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ONTOLOGY REPORT - ANNOTATIONS


Term:granulosa cell tumor
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Accession:DOID:2999 term browser browse the term
Definition:A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Synonyms:exact_synonym: Cancer of Granulosa Cells;   Granulosa Cell Cancer;   Granulosa Cell Cancers;   Granulosa Cell Tumors;   Granulosa Cells Cancer;   Granulosa Cells Cancers;   Granulosa cell neoplasm;   Granulosa cell tumor, adult type;   Granulosa cell tumor, somatic;   Granulosa cell tumour, sarcomatoid;   malignant granulosa cell neoplasm
 primary_id: MESH:D006106
 alt_id: RDO:0000751
 xref: NCI:C3070;   NCI:C4205
For additional species annotation, visit the Alliance of Genome Resources.


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granulosa cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amh anti-Mullerian hormone JBrowse link 7 11,775,155 11,777,503 RGD:2315639
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1643593
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:2289157
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:2296066
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:2296066
G Cmklr1 chemerin chemokine-like receptor 1 JBrowse link 12 48,743,556 48,796,582 RGD:11554173
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1643593
RGD:13592920
G Fancf FA complementation group F JBrowse link 1 107,229,516 107,232,321 RGD:2298508
RGD:11049141
G Fhit fragile histidine triad diadenosine triphosphatase JBrowse link 15 15,697,292 16,862,873 RGD:2298508
G Fshr follicle stimulating hormone receptor JBrowse link 6 12,796,383 12,997,817 RGD:2289157
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:8554872
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:2302173
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:11554173
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 6 12,493,182 12,554,482 RGD:2302176
RGD:2289157
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:2317693
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link 6 51,265,509 51,356,383 RGD:2289157
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2289157
G Rarres2 retinoic acid receptor responder 2 JBrowse link 4 78,205,809 78,208,956 RGD:11554173
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:2289157
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:2299978
G Smad5 SMAD family member 5 JBrowse link 17 8,307,448 8,336,996 RGD:2299978
G St14 suppression of tumorigenicity 14 JBrowse link 8 32,240,113 32,280,813 RGD:2315091
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2315463
G Wif1 Wnt inhibitory factor 1 JBrowse link 7 63,094,955 63,165,158 RGD:1643593
Granulosa Cell Tumor of the Ovary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:8554872
Leydig cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:2293582
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:2293582
G Cga glycoprotein hormones, alpha polypeptide JBrowse link 5 50,362,491 50,393,368 RGD:2293633
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:2290041
G Flt1 Fms related receptor tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:2301251
G Inha inhibin subunit alpha JBrowse link 9 82,700,482 82,703,383 RGD:2290379
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:11554173
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 6 12,493,182 12,554,482 RGD:2302176
RGD:11554173
RGD:2292537
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:2298579
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:2298579
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:2298579
RGD:2298580
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:2298579
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:11554173
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:2299953
multinodular goiter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:8554872
RGD:7240710
Sertoli cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inha inhibin subunit alpha JBrowse link 9 82,700,482 82,703,383 RGD:2290369
Sertoli-Leydig cell tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inha inhibin subunit alpha JBrowse link 9 82,700,482 82,703,383 RGD:2290367
Somatic Leydig Cell Adenoma, with Male-Limited Precocious Puberty term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 6 12,493,182 12,554,482 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15602
    disease of anatomical entity 14933
      endocrine system disease 4837
        endocrine gland cancer 1529
          ovarian cancer 237
            granulosa cell tumor 38
              Abrikosov's Tumor 0
              Granulosa Cell Tumor of the Ovary 1
              testicular granulosa cell tumor + 2
              testicular sex cord-stromal neoplasm + 15
Path 2
Term Annotations click to browse term
  disease 15602
    disease of anatomical entity 14933
      Urogenital Diseases 4016
        Female Urogenital Diseases and Pregnancy Complications 1762
          Female Urogenital Diseases 1472
            female reproductive system disease 1468
              Adnexal Diseases 656
                ovarian disease 650
                  Ovarian Neoplasms 392
                    ovarian cancer 237
                      granulosa cell tumor 38
                        Abrikosov's Tumor 0
                        Granulosa Cell Tumor of the Ovary 1
                        testicular granulosa cell tumor + 2
                        testicular sex cord-stromal neoplasm + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.