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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:migraine
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Accession:DOID:6364 term browser browse the term
Definition:A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Synonyms:exact_synonym: MA;   MFTS;   MGAU;   abdominal migraine;   abdominal migraines;   acute confusional migraine;   acute confusional migraines;   cervical migraine syndrome;   cervical migraine syndromes;   hemicrania migraine;   hemicrania migraines;   migraine disorder;   migraine disorders;   migraine headache;   migraine headaches;   migraine variant;   migraine variants;   migraine with or without aura;   migraines;   sick headache;   sick headaches;   status migrainosus
 related_synonym: MGR1;   MGR11;   MGR12;   MGR2;   MGR3;   MGR5;   MGR8;   migraine with or without aura, susceptibility to, 1;   migraine with or without aura, susceptibility to, 11;   migraine with or without aura, susceptibility to, 12;   migraine with or without aura, susceptibility to, 2;   migraine with or without aura, susceptibility to, 3;   migraine with or without aura, susceptibility to, 5;   migraine with or without aura, susceptibility to, 8;   migraine, resistance to
 primary_id: MESH:D008881
 alt_id: OMIM:157300;   OMIM:300125;   OMIM:607498;   OMIM:607508;   OMIM:609570;   OMIM:610209;   OMIM:611706
 xref: ICD10CM:G43;   ICD9CM:346;   NCI:C89715;   OMIM:PS157300
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
migraine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrip ATR interacting protein ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:30311386 NCBI chrNW_004936529:245,134...264,456 JBrowse link
G Brca2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:15070707, PMID:16030099, PMID:16758124, PMID:17020472, PMID:18783588, PMID:20104584, PMID:20960228, PMID:21232165, PMID:21553119, PMID:21918853, PMID:22430266, PMID:22460208, PMID:22923021, PMID:23479189, PMID:24033266, PMID:25741868, PMID:26026974, PMID:26295337, PMID:26350514, PMID:26467025, PMID:28127413, PMID:28492532, PMID:28503720, PMID:29084914, PMID:29560538 NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO DNA:missense mutation:cds:p.E1015K(human)
ClinVar Annotator: match by term: Migraine
RGD
ClinVar
PMID:1564484, PMID:3358708, PMID:8898206, PMID:8988170, PMID:9005860, PMID:9302278, PMID:9403487, PMID:9436730, PMID:9559993, PMID:9879686, PMID:11179022, PMID:11564488, PMID:11723274, PMID:12707077, PMID:14718690, PMID:15300451, PMID:15483044, PMID:15710862, PMID:16043807, PMID:16325861, PMID:16595610, PMID:17142831, PMID:17495624, PMID:17575281, PMID:18498393, PMID:18541804, PMID:18940563, PMID:19484318, PMID:19811514, PMID:20097664, PMID:20129625, PMID:20156848, PMID:20204399, PMID:20233618, PMID:20682717, PMID:21183743, PMID:22249839, PMID:23441182, PMID:23771276, PMID:23831250, PMID:23934111, PMID:24108129, PMID:25735478, PMID:25741868, PMID:25758715, PMID:26814174, PMID:27476654, PMID:28007337, PMID:28492532, PMID:28742085, PMID:29056246, PMID:29100083, PMID:30283815, PMID:30311386 RGD:10054426 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
G Capn3 calpain 3 ISO ClinVar Annotator: match by term: Migraine headaches ClinVar PMID:7720071, PMID:9266733, PMID:10330340, PMID:10679950, PMID:14578192, PMID:14981715, PMID:15351423, PMID:15689361, PMID:15725583, PMID:16100770, PMID:16141003, PMID:16650086, PMID:17318636, PMID:20635405, PMID:21204801, PMID:21984748, PMID:25741868, PMID:26467025, PMID:27142102, PMID:28492532, PMID:30311386 NCBI chrNW_004936471:5,667,839...5,711,822 JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum RGD PMID:21331754 RGD:5490597 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Clcn1 chloride voltage-gated channel 1 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:8533761, PMID:8845168, PMID:10737121, PMID:12163078, PMID:25741868, PMID:25749817, PMID:26467025, PMID:28492532, PMID:29606556, PMID:30311386 NCBI chrNW_004936527:759,012...791,302 JBrowse link
G Dsp desmoplakin ISO ClinVar Annotator: match by term: Migraine Disorders ClinVar PMID:21606396, PMID:23292937, PMID:23861362, PMID:24033266, PMID:24503780, PMID:25741868, PMID:26230511, PMID:26656175, PMID:27153395, PMID:28492532, PMID:30311386 NCBI chrNW_004936534:5,029,008...5,076,467 JBrowse link
G Ednra endothelin receptor type A susceptibility ISO ClinVar Annotator: match by term: Migraine, resistance to
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:minus-231A>G
OMIM
ClinVar
CTD
RGD
PMID:11376172, PMID:23058564 RGD:734916 NCBI chrNW_004936535:1,950,117...2,005,786 JBrowse link
G Esr1 estrogen receptor 1 susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:15133719 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Fhl5 four and a half LIM domains 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23793025 NCBI chrNW_004936699:1,084,578...1,124,783 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12482207 NCBI chrNW_004936565:335,238...394,683 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO RGD PMID:20236348 RGD:6482182 NCBI chrNW_004936601:3,569,626...3,626,782 JBrowse link
