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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:status epilepticus
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Accession:DOID:1824 term browser browse the term
Definition:A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
Synonyms:exact_synonym: Absence Status;   Complex Partial Status Epilepticus;   Electrographic Status Epilepticus;   Generalized Convulsive Status Epilepticus;   Generalized Status Epilepticus;   Grand Mal Status Epilepticus;   Grand mal status;   Non Convulsive Status Epilepticus;   Petit Mal Status;   Simple Partial Status Epilepticus;   Subclinical Status Epilepticus
 primary_id: MESH:D013226;   RDO:0006616
 xref: GARD:10191;   NCI:C85079
For additional species annotation, visit the Alliance of Genome Resources.


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status epilepticus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IDA RGD PMID:9344635 RGD:1598522 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:14706787 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B IEP
ISO
mRNA:increased expression:dentate gyrus, posterior parahippocampal gyrus (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:14706787, PMID:15380564 RGD:1358367 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:16504477, PMID:16504477 RGD:1598613 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 IEP mRNA:decreased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 IEP protein:increased expression:brain, astrocyte RGD PMID:16190927 RGD:2315587 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acan aggrecan IEP RGD PMID:22934955 RGD:11570543 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 IEP mRNA:increased expression:dentate gyrus RGD PMID:15950787 RGD:1559151 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 IEP mRNA:increased expression:dentate gyrus RGD PMID:15950787 RGD:1559151 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 ISO ClinVar Annotator: match by term: Status epilepticus ClinVar PMID:30311386 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP protein:increased expression:dentate gyrus, brain subventricular zone (rat) RGD PMID:17178407 RGD:2313036 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Alad aminolevulinate dehydratase IEP protein:decreased activity:hippocampus, frontal cortex (rat) RGD PMID:20026167 RGD:4144137 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ank3 ankyrin 3 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19306853, PMID:19306853 RGD:6767290 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 IEP protein:increased expression:brain RGD PMID:11852039 RGD:1599366 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apod apolipoprotein D IEP mRNA:increased expression:hippocampus RGD PMID:10372566 RGD:2311203 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Aqp1 aquaporin 1 IEP RGD PMID:19619613 RGD:2316077 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp4 aquaporin 4 severity IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:20886625, PMID:20886625, PMID:22361023, PMID:22361023 RGD:5148023, RGD:8695999, RGD:8695999 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 IEP RGD PMID:11564418 RGD:2314147 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Ass1 argininosuccinate synthase 1 ISO ClinVar Annotator: match by term: Status epilepticus ClinVar PMID:16475226, PMID:18473344, PMID:19006241, PMID:25179242, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atm ATM serine/threonine kinase IEP protein:increased expression:brain RGD PMID:11852039 RGD:1599366 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15288437 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:22849356 RGD:10054246 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP
IDA
protein:decreased expression:hippocampus RGD PMID:18076646, PMID:22842798 RGD:2293065, RGD:11522734 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 IEP mRNA:increased expression:dentate gyrus (rat) RGD PMID:24051278 RGD:11352818 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:8635431, PMID:8821376, PMID:19366663, PMID:19686240 RGD:4891125, RGD:5684912 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 IEP
ISO
mRNA:protein:increased expression
CTD Direct Evidence: marker/mechanism
CTD PMID:19138675, PMID:19138675 RGD:6483096 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp1 caspase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18571097 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 disease_progression IEP RGD PMID:17627033 RGD:4107076 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:16679645, PMID:18571097, PMID:20214503 RGD:10054104 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 IDA protein:increased expression, increased activity:hippocampus RGD PMID:15749343 RGD:2301314 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 IEP
ISO
protein:increased activity:hippocampus
CTD Direct Evidence: marker/mechanism
