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ONTOLOGY REPORT - ANNOTATIONS


Term:hypothalamic neoplasm
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Accession:DOID:3644 term browser browse the term
Definition:Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)
Synonyms:exact_synonym: Benign Hypothalamic Neoplasm;   Benign Hypothalamic Neoplasms;   Hypothalamic Cancer;   Hypothalamic Cancers;   Hypothalamic Chiasmatic Neoplasms;   Hypothalamic Pituitary Neoplasms;   Hypothalamic Teratoma;   Hypothalamic Teratomas;   Hypothalamic Tumor;   Hypothalamic Tumors;   Hypothalamic-Chiasmatic Neoplasm;   Hypothalamic-Pituitary Neoplasm;   Hypothalamo Neurohypophysial Region Neoplasms;   Hypothalamo-Neurohypophysial Region Neoplasm;   Hypothalamus Neoplasm;   Hypothalamus Neoplasms;   Hypothalamus Tumor;   Hypothalamus Tumors;   Malignant Hypothalamic Neoplasm;   Malignant Hypothalamic Neoplasms;   hypothalamic neoplasms;   neoplasm of the Hypothalamus;   tumor of hypothalamus
 primary_id: MESH:D007029
 alt_id: RDO:0005870
 xref: NCI:C3129
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ACTH-secreting pituitary adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 18 49,986,582 49,992,756 RGD:9068941
G AVPR1B arginine vasopressin receptor 1B JBrowse link 38 2,440,574 2,446,037 RGD:9068941
G BMP4 bone morphogenetic protein 4 JBrowse link 8 29,997,563 30,254,307 RGD:9068941
G GNAI2 G protein subunit alpha i2 JBrowse link 20 39,075,085 39,094,697 RGD:9068941
G GNAS GNAS complex locus JBrowse link 24 43,643,409 43,658,641 RGD:9068941
G USP8 ubiquitin specific peptidase 8 JBrowse link 30 16,341,970 16,408,246 RGD:7240710
RGD:9068941
Culler-Jones syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLI2 GLI family zinc finger 2 JBrowse link 19 29,128,401 29,383,324 RGD:7240710
RGD:9068941
Familial Isolated Pituitary Adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 18 49,986,582 49,992,756 RGD:9068941
growth hormone secreting pituitary adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 18 49,986,582 49,992,756 RGD:7240710
RGD:9068941
G CDH23 cadherin related 23 JBrowse link 4 22,206,972 22,570,875 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 12 5,746,898 5,755,103 RGD:9068941
G GNAS GNAS complex locus JBrowse link 24 43,643,409 43,658,641 RGD:9068941
G GPR101 G protein-coupled receptor 101 JBrowse link X 107,302,200 107,304,733 RGD:9068941
G HPGD 15-hydroxyprostaglandin dehydrogenase JBrowse link 25 24,964,908 24,993,276 RGD:9068941
G MEN1 menin 1 JBrowse link 18 52,346,747 52,352,884 RGD:9068941
G PRL prolactin JBrowse link 35 20,673,830 20,683,824 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 7 19,668,079 19,674,903 RGD:9068941
Pallister-Hall syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLI3 GLI family zinc finger 3 JBrowse link 18 7,800,817 8,071,531 RGD:7240710
RGD:9068941
pituitary adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AVPR1B arginine vasopressin receptor 1B JBrowse link 38 2,440,574 2,446,037 RGD:9068941
G C4H10orf105 chromosome 4 C10orf105 homolog JBrowse link 4 22,472,365 22,478,931 RGD:9068941
G CDH23 cadherin related 23 JBrowse link 4 22,206,972 22,570,875 RGD:9068941
G GRK2 G protein-coupled receptor kinase 2 JBrowse link 18 50,148,566 50,167,422 RGD:9068941
PITUITARY ADENOMA 3, MULTIPLE TYPES term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GNAS GNAS complex locus JBrowse link 24 43,643,409 43,658,641 RGD:7240710
RGD:9068941
PITUITARY ADENOMA 5, MULTIPLE TYPES term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C4H10orf105 chromosome 4 C10orf105 homolog JBrowse link 4 22,472,365 22,478,931 RGD:9068941
G CDH23 cadherin related 23 JBrowse link 4 22,206,972 22,570,875 RGD:7240710
RGD:9068941
PITUITARY ADENOMA, GROWTH HORMONE-SECRETING, 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPR101 G protein-coupled receptor 101 JBrowse link X 107,302,200 107,304,733 RGD:7240710
