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ONTOLOGY REPORT - ANNOTATIONS


Term:osteosarcoma
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Accession:DOID:3347 term browser browse the term
Definition:A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Synonyms:exact_synonym: OSRC;   OSTEOBLASTIC OSTEOSARCOMA;   osteogenic sarcoma;   osteogenic sarcomas;   osteoid sarcoma;   osteosarcoma tumor;   osteosarcoma tumors;   osteosarcomas;   skeletal sarcoma
 narrow_synonym: osteosarcoma, somatic
 primary_id: MESH:D012516
 alt_id: OMIM:259500
 xref: GARD:7284;   NCI:C9145;   ORDO:668
For additional species annotation, visit the Alliance of Genome Resources.


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osteosarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap12 A-kinase anchoring protein 12 JBrowse link 1 40,816,130 40,906,582 RGD:5147850
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:8554872
G Bcor BCL6 co-repressor JBrowse link X 11,570,155 11,692,022 RGD:11554173
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 17 85,360,439 85,370,283 RGD:11554173
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1599505
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:11554173
G Ccnb3 cyclin B3 JBrowse link X 16,300,752 16,402,206 RGD:11554173
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:10047050
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:8554872
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:7240710
RGD:8554872
RGD:11554173
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:5147850
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:11554173
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:11554173
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:5131662
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:11554173
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:13207418
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:8554872
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:11554173
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:11554173
G Folr1 folate receptor alpha JBrowse link 1 166,934,457 166,945,864 RGD:11554173
G Grm4 glutamate metabotropic receptor 4 JBrowse link 20 6,745,682 6,791,521 RGD:11554173
G Gstm3 glutathione S-transferase mu 3 JBrowse link 2 210,685,204 210,688,273 RGD:5135042
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:11554173
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 JBrowse link X 21,696,796 21,699,241 RGD:13792789
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:2317666
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:11554173
G Kcnh1 potassium voltage-gated channel subfamily H member 1 JBrowse link 13 110,920,712 111,232,291 RGD:11554173
G Lox lysyl oxidase JBrowse link 18 47,500,320 47,577,819 RGD:11554173
G Lzic leucine zipper and CTNNBIP1 domain containing JBrowse link 5 166,430,305 166,443,485 RGD:2314410
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:11554173
G Mir106b microRNA 106b JBrowse link 12 19,307,752 19,307,833 RGD:11554173
G Mir130b microRNA 130b JBrowse link 11 88,129,773 88,129,854 RGD:11554173
G Mir328 microRNA 328 JBrowse link 19 37,263,199 37,263,282 RGD:11554173
G Mir93 microRNA 93 JBrowse link 12 19,307,543 19,307,629 RGD:11554173
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:11554173
G Mst1r macrophage stimulating 1 receptor JBrowse link 8 116,686,601 116,700,132 RGD:11554173
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6893634
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:11554173
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:11554173
G Phlda2 pleckstrin homology-like domain, family A, member 2 JBrowse link 1 216,701,345 216,704,479 RGD:11554173
G Prame preferentially expressed antigen in melanoma JBrowse link X 106,082,984 106,091,256 RGD:11535057
G Prdx2 peroxiredoxin 2 JBrowse link 19 26,084,816 26,090,095 RGD:11554173
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7242897
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:7240710
RGD:8554872
RGD:11554173
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:11554173
G Rgs1 regulator of G-protein signaling 1 JBrowse link 13 61,066,196 61,070,772 RGD:11554173
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:11554173
G Serpinf1 serpin family F member 1 JBrowse link 10 62,241,750 62,254,145 RGD:8633656
RGD:8655561
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:11554173
G Taf15 TATA-box binding protein associated factor 15 JBrowse link 10 70,689,863 70,721,892 RGD:11554173
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase JBrowse link 5 56,554,956 56,566,503 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:7240710
RGD:8554872
RGD:11554173
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:8554872
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11554173
G Wt1 WT1 transcription factor JBrowse link 3 95,133,221 95,180,574 RGD:11554173
G Zw10 zw10 kinetochore protein JBrowse link 8 53,365,881 53,390,742 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15851
    disease of cellular proliferation 5881
      cancer 4213
        cell type cancer 3081
          sarcoma 234
            bone sarcoma 79
              osteosarcoma 56
                Oslam syndrome 0
                Premature Aging, Okamoto Type 0
                Retinoblastoma-Related Osteosarcoma 0
                adult extraosseous osteosarcoma 0
                bone leiomyosarcoma 0
                bone osteosarcoma + 0
                breast osteosarcoma 0
                central nervous system osteosarcoma 0
                chondroblastic osteosarcoma 0
                extraosseous osteosarcoma + 0
                juxtacortical osteosarcoma + 0
                kidney osteogenic sarcoma 0
                liposarcoma of bone 0
                localized osteosarcoma 0
                malignant fibrous histiocytoma of bone 0
                metachronous osteosarcoma of the bone 0
                pediatric osteosarcoma 0
Path 2
Term Annotations click to browse term
  disease 15851
    disease of anatomical entity 15243
      musculoskeletal system disease 5504
        connective tissue disease 3985
          bone disease 3447
            Bone Neoplasms 1257
              bone cancer 1243
                bone sarcoma 79
                  osteosarcoma 56
                    Oslam syndrome 0
                    Premature Aging, Okamoto Type 0
                    Retinoblastoma-Related Osteosarcoma 0
                    adult extraosseous osteosarcoma 0
                    bone leiomyosarcoma 0
                    bone osteosarcoma + 0
                    breast osteosarcoma 0
                    central nervous system osteosarcoma 0
                    chondroblastic osteosarcoma 0
                    extraosseous osteosarcoma + 0
                    juxtacortical osteosarcoma + 0
                    kidney osteogenic sarcoma 0
                    liposarcoma of bone 0
                    localized osteosarcoma 0
                    malignant fibrous histiocytoma of bone 0
                    metachronous osteosarcoma of the bone 0
                    pediatric osteosarcoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.