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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:hepatic vascular disease
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Accession:DOID:272 term browser browse the term
Definition:A vascular disease that is located_in the liver. (DO)
Synonyms:exact_synonym: vascular disorder of liver
 primary_id: RDO:9002801
 xref: NCI:C35442
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Banti's Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO protein:increased expression:serum (human) RGD PMID:21290180 RGD:25671452 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
JBrowse link
G ITGB3 integrin subunit beta 3 ISO DNA:missense mutation: :p.L33P (human) RGD PMID:18685811 RGD:10755472 NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451
JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human) RGD PMID:18685811 RGD:10755472 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
G SERPINE1 serpin family E member 1 susceptibility ISO DNA:polymorphism:promoter: RGD PMID:18685811 RGD:10755472 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link
Budd-Chiari syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 ISO protein: decreased expression: plasma (human) RGD PMID:21145806 RGD:25671435 NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943
JBrowse link
G F5 coagulation factor V disease_progression
severity
susceptibility
ISO DNA:missense mutation:cds:R506Q (human)
Factor V Leiden;DNA:missense mutation:cds:G1691A (human)
associated with hyperhomocysteinemia:DNA:missense mutation:cds: (R506Q) (human)
OMIM
RGD
PMID:9245936, PMID:16825912, PMID:26238013, PMID:29771426 RGD:11537993, RGD:14700660, RGD:14700661, RGD:15036813 NCBI chr 7:28,999,481...29,069,603
Ensembl chr 7:28,999,512...29,069,296
JBrowse link
G F7 coagulation factor VII ISO ClinVar Annotator: match by term: Budd-Chiari syndrome ClinVar PMID:7981691, PMID:10862079, PMID:11931672, PMID:15456489, PMID:15735798, PMID:18282149, PMID:22180436, PMID:25582404, PMID:25741868, PMID:30311386, PMID:31064749 NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024
JBrowse link
G INSL6 insulin like 6 ISO ClinVar Annotator: match by term: Budd-Chiari syndrome ClinVar PMID:15781101, PMID:15793561, PMID:15858187, PMID:16081687, PMID:16247455, PMID:16293597, PMID:16325696, PMID:16603627, PMID:16707754, PMID:16709929, PMID:16762626, PMID:17989398, PMID:18256599, PMID:18394554, PMID:19036091, PMID:19287384, PMID:19293426, PMID:20339092, PMID:20631743, PMID:20703299, PMID:21120162, PMID:21689158, PMID:22041374, PMID:22422826, PMID:22571758, PMID:22818858, PMID:22829971, PMID:23115274, PMID:24404189, PMID:24986690, PMID:25043017, PMID:25157968, PMID:25671252, PMID:25741868, PMID:32581362 NCBI chr 1:93,457,854...93,474,777
Ensembl chr 1:93,459,945...93,474,793
JBrowse link
G JAK2 Janus kinase 2 ISO OMIM NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO DNA:transition: :677C>T (human)
DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)
RGD PMID:12221667, PMID:26238013 RGD:10449395, RGD:11537993 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
esophageal varix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin ISO associated with ascites RGD PMID:8664482 RGD:1601159 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G SST somatostatin ISO CTD Direct Evidence: therapeutic CTD PMID:1385068 NCBI chr34:20,063,091...20,064,520
Ensembl chr34:20,063,090...20,064,557
JBrowse link
hepatic veno-occlusive disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO protein:decreased activity:plasma (human) RGD PMID:12040478 RGD:10449042 NCBI chr 9:49,839,252...49,867,295
Ensembl chr 9:49,839,252...49,867,295
JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8602625 NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108
JBrowse link
G F7 coagulation factor VII ISO ClinVar Annotator: match by term: Hepatic veno-occlusive disease ClinVar PMID:7981691, PMID:10862079, PMID:11931672, PMID:15456489, PMID:15735798, PMID:18282149, PMID:22180436, PMID:25582404, PMID:25741868, PMID:30311386, PMID:31064749 NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024
JBrowse link
