Term:Wernicke encephalopathy
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Accession:DOID:2384 term browser browse the term
Definition:An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
Synonyms:exact_synonym: Cerebral Beriberi;   Encephalopathy, Wernickes;   Gayet Wernicke Encephalopathy;   Wernicke Disease;   Wernicke Encephalopathies;   Wernicke Superior Hemorrhagic Polioencephalitis;   Wernicke Syndrome;   Wernicke's Disease;   Wernicke's Encephalopathy;   Wernicke's Superior Hemorrhagic Polioencephalitis;   Wernicke's Syndrome
 primary_id: MESH:D014899;   RDO:0006822
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Wernicke encephalopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2300278
G Tkt transketolase JBrowse link 16 6,609,670 6,634,608 RGD:11554173

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  disease 14875
    Chemically-Induced Disorders 1145
      substance-related disorder 572
        Alcohol-Related Disorders 251
          Wernicke encephalopathy 2
Path 2
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  disease 14875
    Nutritional and Metabolic Diseases 4249
      disease of metabolism 4249
        acquired metabolic disease 2671
          nutrition disease 832
            Malnutrition 182
              nutritional deficiency disease 175
                Avitaminosis 114
                  Vitamin B Deficiency 70
                    thiamine deficiency disease 4
                      Wernicke encephalopathy 2
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