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ONTOLOGY REPORT - ANNOTATIONS


Term:striatonigral degeneration
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Accession:DOID:4751 term browser browse the term
Definition:A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)
Synonyms:exact_synonym: Striatonigral Atrophy;   striatonigral atrophies;   striatonigral degenerations
 narrow_synonym: Striatal Necrosis, Bilateral, with Dystonia
 primary_id: MESH:D020955
 alt_id: RDO:0007452
 xref: NCI:C125695;   OMIM:PS271930
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striatonigral degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NUP62 nucleoporin 62 JBrowse link 19 49,906,825 49,929,504 RGD:13592920
G PDE8B phosphodiesterase 8B JBrowse link 5 77,180,252 77,429,807 RGD:13592920
Bilateral Striatal Necrosis with Dystonia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MT-ND6 mitochondrially encoded NADH dehydrogenase 6 JBrowse link MT 14,149 14,673 RGD:8554872
Striatonigral Degeneration, Childhood-Onset term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G VAC14 VAC14 component of PIKFYVE complex JBrowse link 16 70,687,439 70,801,158 RGD:8554872
RGD:7240710
G VAC14-AS1 VAC14 antisense RNA 1 JBrowse link 16 70,755,095 70,773,251 RGD:8554872
Striatonigral Degeneration, Infantile term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4I1 interleukin 4 induced 1 JBrowse link 19 49,889,654 49,929,504 RGD:8554872
G NUP62 nucleoporin 62 JBrowse link 19 49,906,825 49,929,504 RGD:8554872
RGD:7240710
Striatonigral Degeneration, Infantile, Mitochondrial term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MT-ATP6 mitochondrially encoded ATP synthase 6 JBrowse link MT 8,527 9,207 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16438
    syndrome 5509
      multiple system atrophy 31
        striatonigral degeneration 7
          Bilateral Striatal Necrosis with Dystonia 1
          Striatonigral Degeneration, Childhood-Onset 2
          Striatonigral Degeneration, Infantile 2
          Striatonigral Degeneration, Infantile, Mitochondrial 1
Path 2
Term Annotations click to browse term
  disease 16438
    disease of anatomical entity 15414
      nervous system disease 11682
        central nervous system disease 9559
          brain disease 8980
            movement disease 1108
              multiple system atrophy 31
                striatonigral degeneration 7
                  Bilateral Striatal Necrosis with Dystonia 1
                  Striatonigral Degeneration, Childhood-Onset 2
                  Striatonigral Degeneration, Infantile 2
                  Striatonigral Degeneration, Infantile, Mitochondrial 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.