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ONTOLOGY REPORT - ANNOTATIONS


Term:glioblastoma multiforme
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Accession:DOID:3068 term browser browse the term
Definition:A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Synonyms:exact_synonym: GBM;   adult glioblastoma multiforme;   giant cell glioblastoma;   giant cell glioblastomas;   glioblastoma;   glioblastomas;   grade IV adult astrocytic tumor;   grade IV astrocytoma;   grade IV astrocytomas;   primary glioblastoma multiforme;   spongioblastoma multiforme
 narrow_synonym: glioblastoma multiforme, somatic;   glioblastoma, somatic
 primary_id: MESH:D005909
 xref: GARD:2491;   NCI:C129295;   NCI:C3058;   NCI:C39750;   NCI:C9094
For additional species annotation, visit the Alliance of Genome Resources.


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glioblastoma multiforme term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTR3 actin related protein 3 JBrowse link 2 113,889,934 113,962,596 RGD:11570557
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 8 142,449,649 142,545,009 RGD:13831352
RGD:13831355
G ADGRL4 adhesion G protein-coupled receptor L4 JBrowse link 1 78,889,764 79,006,730 RGD:13838664
RGD:13838665
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:734543
G AKT3 AKT serine/threonine kinase 3 JBrowse link 1 243,488,233 243,851,079 RGD:13674164
G APC APC regulator of WNT signaling pathway JBrowse link 5 112,707,498 112,846,239 RGD:11554173
G ASPM assembly factor for spindle microtubules JBrowse link 1 197,084,127 197,146,694 RGD:13439742
G ATM ATM serine/threonine kinase JBrowse link 11 108,222,484 108,369,102 RGD:8554872
G ATRX ATRX chromatin remodeler JBrowse link X 77,504,878 77,786,235 RGD:13442489
RGD:8554872
G BAG3 BAG cochaperone 3 JBrowse link 10 119,651,380 119,677,819 RGD:5687132
G BCHE butyrylcholinesterase JBrowse link 3 165,772,904 165,837,451 RGD:11554173
G BECN1 beclin 1 JBrowse link 17 42,810,132 42,824,316 RGD:6483102
G BHLHE40 basic helix-loop-helix family member e40 JBrowse link 3 4,979,420 4,985,323 RGD:11554173
G BMI1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 10 22,321,099 22,331,484 RGD:11554173
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 7 140,719,331 140,924,929 RGD:8554872
G BRD2 bromodomain containing 2 JBrowse link 6 32,968,594 32,981,505 RGD:11554173
G BRD4 bromodomain containing 4 JBrowse link 19 15,236,836 15,332,539 RGD:11554173
G BRD7 bromodomain containing 7 JBrowse link 16 50,315,957 50,368,988 RGD:9586441
G C11orf65 chromosome 11 open reading frame 65 JBrowse link 11 108,308,519 108,469,832 RGD:8554872
G CBX6 chromobox 6 JBrowse link 22 38,861,422 38,872,216 RGD:9587354
G CBX7 chromobox 7 JBrowse link 22 39,130,772 39,152,680 RGD:9587354
G CBX8 chromobox 8 JBrowse link 17 79,792,132 79,797,077 RGD:9587354
G CCNH cyclin H JBrowse link 5 87,311,471 87,413,033 RGD:11554173
G CD9 CD9 molecule JBrowse link 12 6,199,946 6,238,266 RGD:11554173
G CDK4 cyclin dependent kinase 4 JBrowse link 12 57,747,727 57,752,310 RGD:13702089
G CDK6 cyclin dependent kinase 6 JBrowse link 7 92,604,921 92,836,573 RGD:11554173
RGD:13702095
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:8552659
G CHAF1B chromatin assembly factor 1 subunit B JBrowse link 21 36,380,145 36,419,015 RGD:9587472
G CHI3L1 chitinase 3 like 1 JBrowse link 1 203,178,931 203,186,704 RGD:4892621
RGD:11554173
G CPEB1 cytoplasmic polyadenylation element binding protein 1 JBrowse link 15 82,543,201 82,648,795 RGD:9685152
G CREBBP CREB binding protein JBrowse link 16 3,725,054 3,880,727 RGD:8554872
G CSTA cystatin A JBrowse link 3 122,325,248 122,341,969 RGD:11554173
G CSTB cystatin B JBrowse link 21 43,773,950 43,776,308 RGD:11554173
G CTNND2 catenin delta 2 JBrowse link 5 10,971,836 11,904,446 RGD:11554173
G CTSB cathepsin B JBrowse link 8 11,842,524 11,868,118 RGD:2315515
RGD:11554173
G CTSH cathepsin H JBrowse link 15 78,921,058 78,945,098 RGD:1549417
G CTSK cathepsin K JBrowse link 1 150,796,208 150,808,260 RGD:11554173
