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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatoid arthritis
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Accession:DOID:7148 term browser browse the term
Definition:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (DO)
Synonyms:exact_synonym: RA;   RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO;   atrophic arthritis;   rheumatic arthritis or polyarthritis
 narrow_synonym: RHEUMATOID ARTHRITIS, PROGRESSION OF
 primary_id: MESH:D001172
 alt_id: OMIM:180300
 xref: ICD10CM:M06.9;   ICD9CM:714.0;   NCI:C2884
For additional species annotation, visit the Alliance of Genome Resources.


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rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20080907, PMID:22104130 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr13:76,193,929...76,476,119
Ensembl chr13:95,349,915...95,582,058
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 3:180,956,139...181,054,112
Ensembl chr 3:189,122,590...189,219,492
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157
JBrowse link
G ACAN aggrecan disease_progression ISO protein:increased degradation:cartilage
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15292528, PMID:16507130 RGD:11570537 NCBI chr15:67,492,494...67,563,265
Ensembl chr15:86,733,853...86,771,420
JBrowse link
G ACKR3 atypical chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr2B:123,795,664...123,810,067
Ensembl chr2B:242,666,173...242,667,261
JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 ISO mRNA:increased expression:synovium RGD PMID:11801682 RGD:10043106 NCBI chr 1:136,602,140...136,611,469
Ensembl chr 1:140,514,247...140,523,623
JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO protein:alternative form:synovium RGD PMID:11801682 RGD:10043106 NCBI chr21:13,352,222...13,402,165
Ensembl chr21:26,744,807...26,788,736
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:12833524, PMID:21789720 RGD:5686424 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189
JBrowse link
G ADRB3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:12739037 RGD:5684893 NCBI chr 8:37,263,730...37,267,475 JBrowse link
G AFF3 AF4/FMR2 family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 Ensembl chr2A:100,535,363...100,993,626 JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO protein:decreased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16385501, PMID:20541603 RGD:7244141 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
JBrowse link
G AHR aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18617548 NCBI chr 7:17,949,254...17,998,737 JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
JBrowse link
G ANG angiogenin ISO RGD PMID:12653852 RGD:6892721 NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393
JBrowse link
G ANKRD55 ankyrin repeat domain 55 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 5:57,788,013...57,923,070
Ensembl chr 5:59,416,641...59,550,255
JBrowse link
G ANXA3 annexin A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 4:45,585,873...45,644,783
Ensembl chr 4:51,432,846...51,491,677
JBrowse link
G APOA4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:20367977 RGD:5685646 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
JBrowse link
G ARID5B AT-rich interaction domain 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963, PMID:23143596 NCBI chr10:58,426,519...58,621,986
Ensembl chr10:60,756,484...60,952,174
JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19193698 NCBI chr2B:102,574,700...102,612,492
Ensembl chr2B:221,159,439...221,197,360
JBrowse link
G B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr2A:62,276,662...62,305,286
Ensembl chr2A:63,435,289...63,436,482
JBrowse link
G B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr16:47,493,804...47,497,908
Ensembl chr16:66,883,954...66,885,162
JBrowse link
G BAIAP2L1 BAR/IMD domain containing adaptor protein 2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 7:6,158,306...6,230,903
Ensembl chr 7:103,758,479...103,828,874
JBrowse link
G BCL2A1 BCL2 related protein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr15:58,925,853...58,935,122
Ensembl chr15:77,882,940...77,893,628
JBrowse link
G BDKRB2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:3488088, PMID:22447331 RGD:6483593, RGD:6483600 NCBI chr 1:131,583,789...131,586,459
Ensembl chr 1:135,413,871...135,416,432
JBrowse link
G BGN biglycan ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr  X:143,045,298...143,059,892
Ensembl chr  X:152,931,608...152,946,292
JBrowse link
G BLK BLK proto-oncogene, Src family tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 8:7,637,680...7,708,914 JBrowse link
G BMP4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752
JBrowse link
G BMP6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649
JBrowse link
G BTNL2 butyrophilin like 2 susceptibility ISO DNA:SNPs: : RGD PMID:23364395 RGD:9685033 NCBI chr 6:32,067,223...32,126,032 JBrowse link
G C3 complement C3 ISO RGD PMID:7561187 RGD:11040775 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
JBrowse link
