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ONTOLOGY REPORT - ANNOTATIONS


Term:rhabdomyosarcoma
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Accession:DOID:3247 term browser browse the term
Definition:A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
Synonyms:exact_synonym: Rhabdomyosarcomas
 narrow_synonym: Rhabdomyosarcoma, somatic
 primary_id: MESH:D012208;   RDO:0003795
 xref: NCI:C3359
For additional species annotation, visit the Alliance of Genome Resources.


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rhabdomyosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:8554872
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:2314204
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:8554872
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:8554872
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:8552662
G Cnr1 cannabinoid receptor 1 JBrowse link 5 49,307,584 49,333,064 RGD:11554173
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 17 9,990,072 10,004,339 RGD:8554872
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:11554173
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:11554173
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:11554173
G Ptma prothymosin alpha JBrowse link 9 93,545,396 93,549,436 RGD:11554173
G Slc22a18 solute carrier family 22, member 18 JBrowse link 1 216,676,330 216,700,632 RGD:8554872
G Timm10 translocase of inner mitochondrial membrane 10 JBrowse link 3 72,226,563 72,230,087 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:8554872
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11554173
alveolar rhabdomyosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:8554872
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:7240710
G Pax3 paired box 3 JBrowse link 9 84,004,004 84,101,226 RGD:1580944
RGD:8554872
RGD:7240710
G Pax7 paired box 7 JBrowse link 5 158,211,001 158,313,510 RGD:7240710
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:11554173
embryonal rhabdomyosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:11554173
G Bcor BCL6 co-repressor JBrowse link X 11,570,155 11,692,022 RGD:11554173
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B JBrowse link 3 110,367,949 110,420,471 RGD:11554173
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:11554173
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:8554872
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:11554173
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:8554872
G Setd2 SET domain containing 2, histone lysine methyltransferase JBrowse link 8 118,802,478 118,888,224 RGD:11554173
G Slc22a18 solute carrier family 22, member 18 JBrowse link 1 216,676,330 216,700,632 RGD:13592920
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:8554872
Rhabdomyosarcoma 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a18 solute carrier family 22, member 18 JBrowse link 1 216,676,330 216,700,632 RGD:7240710
Rhabdomyosarcoma, Embryonal, 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:7240710

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      musculoskeletal system disease 4271
        musculoskeletal system cancer 149
          muscle cancer 45
            rhabdomyosarcoma 30
              Rhabdomyosarcoma 1 1
              Rhabdomyosarcoma, Embryonal, 2 1
              alveolar rhabdomyosarcoma + 5
              anus rhabdomyosarcoma 0
              bile duct rhabdomyosarcoma + 0
              breast rhabdomyosarcoma 0
              central nervous system rhabdomyosarcoma 0
              embryonal rhabdomyosarcoma + 10
              gallbladder rhabdomyosarcoma 0
              liver rhabdomyosarcoma 0
              mediastinum rhabdomyosarcoma 0
              mixed type rhabdomyosarcoma 0
              ovary rhabdomyosarcoma 0
              pleomorphic rhabdomyosarcoma + 0
              prostate rhabdomyosarcoma + 0
              rectum rhabdomyosarcoma 0
              testis rhabdomyosarcoma 0
Path 2
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        peripheral nervous system disease 2125
          neuropathy 1948
            neuromuscular disease 1520
              muscular disease 957
                muscle tissue disease 684
                  Muscle Tissue Neoplasms 122
                    musculoskeletal system benign neoplasm 65
                      muscle benign neoplasm 47
                        skeletal muscle neoplasm 31
                          skeletal muscle cancer 31
                            rhabdomyosarcoma 30
                              Rhabdomyosarcoma 1 1
                              Rhabdomyosarcoma, Embryonal, 2 1
                              alveolar rhabdomyosarcoma + 5
                              anus rhabdomyosarcoma 0
                              bile duct rhabdomyosarcoma + 0
                              breast rhabdomyosarcoma 0
                              central nervous system rhabdomyosarcoma 0
                              embryonal rhabdomyosarcoma + 10
                              gallbladder rhabdomyosarcoma 0
                              liver rhabdomyosarcoma 0
                              mediastinum rhabdomyosarcoma 0
                              mixed type rhabdomyosarcoma 0
                              ovary rhabdomyosarcoma 0
                              pleomorphic rhabdomyosarcoma + 0
                              prostate rhabdomyosarcoma + 0
                              rectum rhabdomyosarcoma 0
                              testis rhabdomyosarcoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.