CTD PMID:18571097, PMID:15036620 RGD:2311439 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:15245787, PMID:15752349, PMID:17383094, PMID:18096215 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase ISO ClinVar Annotator: match by term: Status epilepticus ClinVar PMID:7762555, PMID:8353501, PMID:9587029, PMID:10408774, PMID:12686134, PMID:14722927, PMID:16307898, PMID:20490928, PMID:20506325, PMID:22069143, PMID:22267502, PMID:22612060, PMID:25326637, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19490431, PMID:20034406, PMID:17950261 RGD:2307057 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19490431, PMID:22248156 RGD:8552226 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 IEP mRNA, protein:increased expression:brain RGD PMID:21731074 RGD:5683875 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccnd1 cyclin D1 treatment IDA RGD PMID:24051278 RGD:11352818 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr10:89,086,556...89,088,993
Ensembl chr10:89,086,556...89,088,993
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19490431, PMID:20034406
G Ccr3 C-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19490431 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IEP RGD PMID:22248156 RGD:8552226 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130
JBrowse link
G Cd40 CD40 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:18455351 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cdh2 cadherin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12125071 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cfl1 cofilin 1 treatment IEP RGD PMID:27642592 RGD:11568691 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chd8 chromodomain helicase DNA binding protein 8 ISO ClinVar Annotator: match by term: Status epilepticus ClinVar PMID:30311386 NCBI chr15:28,612,932...28,672,574
Ensembl chr15:28,612,932...28,672,569
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 IEP RGD PMID:20979657 RGD:11565113 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
G Cnr1 cannabinoid receptor 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19368833, PMID:19368833 RGD:2314675 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:7756609 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crp C-reactive protein IEP protein:increased expression:plasma: RGD PMID:23398413 RGD:9586015 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment IMP RGD PMID:21481949 RGD:9491789 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment IMP RGD PMID:21481949 RGD:9491789 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP protein:increased expression:brain, neuron, endothelial cell RGD PMID:21535896 RGD:5134992 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IEP protein:increased expression:brain RGD PMID:19054393 RGD:2306568 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP Protein:increased expression:brain RGD PMID:16780839 RGD:1599696 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Dab1 DAB adaptor protein 1 IEP protein:increased expression:dentate gyrus (rat) RGD PMID:17314278 RGD:2317783 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Dmd dystrophin IEP
ISO
protein:decreased expression:piriform cortex
CTD Direct Evidence: marker/mechanism
CTD PMID:20886625, PMID:20886625 RGD:5148023 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 treatment IEP RGD PMID:22761705 RGD:10045560 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15003282 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Elavl4 ELAV like RNA binding protein 4 IEP mRNA:increased expression:hippocampus: RGD PMID:17577668 RGD:9685310 NCBI chr 5:130,001,387...130,144,557
Ensembl chr 5:130,001,372...130,085,838
JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:16679645, PMID:17166730 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056, PMID:16696126, PMID:18587450, PMID:18988310 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo3 forkhead box O3 ISO protein:decreased expression:hippocampus,mitochondrion: RGD PMID:23278239 RGD:10402198 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO ClinVar Annotator: match by term: Status epilepticus ClinVar PMID:30311386 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gap43 growth associated protein 43 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10366005 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:7854063, PMID:12914250 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Ghsr growth hormone secretagogue receptor IEP mRNA:decreased expression:hippocampus: RGD PMID:23129314 RGD:12907502 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Gjb6 gap junction protein, beta 6 IEP mRNA:increased expression:brain RGD PMID:12359154 RGD:632751 NCBI chr15:37,400,888...37,411,656
Ensembl chr15:37,400,889...37,410,848
JBrowse link
G Glp1r glucagon-like peptide 1 receptor ISO RGD PMID:12925848 RGD:1598440 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 IEP protein:decreased expression:hippocampus (rat) RGD PMID:19914343, PMID:25457025 RGD:4107719, RGD:13792697 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 ISO
IEP
