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ONTOLOGY REPORT - ANNOTATIONS


Term:glioblastoma multiforme
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Accession:DOID:3068 term browser browse the term
Definition:A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Synonyms:exact_synonym: GBM;   Giant Cell Glioblastoma;   Giant Cell Glioblastomas;   Glioblastomas;   adult glioblastoma multiforme;   glioblastoma;   grade IV adult astrocytic tumor;   grade IV astrocytoma;   grade IV astrocytomas;   primary glioblastoma multiforme;   spongioblastoma multiforme
 narrow_synonym: GLIOBLASTOMA, SOMATIC;   glioblastoma multiforme, somatic
 primary_id: MESH:D005909
 alt_id: RDO:0005677
 xref: GARD:2491;   NCI:C129295;   NCI:C3058;   NCI:C39750;   NCI:C9094
For additional species annotation, visit the Alliance of Genome Resources.


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glioblastoma multiforme term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:11570557
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:13831352
RGD:13831355
G Adgrl4 adhesion G protein-coupled receptor L4 JBrowse link 2 256,609,787 256,724,642 RGD:13838664
RGD:13838665
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:734543
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:13674164
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:11554173
G Aspm abnormal spindle microtubule assembly JBrowse link 13 56,546,021 56,591,793 RGD:13439742
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:8554872
G Atrx ATRX, chromatin remodeler JBrowse link X 76,820,110 76,979,155 RGD:13442489
RGD:8554872
G Bag3 Bcl2-associated athanogene 3 JBrowse link 1 199,941,258 199,965,191 RGD:5687132
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:11554173
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6483102
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 4 140,703,619 140,709,319 RGD:11554173
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 17 85,360,439 85,370,283 RGD:11554173
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:8554872
G Brd2 bromodomain containing 2 JBrowse link 20 3,910,555 3,921,074 RGD:11554173
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:11554173
G Brd7 bromodomain containing 7 JBrowse link 19 19,672,780 19,701,484 RGD:9586441
G Cbx6 chromobox 6 JBrowse link 7 121,047,996 121,058,109 RGD:9587354
G Cbx7 chromobox 7 JBrowse link 7 121,136,067 121,153,503 RGD:9587354
G Cbx8 chromobox 8 JBrowse link 10 108,148,073 108,150,511 RGD:9587354
G Ccnh cyclin H JBrowse link 2 13,593,100 13,613,910 RGD:11554173
G Cd9 CD9 molecule JBrowse link 4 157,977,163 158,010,091 RGD:11554173
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:13702089
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:11554173
RGD:13702095
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:8552659
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 RGD:8552659
G Chaf1b chromatin assembly factor 1 subunit B JBrowse link 11 34,101,248 34,121,371 RGD:9587472
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:4892621
RGD:11554173
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 JBrowse link 1 143,171,457 143,278,485 RGD:9685152
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:8554872
G Csta cystatin A JBrowse link 11 67,555,792 67,566,980 RGD:11554173
G Cstb cystatin B JBrowse link 20 10,966,357 10,968,399 RGD:11554173
G Ctnnd2 catenin delta 2 JBrowse link 2 83,227,247 84,094,315 RGD:11554173
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:2315515
RGD:11554173
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:1549417
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:11554173
G Deup1 deuterosome assembly protein 1 JBrowse link 8 14,094,742 14,157,232 RGD:11554173
G Dmbt1 deleted in malignant brain tumors 1 JBrowse link 1
1
201,620,642
203,149,414
201,689,905
203,228,705
RGD:1599778
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:8554872
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:11554173
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:13702471
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:11554173
RGD:13702472
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:11554173
RGD:8554872
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:13204719
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:8554872
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:14928319
G Fabp7 fatty acid binding protein 7 JBrowse link 20 40,769,624 40,773,156 RGD:1578468
G Fat1 FAT atypical cadherin 1 JBrowse link 16 50,372,150 50,501,716 RGD:11554173
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:8554872
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:8554872
G Flt3lg fms-related tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:11049502
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:11554173
G Fosl2 FOS like 2, AP-1 transcription factor subunit JBrowse link 6 25,598,936 25,616,995 RGD:11554173
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:11554173
G Grik2 glutamate ionotropic receptor kainate type subunit 2 JBrowse link 20 53,791,428 54,517,691 RGD:11554173
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:11554173
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:11554173
G H3f3a H3 histone family member 3A JBrowse link 13 99,091,246 99,102,828 RGD:11554173
RGD:8554872
G Heatr1 HEAT repeat containing 1 JBrowse link 17 66,446,135 66,488,303 RGD:10761721
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:11554173
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:11554173
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:11554173
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:13702475
RGD:8554872
RGD:13702872
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 9 71,882,108 71,911,645 RGD:11074562
RGD:8554872
RGD:11522732
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:5024941
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11554173
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:11554173
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:11554173
G Jag2 jagged canonical Notch ligand 2 JBrowse link 6 137,711,144 137,733,331 RGD:11554173
G Kcnc2 potassium voltage-gated channel subfamily C member 2 JBrowse link 7 54,978,453 55,159,362 RGD:9686067
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:13702861
RGD:13702872
G L1cam L1 cell adhesion molecule JBrowse link X 156,901,244 156,928,064 RGD:6483067
G Lrrc56 leucine rich repeat containing 56 JBrowse link 1 214,182,232 214,197,184 RGD:8554872
G Lrrc59 leucine rich repeat containing 59 JBrowse link 10 82,352,390 82,367,047 RGD:11554173
G Ltbp4 latent transforming growth factor beta binding protein 4 JBrowse link 1 84,118,046 84,152,095 RGD:11554173
G Lztr1 leucine-zipper-like transcription regulator 1 JBrowse link 11 87,381,638 87,397,849 RGD:11554173
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:11561946
