17379860, PMID:22414257, PMID:22450443 RGD:6482656 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:7706905, PMID:10637275, PMID:19192274, PMID:19447938 RGD:7174696, RGD:8549810 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il2 interleukin 2 ISO RGD PMID:6421522 RGD:8662948 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il20 interleukin 20 ISO RGD PMID:16947773 RGD:5147395 NCBI chrNW_004936557:5,749,419...5,751,776 JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:19342640 RGD:6892964 NCBI chrNW_004936501:11,100,170...11,112,112 JBrowse link
G Il23a interleukin 23 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936646:743,630...745,998 JBrowse link
G Il23r interleukin 23 receptor susceptibility ISO DNA:SNP::rs1343151(human) RGD PMID:18647855 RGD:8549596 NCBI chrNW_004936591:4,365,598...4,425,053 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:20476861, PMID:23143596 NCBI chrNW_004936484:8,514,333...8,555,392 JBrowse link
G Il2rb interleukin 2 receptor subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936492:3,795,940...3,805,822 JBrowse link
G Il3 interleukin 3 ISO DNA: SNPs: Multiple: gene-gene interaction RGD PMID:20018070 RGD:5686905 NCBI chrNW_004936647:3,102,922...3,104,758 JBrowse link
G Il4r interleukin 4 receptor severity ISO DNA:SNP: :rs1805010 (human) RGD PMID:24782180 RGD:10402783 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22293286 RGD:5687156 NCBI chrNW_004936647:2,647,982...2,651,477 JBrowse link
G Il6r interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16729287, PMID:23143596 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Il6st interleukin 6 signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936809:891,407...900,311 JBrowse link
G Irf5 interferon regulatory factor 5 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD
ClinVar
PMID:15657875, PMID:16642019, PMID:17599733, PMID:18063667, PMID:20453842, PMID:23143596 NCBI chrNW_004936579:6,138,372...6,149,531 JBrowse link
G Irf8 interferon regulatory factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936641:2,608,109...2,622,446 JBrowse link
G Itga6 integrin subunit alpha 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936509:2,508,446...2,587,643 JBrowse link
G Itgb2 integrin subunit beta 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G Itpa inosine triphosphatase treatment ISO DNA:SNP: :94C>A(human) RGD PMID:29441893 RGD:14975307 NCBI chrNW_004936485:15,499,688...15,511,992 JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:21510883 RGD:6483024 NCBI chrNW_004936503:111,722...243,627 JBrowse link
G Kif5a kinesin family member 5A susceptibility ISO DNA:snps:intron, 3' utr:c.2756-43A>C, c.*776C>T (rs775246, rs775251) (human)
CTD Direct Evidence: marker/mechanism
DNA:snp:intron:c.1717-152C>G (rs1678542) (human)
RGD
CTD
PMID:21784728, PMID:23143596, PMID:23378462 RGD:12793072, RGD:12793073 NCBI chrNW_004936646:1,697,531...1,730,376 JBrowse link
G Lcn2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7554268 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
G Lhx2 LIM homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936487:12,395,817...12,413,860 JBrowse link
G LOC101963197 HLA class II histocompatibility antigen, DP beta 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17956852, PMID:22286218 NCBI chrNW_004936476:25,730,800...25,741,089 JBrowse link
G LOC101964209 C-C chemokine receptor type 1 ISO RGD PMID:12860725 RGD:5688170 NCBI chrNW_004936596:177,774...183,186 JBrowse link
G LOC101968486 HLA class II histocompatibility antigen, DQ alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936727:373,464...378,784 JBrowse link
G Lrrk2 leucine rich repeat kinase 2 ISO RGD PMID:17082220 RGD:5508419 NCBI chrNW_004936607:628,469...761,117 JBrowse link
G Ly96 lymphocyte antigen 96 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936648:2,653,252...2,671,453 JBrowse link
G Mab21l2 mab-21 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936689:694,119...696,840 JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936679:2,373,104...2,379,230 JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chrNW_004936497:9,512,350...9,619,250 JBrowse link
G Mbd4 methyl-CpG binding domain 4, DNA glycosylase susceptibility
no_association
ISO DNA:snps:introns:IVS5-140A>G (rs3138355), IVS6-218C>T (rs2005618) (human)
DNA:snps:cds, intron:p.E346K, IVS6-218C>T (rs140693, rs2005618) (human)
RGD PMID:20676650, PMID:22505706 RGD:9588977, RGD:9588978 NCBI chrNW_004936602:956,829...964,653 JBrowse link
G Mdk midkine ISO RGD PMID:15146411 RGD:1581200 NCBI chrNW_004936562:2,687,825...2,690,292 JBrowse link
G Mgarp mitochondria localized glutamic acid rich protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936535:8,321,443...8,336,773 JBrowse link