CTD Direct Evidence: marker/mechanism CTD PMID:19222700, PMID:25457025 RGD:13792697 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 IDA RGD PMID:12724156 RGD:1642496 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IEP RGD PMID:25457025 RGD:13792697 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEP RGD PMID:25457025 RGD:13792697 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grm1 glutamate metabotropic receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15058486, PMID:17446080 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17634364, PMID:18774262 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Grm8 glutamate metabotropic receptor 8 ISO RGD PMID:17430409 RGD:6771183 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Grn granulin precursor IEP mRNA, protein:increased expression:brain RGD PMID:23887054 RGD:10401660 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IEP RGD PMID:22761705 RGD:10045560 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone IDA protein:increased phosphorylation:brain RGD PMID:21613478 RGD:8693708 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IEP RGD PMID:21976514 RGD:9686365 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hmox1 heme oxygenase 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:20971094, PMID:20971094 RGD:4145131 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrh3 histamine receptor H3 IEP mRNA:increased expression:brain RGD PMID:16137576 RGD:1626426 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IEP mRNA:increased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO protein:increased expression:cerebral spinal fluid: RGD PMID:22509781 RGD:7257648 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20971094 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Htra2 HtrA serine peptidase 2 IEP protein:increased expression:hippocampus CA1, neuron, cytoplasm (rat) RGD PMID:21132459 RGD:5688370 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 IDA protein:increased acetylation:hippocampus RGD PMID:29778462 RGD:14985255 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il18 interleukin 18 IDA RGD PMID:20674684 RGD:4889491 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta IEP
IDA
mRNA:increased expression:hippocampus (rat) RGD PMID:14678765, PMID:22960129 RGD:1626682, RGD:7204701 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: therapeutic CTD PMID:19010416 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6st interleukin 6 signal transducer IEP mRNA:increased expression:hippocampus RGD PMID:14614900 RGD:1627571 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 IEP mRNA:decreased expression:subiculum, perirhinal cortex, entorhinal cortex (rat) RGD PMID:17942314, PMID:20971086 RGD:9686050, RGD:10411905 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP mRNA:increased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 IEP protein:decreased expression:hippocampus, astrocyte RGD PMID:18671295 RGD:2316522 NCBI chr 6:27,154,274...27,190,209
Ensembl chr 6:27,151,612...27,190,132
JBrowse link
G Kcnk5 potassium two pore domain channel subfamily K member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19220408 NCBI chr15:4,554,603...4,597,000
Ensembl chr15:4,554,603...4,597,000
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18695509 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19272430 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Mef2c myocyte enhancer factor 2C IEP
ISO
mRNA:increased expression:dentate gyrus
CTD Direct Evidence: marker/mechanism
CTD PMID:18949272, PMID:18949272 RGD:5131610 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mfn1 mitofusin 1 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:27045873 RGD:12436727 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP mRNA:increased expression:hippocampus, astrocyte, dendrite RGD PMID:17928157 RGD:8547922 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase IDA
IMP
protein:increased serine phosphorylation:hippocampus RGD PMID:23211629, PMID:23724051 RGD:7175521, RGD:10041026 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431, PMID:8821376 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nlgn1 neuroligin 1 IEP RGD PMID:22539981 RGD:9831126 NCBI chr 2:111,057,291...111,973,681
Ensembl chr 2:111,057,291...111,793,326
JBrowse link
G Nlgn2 neuroligin 2 IEP RGD PMID:22539981 RGD:9831126 NCBI chr10:56,431,586...56,444,847
Ensembl chr10:56,431,573...56,444,847
JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20149694 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20149694 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npy neuropeptide Y IEP RGD PMID:19270346 RGD:10448969 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:28386312 RGD:13439740 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IEP mRNA:decreased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nt5e 5' nucleotidase, ecto IEP protein:increased activity:cerebral cortex, synaptosome (rat) RGD PMID:16274951 RGD:5134344 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431, PMID:8821376 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase IEP RGD PMID:18295498 RGD:2317139 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pcp4 Purkinje cell protein 4 IEP mRNA,protein:increased expression:brain: RGD PMID:20505763 RGD:9850150 NCBI chr11:36,851,035...36,912,272
Ensembl chr11:36,851,038...36,912,229
JBrowse link
G Pgf placental growth factor IEP protein:increased expression:cerebral cortex, hippocampus RGD PMID:22079325 RGD:6483774 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Plat plasminogen activator, tissue type IDA RGD PMID:17040480 RGD:6484215 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase ISO
IEP
IDA
