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ONTOLOGY REPORT - ANNOTATIONS


Term:bilirubin metabolic disorder
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Accession:DOID:2741 term browser browse the term
Definition:A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.
Synonyms:exact_synonym: Bilirubinemia;   bilirubinemias;   hyperbilirubinaemia;   hyperbilirubinemia;   hyperbilirubinemias
 primary_id: MESH:D006932
 alt_id: RDO:0005829
 xref: NCI:C84761;   OMIM:PS237450
For additional species annotation, visit the Alliance of Genome Resources.


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bilirubin metabolic disorder term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:1598605
RGD:11554173
RGD:11081004
RGD:631914
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:2301069
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:11035235
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11522763
G Calb1 calbindin 1 JBrowse link 5 29,538,380 29,562,774 RGD:633843
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:11554173
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:8554872
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:1304286
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:8548604
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:4144803
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:10402168
G Slc34a1 solute carrier family 34 member 1 JBrowse link 17 9,747,766 9,762,739 RGD:8554872
G Slco1b2 solute carrier organic anion transporter family, member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6482854
RGD:8554872
RGD:11554173
RGD:10769337
RGD:6482855
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:8554872
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:8554872
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:8554872
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8554872
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:8554872
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:8554872
Crigler Najjar Syndrome, Type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:8554872
RGD:7240710
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:8554872
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:8554872
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:8554872
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8554872
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:8554872
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:8554872
Crigler-Najjar syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:1600438
RGD:8554872
RGD:13432067
RGD:11554173
RGD:10769363
RGD:10769340
RGD:7240710
RGD:6482856
RGD:6482851
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:8554872
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:8554872
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:8554872
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8554872
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:8554872
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:8554872
Dubin-Johnson syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:1598616
RGD:8554872
RGD:11554173
RGD:7240710
RGD:69812
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:1598620
G Rdx radixin JBrowse link 8 56,570,728 56,612,851 RGD:13592920
G Slco1a1 solute carrier organic anion transporter family, member 1a1 JBrowse link 4 176,158,174 176,231,331 RGD:1598620
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:1598620
Gilbert syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:8554872
RGD:11554173
RGD:7240710
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:8554872
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:8554872
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:8554872
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8554872
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:8554872
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:8554872
Hereditary Hyperbilirubinemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slco1b2 solute carrier organic anion transporter family, member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:8554872
RGD:7240710
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:1354702
Hyperbilirubinemia, Transient Familial Neonatal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:8554872
RGD:7240710
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:8554872
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:8554872
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:8554872
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8554872
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:8554872
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:8554872
Hyperbiliverdinemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blvra biliverdin reductase A JBrowse link 3 119,552,550 119,577,796 RGD:7240710
RGD:8554872
Jaundice term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:5686894
G Ccl25 C-C motif chemokine ligand 25 JBrowse link 12 2,429,492 2,438,928 RGD:5130926
G Cplane1 ciliogenesis and planar polarity effector 1 JBrowse link 2
2
57,274,175
57,444,373
57,350,003
57,472,465
RGD:8554872
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:11576308
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:2303375
RGD:11576308
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:8554872
G Hbb hemoglobin subunit beta JBrowse link 1 168,971,269 168,972,680 RGD:1600896
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:4145521
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:13432069
kernicterus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:11554173
Neonatal Hyperbilirubinemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:10449110
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:4145302
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:11554173
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:11554173
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:10769330
RGD:11554173
neonatal jaundice term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:10449116
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:11554173
obstructive jaundice term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:11554173
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:7364952
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11036102
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549649
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:9685190
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:7364952
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:9685190
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:10448973
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:7204429
T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptprk protein tyrosine phosphatase, receptor type, K JBrowse link 1 17,445,052 18,058,266 RGD:15036800

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15625
    Pathological Conditions, Signs and Symptoms 8039
      Pathologic Processes 5094
        bilirubin metabolic disorder 56
          Crigler-Najjar syndrome + 8
          Dubin-Johnson syndrome 6
          Gilbert syndrome 7
          Hereditary Hyperbilirubinemia + 15
          Jaundice + 26
          Neonatal Hyperbilirubinemia + 18
          kernicterus + 2
Path 2
Term Annotations click to browse term
  disease 15625
    Developmental Diseases 8759
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 7543
        genetic disease 7038
          inherited metabolic disorder 1862
            bilirubin metabolic disorder 56
              Crigler-Najjar syndrome + 8
              Dubin-Johnson syndrome 6
              Gilbert syndrome 7
              Hereditary Hyperbilirubinemia + 15
              Jaundice + 26
              Neonatal Hyperbilirubinemia + 18
              kernicterus + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.