Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:multiple system atrophy
go back to main search page
Accession:DOID:4752 term browser browse the term
Definition:A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Synonyms:exact_synonym: Multisystem Atrophies;   Multisystem Atrophy;   multiple system atrophies;   multiple system atrophy syndrome;   multisystemic atrophies;   multisystemic atrophy
 primary_id: MESH:D019578
 alt_id: RDO:0003219
 xref: GARD:7079;   NCI:C84909;   NCI:C85066
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants       view all columns           Sort by:
 
multiple system atrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMBRA1 autophagy and beclin 1 regulator 1 JBrowse link 11 46,905,454 47,103,205 RGD:9068941
G COQ2 coenzyme Q2, polyprenyltransferase JBrowse link 4 46,762,458 46,784,014 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 10 89,199,070 89,244,884 RGD:9068941
G GDNF glial cell derived neurotrophic factor JBrowse link 5 77,573,466 77,600,478 RGD:9068941
G IGF2 insulin like growth factor 2 JBrowse link 11 2,202,764 2,228,890 RGD:9068941
G KLK6 kallikrein related peptidase 6 JBrowse link 19 56,815,073 56,826,689 RGD:9068941
G MT3 metallothionein 3 JBrowse link 16 56,007,922 56,009,828 RGD:9068941
G SLC1A1 solute carrier family 1 member 1 JBrowse link 9 4,511,491 4,608,337 RGD:9068941
G SLC6A6 solute carrier family 6 member 6 JBrowse link 3 14,663,949 14,752,326 RGD:9068941
G SNCA synuclein alpha JBrowse link 4 92,737,608 92,851,720 RGD:9068941
olivopontocerebellar atrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APTX aprataxin JBrowse link 9 33,556,419 33,608,416 RGD:9068941
G TSEN54 tRNA splicing endonuclease subunit 54 JBrowse link 17 75,017,357 75,025,166 RGD:9068941
Shy-Drager Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G COQ2 coenzyme Q2, polyprenyltransferase JBrowse link 4 46,762,458 46,784,014 RGD:9068941
G MAPT microtubule associated protein tau JBrowse link 17 11,458,159 11,590,626 RGD:9068941
spinocerebellar ataxia type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATXN2 ataxin 2 JBrowse link 12 112,419,337 112,565,096 RGD:9068941
RGD:7240710
Spinocerebellar Ataxia, X-Linked 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB7 ATP binding cassette subfamily B member 7 JBrowse link X 74,418,754 74,521,726 RGD:9068941
G AMER1 APC membrane recruitment protein 1 JBrowse link X 63,396,335 63,412,289 RGD:9068941
G ATP2B3 ATPase plasma membrane Ca2+ transporting 3 JBrowse link X 152,955,106 153,019,445 RGD:7240710
RGD:9068941
G ATP7A ATPase copper transporting alpha JBrowse link X 77,205,579 77,342,762 RGD:9068941
G NHSL2 NHS like 2 JBrowse link X 71,453,605 71,475,375 RGD:9068941
G PGAM4 phosphoglycerate mutase family member 4 JBrowse link X 77,260,981 77,262,333 RGD:9068941
G PHKA1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 71,900,762 72,033,055 RGD:9068941
G RTL9 retrotransposon Gag like 9 JBrowse link X 109,996,979 110,034,123 RGD:9068941
striatonigral degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NUP62 nucleoporin 62 JBrowse link 19 55,835,593 55,858,165 RGD:9068941
G PDE8B phosphodiesterase 8B JBrowse link 5 38,401,194 38,617,737 RGD:9068941
Striatonigral Degeneration, Childhood-Onset term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G VAC14 VAC14 component of PIKFYVE complex JBrowse link 16 70,520,440 70,634,152 RGD:9068941
RGD:7240710
Striatonigral Degeneration, Infantile term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4I1 interleukin 4 induced 1 JBrowse link 19 55,819,075 55,858,389 RGD:9068941
G NUP62 nucleoporin 62 JBrowse link 19 55,835,593 55,858,165 RGD:7240710
RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11857
    syndrome 4623
      multiple system atrophy 26
        Multiple System Atrophy (MSA) with Orthostatic Hypotension 0
        Shy-Drager Syndrome 2
        olivopontocerebellar atrophy + 11
        striatonigral degeneration + 4
Path 2
Term Annotations click to browse term
  disease 11857
    disease of anatomical entity 11510
      nervous system disease 9239
        central nervous system disease 7452
          brain disease 6955
            movement disease 896
              multiple system atrophy 26
                Multiple System Atrophy (MSA) with Orthostatic Hypotension 0
                Shy-Drager Syndrome 2
                olivopontocerebellar atrophy + 11
                striatonigral degeneration + 4
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.