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ONTOLOGY REPORT - ANNOTATIONS


Term:hypothalamic neoplasm
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Accession:DOID:3644 term browser browse the term
Definition:Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)
Synonyms:exact_synonym: Benign Hypothalamic Neoplasm;   Benign Hypothalamic Neoplasms;   Hypothalamic Cancer;   Hypothalamic Cancers;   Hypothalamic Chiasmatic Neoplasms;   Hypothalamic Pituitary Neoplasms;   Hypothalamic Teratoma;   Hypothalamic Teratomas;   Hypothalamic Tumor;   Hypothalamic Tumors;   Hypothalamic-Chiasmatic Neoplasm;   Hypothalamic-Pituitary Neoplasm;   Hypothalamo Neurohypophysial Region Neoplasms;   Hypothalamo-Neurohypophysial Region Neoplasm;   Hypothalamus Neoplasm;   Hypothalamus Neoplasms;   Hypothalamus Tumor;   Hypothalamus Tumors;   Malignant Hypothalamic Neoplasm;   Malignant Hypothalamic Neoplasms;   hypothalamic neoplasms;   neoplasm of the Hypothalamus;   tumor of hypothalamus
 primary_id: MESH:D007029
 alt_id: RDO:0005870
 xref: NCI:C3129
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ACTH-secreting pituitary adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 11 67,468,179 67,491,108 RGD:11554173
RGD:8554872
G AVPR1B arginine vasopressin receptor 1B JBrowse link 1 206,106,936 206,117,388 RGD:14700670
G BMP4 bone morphogenetic protein 4 JBrowse link 14 53,949,736 53,956,891 RGD:11554173
G GNAI2 G protein subunit alpha i2 JBrowse link 3 50,227,068 50,259,362 RGD:8554872
G GNAS GNAS complex locus JBrowse link 20 58,839,681 58,911,196 RGD:8554872
G USP8 ubiquitin specific peptidase 8 JBrowse link 15 50,424,359 50,514,421 RGD:11554173
RGD:7240710
Culler-Jones syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLI2 GLI family zinc finger 2 JBrowse link 2 120,735,865 120,992,653 RGD:8554872
RGD:7240710
Familial Isolated Pituitary Adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 11 67,468,179 67,491,108 RGD:8554872
growth hormone secreting pituitary adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 11 67,468,179 67,491,108 RGD:8554872
RGD:7240710
G CDH23 cadherin related 23 JBrowse link 10 71,396,920 71,815,947 RGD:8554872
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,250 36,687,339 RGD:8662821
G GH1 growth hormone 1 JBrowse link 17 63,917,203 63,918,839 RGD:11554173
G GNAS GNAS complex locus JBrowse link 20 58,839,681 58,911,196 RGD:8554872
RGD:11554173
G GPR101 G protein-coupled receptor 101 JBrowse link X 137,030,148 137,031,674 RGD:11554173
G HPGD 15-hydroxyprostaglandin dehydrogenase JBrowse link 4 174,490,175 174,522,898 RGD:11667097
G MEN1 menin 1 JBrowse link 11 64,803,514 64,811,294 RGD:13592920
RGD:8554872
G PRL prolactin JBrowse link 6 22,287,246 22,302,897 RGD:11554173
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:11667097
Pallister-Hall syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLI3 GLI family zinc finger 3 JBrowse link 7 41,960,949 42,237,209 RGD:1599838
RGD:12738143
RGD:12738205
RGD:12738222
RGD:8554872
RGD:7240710
RGD:11554173
pituitary adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AVPR1B arginine vasopressin receptor 1B JBrowse link 1 206,106,936 206,117,388 RGD:14700668
G C10orf105 chromosome 10 open reading frame 105 JBrowse link 10 71,711,701 71,737,850 RGD:8554872
G CDH23 cadherin related 23 JBrowse link 10 71,396,920 71,815,947 RGD:8554872
G GRK2 G protein-coupled receptor kinase 2 JBrowse link 11 67,266,420 67,286,556 RGD:13792706
PITUITARY ADENOMA 3, MULTIPLE TYPES term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GNAS GNAS complex locus JBrowse link 20 58,839,681 58,911,196 RGD:8554872
RGD:7240710
PITUITARY ADENOMA 5, MULTIPLE TYPES term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C10orf105 chromosome 10 open reading frame 105 JBrowse link 10 71,711,701 71,737,850 RGD:8554872
G CDH23 cadherin related 23 JBrowse link 10 71,396,920 71,815,947 RGD:8554872
RGD:7240710
