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ONTOLOGY REPORT - ANNOTATIONS


Term:craniopharyngioma
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Accession:DOID:3840 term browser browse the term
Definition:A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)
Synonyms:exact_synonym: Adult Craniopharyngiomas;   Child Craniopharyngioma;   Child Craniopharyngiomas;   Craniopharyngiomas;   Rathke Cleft Neoplasm;   Rathke Pouch Tumor;   Rathke's Cleft Neoplasm;   Rathke's Pouch Tumor;   Rathkes Cleft Neoplasm;   Rathkes pouch tumor;   adult craniopharyngioma;   neoplasm of Rathke's pouch
 narrow_synonym: Adamantinous Craniopharyngioma;   Adamantinous Craniopharyngiomas;   Papillary Craniopharyngioma;   Papillary Craniopharyngiomas
 primary_id: MESH:D003397
 alt_id: RDO:0005290
 xref: GARD:10486;   NCI:C2964
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craniopharyngioma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:8554872
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:8554872
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:11554173
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:8554872
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:8554872
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:11554173
RGD:8554872
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:8554872
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:8554872
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:8554872
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:11080971
G Phox2b paired-like homeobox 2b JBrowse link 14 42,711,169 42,718,707 RGD:8554872
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:8554872
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:8554872
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:8554872
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:8554872
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:8554872
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    disease of cellular proliferation 5796
      Neoplasms by Histologic Type 3579
        Germ Cell and Embryonal Neoplasms 1691
          neuroectodermal tumor 1614
            craniopharyngioma 17
              adamantinous craniopharyngioma 0
              papillary craniopharyngioma 0
Path 2
Term Annotations click to browse term
  disease 15619
    disease of cellular proliferation 5796
      benign neoplasm 1222
        organ system benign neoplasm 917
          nervous system benign neoplasm 91
            central nervous system benign neoplasm 52
              craniopharyngioma 17
                adamantinous craniopharyngioma 0
                papillary craniopharyngioma 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.