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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:euthyroid sick syndrome
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Accession:DOID:2856 term browser browse the term
Definition:Conditions of abnormal THYROID HORMONES release in patients with apparently normal THYROID GLAND during severe systemic illness, physical TRAUMA, and psychiatric disturbances. It can be caused by the loss of endogenous hypothalamic input or by exogenous drug effects. The most common abnormality results in low T3 THYROID HORMONE with progressive decrease in THYROXINE; (T4) and TSH. Elevated T4 with normal T3 may be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased.
Synonyms:exact_synonym: High T4 Syndrome;   High T4 Syndromes;   Low T3 High T4 Syndrome;   Low T3 Low T4 Syndrome;   Low T3 Syndrome;   Low T3 and Low T4 Syndrome;   Non Thyroidal Illness Syndrome;   Syndromes, Non-Thyroidal Illness;   euthyroid sick syndromes
 primary_id: MESH:D005067;   RDO:0005543
 xref: ICD10CM:E07.81;   ICD9CM:790.94;   NCI:C113170
For additional species annotation, visit the Alliance of Genome Resources.


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euthyroid sick syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment IEP associated with congestive heart failure RGD PMID:27737323 RGD:13782084 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16058
    syndrome 6996
      euthyroid sick syndrome 1
Path 2
Term Annotations click to browse term
  disease 16058
    disease of anatomical entity 15305
      endocrine system disease 4987
        thyroid gland disease 367
          euthyroid sick syndrome 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.