G Mif macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Mmel1 membrane metalloendopeptidase like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936737:970,504...997,452 JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Mmp10 matrix metallopeptidase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936551:5,188,395...5,197,477 JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004936551:5,228,950...5,238,948 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:26001728 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :677C>T(human)
CTD
RGD
PMID:22104130, PMID:23685257 RGD:7387222 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:28135245 NCBI chrNW_004936543:3,617,369...3,630,990 JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936481:6,300,894...6,325,878 JBrowse link
G Ndufa4l2 NDUFA4 mitochondrial complex associated like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936646:1,428,025...1,430,215 JBrowse link
G Nfkbie NFKB inhibitor epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936476:15,818,605...15,825,558 JBrowse link
G Nfkbil1 NFKB inhibitor like 1 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
DNA:snp:promoter:c.-132T>A (rs2071592) (human)
OMIM
ClinVar
CTD
RGD
PMID:12509789 RGD:1331681 NCBI chrNW_004936727:1,950,356...1,963,847 JBrowse link
G Notch4 notch receptor 4 ISO mRNA : increased expression: : cd4+ cells RGD PMID:20132067 RGD:6480790 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Npsr1 neuropeptide S receptor 1 ISO RGD PMID:20179762 RGD:4891930 NCBI chrNW_004936478:10,352,894...10,542,949 JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO mRNA:increased expression:paw RGD PMID:18448865 RGD:4892311 NCBI chrNW_004936504:10,960,069...11,056,834 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936524:8,252,321...8,290,747 JBrowse link
G Padi2 peptidyl arginine deiminase 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chrNW_004936474:4,033,703...4,066,468 JBrowse link
G Padi4 peptidyl arginine deiminase 4 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:23143596 NCBI chrNW_004936474:4,219,183...4,239,551 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:1708827 RGD:6482653 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pgf placental growth factor ISO RGD PMID:19180491 RGD:6483591 NCBI chrNW_004936488:4,098,187...4,111,108 JBrowse link
G Pla2g7 phospholipase A2 group VII ISO RGD PMID:17326817 RGD:6482776 NCBI chrNW_004936476:13,609,847...13,646,174 JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:22011479 RGD:6484117 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Plb1 phospholipase B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24520335 NCBI chrNW_004936493:4,112,632...4,210,882 JBrowse link
G Pld4 phospholipase D family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936621:515,710...523,317 JBrowse link
G Plek pleckstrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936491:12,762,421...12,818,249 JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16055108 NCBI chrNW_004936585:4,954,871...4,979,560 JBrowse link
G Prdm1 PR/SET domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596 NCBI chrNW_004936564:2,594,362...2,690,680 JBrowse link
G Prkcq protein kinase C theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chrNW_004936484:8,048,239...8,166,058 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15167967 NCBI chrNW_004936487:10,745,465...10,758,812 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11978490, PMID:19192274, PMID:21905970 RGD:5508313 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936470:10,379,855...10,578,531 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936626:2,390,004...2,472,039 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 susceptibility
no_association
ISO ClinVar Annotator: match by term: Rheumatoid arthritis
DNA:SNP::1858C>T (human)
DNA:snp:cds:p.R263Q (rs33996649) (human)
CTD Direct Evidence: marker/mechanism
DNA:snp:cds:p.R620W (rs2476601) (human)
OMIM
ClinVar
RGD
CTD
PMID:15004560, PMID:15208781, PMID:15273934, PMID:15580548, PMID:15719322, PMID:15744042, PMID:16273109, PMID:16339849, PMID:16470599, PMID:17170052, PMID:17436241, PMID:17554300, PMID:17878369, PMID:18301444, PMID:18978792, PMID:19265110, PMID:19430480, PMID:19898480, PMID:20453842, PMID:21190368, PMID:21279993, PMID:21467606, PMID:21841778, PMID:23143596, PMID:28492532, PMID:30224649 RGD:6484535, RGD:6484595, RGD:7829746 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936567:5,266,653...5,378,464 JBrowse link
G Pxk PX domain containing serine/threonine kinase like ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chrNW_004936473:2,587,145...2,635,083 JBrowse link
G Rab8a RAB8A, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936596:4,385,788...4,403,393 JBrowse link