G CALD1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 7:126,743,466...126,935,412
Ensembl chr 7:139,337,692...139,440,643
JBrowse link
G CASP7 caspase 7 ISO RGD PMID:18785314 RGD:5684540 NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626
JBrowse link
G CAST calpastatin ISO RGD PMID:7706496 RGD:5683620 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650
JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
JBrowse link
G CAV2 caveolin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 7:108,254,074...108,480,716
Ensembl chr 7:121,168,579...121,177,415
JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:serum RGD PMID:20056091 RGD:4891442 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
JBrowse link
G CCL21 C-C motif chemokine ligand 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr 9:34,545,248...34,546,801
Ensembl chr 9:35,353,768...35,354,924
JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chr16:37,631,861...37,640,208
Ensembl chr16:56,765,367...56,771,213
JBrowse link
G CCL8 C-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr17:22,468,080...22,470,443
Ensembl chr17:22,761,064...22,763,933
JBrowse link
G CCN1 cellular communication network factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147
JBrowse link
G CCN2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 6:129,729,572...129,733,113
Ensembl chr 6:133,836,319...133,842,077
JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:12860725 RGD:5688170 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755
JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630
JBrowse link
G CCR4 C-C motif chemokine receptor 4 ISO mRNA:increased expression:synovium:
protein:increased expression:synovial membrane:
RGD PMID:19942450, PMID:25430645 RGD:10054497, RGD:10054499 NCBI chr 3:32,882,419...32,887,442
Ensembl chr 3:33,188,482...33,189,564
JBrowse link
G CCR5 C-C motif chemokine receptor 5 no_association
resistance
ISO DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD PMID:16541097, PMID:17565662 RGD:1626283, RGD:1626290 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
JBrowse link
G CCR6 C-C motif chemokine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453841, PMID:20453842, PMID:23143596 NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779
JBrowse link
G CD2 CD2 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:85,752,522...85,767,323
Ensembl chr 1:120,749,918...120,764,659
JBrowse link
G CD244 CD244 molecule susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:18794858 NCBI chr 1:136,186,906...136,219,669
Ensembl chr 1:140,110,808...140,123,065
JBrowse link
G CD28 CD28 molecule ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:19075187, PMID:19898481, PMID:20453842, PMID:23143596 RGD:5131619 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213
JBrowse link
G CD3E CD3e molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr11:113,142,200...113,153,928
Ensembl chr11:117,074,041...117,085,625
JBrowse link
G CD40 CD40 molecule ISO DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:18794853, PMID:20453842, PMID:20498205, PMID:23143596 RGD:5490972 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
JBrowse link
G CD5 CD5 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr11:56,362,415...56,388,469
Ensembl chr11:59,801,808...59,826,448
JBrowse link
G CD80 CD80 molecule ISO protein:increased expression:serum RGD PMID:22917707 RGD:6893647 NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870
JBrowse link
G CD83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 6:13,961,342...13,980,686
Ensembl chr 6:14,330,752...14,349,946
JBrowse link
G CDK6 cyclin dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853 NCBI chr 7:84,603,419...84,835,082 JBrowse link
G CEBPB CCAAT enhancer binding protein beta ISO protein:increased expression:knee, articular cartilage (human) RGD PMID:19248099 RGD:10401213 NCBI chr20:46,533,163...46,535,282 JBrowse link
G CHI3L1 chitinase 3 like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:10461474 RGD:4892605 NCBI chr 1:178,778,081...178,789,704
Ensembl chr 1:183,075,312...183,083,229
JBrowse link
G CIITA class II major histocompatibility complex transactivator susceptibility
no_association
ISO ClinVar Annotator: match by term: Rheumatoid arthritis
DNA:haplotype:promoter/CDS:rs3087456G/rs4774C
DNA:polymorphism:promoter:rs3087456, no association in a German cohort
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
RGD
CTD
PMID:15821736, PMID:16426246, PMID:16849401, PMID:19221398 RGD:5491176, RGD:5491189 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485
JBrowse link
G CLEC12A C-type lectin domain family 12 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr12:9,999,334...10,056,108
Ensembl chr12:10,248,209...10,272,070
JBrowse link
G CLEC16A C-type lectin domain containing 16A ISO DNA:polymorphism:intron:rs6498169G RGD PMID:19221398 RGD:5491176 NCBI chr16:9,887,877...10,124,500
Ensembl chr16:11,109,869...11,343,512
JBrowse link
G COL2A1 collagen type II alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:27028940, PMID:29935983 NCBI chr12:40,726,137...40,757,690 JBrowse link