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:11554173
G DEUP1 deuterosome assembly protein 1 JBrowse link 11 93,329,079 93,438,470 RGD:11554173
G DMBT1 deleted in malignant brain tumors 1 JBrowse link 10 122,560,665 122,643,736 RGD:1599778
G DNMT3A DNA methyltransferase 3 alpha JBrowse link 2 25,227,874 25,342,590 RGD:8554872
G DUSP6 dual specificity phosphatase 6 JBrowse link 12 89,347,235 89,352,501 RGD:11554173
G E2F1 E2F transcription factor 1 JBrowse link 20 33,675,477 33,686,385 RGD:13702471
G EGF epidermal growth factor JBrowse link 4 109,912,883 110,013,766 RGD:11554173
RGD:13702472
G EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:8554872
RGD:11554173
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 6 131,808,020 131,895,155 RGD:13204719
G ERBB2 erb-b2 receptor tyrosine kinase 2 JBrowse link 17 39,688,084 39,728,662 RGD:8554872
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 7 148,807,374 148,884,344 RGD:14928319
G FABP7 fatty acid binding protein 7 JBrowse link 6 122,749,201 122,784,077 RGD:1578468
G FAT1 FAT atypical cadherin 1 JBrowse link 4 186,587,789 186,726,696 RGD:11554173
G FBXW7 F-box and WD repeat domain containing 7 JBrowse link 4 152,320,544 152,536,873 RGD:8554872
G FGFR1 fibroblast growth factor receptor 1 JBrowse link 8 38,411,138 38,468,834 RGD:8554872
G FLT3LG fms related receptor tyrosine kinase 3 ligand JBrowse link 19 49,474,172 49,487,037 RGD:11049502
G FN1 fibronectin 1 JBrowse link 2 215,360,440 215,436,167 RGD:11554173
G FOSL2 FOS like 2, AP-1 transcription factor subunit JBrowse link 2 28,392,855 28,417,317 RGD:11554173
G GDNF glial cell derived neurotrophic factor JBrowse link 5 37,812,677 37,840,044 RGD:11554173
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 JBrowse link 6 101,393,708 102,070,083 RGD:11554173
G GSTT1 glutathione S-transferase theta 1 RGD:11554173
G H2AX H2A.X variant histone JBrowse link 11 119,093,874 119,095,465 RGD:11554173
G H3-3A H3.3 histone A JBrowse link 1 226,062,716 226,072,019 RGD:8554872
RGD:11554173
G H3C2 H3 clustered histone 2 JBrowse link 6 26,031,589 26,032,099 RGD:11554173
G HEATR1 HEAT repeat containing 1 JBrowse link 1 236,549,005 236,604,516 RGD:10761721
G HES1 hes family bHLH transcription factor 1 JBrowse link 3 194,136,148 194,138,732 RGD:11554173
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 JBrowse link 8 79,764,010 79,767,863 RGD:11554173
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 14 61,695,513 61,748,259 RGD:11554173
G HRAS HRas proto-oncogene, GTPase JBrowse link 11 532,242 535,576 RGD:13702475
RGD:8554872
RGD:13702872
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 2 208,236,227 208,255,143 RGD:11074562
RGD:8554872
RGD:11522732
G IFNA2 interferon alpha 2 JBrowse link 9 21,384,255 21,385,398 RGD:11554173
G IL16 interleukin 16 JBrowse link 15 81,196,879 81,314,058 RGD:5024941
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:11554173
G IL2 interleukin 2 JBrowse link 4 122,449,479 122,456,725 RGD:11554173
G JAG1 jagged canonical Notch ligand 1 JBrowse link 20 10,637,684 10,673,999 RGD:11554173
G JAG2 jagged canonical Notch ligand 2 JBrowse link 14 105,140,981 105,168,776 RGD:11554173
G KCNC2 potassium voltage-gated channel subfamily C member 2 JBrowse link 12 75,040,078 75,209,839 RGD:9686067
G KRAS KRAS proto-oncogene, GTPase JBrowse link 12 25,205,246 25,250,929 RGD:13702861
RGD:13702872
G L1CAM L1 cell adhesion molecule JBrowse link X 153,861,514 153,886,173 RGD:6483067
G LRRC56 leucine rich repeat containing 56 JBrowse link 11 518,967 554,916 RGD:8554872
G LRRC59 leucine rich repeat containing 59 JBrowse link 17 50,381,238 50,397,523 RGD:11554173
G LTBP4 latent transforming growth factor beta binding protein 4 JBrowse link 19 40,593,166 40,629,820 RGD:11554173
G LZTR1 leucine zipper like transcription regulator 1 JBrowse link 22 20,982,297 20,999,032 RGD:11554173
G MACIR macrophage immunometabolism regulator JBrowse link 5 103,258,763 103,278,660 RGD:11554173
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha JBrowse link 20 34,546,823 34,560,345 RGD:11561946
