ONTOLOGY REPORT - ANNOTATIONS


Term:hypersensitivity reaction type IV disease
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Accession:DOID:2916 term browser browse the term
Definition:A hypersensitivity reaction disease that is characterized by a cell-mediated response to antigens, where Th1 helper T cells react with antigens on antigen-presenting cells and cause a delayed type immune response. (DO)
Synonyms:related_synonym: immunoproliferative disease
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autoimmune lymphoproliferative syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:8554872
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:7240710
RGD:8554872
RGD:12904015
RGD:12903983
RGD:12903956
RGD:11554173
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:8554872
RGD:7240710
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:13204846
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:11554173
autoimmune lymphoproliferative syndrome type 2B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:8554872
RGD:7240710
autoimmune lymphoproliferative syndrome type 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:7240710
RGD:8554872
autoimmune lymphoproliferative syndrome type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:7240710
RGD:8554872
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:7240710
RGD:8554872
Autoimmune Lymphoproliferative Syndrome, Type IA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:8554872
Autoimmune Lymphoproliferative Syndrome, Type V term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:7240710
RGD:8554872
Blau syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:7240710
RGD:8554872
RGD:11554173
RGD:8547518
RGD:8547515
RGD:8158051
RGD:8158040
cryoglobulinemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:11354974
G Ifnl3 interferon, lambda 3 JBrowse link 1 85,236,243 85,237,775 RGD:11528546
G Tcn2 transcobalamin 2 JBrowse link 14 84,173,992 84,189,299 RGD:11060121
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10450529
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:13592920
Early-Onset Sarcoidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:8554872
RGD:11554173
Familial Mixed Cryoglobulinemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr3a Fc fragment of IgG receptor IIIa JBrowse link 13 89,385,775 89,396,047 RGD:11344956
pulmonary sarcoidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase JBrowse link 3 4,374,679 4,394,374 RGD:5128833
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:5128856
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:4891110
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:5129502
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:5130912
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:4891436
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:4892099
RGD:4892066
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:5130912
G Cftr cystic fibrosis transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:4139905
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:4892634
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:5131289
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:5135438
RGD:5135492
G Cxcl11 C-X-C motif chemokine ligand 11 JBrowse link 14 17,195,395 17,198,170 RGD:5135438
G Cxcl6 C-X-C motif chemokine ligand 6 JBrowse link 14 18,860,201 18,920,839 RGD:5135244
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:5135438
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:5135492
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:4780358
G Defb1 defensin beta 1 JBrowse link 16 75,294,385 75,309,127 RGD:4892262
G Defb4 defensin beta 4 JBrowse link 16 75,634,598 75,637,789 RGD:4892262
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:5131899
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:4145349
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:4990461
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:4889863
RGD:4889823
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:5024944
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:4143198
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:4143248
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:5131177
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:4891110
RGD:5144061
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:4891449
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:4892566
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:4891110
RGD:5144061
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:4891110
G Sftpa1 surfactant protein A1 JBrowse link 16 18,716,019 18,719,404 RGD:4143437
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:4145294
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:4145301
RGD:8553184
G Tnc tenascin C JBrowse link 5 79,789,686 79,874,555 RGD:4889595
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:4143236
RGD:4143466
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:5131275
G Vip vasoactive intestinal peptide JBrowse link 1 42,169,307 42,177,582 RGD:5685623
sarcoidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1331525
RGD:11039025
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:5129164
RGD:5129165
G Anxa11 annexin A11 JBrowse link 16 3,867,193 3,912,043 RGD:11554173
G Btnl2 butyrophilin-like 2 JBrowse link 20 4,140,184 4,156,365 RGD:8554872
RGD:7240710
RGD:7365045
G Ccl17 C-C motif chemokine ligand 17 JBrowse link 19 10,619,220 10,620,671 RGD:4145494
G Ccr2 C-C motif chemokine receptor 2 RGD:4144898
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:4892086
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:4144780
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:8662819
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:7365014
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:5128561
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:4891520
G Hp haptoglobin JBrowse link 19 42,096,255 42,100,805 RGD:5147442
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:4889815
RGD:11554173
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:8549545
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5135505
RGD:5135507
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:5147648
G RT1-CE13 RT1 class I, locus CE13 RGD:7364872
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:7365045
RGD:7240710
RGD:11554173
RGD:7365081
G Sftpd surfactant protein D JBrowse link 16 18,753,535 18,766,100 RGD:4143491
G Slc11a1 solute carrier family 11 member 1 JBrowse link 9 81,655,590 81,666,697 RGD:5684925
RGD:11554173
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
Schnitzler syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:7794711
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:11522758
RGD:11554173
uveoparotid fever term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147562

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14919
    disease of anatomical entity 14083
      immune system disease 2424
        hypersensitivity reaction disease 1464
          hypersensitivity reaction type IV disease 74
            POEMS syndrome 0
            Schnitzler syndrome 2
            autoimmune lymphoproliferative syndrome + 9
            chronic NK-cell lymphocytosis 0
            cryoglobulinemia + 6
            heavy chain disease + 0
            sarcoidosis + 60
Path 2
Term Annotations click to browse term
  disease 14919
    disease of anatomical entity 14083
      Immune & Inflammatory Diseases 3002
        immune system disease 2424
          hypersensitivity reaction disease 1464
            hypersensitivity reaction type IV disease 74
              POEMS syndrome 0
              Schnitzler syndrome 2
              autoimmune lymphoproliferative syndrome + 9
              chronic NK-cell lymphocytosis 0
              cryoglobulinemia + 6
              heavy chain disease + 0
              sarcoidosis + 60
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.