RGD:9068941
pituitary cancer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACVRL1 activin A receptor like type 1 JBrowse link 27 3,075,373 3,090,549 RGD:9068941
pituitary carcinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCA2 BRCA2 DNA repair associated JBrowse link 25 7,734,450 7,797,851 RGD:9068941
G PMS2 PMS1 homolog 2, mismatch repair system component JBrowse link 6 11,411,062 11,438,767 RGD:9068941
Pituitary Neoplasms term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGTR1 angiotensin II receptor type 1 JBrowse link 23 43,569,658 43,617,113 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 12 5,746,898 5,755,103 RGD:9068941
G CDKN1B cyclin dependent kinase inhibitor 1B JBrowse link 27 33,609,154 33,613,558 RGD:9068941
G CLU clusterin JBrowse link 25 29,982,811 29,999,565 RGD:9068941
G DRD2 dopamine receptor D2 JBrowse link 5 19,732,842 19,795,241 RGD:9068941
G ESR2 estrogen receptor 2 JBrowse link 8 38,645,917 38,715,347 RGD:9068941
G GHRH growth hormone releasing hormone JBrowse link 24 25,893,224 25,902,095 RGD:9068941
G GNAS GNAS complex locus JBrowse link 24 43,643,409 43,658,641 RGD:9068941
G HNRNPK heterogeneous nuclear ribonucleoprotein K JBrowse link 1 75,499,334 75,511,525 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 15 41,203,320 41,275,964 RGD:9068941
G IL6ST interleukin 6 signal transducer JBrowse link 2 43,214,050 43,273,014 RGD:9068941
G MEN1 menin 1 JBrowse link 18 52,346,747 52,352,884 RGD:9068941
G PRKCA protein kinase C alpha JBrowse link 9 13,638,106 13,879,571 RGD:9068941
G PRL prolactin JBrowse link 35 20,673,830 20,683,824 RGD:9068941
G PTTG1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 4 50,301,868 50,309,636 RGD:9068941
G RB1 RB transcriptional corepressor 1 JBrowse link 22 3,061,621 3,204,625 RGD:9068941
G SRSF1 serine and arginine rich splicing factor 1 JBrowse link 9 32,692,517 32,696,325 RGD:9068941
prolactinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 18 49,986,582 49,992,756 RGD:9068941
G BMP4 bone morphogenetic protein 4 JBrowse link 8 29,997,563 30,254,307 RGD:9068941
G CEBPD CCAAT enhancer binding protein delta JBrowse link 35 74,994 77,816 RGD:9068941
G HPGD 15-hydroxyprostaglandin dehydrogenase JBrowse link 25 24,964,908 24,993,276 RGD:9068941
G LRP2 LDL receptor related protein 2 JBrowse link 36 13,910,450 14,107,081 RGD:9068941
G MEN1 menin 1 JBrowse link 18 52,346,747 52,352,884 RGD:9068941
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 13 25,200,772 25,205,309 RGD:9068941
G NOG noggin JBrowse link 9 31,453,604 31,456,060 RGD:9068941
G NPY5R neuropeptide Y receptor Y5 JBrowse link 15 59,600,212 59,608,576 RGD:9068941
G PRL prolactin JBrowse link 35 20,673,830 20,683,824 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 7 19,668,079 19,674,903 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12029
    disease of anatomical entity 11678
      nervous system disease 9370
        central nervous system disease 7549
          brain disease 7050
            hypothalamic disease 155
              hypothalamic neoplasm 38
                Pallister-Hall syndrome + 2
                Pituitary Neoplasms + 36
Path 2
Term Annotations click to browse term
  disease 12029
    disease of anatomical entity 11678
      nervous system disease 9370
        central nervous system disease 7549
          brain disease 7050
            Brain Neoplasms 919
              Supratentorial Neoplasms 809
                supratentorial cancer 809
                  diencephalic neoplasm 38
                    thalamic neoplasm 38
                      hypothalamic neoplasm 38
                        Pallister-Hall syndrome + 2
                        Pituitary Neoplasms + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.