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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:anti-basement membrane glomerulonephritis
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Accession:DOID:4780 term browser browse the term
Definition:A Goodpasture syndrome that is characterized by damage to only kidney capillaries. (DO)
Synonyms:exact_synonym: Anti GBM Disease;   Anti-GBM Nephritis;   Anti-Glomerular Basement Membrane Disease;   Anti-Glomerular Basement Membrane Glomerulonephritis;   anti-GBM glomerulonephritis
 primary_id: MESH:D019867
 alt_id: RDO:0007296
 xref: NCI:C35798
For additional species annotation, visit the Alliance of Genome Resources.


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anti-basement membrane glomerulonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IEP protein:increased expression:kidney, urine
mRNA, protein:increased expression:liver, plasma
RGD PMID:21282555, PMID:7550093 RGD:5129185, RGD:11039051 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP protein:increased expression:kidney RGD PMID:21282555 RGD:5129185 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP mRNA, protein:increased expression:kidney RGD PMID:12234300 RGD:1579984 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA, protein:decreased expression:kidney RGD PMID:12234300 RGD:1579984 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 IEP mRNA:increased expression:glomerulus RGD PMID:20071465 RGD:4145614 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IEP
IDA
mRNA:increased expression:glomerulus RGD PMID:17898087, PMID:20071465, PMID:21894146 RGD:2307059, RGD:4145614, RGD:6218988 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 IMP mRNA, protein:increased expression:glomerulus RGD PMID:12651599 RGD:2306306 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 IEP mRNA:increased expression:glomerulus RGD PMID:17898087 RGD:2307059 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP mRNA:increased expression:glomerulus RGD PMID:17898087 RGD:2307059 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd274 CD274 molecule treatment ISO RGD PMID:21965585 RGD:7248671 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:15210767 RGD:7248442 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand IMP RGD PMID:15458437 RGD:5508170 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd80 Cd80 molecule IMP RGD PMID:10712436 RGD:6902936 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cfb complement factor B ISO RGD PMID:22492944 RGD:7242700 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Clu clusterin IEP protein:increased expression:urine RGD PMID:23791361 RGD:9068422 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Csf1 colony stimulating factor 1 treatment IDA RGD PMID:19242505 RGD:7257569 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf1r colony stimulating factor 1 receptor treatment IDA RGD PMID:19242505 RGD:7257569 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment ISO RGD PMID:10712436, PMID:8206086, PMID:10712436 RGD:6902936, RGD:11352257, RGD:6902936 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP mRNA, protein:increased expression:glomerulus RGD PMID:19590241 RGD:4891946 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP mRNA, protein:increased expression:glomerulus RGD PMID:19590241 RGD:4891946 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IEP mRNA:increased expression:glomerulus RGD PMID:17557270 RGD:2306579 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dusp1 dual specificity phosphatase 1 IEP mRNA:increased expression:glomerulus RGD PMID:8587253 RGD:633769 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa no_association ISO DNA:cnv: :
DNA:polymorphism:exon:(rs396991)(human)
RGD PMID:19946017, PMID:19640933 RGD:5508400, RGD:5508403 NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051
JBrowse link
G Gp6 glycoprotein VI ISO RGD PMID:20651232 RGD:7242710 NCBI chr 1:72,994,977...73,064,639
Ensembl chr 1:73,040,901...73,064,641
JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:23826305 RGD:7365004 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A treatment IDA RGD PMID:23826305 RGD:7365004 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 ISO RGD PMID:22046355 RGD:6893447 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta ISO
IEP
mRNA:increased expression:kidney (mouse)
mRNA, protein:increased expression:kidney
RGD PMID:22046355, PMID:9198037 RGD:6893447, RGD:7401232 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist IDA RGD PMID:20071465 RGD:4145614 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il4 interleukin 4 IMP
IDA
RGD PMID:9350645, PMID:17898087 RGD:2317673, RGD:2307059 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itga4 integrin subunit alpha 4 treatment IDA
IMP
RGD PMID:9032136, PMID:7679412 RGD:2308810, RGD:9698425 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Mapk14 mitogen activated protein kinase 14 IEP RGD PMID:21894146 RGD:6218988 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP RGD PMID:21894146 RGD:6218988 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mif macrophage migration inhibitory factor IDA RGD PMID:10780884 RGD:1642011 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp12 matrix metallopeptidase 12 IEP RGD PMID:21894146 RGD:6218988 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp14 matrix metallopeptidase 14 IEP mRNA:increased expression:kidney, macrophage RGD PMID:10878552 RGD:2314954 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Nos2 nitric oxide synthase 2 IEP RGD PMID:21894146 RGD:6218988 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppb natriuretic peptide B ISO RGD PMID:11729234 RGD:7248605 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pdcd1 programmed cell death 1 treatment IEP RGD PMID:21965585 RGD:7248671 NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO RGD PMID:17888025 RGD:5563035 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IEP protein:increased expression:glomerulus RGD PMID:11774117 RGD:729912 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 IEP protein:increased expression:renal glomerulus RGD PMID:18784646 RGD:11534983 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphism (human) RGD PMID:21569485 RGD:5147561 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Selp selectin P IDA RGD PMID:21894146 RGD:6218988 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Slc34a1 solute carrier family 34 member 1 ISO protein:decreased expression:kidney, brush border membrane (mouse) RGD PMID:19193726 RGD:7242947 NCBI chr17:9,747,766...9,762,739
Ensembl chr17:9,747,752...9,762,813
JBrowse link
G Slit2 slit guidance ligand 2 IEP mRNA:decreased expression:kidney, glomerulus RGD PMID:15215188 RGD:2316132 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:20504883 RGD:6903276 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Syk spleen associated tyrosine kinase IMP RGD PMID:21894146 RGD:6218988 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tnf tumor necrosis factor IEP RGD PMID:21894146 RGD:6218988 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:urine, serum: RGD PMID:23460853 RGD:7241232 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 IEP mRNA:increased expression:glomerulus RGD PMID:9717977 RGD:8693304 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    syndrome 6992
      Goodpasture syndrome 55
        anti-basement membrane glomerulonephritis 55
Path 2
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      Immune & Inflammatory Diseases 3511
        immune system disease 2931
          primary immunodeficiency disease 2348
            autoimmune disease 1670
              autoimmune disease of urogenital tract 55
                Goodpasture syndrome 55
                  anti-basement membrane glomerulonephritis 55
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.