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:13702862
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:1641940
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:13702089
G Mdm4 MDM4 regulator of p53 JBrowse link 13 49,786,776 49,828,780 RGD:11554173
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:8554872
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:11554173
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:2317667
RGD:11554173
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:7207145
RGD:11554173
G Mmp7 matrix metallopeptidase 7 JBrowse link 8 5,893,253 5,900,965 RGD:7207145
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:7207145
RGD:11554173
RGD:8547973
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:8554872
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:8554872
RGD:11554173
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:11554173
G Mycn MYCN proto-oncogene, bHLH transcription factor JBrowse link 6 38,222,554 38,228,419 RGD:8554872
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:11554173
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:11554173
G Ndrg4 NDRG family member 4 JBrowse link 19 9,766,439 9,802,396 RGD:7247726
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:11554173
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:11554173
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:11554173
G Notch3 notch receptor 3 JBrowse link 7 14,138,495 14,189,688 RGD:11554173
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:8554872
RGD:13702876
RGD:13702875
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6482799
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:13702903
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:2292241
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6771207
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6483585
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8554872
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:11343921
RGD:13782050
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:13782051
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:8554872
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:11554173
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:11554173
G Pole DNA polymerase epsilon, catalytic subunit JBrowse link 12 52,403,533 52,452,075 RGD:8554872
G Polk DNA polymerase kappa JBrowse link 2 27,305,718 27,364,906 RGD:11554173
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:11554173
G Prom1 prominin 1 JBrowse link 14 71,532,321 71,637,400 RGD:11554173
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2290476
RGD:8554872
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:5688245
RGD:5688250
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5688245
RGD:5688250
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:11554173
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:13782067
G Reck reversion-inducing-cysteine-rich protein with kazal motifs JBrowse link 5 59,348,568 59,415,169 RGD:11554173
G RGD1311251 similar to RIKEN cDNA 4930550C14 JBrowse link 8 57,983,168 58,012,474 RGD:8554872
G RGD1562136 similar to D1Ertd622e protein JBrowse link 9 111,327,333 111,347,428 RGD:11554173
G Rpl35a ribosomal protein L35a JBrowse link 11 70,963,223 70,967,146 RGD:11535077
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:11535147
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:11554173
G Runx3 RUNX family transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:11554173
G Septin14 septin 14 JBrowse link 12 30,600,162 30,623,173 RGD:11554173
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:13525003
G Slc22a22 solute carrier family 22 (organic cation transporter), member 22 JBrowse link 7 97,042,176 97,071,984 RGD:11554173
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:8554872
G Srrt serrate, RNA effector molecule JBrowse link 12 22,457,898 22,471,090 RGD:11554173
G Suz12 SUZ12 polycomb repressive complex 2 subunit JBrowse link 10 67,325,101 67,371,588 RGD:11554173
G Tes testin LIM domain protein JBrowse link 4 44,321,883 44,360,407 RGD:11554173
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:11554173
G Tmem135 transmembrane protein 135 JBrowse link 1 152,886,496 153,096,225 RGD:11554173
G Tnc tenascin C JBrowse link 5 79,789,686 79,874,555 RGD:4889612
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:8554872
RGD:13592920
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:11554173
G Trmt11 tRNA methyltransferase 11 homolog JBrowse link 1 29,432,109 29,576,079 RGD:11554173
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11554173
G Wt1 WT1 transcription factor JBrowse link 3 95,133,221 95,180,574 RGD:11554173
G Zbtb7a zinc finger and BTB domain containing 7a JBrowse link 7 11,429,266 11,446,119 RGD:11554173
brain glioblastoma multiforme term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mir139 microRNA 139 JBrowse link 1 166,589,545 166,589,612 RGD:13838722
glioblastoma proneural subtype term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:13782062
gliosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:11526112
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:11554173
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 JBrowse link 1 258,074,797 258,139,176 RGD:11554173
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:7241591
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:11554173
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:5688250
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5688250
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    disease of cellular proliferation 5796
      cancer 4113
        cell type cancer 2920
          malignant glioma 1069
            astrocytoma 784
              glioblastoma multiforme 151
                brain glioblastoma multiforme 1
                giant cell glioblastoma 0
                glioblastoma classical subtype 0
                glioblastoma mesenchymal subtype 0
                glioblastoma neural subtype 0
                glioblastoma proneural subtype 1
                gliosarcoma 8
Path 2
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        Nervous System Neoplasms 1758
          nervous system cancer 1708
            central nervous system cancer 956
              brain cancer 940
                supratentorial cancer 851
                  cerebrum cancer 788
                    astrocytoma 784
                      glioblastoma multiforme 151
                        brain glioblastoma multiforme 1
                        giant cell glioblastoma 0
                        glioblastoma classical subtype 0
                        glioblastoma mesenchymal subtype 0
                        glioblastoma neural subtype 0
                        glioblastoma proneural subtype 1
                        gliosarcoma 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.