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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pituitary adenoma
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Accession:DOID:3829 term browser browse the term
Definition:A pituitary gland benign neoplasm that derives_from glandular epithelial cells. (DO)
Synonyms:exact_synonym: adenoma of the pituitary gland;   pituitary adenomas
 related_synonym: pituitary adenoma, multiple types
 xref: NCI:C3329;   OMIM:PS102200;   ORDO:99408
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
pituitary adenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:28692683 RGD:14700668 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO mRNA:altered expression:pituitary gland (human) RGD PMID:24169548 RGD:13792706 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
ACTH-secreting pituitary adenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: PITUITARY ADENOMA 4, ACTH-SECRETING
CTD
ClinVar
PMID:17360484, PMID:18381572, PMID:19366855, PMID:20506337, PMID:20530095, PMID:21454441, PMID:21753072, PMID:22319033, PMID:22720333, PMID:23300914, PMID:23321498, PMID:23633209, PMID:24033266, PMID:25093619, PMID:25184284, PMID:25203624, PMID:25333069, PMID:25741868, PMID:27153395, PMID:28492532, PMID:29074612, PMID:30461320, PMID:32324286 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:23884782 RGD:14700670 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16195406 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO CTD Direct Evidence: marker/mechanism CTD
OMIM
PMID:25485838 NCBI chr 3:119,173,818...119,222,499
Ensembl chr 3:119,173,818...119,222,484
JBrowse link
Familial Isolated Pituitary Adenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: Familial Isolated Pituitary Adenomas
ClinVar Annotator: match by term: Pituitary adenoma, familial isolated
ClinVar PMID:26186299 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO ClinVar Annotator: match by term: Familial Isolated Pituitary Adenomas ClinVar PMID:25741868 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
growth hormone secreting pituitary adenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by OMIM:102200
ClinVar Annotator: match by term: Somatotroph adenoma
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:2200621, PMID:5320367, PMID:12213383, PMID:16728643, PMID:17242703, PMID:17244780, PMID:17299063, PMID:17341560, PMID:17360484, PMID:17371465, PMID:17609395, PMID:18381572, PMID:18484068, PMID:19366855, PMID:19474519, PMID:19556287, PMID:19955762, PMID:20354355, PMID:20457215, PMID:20506337, PMID:20507346, PMID:20530095, PMID:20570174, PMID:20595802, PMID:20685857, PMID:21208107, PMID:21340166, PMID:21348957, PMID:21454441, PMID:21512261, PMID:21753072, PMID:21984905, PMID:22287093, PMID:22319033, PMID:22720333, PMID:22915287, PMID:23038625, PMID:23038925, PMID:23300914, PMID:23321498, PMID:23371967, PMID:23633209, PMID:23743763, PMID:24033266, PMID:24050928, PMID:24423289, PMID:25019383, PMID:25093619, PMID:25184284, PMID:25203624, PMID:25333069, PMID:25350067, PMID:25614825, PMID:25741868, PMID:26186299, PMID:26792934, PMID:27033541, PMID:27153395, PMID:27253664, PMID:27267386, PMID:27650164, PMID:28220018, PMID:28255869, PMID:28427099, PMID:28492532, PMID:28634279, PMID:29074612, PMID:29308445, PMID:29729370, PMID:30262796, PMID:30461320, PMID:30941100, PMID:32324286 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO protein:increased expression:pituitary gland: RGD PMID:18981426 RGD:8662821 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Gh1 growth hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1611713, PMID:2042694 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:11254676 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpr101 G protein-coupled receptor 101 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr  X:140,296,220...140,303,743
Ensembl chr  X:140,299,770...140,303,686
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Men1 menin 1 ISS
ISO
OMIM:102200
ClinVar Annotator: match by term: Somatotroph adenoma
MouseDO
ClinVar
PMID:30630164 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2042694 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
growth hormone secreting pituitary adenoma 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr101 G protein-coupled receptor 101 ISO ClinVar Annotator: match by term: Pituitary adenoma, growth hormone-secreting, 2 OMIM
ClinVar
PMID:25470569, PMID:25806919, PMID:25806920, PMID:25806921, PMID:26792934, PMID:26815903, PMID:27245663, PMID:27498687, PMID:28492532, PMID:29389097 NCBI chr  X:140,296,220...140,303,743
Ensembl chr  X:140,299,770...140,303,686
JBrowse link
pituitary adenoma 1 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 1, MULTIPLE TYPES ClinVar
OMIM
