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Term:multiple system atrophy
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Accession:DOID:4752 term browser browse the term
Definition:A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Synonyms:exact_synonym: Multisystem Atrophies;   Multisystem Atrophy;   multiple system atrophies;   multiple system atrophy syndrome;   multisystemic atrophies;   multisystemic atrophy
 primary_id: MESH:D019578
 alt_id: RDO:0003219
 xref: GARD:7079
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multiple system atrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ambra1 autophagy and beclin 1 regulator 1 JBrowse link 3 80,634,470 80,830,068 RGD:14390070
G Coq2 coenzyme Q2, polyprenyltransferase JBrowse link 14 10,581,102 10,601,093 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:8663486
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:5688775
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:5509960
G Klk6 kallikrein related-peptidase 6 JBrowse link 1 99,762,195 99,769,486 RGD:1358597
G Mir96 microRNA 96 JBrowse link 4 57,463,366 57,463,471 RGD:11553929
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:6480516
G Slc1a1 solute carrier family 1 member 1 JBrowse link 1 246,955,017 247,035,159 RGD:11553929
G Slc6a6 solute carrier family 6 member 6 JBrowse link 4 123,638,619 123,713,469 RGD:11553929
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480091
Bilateral Striatal Necrosis with Dystonia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mt-nd6 mitochondrially encoded NADH dehydrogenase 6 JBrowse link MT 13,543 14,061 RGD:8554872
olivopontocerebellar atrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aptx aprataxin JBrowse link 5 56,987,714 57,009,481 RGD:10054301
G Tsen54 tRNA splicing endonuclease subunit 54 JBrowse link 10 104,358,401 104,366,926 RGD:8554872
Shy-Drager Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:11554173
G Coq2 coenzyme Q2, polyprenyltransferase JBrowse link 14 10,581,102 10,601,093 RGD:8554872
spinocerebellar ataxia type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atxn2 ataxin 2 JBrowse link 12 40,264,601 40,335,637 RGD:7240710
RGD:8554872
Spinocerebellar Ataxia, X-Linked 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb7 ATP binding cassette subfamily B member 7 JBrowse link X 75,150,511 75,291,950 RGD:8554872
G Amer1 APC membrane recruitment protein 1 JBrowse link X 64,686,620 64,702,504 RGD:8554872
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 JBrowse link X 157,236,400 157,312,028 RGD:7240710
RGD:8554872
G Atp7a ATPase copper transporting alpha JBrowse link X 77,076,085 77,193,644 RGD:8554872
G Nhsl2 NHS-like 2 JBrowse link X 71,895,202 71,980,019 RGD:8554872
G Phka1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:8554872
G Rtl9 retrotransposon Gag like 9 JBrowse link X 114,367,028 114,379,646 RGD:8554872
striatonigral degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:13592920
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:13592920
Striatonigral Degeneration Infantile term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4i1 interleukin 4 induced 1 JBrowse link 1 100,811,727 100,836,901 RGD:8554872
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:7240710
RGD:8554872
STRIATONIGRAL DEGENERATION, CHILDHOOD-ONSET term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vac14 Vac14, PIKFYVE complex component JBrowse link 19 40,927,007 41,029,206 RGD:8554872
RGD:7240710
RGD:11554173
Striatonigral Degeneration, Infantile, Mitochondrial term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mt-atp6 mitochondrially encoded ATP synthase 6 JBrowse link MT 7,919 8,599 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14759
    syndrome 4210
      multiple system atrophy 28
        Multiple System Atrophy (MSA) with Orthostatic Hypotension 0
        Shy-Drager Syndrome 2
        olivopontocerebellar atrophy + 10
        striatonigral degeneration + 6
Path 2
Term Annotations click to browse term
  disease 14759
    disease of anatomical entity 13978
      nervous system disease 9097
        central nervous system disease 6892
          brain disease 6396
            movement disease 989
              multiple system atrophy 28
                Multiple System Atrophy (MSA) with Orthostatic Hypotension 0
                Shy-Drager Syndrome 2
                olivopontocerebellar atrophy + 10
                striatonigral degeneration + 6
paths to the root