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:30311386 NCBI chrNW_004936740:489,357...514,235 JBrowse link
G Lrp1 LDL receptor related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21666692 NCBI chrNW_004936646:1,326,900...1,407,236 JBrowse link
G Maoa monoamine oxidase A no_association ISO RGD PMID:15088153 RGD:1600725 NCBI chrNW_004936502:9,816,443...9,888,002 JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868 NCBI chrNW_004936588:2,338,127...2,377,090 JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:trigeminal ganglion (rat) RGD PMID:27984195 RGD:12910755 NCBI chrNW_004936566:3,737,315...3,775,894 JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:SNP:cds:677C>T(human) RGD PMID:21635773 RGD:7387244 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Nf2 neurofibromin 2 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868, PMID:28492532, PMID:30311386 NCBI chrNW_004936657:3,536,212...3,622,999 JBrowse link
G Nos3 nitric oxide synthase 3 ISO associated with Glaucoma;DNA:snp, haplotype:promoter:g.-786T>C (human) RGD PMID:16123422 RGD:7771539 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868, PMID:30311386 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
G Nppb natriuretic peptide B ISO protein:increased expression:serum RGD PMID:22165670 RGD:5685652 NCBI chrNW_004936474:683,325...684,662 JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:30311386 NCBI chrNW_004936569:799,963...865,462 JBrowse link
G Ppox protoporphyrinogen oxidase ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868 NCBI chrNW_004936903:470,317...474,705 JBrowse link
G Prdm16 PR/SET domain 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21666692 NCBI chrNW_004936737:400,819...446,768 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Migraine Disorders ClinVar PMID:11804990, PMID:19056759, PMID:22581653, PMID:24033266, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868, PMID:30311386 NCBI chrNW_004936474:24,205,878...24,236,611 JBrowse link
G Stim1 stromal interaction molecule 1 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868 NCBI chrNW_004936498:849,775...1,063,552 JBrowse link
G Sugct succinyl-CoA:glutarate-CoA transferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23793025 NCBI chrNW_004936478:15,424,010...16,102,401 JBrowse link
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868 NCBI chrNW_004936489:2,371,953...2,421,882 JBrowse link
G Tbc1d24 TBC1 domain family member 24 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:28492532, PMID:30311386 NCBI chrNW_004936694:1,556,717...1,582,019 JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16885183 NCBI chrNW_004936473:21,324,669...21,409,430 JBrowse link
G Tnf tumor necrosis factor susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Trex1 three prime repair exonuclease 1 ISO ClinVar Annotator: match by term: Migraine ClinVar PMID:30311386 NCBI chrNW_004936529:264,535...266,451 JBrowse link
G Trpm8 transient receptor potential cation channel subfamily M member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21666692 NCBI chrNW_004936525:3,413,730...3,491,815 JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO DNA:snp:intron:g.IVS2+2841C>T rs222741 (human) RGD PMID:22162417 RGD:7175557 NCBI chrNW_004936677:277,304...326,907 JBrowse link
Familial Basilar Migraine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 ISO ClinVar Annotator: match by term: Migraine, familial basilar ClinVar PMID:16344534 NCBI chrNW_004936740:489,357...514,235 JBrowse link
familial hemiplegic migraine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igsf8 immunoglobulin superfamily member 8 ISO ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:28492532 NCBI chrNW_004936740:528,826...535,776 JBrowse link
G Kcnj10 potassium inwardly rectifying channel subfamily J member 10 ISO ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:28492532 NCBI chrNW_004936740:555,948...589,219 JBrowse link
G Kcnj9 potassium inwardly rectifying channel subfamily J member 9 ISO ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:28492532 NCBI chrNW_004936740:536,397...545,137 JBrowse link
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 ISO ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:1361034, PMID:11439943, PMID:12023326, PMID:14667076, PMID:15159495, PMID:15174025, PMID:15286158, PMID:16088919, PMID:16344534, PMID:16538223, PMID:17473835, PMID:17877748, PMID:17952365, PMID:18056581, PMID:18414213, PMID:18513263, PMID:18728015, PMID:18957371, PMID:19458722, PMID:19874388, PMID:20837964, PMID:21352219, PMID:21533730, PMID:22117059, PMID:23918834, PMID:23954377, PMID:24396618, PMID:24921013, PMID:25138102, PMID:25741868, PMID:26467025, PMID:27226003, PMID:27864847, PMID:28492532, PMID:28811059, PMID:29062094, PMID:29655203, PMID:29778030, PMID:29956301, PMID:30311386 NCBI chrNW_004936740:489,357...514,235 JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 ISO ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:25741868, PMID:28492532 NCBI chrNW_004936469:13,194,769...13,345,979 JBrowse link
