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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:ovarian hyperstimulation syndrome
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Accession:DOID:5425 term browser browse the term
Definition:A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
Synonyms:exact_synonym: OHSS;   Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous;   Ovarian Hyperstimulation Syndromes;   Ovarian response to FSH stimulation;   secondary Meig's syndrome
 primary_id: MESH:D016471;   RDO:0006959
 alt_id: OMIM:608115
For additional species annotation, visit the Alliance of Genome Resources.

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ovarian hyperstimulation syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 treatment IDA RGD PMID:25217874 RGD:13506956 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G F3 coagulation factor III, tissue factor severity ISO protein:increased expression:plasma RGD PMID:12695751 RGD:11340210 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fshr follicle stimulating hormone receptor ISO DNA:point mutation:exon:D567N
ClinVar Annotator: match by term: Ovarian hyperstimulation syndrome
ClinVar Annotator: match by term: Ovarian response to FSH stimulation
ClinVar Annotator: match by OMIM:608115
PMID:8894317, PMID:9402264, PMID:9769327, PMID:10022448, PMID:11036902, PMID:11213123, PMID:12930927, PMID:12930928, PMID:15080154, PMID:15249125, PMID:15579795, PMID:15886248, PMID:16084888, PMID:16278261, PMID:16864747, PMID:17721928, PMID:17826728, PMID:18159088, PMID:19400992, PMID:21752882, PMID:22401810, PMID:23419799, PMID:25741868, PMID:28492532, PMID:12930928 RGD:1601236 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:serum, ascites (human) RGD PMID:9322101 RGD:11062135 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISS OMIM:608115 MouseDO NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human protein in a mouse model RGD PMID:23295464 RGD:8635395 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Tfpi tissue factor pathway inhibitor severity ISO protein:decreased expression:plasma RGD PMID:12695751 RGD:11340210 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16058
    syndrome 6996
      ovarian hyperstimulation syndrome 7
Path 2
Term Annotations click to browse term
  disease 16058
    disease of anatomical entity 15305
      Urogenital Diseases 4146
        Female Urogenital Diseases and Pregnancy Complications 1904
          Female Urogenital Diseases 1599
            female reproductive system disease 1595
              Adnexal Diseases 673
                ovarian disease 665
                  ovarian hyperstimulation syndrome 7
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.