G HFE homeostatic iron regulator susceptibility ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:15834437 RGD:8694354 NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413
JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:19387321 RGD:4145318 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G INSL6 insulin like 6 ISO ClinVar Annotator: match by term: Hepatic veno-occlusive disease ClinVar PMID:15781101, PMID:15793561, PMID:15858187, PMID:16081687, PMID:16247455, PMID:16293597, PMID:16325696, PMID:16603627, PMID:16707754, PMID:16709929, PMID:16762626, PMID:17989398, PMID:18256599, PMID:18394554, PMID:19036091, PMID:19287384, PMID:19293426, PMID:20339092, PMID:20631743, PMID:20703299, PMID:21120162, PMID:21689158, PMID:22041374, PMID:22422826, PMID:22571758, PMID:22818858, PMID:22829971, PMID:23115274, PMID:24404189, PMID:24986690, PMID:25043017, PMID:25157968, PMID:25671252, PMID:25741868, PMID:32581362 NCBI chr 1:93,457,854...93,474,777
Ensembl chr 1:93,459,945...93,474,793
JBrowse link
G JAK2 Janus kinase 2 ISO ClinVar Annotator: match by term: Hepatic veno-occlusive disease ClinVar PMID:15781101, PMID:15793561, PMID:15858187, PMID:16081687, PMID:16247455, PMID:16293597, PMID:16325696, PMID:16603627, PMID:16707754, PMID:16709929, PMID:16762626, PMID:17989398, PMID:18256599, PMID:18394554, PMID:19036091, PMID:19287384, PMID:19293426, PMID:20339092, PMID:20631743, PMID:20703299, PMID:21120162, PMID:21689158, PMID:22041374, PMID:22422826, PMID:22571758, PMID:22818858, PMID:22829971, PMID:23115274, PMID:24404189, PMID:24986690, PMID:25043017, PMID:25157968, PMID:25671252, PMID:25741868, PMID:32581362 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:blood, liver, lung RGD PMID:23303633 RGD:13204885 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human) RGD PMID:24583625 RGD:14696752 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
G OCLN occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17015055 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
JBrowse link
Hepatic Venoocclusive Disease with Immunodeficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SP110 SP110 nuclear body protein ISO OMIM NCBI chr25:42,418,565...42,459,098
Ensembl chr25:42,419,980...42,459,051
JBrowse link
G SP140 SP140 nuclear body protein ISO ClinVar Annotator: match by term: Hepatic venoocclusive disease with immunodeficiency
ClinVar Annotator: match by term: Hepatic Veno-occlusive Disease with Immunodeficiency
ClinVar PMID:16648851, PMID:16803959, PMID:21536091, PMID:22621957, PMID:24033266, PMID:27577878, PMID:28492532 NCBI chr25:42,459,013...42,527,141
Ensembl chr25:42,459,084...42,527,093
JBrowse link
peliosis hepatis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL3 F2R like thrombin or trypsin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20974703 NCBI chr20:45,738,587...45,740,564
Ensembl chr20:45,738,587...45,740,473
JBrowse link
portal hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin ISO mRNA:increased expression:liver RGD PMID:15086360 RGD:1625304 NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO associated with Liver Cirrhosis, Experimental RGD PMID:11832453 RGD:1626153 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
JBrowse link
G ANGPT2 angiopoietin 2 ISO RGD PMID:19070926 RGD:2314171 NCBI chr16:58,404,049...58,458,344
Ensembl chr16:58,405,259...58,457,701
JBrowse link
G ARRB2 arrestin beta 2 treatment ISO associated with Liver Cirrhosis, Experimental
associated with Liver Cirrhosis;protein:increased expression:mesenteric artery
RGD PMID:24337852, PMID:24719556 RGD:13506899, RGD:13506901 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454
JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: therapeutic CTD
RGD
PMID:6696534, PMID:18987488 RGD:2301924 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
JBrowse link
G AVPR1A arginine vasopressin receptor 1A ISO associated with Liver Cirrhosis;mRNA:increased expression:liver, artery RGD PMID:12641544 RGD:2300334 NCBI chr10:6,266,217...6,269,662
Ensembl chr10:6,265,998...6,269,662
JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:19950773 RGD:4891055 NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407
JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO associated with biliary atresia; RGD PMID:17161183 RGD:14995924 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 treatment ISO protein:increased expression:mesentary RGD PMID:26627607 RGD:11528851 NCBI chr 3:54,405,140...54,499,614
Ensembl chr 3:54,405,717...54,500,221
JBrowse link
G CPEB4 cytoplasmic polyadenylation element binding protein 4 treatment ISO protein:increased expression:mesentary RGD PMID:26627607 RGD:11528851 NCBI chr 4:38,604,065...38,665,200
Ensembl chr 4:38,607,948...38,664,821
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:21347560 RGD:9491791 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:21347560 RGD:9491791 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
JBrowse link
G DBH dopamine beta-hydroxylase ISO protein:decreased expression:mesenteric artery (rat) RGD PMID:19968782 RGD:5129480 NCBI chr 9:50,004,806...50,024,130
Ensembl chr 9:50,004,806...50,024,130
JBrowse link
G DDC dopa decarboxylase ISO mRNA:decreased expression:superior mesenteric artery (rat) RGD PMID:18457899 RGD:5129683 NCBI chr18:1,802,239...1,876,714
Ensembl chr18:1,803,273...1,867,616
JBrowse link
G DGUOK deoxyguanosine kinase ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr17:49,107,085...49,139,366
Ensembl chr17:49,104,546...49,168,782
JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO mRNA, protein:increased expression:stomach mucosa RGD PMID:11758828 RGD:2298677 NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514
JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:17214938 RGD:4892595 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
G EDNRA endothelin receptor type A ISO RGD PMID:17214938 RGD:4892595 NCBI chr15:45,823,472...45,878,527
Ensembl chr15:45,823,560...45,876,463
JBrowse link
G EDNRB endothelin receptor type B ISO RGD PMID:17214938 RGD:4892595 NCBI chr22:31,415,324...31,438,772
Ensembl chr22:31,417,308...31,437,587
JBrowse link
G F5 coagulation factor V ISO associated with Acute Hepatitis;protein:decreased expression:serum (human) RGD PMID:2777210 RGD:14700665 NCBI chr 7:28,999,481...29,069,603
Ensembl chr 7:28,999,512...29,069,296
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO protein:increased expression:endothelial cell, liver sinusoid RGD PMID:16142243, PMID:25469036 RGD:13514048, RGD:1580269 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428
JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:16830363 RGD:1582701 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 ISO mRNA:decreased expression:stomach (rat) RGD PMID:19383083 RGD:5686823 NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243
JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:serum RGD PMID:15951934 RGD:1626634 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G JAK2 Janus kinase 2 severity ISO associated with liver cirrhosis RGD PMID:26385087 RGD:18337263 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO associated with Liver Cirrhosis RGD PMID:24404143 RGD:10041031 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114
JBrowse link
G NGFR nerve growth factor receptor ISO protein:increased expression:superior mesenteric ganglion RGD PMID:22292477 RGD:10414081 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274
JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO associated with liver cirrhosis RGD PMID:10727442 RGD:13824993 NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO associated with Liver Cirrhosis, Biliary
CTD Direct Evidence: therapeutic
mRNA:increased expression:aorta (rat)
RGD
CTD
PMID:10889169, PMID:16142243, PMID:18070013, PMID:29263339 RGD:13504710, RGD:1580269, RGD:7794685 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 treatment ISO associated with Cholestasis RGD PMID:24497272 RGD:10448995 NCBI chr 9:22,461,556...22,469,243
Ensembl chr 9:22,461,705...22,469,053
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 treatment ISO associated with liver cirrhosis;mRNA:altered expression:liver (rat) RGD PMID:19418582 RGD:15042868 NCBI chr15:39,497,313...39,608,120
Ensembl chr15:39,536,290...39,608,116
