ONTOLOGY REPORT - ANNOTATIONS


Term:antiphospholipid syndrome
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Accession:DOID:2988 term browser browse the term
Definition:The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
Synonyms:exact_synonym: Anti Phospholipid Antibody Syndrome;   Anti Phospholipid Syndrome;   Antiphospholipid Antibody Syndrome;   Antiphospholipid Antibody Syndromes;   Hughes Syndrome
 primary_id: MESH:D016736;   RDO:0000048
 xref: GARD:5824
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antiphospholipid syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoh apolipoprotein H JBrowse link 10 96,640,013 96,653,939 RGD:10054118
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:10058961
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11344980
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6907402
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:1580877
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:11554173
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:11099994
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:5147862
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:5147862
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147862

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  disease 14875
    syndrome 4220
      antiphospholipid syndrome 10
        Familial Antiphospholipid Syndrome 0
Path 2
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  disease 14875
    disease of anatomical entity 14051
      Immune & Inflammatory Diseases 2988
        immune system disease 2414
          Autoimmune Diseases 1447
            autoimmune hypersensitivity disease 1162
              antiphospholipid syndrome 10
                Familial Antiphospholipid Syndrome 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.