familial hemiplegic migraine 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO OMIM NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
familial hemiplegic migraine 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 ISO OMIM NCBI chrNW_004936740:489,357...514,235 JBrowse link
familial hemiplegic migraine 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1a sodium voltage-gated channel alpha subunit 1 ISO OMIM NCBI chrNW_004936469:13,194,769...13,345,979 JBrowse link
migraine with aura term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO DNA:mutation:cds:P.V1457L(human) RGD PMID:10408532 RGD:10054422 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
G Dbh dopamine beta-hydroxylase ISO DNA:insertion, deletion:5' utr:g.-4767+?--4688-? (human) RGD PMID:17095019 RGD:1625569 NCBI chrNW_004936669:3,302,014...3,326,233 JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:snp:cds:p.H313H (human) RGD PMID:9513185 RGD:1358603 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 susceptibility ISO ClinVar Annotator: match by term: MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:20871611, PMID:25741868, PMID:28492532 NCBI chrNW_004936486:7,041,623...7,075,224 JBrowse link
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 ISO RGD PMID:12953268 RGD:1358436 NCBI chrNW_004936740:489,357...514,235 JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:SNP:cds:677C>T(human) RGD PMID:21635773 RGD:7387244 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Migraine with aura ClinVar PMID:30311386, PMID:32581362 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
G Trpv3 transient receptor potential cation channel subfamily V member 3 ISO DNA:snp:intron:g.36670T>C rs7217270 (human) RGD PMID:22162417 RGD:7175557 NCBI chrNW_004936677:239,133...270,512 JBrowse link
migraine without aura term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chrNW_004936487:5,409,413...5,854,418 JBrowse link
G Eno2 enolase 2 ISO protein:increased expression:serum RGD PMID:21293918 RGD:5508769 NCBI chrNW_004936709:904,647...913,445 JBrowse link
G Ldlr low density lipoprotein receptor ISO DNA:repeat:exon (human) RGD PMID:12873747 RGD:5490245 NCBI chrNW_004936659:1,259,405...1,300,545 JBrowse link
G Lrp1 LDL receptor related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chrNW_004936646:1,326,900...1,407,236 JBrowse link
G Mef2d myocyte enhancer factor 2D ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chrNW_004936580:5,660,306...5,685,333 JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Migraine without aura ClinVar PMID:8878478, PMID:9388399, PMID:12754354, PMID:15229130, PMID:15287509, PMID:15857853, PMID:20071773, PMID:21940951, PMID:24425116, PMID:24886907, PMID:25412914, PMID:25741868, PMID:26467025, PMID:28334938, PMID:32581362 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
G Phactr1 phosphatase and actin regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chrNW_004936534:42,354...323,735 JBrowse link
G Tac1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11304026 NCBI chrNW_004936585:2,932,783...2,941,141 JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:14718719 RGD:1580316 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Trpm8 transient receptor potential cation channel subfamily M member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22683712 NCBI chrNW_004936525:3,413,730...3,491,815 JBrowse link
Sporadic Hemiplegic Migraine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO ClinVar Annotator: match by term: Migraine, sporadic hemiplegic ClinVar PMID:10408534, PMID:10734061, PMID:11176968, PMID:11439943, PMID:12056940, PMID:12707077, PMID:17142831, PMID:18056581, PMID:22527033, PMID:24486772, PMID:24498617, PMID:25969684, PMID:26467025 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
Stormorken syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stim1 stromal interaction molecule 1 ISO OMIM NCBI chrNW_004936498:849,775...1,063,552 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11942
    disease of anatomical entity 11503
      nervous system disease 9434
        central nervous system disease 7978
          brain disease 7383
            Headache Disorders 50
              Primary Headache Disorders 50
                migraine 50
                  Alice in Wonderland Syndrome 0
                  Familial Basilar Migraine 1
                  Ophthalmoplegic Migraine 0
                  Sensorineural Deafness and Migraine 0
                  Stormorken syndrome 1
                  migraine with aura + 12
                  migraine without aura + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.