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO protein:altered localization, increased tyrosine phosphorylation:plasma membrane, stomach mucosa RGD PMID:11826414 RGD:1625216 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
JBrowse link
G PRKCD protein kinase C delta ISO mRNA:decreased expression:spleen, macrophage RGD PMID:17659678 RGD:1642521 NCBI chr20:36,723,491...36,751,982
Ensembl chr20:36,723,809...36,752,191
JBrowse link
G PRL prolactin ISO protein:decreased expression:plasma RGD PMID:17119344 RGD:1642556 NCBI chr35:20,673,830...20,683,824
Ensembl chr35:20,673,839...20,683,824
JBrowse link
G PTEN phosphatase and tensin homolog ISO RGD PMID:14525948 RGD:1581280 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:17876871 RGD:1642587 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G REN renin ISO RGD PMID:12854169 RGD:1580698 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G SERPINF1 serpin family F member 1 ISO protein:increased expression:gastric wall (rat) RGD PMID:22024088 RGD:8655539 NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765
JBrowse link
G TH tyrosine hydroxylase ISO mRNA:decreased expression:superior mesenteric artery (rat) RGD PMID:19968782 RGD:5129480 NCBI chr18:46,327,136...46,334,973
Ensembl chr18:46,327,137...46,335,602
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO associated with Liver Cirrhosis, Experimental RGD PMID:17351970 RGD:2290408 NCBI chr 9:2,521,882...2,533,883
Ensembl chr 9:2,521,882...2,533,989
JBrowse link
G TNF tumor necrosis factor treatment ISO mRNA:increased expression:stomach (rat) RGD PMID:7875478, PMID:9198288, PMID:9537427, PMID:9834372, PMID:10070045 RGD:14688051, RGD:14975128, RGD:14985259, RGD:14995425, RGD:14995426 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G VASH1 vasohibin 1 treatment
disease_progression
ISO RGD PMID:24390792 RGD:15003198 NCBI chr 8:49,631,029...49,651,693
Ensembl chr 8:49,631,910...49,648,168
JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: therapeutic
protein:increased expression:mesentary
CTD
RGD
PMID:18416461, PMID:26627607 RGD:11528851 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
JBrowse link
G XDH xanthine dehydrogenase ISO protein:alternative form:jejunum RGD PMID:10562591 RGD:13209137 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935
JBrowse link
portal vein thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin severity ISO associated with liver cirrhosis;protein:increased expression:plasma (human) RGD PMID:28465646 RGD:14985237 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459
JBrowse link
G IGF1R insulin like growth factor 1 receptor susceptibility ISO associated with hepatocellular carcinoma;DNA:SNP:3'UTR:rs3743251(human) RGD PMID:24758241 RGD:14985227 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO DNA:SNP: :677C>T(human) RGD PMID:25987440, PMID:27221722 RGD:14696705, RGD:14696749 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
G SERPINE1 serpin family E member 1 susceptibility ISO DNA:polymorphism:promoter: RGD PMID:25987440 RGD:14696749 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12699
    disease of anatomical entity 12239
      cardiovascular system disease 3358
        vascular disease 2428
          hepatic vascular disease 63
            Budd-Chiari syndrome + 6
            hemangioma of liver 0
            hepatic infarction 0
            hepatic veno-occlusive disease + 12
            liver angiosarcoma + 0
            nutmeg liver 0
            peliosis hepatis 1
            portal hypertension + 50
            portal vein thrombosis 4
Path 2
Term Annotations click to browse term
  disease 12699
    disease of anatomical entity 12239
      gastrointestinal system disease 4073
        hepatobiliary disease 0
          liver disease 2243
            hepatic vascular disease 63
              Budd-Chiari syndrome + 6
              hemangioma of liver 0
              hepatic infarction 0
              hepatic veno-occlusive disease + 12
              liver angiosarcoma + 0
              nutmeg liver 0
              peliosis hepatis 1
              portal hypertension + 50
              portal vein thrombosis 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.