G CP ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr 3:146,180,527...146,239,833
Ensembl chr 3:153,764,830...153,817,544
JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:1568518, PMID:22173958 RGD:6904209 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CSF2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
JBrowse link
G CTSD cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr11:1,789,326...1,800,524 JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:11465708 RGD:4892002 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:19192274 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647
JBrowse link
G DDIT4 DNA damage inducible transcript 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr10:68,796,712...68,798,840
Ensembl chr10:71,264,029...71,266,149
JBrowse link
G DDX6 DEAD-box helicase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr11:113,587,220...113,630,995
Ensembl chr11:117,515,778...117,559,364
JBrowse link
G DHFR dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003
JBrowse link
G DNASE1L3 deoxyribonuclease 1 like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr 3:58,127,491...58,146,177
Ensembl chr 3:59,542,243...59,560,363
JBrowse link
G DNMT1 DNA methyltransferase 1 severity ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr19:9,681,847...9,745,334
Ensembl chr19:10,342,478...10,406,972
JBrowse link
G DNMT3B DNA methyltransferase 3 beta disease_progression ISO DNA:polymorphism:promoter:-283C>T(human) RGD PMID:19777235 RGD:9589110 NCBI chr20:29,049,993...29,096,957
Ensembl chr20:30,186,069...30,215,487
JBrowse link
G EDN1 endothelin 1 treatment ISO RGD PMID:22249931 RGD:8661695 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
JBrowse link
G ELN elastin ISO RGD PMID:12643515 RGD:9585739
G ENO1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898480 NCBI chr 1:7,619,490...7,637,558
Ensembl chr 1:8,855,074...8,873,215
JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560
JBrowse link
G ESR2 estrogen receptor 2 severity ISO DNA:SNP:exon:rs1256049(human) RGD PMID:21523342 RGD:5508794 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303
JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G FAS Fas cell surface death receptor susceptibility ISO protein:increased expression:serum (human)
DNA:snp:promoter:g.-670A>G (human)
RGD PMID:12148596, PMID:20875116, PMID:23053964 RGD:12903969, RGD:8662433, RGD:8662455 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612
JBrowse link
G FASLG Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281
JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia ISO protein:increased expression:synovial joint: RGD PMID:16670289 RGD:9685708 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa ISO DNA:polymorphism: :p.H131R (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:8254199, PMID:12508778, PMID:20453842, PMID:23143596 RGD:5147978, RGD:5147984 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G FKBP5 FKBP prolyl isomerase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 6:35,135,745...35,250,860
Ensembl chr 6:36,337,883...36,452,664
JBrowse link
G FOXO3 forkhead box O3 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell,synovium: RGD PMID:19435720 RGD:10402186 NCBI chr 6:106,360,519...106,485,676
Ensembl chr 6:110,406,266...110,516,272
JBrowse link
G FOXP3 forkhead box P3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20476861 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029
JBrowse link
G FPGS folylpolyglutamate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 9:98,921,986...98,933,542
Ensembl chr 9:127,593,592...127,604,200
JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr21:19,871,656...19,909,893
Ensembl chr21:33,244,457...33,282,331
JBrowse link
G GATA3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272
JBrowse link
G GC GC vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:plasma
CTD
RGD
PMID:3874814, PMID:9548303 RGD:5509931 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073
JBrowse link
G GDF5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18830904 NCBI chr20:31,761,199...31,766,229
Ensembl chr20:32,882,094...32,886,899
JBrowse link
G GGH gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 8:59,547,821...59,571,523
Ensembl chr 8:61,222,194...61,246,252
JBrowse link
G GIN1 gypsy retrotransposon integrase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 5:98,440,271...98,475,300
Ensembl chr 5:104,124,849...104,175,826
JBrowse link
G GPRC5A G protein-coupled receptor class C group 5 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr12:12,905,682...12,928,596
Ensembl chr12:13,282,865...13,305,727
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO protein: decreased expression: mononuclear leukocytes
DNA: deletion: : heterozygous
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 no_association ISO protein: : mononuclear blood cells
DNA: deletion::GRK2 and GRK6 deletions resulted in more severe arthritis
RGD PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO protein: decreased expression: mononuclear leukocytes
