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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:olfactory neuroblastoma
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Accession:DOID:369 term browser browse the term
Definition:A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Synonyms:exact_synonym: Aesthesioneuroblastoma;   Aesthesioneuroblastomas;   Asthesioneuroblastoma;   Esthesioneuroblastoma;   Esthesioneuroblastomas;   Esthesioneuroepithelioma;   Olfactory Esthesioneuroblastomas;   Olfactory Neuroblastomas;   Paranasal Sinus Nasal Cavity Esthesioneuroblastoma;   olfactory esthesioneuroblastoma;   paranasal sinus Olfactory neuroblastoma
 primary_id: MESH:D018304
 alt_id: RDO:0007173
 xref: GARD:2197;   NCI:C3789;   NCI:C6016
For additional species annotation, visit the Alliance of Genome Resources.


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olfactory neuroblastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha severity ISO protein:increased expression:neuroblastoma (human) RGD PMID:18431543 RGD:8694471 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12752
    disease of cellular proliferation 5480
      Neoplasms by Site 4880
        Nervous System Neoplasms 1621
          peripheral nervous system neoplasm 116
            autonomic nervous system neoplasm 79
              neuroblastoma 79
                olfactory neuroblastoma 1
                  nasal cavity olfactory neuroblastoma 0
Path 2
Term Annotations click to browse term
  disease 12752
    disease of anatomical entity 12282
      nervous system disease 10043
        Nervous System Neoplasms 1621
          Central Nervous System Neoplasms 1325
            central nervous system cancer 1276
              brain cancer 1260
                supratentorial cancer 1016
                  cerebrum cancer 988
                    astrocytoma 986
                      astroblastoma 240
                        Primitive Neuroectodermal Tumors 142
                          Primitive Peripheral Neuroectodermal Tumors 80
                            neuroblastoma 79
                              olfactory neuroblastoma 1
                                nasal cavity olfactory neuroblastoma 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.