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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:hypersplenism
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Accession:DOID:6376 term browser browse the term
Definition:Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
Synonyms:exact_synonym: Splenic Anemia;   Splenic Anemias;   hypersplenia
 primary_id: MESH:D006971
 alt_id: RDO:0005852
 xref: ICD10CM:D73.1;   ICD9CM:289.4;   NCI:C34714
For additional species annotation, visit the Alliance of Genome Resources.


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hypersplenism term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15877736 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      immune system disease 2927
        lymphatic system disease 1097
          splenic disease 131
            hypersplenism 1
              Splenomegaly Syndrome with Splenic Germinal Center Hypoplasia and Reduced Circulating T-Helper Cells 0
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      Immune & Inflammatory Diseases 3513
        immune system disease 2927
          lymphatic system disease 1097
            splenic disease 131
              hypersplenism 1
                Splenomegaly Syndrome with Splenic Germinal Center Hypoplasia and Reduced Circulating T-Helper Cells 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.