G MAP2K2 mitogen-activated protein kinase kinase 2 JBrowse link 19 4,090,321 4,124,184 RGD:13702862
G MAP2K3 mitogen-activated protein kinase kinase 3 JBrowse link 17 21,284,679 21,315,240 RGD:1641940
G MDM2 MDM2 proto-oncogene JBrowse link 12 68,808,149 68,850,686 RGD:13702089
G MDM4 MDM4 regulator of p53 JBrowse link 1 204,516,377 204,558,120 RGD:11554173
G MED12 mediator complex subunit 12 JBrowse link X 71,118,596 71,142,450 RGD:8554872
G MET MET proto-oncogene, receptor tyrosine kinase JBrowse link 7 116,672,196 116,798,386 RGD:11554173
G MGMT O-6-methylguanine-DNA methyltransferase JBrowse link 10 129,467,214 129,770,983 RGD:2317667
RGD:11554173
G MIR518B microRNA 518b JBrowse link 19 53,702,737 53,702,819 RGD:13703042
G MIR663A microRNA 663a JBrowse link 20 26,208,186 26,208,278 RGD:13782051
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:7207145
RGD:11554173
G MMP7 matrix metallopeptidase 7 JBrowse link 11 102,520,508 102,530,747 RGD:7207145
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:7207145
RGD:11554173
RGD:8547973
G MSH2 mutS homolog 2 JBrowse link 2 47,403,067 47,634,501 RGD:8554872
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,106,535 11,273,497 RGD:8554872
RGD:11554173
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:11554173
G MYCN MYCN proto-oncogene, bHLH transcription factor JBrowse link 2 15,940,550 15,947,004 RGD:8554872
G MYCNOS MYCN opposite strand JBrowse link 2 15,936,265 15,942,433 RGD:8554872
G NCOR1 nuclear receptor corepressor 1 JBrowse link 17 16,029,157 16,216,475 RGD:11554173
G NDRG1 N-myc downstream regulated 1 JBrowse link 8 133,237,175 133,297,252 RGD:11554173
G NDRG4 NDRG family member 4 JBrowse link 16 58,463,645 58,515,403 RGD:7247726
G NF1 neurofibromin 1 JBrowse link 17 31,094,927 31,377,677 RGD:11554173
G NOTCH1 notch receptor 1 JBrowse link 9 136,494,433 136,546,048 RGD:11554173
G NOTCH2 notch receptor 2 JBrowse link 1 119,911,553 120,069,703 RGD:11554173
G NOTCH3 notch receptor 3 JBrowse link 19 15,159,038 15,200,995 RGD:11554173
G NRAS NRAS proto-oncogene, GTPase JBrowse link 1 114,704,469 114,716,771 RGD:8554872
RGD:13702876
RGD:13702875
G PDGFB platelet derived growth factor subunit B JBrowse link 22 39,223,359 39,244,982 RGD:6482799
G PDGFRB platelet derived growth factor receptor beta JBrowse link 5 150,113,839 150,155,845 RGD:13702903
G PDPN podoplanin JBrowse link 1 13,583,757 13,617,957 RGD:2292241
G PECAM1 platelet and endothelial cell adhesion molecule 1 JBrowse link 17 64,319,415 64,413,844 RGD:6771207
G PGF placental growth factor JBrowse link 14 74,941,830 74,955,764 RGD:6483585
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 179,148,114 179,240,093 RGD:8554872
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 3 138,652,698 138,834,928 RGD:11343921
RGD:13782050
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 1 9,629,889 9,729,114 RGD:13782051
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 5 68,215,737 68,301,821 RGD:8554872
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 6 37,170,152 37,175,428 RGD:11554173
G PML promyelocytic leukemia JBrowse link 15 73,994,673 74,047,827 RGD:11554173
G POLE DNA polymerase epsilon, catalytic subunit JBrowse link 12 132,623,758 132,687,519 RGD:8554872
G POLK DNA polymerase kappa JBrowse link 5 75,511,308 75,605,820 RGD:11554173
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:11554173
G PROM1 prominin 1 JBrowse link 4 15,968,226 16,084,059 RGD:11554173
G PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:2290476
RGD:8554872
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 122,369,906 122,395,703 RGD:5688245
RGD:5688250
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:5688245
RGD:5688250
G PTK2 protein tyrosine kinase 2 JBrowse link 8 140,657,900 141,002,079 RGD:11554173
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,747 48,481,890 RGD:13782067
G RECK reversion inducing cysteine rich protein with kazal motifs JBrowse link 9 36,036,905 36,124,455 RGD:11554173
G RPL35A ribosomal protein L35a JBrowse link 3 197,950,190 197,956,610 RGD:11535077
