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ONTOLOGY REPORT - ANNOTATIONS


Term:myelofibrosis
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Accession:DOID:4971 term browser browse the term
Definition:A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Synonyms:exact_synonym: Agnogenic Myeloid Metaplasia;   Agnogenic Myeloid Metaplasias;   Aleukemic myelosis;   Bone Marrow Fibroses;   Bone Marrow Fibrosis;   CIMF;   Chronic Idiopathic Myelofibrosis;   Idiopathic Myelofibrosis;   MYELOFIBROSIS, SOMATIC;   Megakaryocytic myelosclerosis;   Myelofibroses;   Myeloid Metaplasia;   Myeloid Metaplasias;   Myeloscleroses;   Myelosclerosis;   Nonleukemic Myeloses;   Nonleukemic Myelosis;   Primary Myelofibroses;   primary myelofibrosis
 narrow_synonym: MMM;   MYELOFIBROSIS WITH MYELOID METAPLASIA
 primary_id: MESH:D055728;   RDO:0002558
 alt_id: OMIM:254450
 xref: GARD:8618;   NCI:C2862;   NCI:C3248
For additional species annotation, visit the Alliance of Genome Resources.


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myelofibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asxl1 ASXL transcriptional regulator 1 JBrowse link 3 148,832,231 148,902,356 RGD:11038705
RGD:11038768
G Atg2b autophagy related 2B JBrowse link 6 129,449,451 129,519,599 RGD:8554872
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:8554872
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:8554872
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:7240710
RGD:11352753
RGD:11352747
RGD:8554872
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:11252175
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:11252191
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:10450870
RGD:11554173
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:11049484
G Flt3lg fms-related tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:11049484
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:10450748
RGD:13592920
G Gskip GSK3B interacting protein JBrowse link 6 129,512,950 129,536,320 RGD:8554872
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:10755491
G Insl6 insulin-like 6 JBrowse link 1 247,473,292 247,476,827 RGD:8554872
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1627655
RGD:8554872
RGD:11554173
RGD:10449377
RGD:7240710
G LOC100909954 uncharacterized LOC100909954 JBrowse link 6 129,259,581 129,322,113 RGD:8554872
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:7240710
RGD:8554872
RGD:10449004
G Myb MYB proto-oncogene, transcription factor JBrowse link 1 16,658,178 16,690,135 RGD:13592920
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:13592920
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:7240710
RGD:8554872
G Tcl1a T-cell leukemia/lymphoma 1A JBrowse link 6 128,888,768 128,894,761 RGD:8554872
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11073609
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:11073713
Familial Myelofibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:10450737
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:8554872
G Vps45 vacuolar protein sorting 45 homolog JBrowse link 2 198,123,747 198,184,739 RGD:11554173
Thrombocytopenia, Anemia, and Myelofibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpig6b megakaryocyte and platelet inhibitory receptor G6b JBrowse link 20 5,054,419 5,056,655 RGD:8554872
RGD:7240710

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      hematopoietic system disease 1426
        bone marrow disease 401
          myeloid neoplasm 228
            myelofibrosis 25
              Familial Myelofibrosis + 4
              Panostotic Fibrous Dysplasia 0
              cellular phase chronic idiopathic myelofibrosis 0
Path 2
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      Hemic and Lymphatic Diseases 1704
        hematopoietic system disease 1426
          Hematologic Neoplasms 788
            hematologic cancer 787
              bone marrow cancer 289
                myeloid neoplasm 228
                  myelofibrosis 25
                    Familial Myelofibrosis + 4
                    Panostotic Fibrous Dysplasia 0
                    cellular phase chronic idiopathic myelofibrosis 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.