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Term:atopic dermatitis
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Accession:DOID:3310 term browser browse the term
Definition:A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Synonyms:exact_synonym: ATOD;   Allergic;   Atopic Eczema;   Atopic Neurodermatitides;   Atopic Neurodermatitis;   Besnier's prurigo;   Disseminated Neurodermatitides;   Disseminated Neurodermatitis;   allergic dermatitis;   atopic dermatitides;   infantile eczema
 primary_id: MESH:D003876
 alt_id: RDO:0005348
 xref: OMIM:PS603165
For additional species annotation, visit the Alliance of Genome Resources.


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atopic dermatitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actl9 actin-like 9 JBrowse link 7 18,310,624 18,312,001 RGD:11554173
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:13592920
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11040546
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:8657028
RGD:8657069
RGD:8657067
RGD:8657065
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:7401273
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:11554173
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:13592920
G Ccdc80 coiled-coil domain containing 80 JBrowse link 11 60,645,660 60,679,249 RGD:11554173
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:11554173
G Ccl17 C-C motif chemokine ligand 17 JBrowse link 19 10,619,220 10,620,671 RGD:11554173
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:7483580
RGD:7483583
G Ccl22 C-C motif chemokine ligand 22 JBrowse link 19 10,674,189 10,681,145 RGD:11554173
G Ccl24 C-C motif chemokine ligand 24 JBrowse link 12 24,131,529 24,152,626 RGD:11554173
G Ccl26 C-C motif chemokine ligand 26 JBrowse link 12 24,157,182 24,161,870 RGD:11087554
G Ccl27 C-C motif chemokine ligand 27 JBrowse link 5 58,159,066 58,166,182 RGD:1626250
G Ccl28 C-C motif chemokine ligand 28 JBrowse link 2 52,379,341 52,403,979 RGD:4892193
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:11554173
G Ccr2 C-C motif chemokine receptor 2 RGD:8661734
G Ccr3 C-C motif chemokine receptor 3 JBrowse link 8 133,026,539 133,040,999 RGD:6893391
RGD:11554173
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:6893391
RGD:11554173
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:5132274
G Cldn1 claudin 1 JBrowse link 11 77,815,216 77,830,373 RGD:11344875
G Cldn23 claudin 23 JBrowse link 16 59,988,603 59,990,327 RGD:11344875
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1625394
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:7411698
RGD:7411700
G Ctse cathepsin E JBrowse link 13 48,426,833 48,449,493 RGD:13592920
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:9491761
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:9491393
RGD:9491761
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:11554173
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:11554173
G Emsy EMSY BRCA2-interacting transcriptional repressor JBrowse link 1 163,541,071 163,618,576 RGD:11554173
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:5147756
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:5147985
RGD:5508430
G Flg filaggrin JBrowse link 2 193,565,401 193,574,297 RGD:11554173
G Glb1 galactosidase, beta 1 JBrowse link 8 122,439,328 122,511,939 RGD:11554173
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:5490539
RGD:5490981
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:5490540
RGD:5490981
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:5490540
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:5128852
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:5128889
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:8157618
RGD:11554173
G Ifnl3 interferon, lambda 3 JBrowse link 1 85,236,243 85,237,775 RGD:11554173
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:7364805
RGD:11554173
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:5684364
RGD:11554173
RGD:8549583
RGD:8549539
RGD:8549531
RGD:8549529
RGD:8549509
G Il13ra1 interleukin 13 receptor subunit alpha 1 JBrowse link X 122,724,081 122,783,801 RGD:8549525
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:8549521
RGD:8549556
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:8698670
RGD:9068436
RGD:9068417
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655872
RGD:13592920
RGD:8655914
RGD:8655908
RGD:8655876
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11554173
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:8662961
RGD:8693325
RGD:8549583
RGD:8663473
RGD:8663444
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:6892938
G Il31 interleukin 31 JBrowse link 12 38,527,575 38,538,086 RGD:11554173
G Il33 interleukin 33 JBrowse link 1 248,112,611 248,147,030 RGD:11554173
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:7829786
RGD:11554173
RGD:7829795
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:11530001
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:5687175
RGD:11554173
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11554173
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:11554173
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:8693720
G Mc1r melanocortin 1 receptor JBrowse link 19 56,215,420 56,219,987 RGD:5687321
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:13204759
G Ms4a2 membrane spanning 4-domains A2 JBrowse link 1 227,957,363 227,965,312 RGD:1599903
G Nat2 N-acetyltransferase 2 JBrowse link 16 23,960,709 23,991,570 RGD:8552664
RGD:8552668
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:13592920
G Nfkbiz NFKB inhibitor zeta JBrowse link 11 47,243,342 47,271,487 RGD:13592920
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:8657069
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508452
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:5144116
RGD:5684771
G Ovol1 ovo like transcriptional repressor 1 JBrowse link 1 220,927,309 220,938,814 RGD:11554173
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:5509940
RGD:11554173
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:7777149
RGD:13592920
G S100a8 S100 calcium binding protein A8 JBrowse link 2 190,073,239 190,074,333 RGD:11554173
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:11554173
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:1599904
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:13592920
G Slc11a1 solute carrier family 11 member 1 JBrowse link 9 81,655,590 81,666,697 RGD:11554173
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1331525
RGD:7394812
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:8552997
RGD:8553048
RGD:8552999
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7794689
RGD:7794745
G Tmem79 transmembrane protein 79 JBrowse link 2 187,701,522 187,706,452 RGD:13592920
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7401246
G Tnfaip6 TNF alpha induced protein 6 JBrowse link 3 37,545,238 37,564,704 RGD:7777183
G Traf3ip2 Traf3 interacting protein 2 JBrowse link 20 44,679,861 44,722,874 RGD:13592920
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 JBrowse link 10 59,829,755 59,863,780 RGD:13592920
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:11554173
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:8157625
G Vnn1 vanin 1 JBrowse link 1 22,614,832 22,625,134 RGD:11554173
G Zfp365 zinc finger protein 365 JBrowse link 20 22,060,160 22,083,766 RGD:11554173
atopic dermatitis 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flg filaggrin JBrowse link 2 193,565,401 193,574,297 RGD:7240710
RGD:8554872
atopic dermatitis 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:7240710

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14759
    sensory system disease 4231
      skin disease 2240
        Eczematous Skin Diseases 250
          atopic dermatitis 90
            Atopic Dermatitis 1 0
            MOMES Syndrome 0
            Neural Deafness with Atypical Atopic Dermatitis 0
            atopic dermatitis 2 1
            atopic dermatitis 3 0
            atopic dermatitis 4 1
            atopic dermatitis 5 0
            atopic dermatitis 6 0
            atopic dermatitis 7 0
            atopic dermatitis 8 0
            atopic dermatitis 9 0
Path 2
Term Annotations click to browse term
  disease 14759
    disease of anatomical entity 13978
      Immune & Inflammatory Diseases 2999
        immune system disease 2432
          hypersensitivity reaction disease 1483
            allergic hypersensitivity disease 543
              Immediate Hypersensitivity 415
                atopic dermatitis 90
                  Atopic Dermatitis 1 0
                  MOMES Syndrome 0
                  Neural Deafness with Atypical Atopic Dermatitis 0
                  atopic dermatitis 2 1
                  atopic dermatitis 3 0
                  atopic dermatitis 4 1
                  atopic dermatitis 5 0
                  atopic dermatitis 6 0
                  atopic dermatitis 7 0
                  atopic dermatitis 8 0
                  atopic dermatitis 9 0
paths to the root