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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:malignant mesothelioma
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Accession:DOID:1790 term browser browse the term
Definition:A cell type cancer that has_material_basis_in mesothelial tissue that develops from the thin layer of tissue that covers many of the internal organs. (DO)
Synonyms:exact_synonym: Diffuse malignant Mesothelioma;   MESOM;   advanced malignant mesothelioma;   asbestos-related malignant mesothelioma;   malignant tumor of Mesothelium;   somatic mesothelioma
 primary_id: MESH:C562839
 alt_id: OMIM:156240;   RDO:0012386
 xref: NCI:C27926;   NCI:C4456;   NCI:C60453;   NCI:C7865;   NCI:C8420
For additional species annotation, visit the Alliance of Genome Resources.


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malignant mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26139392 NCBI chrNW_004955408:1,157,826...1,367,146 JBrowse link
G Ago1 argonaute RISC component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955452:13,935,028...13,967,281 JBrowse link
G Ago2 argonaute RISC catalytic component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955461:14,194,268...14,260,949 JBrowse link
G Anxa2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20682992 NCBI chrNW_004955450:14,545,586...14,574,161 JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955412:18,170,331...18,172,298 JBrowse link
G Bap1 BRCA1 associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:24928783, PMID:25231345, PMID:26463840, PMID:26928227, PMID:29112861 RGD:9586039 NCBI chrNW_004955430:2,391,970...2,400,645 JBrowse link
G Bcl10 BCL10 immune signaling adaptor ISO OMIM NCBI chrNW_004955423:8,710,231...8,720,530 JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:16850164 NCBI chrNW_004955402:46,911,125...47,084,214 JBrowse link
G C9 complement C9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955426:23,790,792...23,824,117 JBrowse link
G Calb2 calbindin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955484:4,075,103...4,103,509 JBrowse link
G Ccl27 C-C motif chemokine ligand 27 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955472:1,470,407...1,474,800 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955481:10,293,758...10,301,118 JBrowse link
G Ccne2 cyclin E2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955417:11,027,749...11,039,945 JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:22002241 RGD:11522742 NCBI chrNW_004955445:11,191,817...11,202,156 JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955432:9,521,794...9,727,772 JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11453316 NCBI chrNW_004955437:6,254,638...6,261,278 JBrowse link
G Cfap45 cilia and flagella associated protein 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955468:11,672,332...11,711,395 JBrowse link
G Clec11a C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955559:515,341...517,521 JBrowse link
G Col12a1 collagen type XII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955488:8,128,816...8,240,714 JBrowse link
G Copg1 COPI coat complex subunit gamma 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26463840 NCBI chrNW_004955429:13,582,676...13,615,801 JBrowse link
G Csf1 colony stimulating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955435:13,404,236...13,423,059 JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955420:29,030,716...29,047,447 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955546:1,929,269...1,941,690 JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955433:2,123,190...2,129,119 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955474:247,326...250,355 JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955433:724,566...731,945 JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955565:1,387,043...1,403,624 JBrowse link
G Ddx51 DEAD-box helicase 51 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955482:632,030...636,959 JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chrNW_004955424:27,181,717...27,240,067 JBrowse link
G Egfr epidermal growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chrNW_004955456:321,222...456,431 JBrowse link
G Enox2 ecto-NOX disulfide-thiol exchanger 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26807072 NCBI chrNW_004955473:4,123,403...4,455,268 JBrowse link
G Ephx1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16697254 NCBI chrNW_004955520:116,363...142,983 JBrowse link
G F9 coagulation factor IX ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955489:5,747,718...5,780,899 JBrowse link
G Fgd6 FYVE, RhoGEF and PH domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955405:31,700,706...31,801,992 JBrowse link
G Fgf18 fibroblast growth factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955408:24,225,459...24,260,057 JBrowse link
G Fgf9 fibroblast growth factor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955497:2,199,424...2,232,088 JBrowse link
G Fn1 fibronectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955457:629,599...694,948 JBrowse link
G Fth1 ferritin heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26818092 NCBI chrNW_004955511:5,772,374...5,773,224 JBrowse link
G Gpr27 G protein-coupled receptor 27 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955421:16,352,643...16,353,094 JBrowse link
G Gpr37 G protein-coupled receptor 37 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955479:6,061,424...6,080,129 JBrowse link
G Hdac4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955542:1,629,691...1,886,160 JBrowse link
G Heph hephaestin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26818092 NCBI chrNW_004955475:5,625,177...5,704,234 JBrowse link
G Hgf hepatocyte growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955410:4,114,280...4,181,953 JBrowse link
G Icam2 intercellular adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955478:7,846,460...7,851,889 JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955458:14,643,333...14,648,020 JBrowse link
G Igf2bp3 insulin like growth factor 2 mRNA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23621518 NCBI chrNW_004955410:25,605,323...25,734,845 JBrowse link
G Il12b interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955408:13,302,506...13,316,300 JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955470:1,527,710...1,538,418 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955421:22,642,004...22,694,729 JBrowse link
