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Term:glioblastoma multiforme
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Accession:DOID:3068 term browser browse the term
Definition:A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Synonyms:exact_synonym: GBM;   adult glioblastoma multiforme;   glioblastoma;   glioblastomas;   grade IV adult astrocytic tumor;   grade IV astrocytoma;   grade IV astrocytomas;   primary glioblastoma multiforme;   spongioblastoma multiforme
 narrow_synonym: glioblastoma multiforme, somatic;   glioblastoma, somatic
 primary_id: MESH:D005909
 xref: GARD:2491;   NCI:C129295;   NCI:C3058;   NCI:C39750;   NCI:C9094
For additional species annotation, visit the Alliance of Genome Resources.

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glioblastoma multiforme term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr3 actin related protein 3 JBrowse link NW_004955459 15,216,914 15,284,013 RGD:9068941
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link NW_004955454 1,250,261 1,313,547 RGD:9068941
G Adgrl4 adhesion G protein-coupled receptor L4 JBrowse link NW_004955423 14,395,712 14,487,803 RGD:9068941
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004955538 3,208,711 3,224,386 RGD:9068941
G Akt3 AKT serine/threonine kinase 3 JBrowse link NW_004955406 6,907,876 7,163,672 RGD:9068941
G Apc APC regulator of WNT signaling pathway JBrowse link NW_004955418 2,567,804 2,675,062 RGD:9068941
G Aspm assembly factor for spindle microtubules JBrowse link NW_004955406 33,665,675 33,720,468 RGD:9068941
G Atm ATM serine/threonine kinase JBrowse link NW_004955412 10,422,753 10,531,406 RGD:9068941
G Atrx ATRX chromatin remodeler JBrowse link NW_004955557 947,368 1,252,701 RGD:9068941
G Bag3 BAG cochaperone 3 JBrowse link NW_004955551 446,322 468,329 RGD:9068941
G Bche butyrylcholinesterase JBrowse link NW_004955448 15,327,374 15,396,827 RGD:9068941
G Becn1 beclin 1 JBrowse link NW_004955451 16,616,595 16,625,731 RGD:9068941
G Bhlhe40 basic helix-loop-helix family member e40 JBrowse link NW_004955421 8,463,337 8,468,877 RGD:9068941
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link NW_004955429 6,548,586 6,553,730 RGD:9068941
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004955494 2,567,238 2,712,708 RGD:9068941
G Brd2 bromodomain containing 2 JBrowse link NW_004955437 1,584,890 1,592,486 RGD:9068941
G Brd4 bromodomain containing 4 JBrowse link NW_004955495 7,959,033 7,989,216 RGD:9068941
G Brd7 bromodomain containing 7 JBrowse link NW_004955433 8,425,976 8,462,431 RGD:9068941
G Cbx6 chromobox 6 JBrowse link NW_004955413 24,955,721 24,966,015 RGD:9068941
G Cbx7 chromobox 7 JBrowse link NW_004955413 25,079,627 25,100,039 RGD:9068941
G Cbx8 chromobox 8 JBrowse link NW_004955506 3,035,510 3,038,204 RGD:9068941
G Ccnh cyclin H JBrowse link NW_004955418 23,790,398 23,807,509 RGD:9068941
G Cd9 CD9 molecule JBrowse link NW_004955413 3,891,874 3,924,065 RGD:9068941
G Cdk4 cyclin dependent kinase 4 JBrowse link NW_004955458 5,457,927 5,460,718 RGD:9068941
G Cdk6 cyclin dependent kinase 6 JBrowse link NW_004955432 9,521,794 9,727,772 RGD:9068941
G Chaf1b chromatin assembly factor 1 subunit B JBrowse link NW_004955407 35,601,992 35,618,287 RGD:9068941
G Chi3l1 chitinase 3 like 1 JBrowse link NW_004955406 39,195,101 39,201,808 RGD:9068941
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 JBrowse link NW_004955416 13,963,300 14,038,691 RGD:9068941
G Crebbp CREB binding protein JBrowse link NW_004955442 13,559,496 13,691,913 RGD:9068941
G Csta cystatin A JBrowse link NW_004955427 21,617,099 21,630,712 RGD:9068941
G Cstb cystatin B JBrowse link NW_004955407 41,475,533 41,478,943 RGD:9068941
G Ctnnd2 catenin delta 2 JBrowse link NW_004955426 635,287 1,007,389 RGD:9068941
G Ctsb cathepsin B JBrowse link NW_004955403 53,086,236 53,100,217 RGD:9068941
G Ctsh cathepsin H JBrowse link NW_004955533 39,237 54,881 RGD:9068941
G Ctsk cathepsin K JBrowse link NW_004955588 149,036 158,093 RGD:9068941
G CUNH11orf65 chromosome unknown C11orf65 homolog JBrowse link NW_004955412 10,533,174 10,567,364 RGD:9068941
