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ONTOLOGY REPORT - ANNOTATIONS


Term:striatonigral degeneration
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Accession:DOID:4751 term browser browse the term
Definition:A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)
Synonyms:exact_synonym: Striatonigral Atrophy;   striatonigral atrophies;   striatonigral degenerations
 narrow_synonym: Striatal Necrosis, Bilateral, with Dystonia
 primary_id: MESH:D020955
 alt_id: RDO:0007452
 xref: NCI:C125695;   OMIM:PS271930
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striatonigral degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:13592920
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:13592920
Bilateral Striatal Necrosis with Dystonia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mt-nd6 mitochondrially encoded NADH dehydrogenase 6 JBrowse link MT 13,543 14,061 RGD:8554872
Striatonigral Degeneration, Childhood-Onset term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vac14 VAC14 component of PIKFYVE complex JBrowse link 19 40,927,007 41,029,206 RGD:8554872
RGD:7240710
Striatonigral Degeneration, Infantile term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4i1 interleukin 4 induced 1 JBrowse link 1 100,811,727 100,836,901 RGD:8554872
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:7240710
RGD:8554872
Striatonigral Degeneration, Infantile, Mitochondrial term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mt-atp6 mitochondrially encoded ATP synthase 6 JBrowse link MT 7,919 8,599 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    syndrome 5154
      multiple system atrophy 29
        striatonigral degeneration 6
          Bilateral Striatal Necrosis with Dystonia 1
          Striatonigral Degeneration, Childhood-Onset 1
          Striatonigral Degeneration, Infantile 2
          Striatonigral Degeneration, Infantile, Mitochondrial 1
Path 2
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        central nervous system disease 8092
          brain disease 7561
            movement disease 1000
              multiple system atrophy 29
                striatonigral degeneration 6
                  Bilateral Striatal Necrosis with Dystonia 1
                  Striatonigral Degeneration, Childhood-Onset 1
                  Striatonigral Degeneration, Infantile 2
                  Striatonigral Degeneration, Infantile, Mitochondrial 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.