G Rap2a RAP2A, member of RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936472:12,634,563...12,671,656 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936471:2,152,231...2,222,260 JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
G Rcan1 regulator of calcineurin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936500:7,942,099...7,950,256 JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19503088, PMID:20453842, PMID:23143596 NCBI chrNW_004936491:6,405,493...6,435,096 JBrowse link
G Rgmb repulsive guidance molecule BMP co-receptor b ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936523:5,050,765...5,078,777 JBrowse link
G Runx1 RUNX family transcription factor 1 no_association ISO DNA:SNPs: :rs2242720, rs4816502 (human)
DNA:SNP:intron:24658G>C (human)
DNA:SNP: :rs2268277 (human)
RGD PMID:16821265, PMID:18087673, PMID:18328148, PMID:20018071 RGD:6482836, RGD:6482837, RGD:6482839, RGD:6482840 NCBI chrNW_004936500:7,621,328...7,710,909 JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936476:14,695,965...14,818,246 JBrowse link
G Sema3c semaphorin 3C ISO protein:increased expression:knee, synovium (human) RGD PMID:15077297 RGD:1580084 NCBI chrNW_004936810:903,306...1,063,024 JBrowse link
G Slc11a1 solute carrier family 11 member 1 severity ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphisms, deletion: :823C>T, p.D543N (human)
DNA:polymorphism:promoter (human)
CTD
RGD
PMID:10719815, PMID:12135431, PMID:16597321 RGD:5684967, RGD:5684971 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Slc22a4 solute carrier family 22 member 4 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:14608356 NCBI chrNW_004936647:2,825,814...2,874,786 JBrowse link
G Slc25a12 solute carrier family 25 member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936509:1,994,082...2,077,731 JBrowse link
G Sms spermine synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936624:2,345,573...2,402,157 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:15292528, PMID:24313545 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15761492 RGD:1581382 NCBI chrNW_004936905:148,956...156,023 JBrowse link
G Spred2 sprouty related EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936491:10,053,546...10,170,950 JBrowse link
G St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:17568789 NCBI chrNW_004936571:3,815,867...3,971,219 JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936506:7,196,860...7,235,854 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO associated with T-cell large granular lymphocyte leukemia
ClinVar Annotator: match by term: Rheumatoid arthritis
RGD
ClinVar
PMID:22591296, PMID:28492532, PMID:30311386 RGD:6892936 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936644:1,328,327...1,395,856 JBrowse link
G Supt20h SPT20 homolog, SAGA complex component ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chrNW_004936472:31,119,671...31,129,939 JBrowse link
G Tagap T cell activation RhoGTPase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936489:10,615,324...10,623,720 JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:9645419 RGD:6482275 NCBI chrNW_004936476:25,913,699...25,923,419 JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:17379860 NCBI chrNW_004936803:69,296...90,270 JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15700117 RGD:5685020 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Tle3 TLE family member 3, transcriptional corepressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936471:29,682,313...29,730,229 JBrowse link
G Tlr2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tmpo thymopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936492:14,972,391...15,000,115 JBrowse link
G Tnf tumor necrosis factor treatment
no_association
ISO DNA:SNP:promoter:-857C>T (human)
DNA:SNP:promoter:-238G>A, -308G>A (human)
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:2001072, PMID:8391952, PMID:12563673, PMID:12566094, PMID:22450443, PMID:25311255 RGD:10450537, RGD:12904065 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfaip2 TNF alpha induced protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936621:1,891,326...1,903,504 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:21841782, PMID:23143596, PMID:30224649 NCBI chrNW_004936560:5,124,955...5,138,988 JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b ISO CTD Direct Evidence: therapeutic CTD PMID:23333834 NCBI chrNW_004936470:27,571,263...27,598,725 JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chrNW_004936737:1,008,228...1,013,575 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment ISO DNA:SNP:promoter:36G>A (human) RGD PMID:25311255 RGD:12904065 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Tnfsf14 TNF superfamily member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936588:3,976,492...3,979,825 JBrowse link
