ONTOLOGY REPORT - ANNOTATIONS


Term:Landau-Kleffner syndrome
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Accession:DOID:2538 term browser browse the term
Definition:A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495)
Synonyms:exact_synonym: Acquired Aphasia with Convulsive Disorder;   Acquired Aphasia with Epilepsy;   Acquired Childhoood Aphasia with Convulsive Disorder;   Acquired Epileptic Aphasia;   Acquired Epileptic Aphasias;   Acquired Epileptiform Aphasia;   Acquired Epileptiform Aphasias;   LKS;   Landau Kleffner Acquired Epileptiform Aphasia
 primary_id: MESH:D018887;   RDO:0007242
 xref: GARD:6855
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Landau-Kleffner syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:8554872
RGD:11554173

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  disease 14875
    syndrome 4220
      Landau-Kleffner syndrome 1
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  disease 14875
    disease of anatomical entity 14051
      nervous system disease 9116
        central nervous system disease 6913
          brain disease 6418
            epilepsy 1017
              electroclinical syndrome 282
                absence epilepsy 95
                  childhood electroclinical syndrome 73
                    Landau-Kleffner syndrome 1
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