G Cxcl8 C-X-C motif chemokine ligand 8 JBrowse link NW_004955474 247,326 250,355 RGD:9068941
G Deup1 deuterosome assembly protein 1 JBrowse link NW_004955414 1,062,968 1,126,698 RGD:9068941
G Dmbt1 deleted in malignant brain tumors 1 JBrowse link NW_004955477 863,388 899,703 RGD:9068941
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link NW_004955469 7,264,431 7,367,059 RGD:9068941
G Dusp6 dual specificity phosphatase 6 JBrowse link NW_004955405 26,662,018 26,666,314 RGD:9068941
G E2f1 E2F transcription factor 1 JBrowse link NW_004955422 27,638,625 27,643,261 RGD:9068941
G Egf epidermal growth factor JBrowse link NW_004955496 325,954 401,430 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004955456 321,222 456,431 RGD:9068941
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link NW_004955436 12,416,147 12,477,214 RGD:9068941
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link NW_004955491 4,215,353 4,292,229 RGD:9068941
G Fabp7 fatty acid binding protein 7 JBrowse link NW_004955436 4,642,584 4,646,172 RGD:9068941
G Fat1 FAT atypical cadherin 1 JBrowse link NW_004955403 22,502,625 22,618,513 RGD:9068941
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link NW_004955471 6,852,459 7,026,590 RGD:9068941
G Fgfr1 fibroblast growth factor receptor 1 JBrowse link NW_004955463 14,013,247 14,064,354 RGD:9068941
G Flt3lg fms related receptor tyrosine kinase 3 ligand JBrowse link NW_004955559 1,364,056 1,371,245 RGD:9068941
G Fn1 fibronectin 1 JBrowse link NW_004955457 629,599 694,948 RGD:9068941
G Fosl2 FOS like 2, AP-1 transcription factor subunit JBrowse link NW_004955469 10,297,179 10,319,180 RGD:9068941
G Gdnf glial cell derived neurotrophic factor JBrowse link NW_004955426 22,386,613 22,412,324 RGD:9068941
G Grik2 glutamate ionotropic receptor kainate type subunit 2 JBrowse link NW_004955411 27,096,214 27,759,503 RGD:9068941
G H3f3a H3 histone, family 3A JBrowse link NW_004955489 269,900 278,398 RGD:9068941
G Heatr1 HEAT repeat containing 1 JBrowse link NW_004955492 3,627,889 3,672,269 RGD:9068941
G Hes1 hes family bHLH transcription factor 1 JBrowse link NW_004955420 14,565,921 14,568,447 RGD:9068941
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 JBrowse link NW_004955444 1,498,444 1,502,099 RGD:9068941
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link NW_004955466 8,000,311 8,022,497 RGD:9068941
G Hras HRas proto-oncogene, GTPase JBrowse link NW_004955476 11,508,446 11,510,333 RGD:9068941
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link NW_004955457 6,851,542 6,869,452 RGD:9068941
G Il16 interleukin 16 JBrowse link NW_004955416 11,876,317 11,987,548 RGD:9068941
G Il1b interleukin 1 beta JBrowse link NW_004955470 1,486,936 1,491,888 RGD:9068941
G Il2 interleukin 2 JBrowse link NW_004955428 18,163,010 18,168,157 RGD:9068941
G Jag1 jagged canonical Notch ligand 1 JBrowse link NW_004955415 20,490,414 20,526,068 RGD:9068941
G Jag2 jagged canonical Notch ligand 2 JBrowse link NW_004955538 3,421,685 3,433,829 RGD:9068941
G Kcnc2 potassium voltage-gated channel subfamily C member 2 JBrowse link NW_004955405 14,420,447 14,599,780 RGD:9068941
G Kras KRAS proto-oncogene, GTPase JBrowse link NW_004955413 20,298,852 20,328,756 RGD:9068941
G L1cam L1 cell adhesion molecule JBrowse link NW_004955580 548,442 561,580 RGD:9068941
G LOC102025775 histone H2AX JBrowse link NW_004955412 20,203,173 20,204,714 RGD:9068941
G Lrrc56 leucine rich repeat containing 56 JBrowse link NW_004955476 11,493,299 11,507,022 RGD:9068941
G Lrrc59 leucine rich repeat containing 59 JBrowse link NW_004955451 11,316,139 11,328,107 RGD:9068941
G Ltbp4 latent transforming growth factor beta binding protein 4 JBrowse link NW_004955578 685,960 712,809 RGD:9068941
G Lztr1 leucine zipper like transcription regulator 1 JBrowse link NW_004955442 19,315,427 19,333,361 RGD:9068941
G Macir macrophage immunometabolism regulator JBrowse link NW_004955418 10,752,250 10,767,791 RGD:9068941
G Map1lc3a microtubule associated protein 1 light chain 3 alpha JBrowse link NW_004955422 26,774,466 26,776,024 RGD:9068941
G Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link NW_004955495 4,695,239 4,718,380 RGD:9068941
G Map2k3 mitogen-activated protein kinase kinase 3 JBrowse link NW_004955577 1,225,033 1,249,510 RGD:9068941
G Mdm2 MDM2 proto-oncogene JBrowse link NW_004955458 15,264,028 15,287,290 RGD:9068941
G Mdm4 MDM4 regulator of p53 JBrowse link NW_004955406 40,346,617 40,387,977 RGD:9068941
G Med12 mediator complex subunit 12 JBrowse link NW_004955475 10,687,168 10,710,286 RGD:9068941
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link NW_004955432 22,440,671 22,519,592 RGD:9068941
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link NW_004955477 7,103,035 7,375,073 RGD:9068941
G Mmp2 matrix metallopeptidase 2 JBrowse link NW_004955433 13,024,844 13,050,041 RGD:9068941
G Mmp7 matrix metallopeptidase 7 JBrowse link NW_004955412 5,780,772 5,792,485 RGD:9068941
G Mmp9 matrix metallopeptidase 9 JBrowse link NW_004955445 11,295,500 11,303,322 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004955441 14,188,315 14,247,608 RGD:9068941
G Mtor mechanistic target of rapamycin kinase JBrowse link NW_004955486 2,487,642 2,599,694 RGD:9068941
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link NW_004955461 2,714,022 2,718,872 RGD:9068941
G Mycn MYCN proto-oncogene, bHLH transcription factor JBrowse link NW_004955487 9,219,528 9,224,818 RGD:9068941
G Ncor1 nuclear receptor corepressor 1 JBrowse link NW_004955467 1,408,292 1,568,539 RGD:9068941
G Ndrg1 N-myc downstream regulated 1 JBrowse link NW_004955461 7,787,068 7,836,380 RGD:9068941
G Ndrg4 NDRG family member 4 JBrowse link NW_004955433 15,914,884 15,933,000 RGD:9068941
G Nf1 neurofibromin 1 JBrowse link NW_004955481 6,145,855 6,404,179 RGD:9068941
G Notch1 notch receptor 1 JBrowse link NW_004955513 4,225,939 4,264,875 RGD:9068941
G Notch2 notch receptor 2 JBrowse link NW_004955568 1,660,357 1,812,285 RGD:9068941
G Notch3 notch receptor 3 JBrowse link NW_004955495 8,012,370 8,048,616 RGD:9068941
G Nras NRAS proto-oncogene, GTPase JBrowse link NW_004955435 18,001,517 18,009,105 RGD:9068941
G Pdgfb platelet derived growth factor subunit B JBrowse link NW_004955413 25,150,702 25,166,987 RGD:9068941
G Pdgfrb platelet derived growth factor receptor beta JBrowse link NW_004955415 4,365,848 4,403,317 RGD:9068941
G Pdpn podoplanin JBrowse link NW_004955527 4,183,639 4,215,200 RGD:9068941
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link NW_004955478 7,448,584 7,531,860 RGD:9068941
G Pgf placental growth factor JBrowse link NW_004955523 616,196 627,055 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004955420 8,355,415 8,427,024 RGD:9068941
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link NW_004955501 251,829 381,255 RGD:9068941
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link NW_004955486 3,813,923 3,837,563 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004955446 1,020,707 1,098,327 RGD:9068941
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link NW_004955437 5,940,825 5,945,367 RGD:9068941
G Pml PML nuclear body scaffold JBrowse link NW_004955450 3,654,854 3,692,057 RGD:9068941
G Pole DNA polymerase epsilon, catalytic subunit JBrowse link NW_004955482 373,467 418,000 RGD:9068941
G Polk DNA polymerase kappa JBrowse link NW_004955425 25,164,749 25,228,064 RGD:9068941
G Pparg peroxisome proliferator activated receptor gamma JBrowse link NW_004955429 14,814,690 14,936,869 RGD:9068941
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link NW_004955439 18,664,230 19,953,358 RGD:9068941
G Prom1 prominin 1 JBrowse link NW_004955480 7,955,501 8,059,537 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004955425 5,007,811 5,091,829 RGD:9068941
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link NW_004955419 5,678,750 5,699,305 RGD:9068941
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link NW_004955406 25,077,988 25,086,259 RGD:9068941
G Ptk2 protein tyrosine kinase 2 JBrowse link NW_004955461 14,337,914 14,622,779 RGD:9068941
G Rb1 RB transcriptional corepressor 1 JBrowse link NW_004955431 1,960,765 2,124,576 RGD:9068941