G Traf1 TNF receptor associated factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:23143596 NCBI chrNW_004936487:9,349,883...9,368,946 JBrowse link
G Traf6 TNF receptor associated factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936533:1,857,685...1,874,973 JBrowse link
G Trappc2 trafficking protein particle complex 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chrNW_004936470:3,278,415...3,292,905 JBrowse link
G Txndc5 thioredoxin domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326410 NCBI chrNW_004936534:4,679,636...4,706,682 JBrowse link
G Txnip thioredoxin interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936867:722,544...726,595 JBrowse link
G Tyk2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chrNW_004936659:681,463...704,484 JBrowse link
G Tyms thymidylate synthetase treatment ISO DNA:polymorphism: : RGD PMID:22763757 RGD:11075093 NCBI chrNW_004936550:33,797...42,233 JBrowse link
G Vdr vitamin D receptor no_association ISO DNA:SNP:exon:rs2228570 (human)
DNA:SNP: :rs1544410 (human)
RGD PMID:21820934 RGD:8158077 NCBI chrNW_004936512:5,741,836...5,800,999 JBrowse link
G Vegfa vascular endothelial growth factor A disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:
CTD
RGD
PMID:16368150, PMID:24387171 RGD:8548659 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Vim vimentin ISO RGD PMID:21792832 RGD:6480508 NCBI chrNW_004936520:10,051,692...10,059,324 JBrowse link
scleroderma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cilp cartilage intermediate layer protein ISO ClinVar Annotator: match by term: Scleroderma ClinVar PMID:30311386 NCBI chrNW_004936471:25,501,538...25,517,033 JBrowse link
G Slc39a13 solute carrier family 39 member 13 ISO ClinVar Annotator: match by term: Scleroderma ClinVar PMID:25741868, PMID:28492532 NCBI chrNW_004936562:1,811,479...1,825,857 JBrowse link
Sclerotylosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smarcad1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 ISO OMIM NCBI chrNW_004936687:1,728,848...1,803,992 JBrowse link
Sjogren's syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E onset ISO DNA:polymorphism:exon: RGD PMID:15328426 RGD:7495765 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Bdnf brain derived neurotrophic factor severity ISO protein:increased expression:serum: RGD PMID:18830907 RGD:8657019 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G C3 complement C3 ISO RGD PMID:17675493 RGD:7401265 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cast calpastatin ISO associated with Lupus Erythematosus, Systemic RGD PMID:15540513 RGD:5683622 NCBI chrNW_004936523:6,688,153...6,798,184 JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:salivary ductal epithelium (human) RGD PMID:12472667 RGD:11520791 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Crp C-reactive protein ISO associated with Arthritis, Rheumatoid;protein:increased expression:serum: RGD PMID:2353152, PMID:16013223 RGD:9491774, RGD:9491835 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO mRNA:increased expression:salivary gland:
DNA:SNPs,haplotype: :+49A/G (rs231775),(rs3087243)(human)
RGD PMID:12528117, PMID:16869018 RGD:7421506, RGD:7421519 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Dgkq diacylglycerol kinase theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:serum (human)
protein:decreased expression:lacrimal gland, lymphocyte (mouse)
RGD PMID:9870874, PMID:9890678, PMID:11157873 RGD:8662410, RGD:8662436, RGD:8662451 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO RGD PMID:9853108 RGD:6218983 NCBI chrNW_004936518:4,291,391...4,310,752 JBrowse link
G Gtf2i general transcription factor IIi ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066 NCBI chrNW_004936543:3,521,763...3,611,410 JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:24941846 RGD:10450595 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 ISO RGD PMID:19264855 RGD:10054311 NCBI chrNW_004936739:1,135,282...1,144,643 JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO protein:increased expression:plasma
protein:increased expression:salivary gland
RGD PMID:11359451, PMID:15037117, PMID:21589878 RGD:8158122, RGD:8547696, RGD:8547705 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Ifng interferon gamma ISO RGD PMID:15584966, PMID:28421993 RGD:14975117, RGD:8142390 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 ISO RGD PMID:12233881 RGD:1580479 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il12a interleukin 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936519:6,166,060...6,180,652 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il17a interleukin 17A ISO RGD PMID:21182786 RGD:8696035 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:saliva RGD