G RPL5 ribosomal protein L5 JBrowse link 1 92,831,986 92,841,924 RGD:11535147
G RUNX1 RUNX family transcription factor 1 JBrowse link 21 34,787,801 35,049,334 RGD:11554173
G RUNX3 RUNX family transcription factor 3 JBrowse link 1 24,899,511 24,965,158 RGD:11554173
G SEPTIN14 septin 14 JBrowse link 7 55,793,540 55,862,752 RGD:11554173
G SERPING1 serpin family G member 1 JBrowse link 11 57,597,685 57,614,848 RGD:13525003
G SLC22A10 solute carrier family 22 member 10 JBrowse link 11 63,268,257 63,311,983 RGD:11554173
G SLX4 SLX4 structure-specific endonuclease subunit JBrowse link 16 3,579,653 3,611,639 RGD:8554872
G SRRT serrate, RNA effector molecule JBrowse link 7 100,874,971 100,888,664 RGD:11554173
G SUZ12 SUZ12 polycomb repressive complex 2 subunit JBrowse link 17 31,937,007 32,001,040 RGD:11554173
G TES testin LIM domain protein JBrowse link 7 116,210,539 116,258,786 RGD:11554173
G TGM2 transglutaminase 2 JBrowse link 20 38,127,385 38,166,508 RGD:11554173
G TMEM135 transmembrane protein 135 JBrowse link 11 87,037,934 87,328,824 RGD:11554173
G TNC tenascin C JBrowse link 9 115,019,575 115,118,244 RGD:4889612
G TNFSF10 TNF superfamily member 10 JBrowse link 3 172,505,508 172,523,430 RGD:11554173
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:8554872
RGD:13592920
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 15 43,403,061 43,510,640 RGD:11554173
G TRMT11 tRNA methyltransferase 11 homolog JBrowse link 6 125,986,430 126,079,728 RGD:11554173
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:11554173
G WT1 WT1 transcription factor JBrowse link 11 32,387,775 32,435,539 RGD:11554173
G ZBTB7A zinc finger and BTB domain containing 7A JBrowse link 19 4,043,303 4,066,899 RGD:11554173
brain glioblastoma multiforme term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MIR139 microRNA 139 JBrowse link 11 72,615,063 72,615,130 RGD:13838722
glioblastoma proneural subtype term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,747 48,481,890 RGD:13782062
gliosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:11526112
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:11554173
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 JBrowse link 10 94,683,729 94,736,190 RGD:11554173
G PLAU plasminogen activator, urokinase JBrowse link 10 73,909,182 73,917,501 RGD:7241591
G POR cytochrome p450 oxidoreductase JBrowse link 7 75,915,155 75,986,855 RGD:11554173
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 122,369,906 122,395,703 RGD:5688250
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:5688250
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16490
    disease of cellular proliferation 6563
      Neoplasms by Histologic Type 3843
        cell type cancer 3291
          malignant glioma 1377
            astrocytoma 1142
              glioblastoma multiforme 155
                brain glioblastoma multiforme 1
                giant cell glioblastoma 0
                glioblastoma classical subtype 0
                glioblastoma mesenchymal subtype 0
                glioblastoma neural subtype 0
                glioblastoma proneural subtype 1
                gliosarcoma 8
Path 2
Term Annotations click to browse term
  disease 16490
    disease of cellular proliferation 6563
      Neoplasms by Site 5749
        Nervous System Neoplasms 1783
          Central Nervous System Neoplasms 1280
            central nervous system cancer 1226
              brain cancer 1210
                supratentorial cancer 1173
                  cerebrum cancer 1144
                    astrocytoma 1142
                      glioblastoma multiforme 155
                        brain glioblastoma multiforme 1
                        giant cell glioblastoma 0
                        glioblastoma classical subtype 0
                        glioblastoma mesenchymal subtype 0
                        glioblastoma neural subtype 0
                        glioblastoma proneural subtype 1
                        gliosarcoma 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.