G Reck reversion inducing cysteine rich protein with kazal motifs JBrowse link NW_004955472 222,261 276,869 RGD:9068941
G Rpl35a ribosomal protein L35a JBrowse link NW_004955420 11,957,070 11,960,713 RGD:9068941
G Rpl5 ribosomal protein L5 JBrowse link NW_004955423 1,748,809 1,758,622 RGD:9068941
G Runx3 RUNX family transcription factor 3 JBrowse link NW_004955452 4,580,444 4,606,820 RGD:9068941
G Septin14 septin 14 JBrowse link NW_004955456 8,066,570 8,102,318 RGD:9068941
G Serping1 serpin family G member 1 JBrowse link NW_004955511 2,545,337 2,557,850 RGD:9068941
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link NW_004955442 13,765,660 13,792,106 RGD:9068941
G Srrt serrate, RNA effector molecule JBrowse link NW_004955573 86,975 101,538 RGD:9068941
G Suz12 SUZ12 polycomb repressive complex 2 subunit JBrowse link NW_004955481 6,867,175 6,917,548 RGD:9068941
G Tes testin LIM domain protein JBrowse link NW_004955432 21,992,708 22,035,441 RGD:9068941
G Tgm2 transglutaminase 2 JBrowse link NW_004955445 18,544,192 18,576,576 RGD:9068941
G Tmem135 transmembrane protein 135 JBrowse link NW_004955414 5,810,639 6,016,949 RGD:9068941
G Tnc tenascin C JBrowse link NW_004955419 12,569,620 12,662,897 RGD:9068941
G Tnfsf10 TNF superfamily member 10 JBrowse link NW_004955420 2,550,392 2,566,448 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004955467 9,241,391 9,256,716 RGD:9068941
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link NW_004955416 9,962,736 10,035,433 RGD:9068941
G Trmt11 tRNA methyltransferase 11 homolog JBrowse link NW_004955436 7,274,848 7,318,762 RGD:9068941
G Vegfa vascular endothelial growth factor A JBrowse link NW_004955437 9,527,445 9,541,908 RGD:9068941
G Wt1 WT1 transcription factor JBrowse link NW_004955476 10,464,688 10,504,473 RGD:9068941
G Zbtb7a zinc finger and BTB domain containing 7A JBrowse link NW_004955495 4,747,905 4,754,066 RGD:9068941
glioblastoma proneural subtype term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rb1 RB transcriptional corepressor 1 JBrowse link NW_004955431 1,960,765 2,124,576 RGD:9068941
gliosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plau plasminogen activator, urokinase JBrowse link NW_004955437 17,995,726 18,000,542 RGD:9068941
G Por P450 (cytochrome) oxidoreductase JBrowse link NW_004955456 14,698,589 14,748,520 RGD:9068941
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link NW_004955419 5,678,750 5,699,305 RGD:9068941
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link NW_004955406 25,077,988 25,086,259 RGD:9068941
G Vegfa vascular endothelial growth factor A JBrowse link NW_004955437 9,527,445 9,541,908 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11744
    disease of cellular proliferation 5112
      Neoplasms by Histologic Type 3289
        cell type cancer 2780
          malignant glioma 1129
            astrocytoma 911
              glioblastoma multiforme 142
                brain glioblastoma multiforme 0
                giant cell glioblastoma 0
                glioblastoma classical subtype 0
                glioblastoma mesenchymal subtype 0
                glioblastoma neural subtype 0
                glioblastoma proneural subtype 1
                gliosarcoma 5
Path 2
Term Annotations click to browse term
  disease 11744
    disease of anatomical entity 11304
      nervous system disease 9202
        Nervous System Neoplasms 1510
          Central Nervous System Neoplasms 1232
            central nervous system cancer 1190
              brain cancer 1178
                supratentorial cancer 940
                  cerebrum cancer 913
                    astrocytoma 911
                      glioblastoma multiforme 142
                        brain glioblastoma multiforme 0
                        giant cell glioblastoma 0
                        glioblastoma classical subtype 0
                        glioblastoma mesenchymal subtype 0
                        glioblastoma neural subtype 0
                        glioblastoma proneural subtype 1
                        gliosarcoma 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.