PITUITARY ADENOMA, GROWTH HORMONE-SECRETING, 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPR101 G protein-coupled receptor 101 JBrowse link X 137,030,148 137,031,674 RGD:7240710
RGD:8554872
pituitary cancer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACVRL1 activin A receptor like type 1 JBrowse link 12 51,906,913 51,923,361 RGD:8554872
pituitary carcinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCA2 BRCA2 DNA repair associated JBrowse link 13 32,315,480 32,399,672 RGD:8554872
G PMS2 PMS1 homolog 2, mismatch repair system component JBrowse link 7 5,970,925 6,009,106 RGD:8554872
Pituitary Neoplasms term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGTR1 angiotensin II receptor type 1 JBrowse link 3 148,697,871 148,743,003 RGD:11554173
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,250 36,687,339 RGD:8662821
G CDKN1B cyclin dependent kinase inhibitor 1B JBrowse link 12 12,717,270 12,722,383 RGD:11554173
G CLU clusterin JBrowse link 8 27,596,917 27,615,031 RGD:8699506
G DRD2 dopamine receptor D2 JBrowse link 11 113,409,595 113,475,398 RGD:11554173
G ESR2 estrogen receptor 2 JBrowse link 14 64,226,707 64,338,631 RGD:8694115
G GH1 growth hormone 1 JBrowse link 17 63,917,203 63,918,839 RGD:11554173
G GHRH growth hormone releasing hormone JBrowse link 20 37,251,086 37,261,817 RGD:5687177
G GNAS GNAS complex locus JBrowse link 20 58,839,681 58,911,196 RGD:1601376
G HNRNPK heterogeneous nuclear ribonucleoprotein K JBrowse link 9 83,968,083 83,980,782 RGD:10058970
G IGF1 insulin like growth factor 1 JBrowse link 12 102,395,860 102,481,839 RGD:11554173
G IL6ST interleukin 6 signal transducer JBrowse link 5 55,935,095 55,994,963 RGD:1627046
G MEN1 menin 1 JBrowse link 11 64,803,514 64,811,294 RGD:2317360
G PRKCA protein kinase C alpha JBrowse link 17 66,302,613 66,810,743 RGD:1601471
G PRL prolactin JBrowse link 6 22,287,246 22,302,897 RGD:11554173
G PTTG1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 5 160,421,855 160,428,744 RGD:68295
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,747 48,481,890 RGD:8547989
G SRSF1 serine and arginine rich splicing factor 1 JBrowse link 17 58,000,919 58,007,346 RGD:11038736
prolactinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 11 67,468,179 67,491,108 RGD:8554872
G BMP4 bone morphogenetic protein 4 JBrowse link 14 53,949,736 53,956,891 RGD:629544
RGD:11554173
G CEBPD CCAAT enhancer binding protein delta JBrowse link 8 47,736,913 47,738,164 RGD:11554173
G HPGD 15-hydroxyprostaglandin dehydrogenase JBrowse link 4 174,490,175 174,522,898 RGD:11667097
G LRP2 LDL receptor related protein 2 JBrowse link 2 169,127,109 169,362,597 RGD:8554872
G MEN1 menin 1 JBrowse link 11 64,803,514 64,811,294 RGD:13592920
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:7240531
G NOG noggin JBrowse link 17 56,593,699 56,595,611 RGD:629544
G NPY5R neuropeptide Y receptor Y5 JBrowse link 4 163,336,968 163,352,277 RGD:1625506
G PRL prolactin JBrowse link 6 22,287,246 22,302,897 RGD:1642576
RGD:11554173
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:11667097

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16450
    disease of anatomical entity 15425
      nervous system disease 11699
        central nervous system disease 9574
          brain disease 8995
            hypothalamic disease 163
              hypothalamic neoplasm 39
                Pallister-Hall syndrome + 2
                Pituitary Neoplasms + 37
Path 2
Term Annotations click to browse term
  disease 16450
    disease of anatomical entity 15425
      nervous system disease 11699
        central nervous system disease 9574
          brain disease 8995
            Brain Neoplasms 1019
              Supratentorial Neoplasms 903
                supratentorial cancer 903
                  diencephalic neoplasm 39
                    thalamic neoplasm 39
                      hypothalamic neoplasm 39
                        Pallister-Hall syndrome + 2
                        Pituitary Neoplasms + 37
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.