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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Wernicke encephalopathy
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Accession:DOID:2384 term browser browse the term
Definition:An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
Synonyms:exact_synonym: Cerebral Beriberi;   Encephalopathy, Wernickes;   Gayet Wernicke Encephalopathy;   Wernicke Disease;   Wernicke Encephalopathies;   Wernicke Superior Hemorrhagic Polioencephalitis;   Wernicke Syndrome;   Wernicke's Disease;   Wernicke's Encephalopathy;   Wernicke's Superior Hemorrhagic Polioencephalitis;   Wernicke's Syndrome
 primary_id: MESH:D014899;   RDO:0006822
 xref: ICD10CM:E51.2
For additional species annotation, visit the Alliance of Genome Resources.


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Wernicke encephalopathy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP mRNA, protein:increased expression:medial thalamic group, inferior colliculus, neuron RGD PMID:18481165 RGD:2300278 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tkt transketolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:3762968 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Chemically-Induced Disorders 1196
      substance-related disorder 613
        Alcohol-Related Disorders 288
          Wernicke encephalopathy 2
Path 2
Term Annotations click to browse term
  disease 16023
    Nutritional and Metabolic Diseases 4727
      disease of metabolism 4727
        acquired metabolic disease 2786
          nutrition disease 921
            Malnutrition 201
              nutritional deficiency disease 193
                Avitaminosis 109
                  Vitamin B Deficiency 68
                    thiamine deficiency disease 4
                      Wernicke encephalopathy 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.