G Il4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Ilk integrin linked kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23045294 NCBI chrNW_004955414:22,316,243...22,322,979 JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955447:16,149,014...16,226,151 JBrowse link
G Limch1 LIM and calponin homology domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955443:5,984,027...6,305,014 JBrowse link
G Lta lymphotoxin alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955437:114,216...116,003 JBrowse link
G Mcam melanoma cell adhesion molecule disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:22784439, PMID:23621518 RGD:7364782 NCBI chrNW_004955412:20,396,056...20,404,777 JBrowse link
G Mdk midkine ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955422:1,655,351...1,657,026 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955432:22,440,671...22,519,592 JBrowse link
G Mif macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955455:8,367,566...8,368,460 JBrowse link
G Mlana melan-A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955434:9,877,301...9,893,079 JBrowse link
G Mtmr4 myotubularin related protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955451:4,531,966...4,557,528 JBrowse link
G Muc1 mucin 1, cell surface associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955545:1,657,728...1,662,112 JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955431:23,538,224...23,540,039 JBrowse link
G Nf2 neurofibromin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23435014, PMID:26463840, PMID:26678224, PMID:26928227, PMID:29112861 NCBI chrNW_004955455:3,862,804...3,950,669 JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chrNW_004955435:18,581,889...18,633,330 JBrowse link
G Osmr oncostatin M receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955426:23,395,286...23,465,078 JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21543585 NCBI chrNW_004955489:520,875...557,609 JBrowse link
G Pdpn podoplanin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955527:4,183,639...4,215,200 JBrowse link
G Pllp plasmolipin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955433:14,896,087...14,915,794 JBrowse link
G Ptprf protein tyrosine phosphatase receptor type F ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955537:3,096,601...3,185,682 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955429:17,980,956...18,049,723 JBrowse link
G Rxra retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955513:3,313,544...3,386,544 JBrowse link
G Ryr2 ryanodine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955492:2,647,597...3,275,512 JBrowse link
G Sdc1 syndecan 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chrNW_004955469:2,762,696...2,773,697 JBrowse link
G Sema4f ssemaphorin 4F ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955424:11,123,326...11,152,909 JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955420:25,070,626...25,178,410 JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955588:290,497...338,438 JBrowse link
G Sf3b1 splicing factor 3b subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955403:3,134,960...3,163,395 JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955537:2,408,042...2,438,788 JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955434:6,420,850...6,592,797 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20617513 NCBI chrNW_004955439:21,209,101...21,223,538 JBrowse link
G Tbl1xr1 TBL1X receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955420:6,546,529...6,705,481 JBrowse link
G Tfdp2 transcription factor Dp-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955508:3,722,412...3,844,340 JBrowse link
G Tgfb2 transforming growth factor beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955406:174,949...249,248 JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chrNW_004955486:1,839,642...1,910,080 JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955467:9,241,391...9,256,716 JBrowse link
G Traf7 TNF receptor associated factor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955442:15,092,955...15,112,842 JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chrNW_004955467:818,975...894,103 JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chrNW_004955429:10,708,852...10,716,743 JBrowse link
G Wt1 WT1 transcription factor ISO OMIM NCBI chrNW_004955476:10,464,688...10,504,473 JBrowse link
G Wwc1 WW and C2 domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chrNW_004955408:21,362,644...21,529,164 JBrowse link
peritoneal mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lats1 large tumor suppressor kinase 1 ISO ClinVar Annotator: match by term: Peritoneal mesothelioma ClinVar NCBI chrNW_004955439:11,559,655...11,611,287 JBrowse link
G Lats2 large tumor suppressor kinase 2 ISO ClinVar Annotator: match by term: Peritoneal mesothelioma ClinVar NCBI chrNW_004955497:1,711,882...1,768,177 JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO ClinVar Annotator: match by term: Peritoneal mesothelioma ClinVar NCBI chrNW_004955448:18,259,847...18,542,085 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11812
    disease of anatomical entity 11367
      respiratory system disease 2320
        Respiratory Tract Neoplasms 696
          Lung Neoplasms 684
            malignant mesothelioma 94
              malignant biphasic mesothelioma 0
              malignant epithelial mesothelioma 0
              malignant pleural mesothelioma + 0
              pericardial mesothelioma 0
              peritoneal mesothelioma 3
              sarcomatoid mesothelioma 0
Path 2
Term Annotations click to browse term
  disease 11812
    disease of anatomical entity 11367
      respiratory system disease 2320
        thoracic disease 1439
          Thoracic Neoplasms 1041
            Respiratory Tract Neoplasms 696
              Lung Neoplasms 684
                malignant mesothelioma 94
                  malignant biphasic mesothelioma 0
                  malignant epithelial mesothelioma 0
                  malignant pleural mesothelioma + 0
                  pericardial mesothelioma 0
                  peritoneal mesothelioma 3
                  sarcomatoid mesothelioma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.