mRNA, protein:increased expression:hippocampus (rat) RGD PMID:20026272, PMID:19527776, PMID:17040480 RGD:6483805, RGD:6483810, RGD:6484215 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor IEP mRNA:increased expression:hippocampus RGD PMID:19527776 RGD:6483810 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19356691 NCBI chr10:84,874,926...84,881,190
Ensembl chr10:84,874,927...84,881,190
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit IEP RGD PMID:18295498 RGD:2317139 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B IDA protein:increased phosphorylation:brain RGD PMID:25219249 RGD:13515071 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prkcb protein kinase C, beta IEP protein:increased expression:hippocampus RGD PMID:15058486 RGD:1625525 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prox1 prospero homeobox 1 IEP protein:increased expression:dentate gyrus hilus RGD PMID:17042797 RGD:5133273 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:18988310, PMID:20643531 RGD:5135057 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IEP
ISO
protein:increased phosphorylation:hippocampus, postsynaptic density
CTD Direct Evidence: marker/mechanism
CTD PMID:16600505, PMID:16600505 RGD:1581409 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 IEP RGD PMID:10582521 RGD:9589822 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Qdpr quinoid dihydropteridine reductase IEP protein:increased expression:hippocampus (rat) RGD PMID:17366478 RGD:5128581 NCBI chr14:70,164,682...70,178,284
Ensembl chr14:70,164,650...70,178,284
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IDA protein:increased expression:nucleus, hippocampus RGD PMID:17727632 RGD:2298852 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin IEP protein:decreased expression:dentate gyrus (rat) RGD PMID:17314278 RGD:2317783 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:12914250 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IEP RGD PMID:19126440 RGD:13524534 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19306853 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
JBrowse link
G Slc12a5 solute carrier family 12 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20600929 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO RGD PMID:18394802 RGD:5686685 NCBI chr16:8,682,668...8,685,529
Ensembl chr16:8,682,669...8,685,529
JBrowse link
G Slc6a8 solute carrier family 6 member 8 IEP RGD PMID:20979657 RGD:11565113 NCBI chr  X:157,129,987...157,139,321
Ensembl chr  X:157,129,987...157,139,291
JBrowse link
G Slc8a1 solute carrier family 8 member A1 IEP
ISO
protein:decreased expression:brain
CTD Direct Evidence: marker/mechanism
CTD PMID:20888801, PMID:15461673 RGD:2316980 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Slc8a2 solute carrier family 8 member A2 IEP RGD PMID:15461673 RGD:2316980 NCBI chr 1:78,029,555...78,054,042
Ensembl chr 1:78,025,995...78,060,111
JBrowse link
G Slc8a3 solute carrier family 8 member A3 IEP
ISO
protein:decreased expression:brain
CTD Direct Evidence: marker/mechanism
CTD PMID:20888801, PMID:15461673 RGD:2316980 NCBI chr 6:104,889,500...105,099,408
Ensembl chr 6:104,891,376...105,097,054
JBrowse link
G Snta1 syntrophin, alpha 1 IEP
ISO
protein:decreased expression:piriform cortex
CTD Direct Evidence: marker/mechanism
CTD PMID:20886625, PMID:20886625 RGD:5148023 NCBI chr 3:149,874,023...149,905,980
Ensembl chr 3:149,874,030...149,905,944
JBrowse link
G Socs3 suppressor of cytokine signaling 3 IEP mRNA:increased expression:hippocampus RGD PMID:14614901 RGD:1625688 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 IEP mRNA, protein:increased expression:hippocampus RGD PMID:25333348 RGD:11035304 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:16600505, PMID:16600505 RGD:1581409 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sstr1 somatostatin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611
JBrowse link
G Sstr2 somatostatin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
JBrowse link
G Sstr3 somatostatin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Sstr4 somatostatin receptor 4 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:18951627, PMID:18951627 RGD:2324996 NCBI chr 3:142,739,781...142,741,644
Ensembl chr 3:142,739,781...142,741,644
JBrowse link
G Sstr5 somatostatin receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr10:14,847,749...14,853,827
Ensembl chr10:14,847,749...14,853,827
JBrowse link
G Tfam transcription factor A, mitochondrial IEP RGD PMID:21854834 RGD:6767574 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tnf tumor necrosis factor IEP
ISO
protein:increased expression:brain
CTD Direct Evidence: marker/mechanism
CTD PMID:18455351, PMID:20649973 RGD:4143383 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17533168 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xrn2 5'-3' exoribonuclease 2 IEP mRNA:increased expression:hippocampus (rat) RGD PMID:26869208 RGD:11041797 NCBI chr 3:141,224,858...141,298,272
Ensembl chr 3:141,225,290...141,298,265
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 16058
    disease of anatomical entity 15305
      nervous system disease 10879
        central nervous system disease 9021
          brain disease 8346
            epilepsy 1528
              status epilepticus 160
                Epilepsia Partialis Continua 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.