PMID:16728643, PMID:17341560, PMID:17360484, PMID:18381572, PMID:19366855, PMID:20506337, PMID:20530095, PMID:21454441, PMID:21753072, PMID:22319033, PMID:22720333, PMID:23300914, PMID:23321498, PMID:23633209, PMID:24033266, PMID:25093619, PMID:25184284, PMID:25203624, PMID:25333069, PMID:25741868, PMID:27153395, PMID:28492532, PMID:29074612, PMID:30461320, PMID:32324286 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
pituitary adenoma 3 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnas GNAS complex locus ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 3, MULTIPLE TYPES ClinVar
OMIM
PMID:1594625, PMID:1944469, PMID:2549426, PMID:3720010, PMID:7737262, PMID:7739708, PMID:8766942, PMID:9626141, PMID:12727968, PMID:12970318, PMID:15126527, PMID:16507630, PMID:17493233, PMID:21835143, PMID:23536913, PMID:24855271, PMID:25157968, PMID:26619011 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
pituitary adenoma 5 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh23 cadherin-related 23 ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES ClinVar
OMIM
PMID:11138009, PMID:11857743, PMID:12075507, PMID:15353998, PMID:16679490, PMID:17407589, PMID:18273900, PMID:18429043, PMID:19683999, PMID:20513143, PMID:20613545, PMID:21436283, PMID:21569298, PMID:21940737, PMID:24033266, PMID:24498627, PMID:25404053, PMID:25468891, PMID:25472526, PMID:25741868, PMID:27068579, PMID:27743452, PMID:28413019, PMID:28492532 NCBI chr20:29,857,018...30,263,758
Ensembl chr20:29,857,637...29,990,111
JBrowse link
G LOC100361018 rCG22048-like ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES ClinVar PMID:24033266, PMID:25741868, PMID:28413019, PMID:28492532 NCBI chr20:29,947,427...29,954,869
Ensembl chr20:29,951,637...29,952,023
JBrowse link
prolactinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEP
ISO
protein:increased expression:pituitary gland
CTD Direct Evidence: marker/mechanism
CTD PMID:16809920, PMID:12552124 RGD:629544 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:21980073 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Lrp2 LDL receptor related protein 2 ISO ClinVar Annotator: match by term: Prolactin-secreting pituitary adenoma ClinVar PMID:25741868 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Men1 menin 1 ISS
ISO
OMIM:600634
ClinVar Annotator: match by term: Prolactin-secreting pituitary adenoma
MouseDO
ClinVar
PMID:25741868, PMID:30311386 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEP mRNA:increased expression:pituitary gland (rat) RGD PMID:22635680 RGD:7240531 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nog noggin ISO mRNA, protein:decreased expression:pituitary RGD PMID:12552124 RGD:629544 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Npy5r neuropeptide Y receptor Y5 IEP protein:increased expression:pars anterior RGD PMID:11026575 RGD:1625506 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Prl prolactin IEP
ISO
IAGP
mRNA:increased expression:pituitary gland
CTD Direct Evidence: marker/mechanism
DNA:mutation
CTD PMID:718334, PMID:1407345, PMID:3776530, PMID:9617019, PMID:17260475, PMID:17260475 RGD:1642576, RGD:1642576 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease of cellular proliferation 5918
      benign neoplasm 972
        cell type benign neoplasm 793
          adenoma 303
            pituitary adenoma 25
              acidophil adenoma 0
              basophil adenoma 0
              chromophobe adenoma 0
              functioning pituitary adenoma + 18
              functionless pituitary adenoma 0
              pituitary adenoma 1 1
              pituitary adenoma 3 1
              pituitary adenoma 5 2
              prolactinoma 10
Path 2
Term Annotations click to browse term
  disease 16023
    disease of cellular proliferation 5918
      Neoplasms by Site 5283
        Nervous System Neoplasms 1662
          Central Nervous System Neoplasms 1337
            central nervous system cancer 1288
              brain cancer 1272
                supratentorial cancer 1019
                  diencephalic neoplasm 60
                    thalamic neoplasm 60
                      hypothalamic neoplasm 60
                        Pituitary Neoplasms 58
                          pituitary gland benign neoplasm 25
                            pituitary adenoma 25
                              acidophil adenoma 0
                              basophil adenoma 0
                              chromophobe adenoma 0
                              functioning pituitary adenoma + 18
                              functionless pituitary adenoma 0
                              pituitary adenoma 1 1
                              pituitary adenoma 3 1
                              pituitary adenoma 5 2
                              prolactinoma 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.