DNA: deletion: : homozygous
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chr 5:172,704,978...172,744,907
Ensembl chr 5:179,790,662...179,807,410
JBrowse link
G GSDME gasdermin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 7:25,373,485...25,433,001
Ensembl chr 7:24,977,838...25,039,525
JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility ISO DNA:deletion: :
DNA:deletion: :
RGD PMID:15940757, PMID:16870093, PMID:16887863 RGD:5490993, RGD:5490994, RGD:5490998 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HAPLN1 hyaluronan and proteoglycan link protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 5:31,560,282...31,643,138
Ensembl chr 5:31,879,276...31,964,562
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 3:118,733,505...118,763,177
Ensembl chr 3:125,642,973...125,669,095
JBrowse link
G HDAC1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289289 NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410
JBrowse link
G HFE homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591
JBrowse link
G HGF hepatocyte growth factor disease_progression ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 severity ISO RGD PMID:18025202 RGD:9685481 NCBI chr 7:26,835,881...26,846,578
Ensembl chr 7:26,439,443...26,449,985
JBrowse link
G HOXD10 homeobox D10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr2B:63,395,636...63,399,704
Ensembl chr2B:181,104,876...181,110,963
JBrowse link
G HOXD11 homeobox D11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr2B:63,386,806...63,398,777 JBrowse link
G HOXD13 homeobox D13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr2B:63,372,517...63,375,731 JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:185,262,599...185,311,417
Ensembl chr 1:190,086,449...190,116,765
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr14:82,700,881...82,707,020
Ensembl chr14:102,519,699...102,576,723
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:peripheral blood lymphocyte (human) RGD PMID:22047640 RGD:5688784 NCBI chr 5:128,463,186...128,517,563
Ensembl chr 5:134,619,076...134,673,658
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO protein:increased expression:synovial joint RGD PMID:11315915 RGD:5685639 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO protein:increased expression:synovial cell: RGD PMID:23739258 RGD:10402561 NCBI chr 5:133,934,859...133,955,048
Ensembl chr 5:140,064,207...140,084,551
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO protein:increased expression:serum: RGD PMID:21417552 RGD:10402843 NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959
JBrowse link
G IFNG interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:1417133, PMID:22450443 RGD:8157623 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IGF2 insulin like growth factor 2 ISO DNA:loss of imprinting:synovial cell
protein:decreased expression:plasma
RGD PMID:11247331, PMID:19556211 RGD:5510001, RGD:5510014 NCBI chr11:2,170,190...2,199,442
Ensembl chr11:2,202,743...2,228,890
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 7:46,564,234...46,573,145 JBrowse link
G IL10 interleukin 10 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:12847677, PMID:22450443 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
JBrowse link
G IL17A interleukin 17A treatment ISO RGD PMID:20926833 RGD:9068415 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
JBrowse link
G IL18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16368150 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
JBrowse link
G IL19 interleukin 19 ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of ClinVar PMID:12847677 NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748
JBrowse link
G IL1A interleukin 1 alpha severity ISO protein:increased expression:plasma, synovial fluid
associated with lung disease, interstitial
RGD PMID:8162643, PMID:11192540 RGD:4142818, RGD:7794716 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801
JBrowse link
G IL1B interleukin 1 beta ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12566094, PMID:17379860, PMID:22414257, PMID:22450443 RGD:6482656 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL2 interleukin 2 ISO RGD PMID:6421522 RGD:8662948 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
JBrowse link
G IL20 interleukin 20 ISO RGD PMID:16947773 RGD:5147395 NCBI chr 1:182,468,571...182,472,440
Ensembl chr 1:186,747,086...186,750,952
JBrowse link
G IL21R interleukin 21 receptor ISO RGD PMID:19342640 RGD:6892964 Ensembl chr16:27,774,864...27,821,769 JBrowse link
G IL23A interleukin 23 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617
JBrowse link
G IL23R interleukin 23 receptor susceptibility ISO DNA:SNP::rs1343151(human) RGD PMID:18647855 RGD:8549596 NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:20476861, PMID:23143596 NCBI chr10:6,053,549...6,103,863 JBrowse link
G IL2RB interleukin 2 receptor subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr22:18,039,469...18,069,952
Ensembl chr22:35,874,898...35,899,038
JBrowse link
G IL3 interleukin 3 ISO DNA: SNPs: Multiple: gene-gene interaction RGD PMID:20018070 RGD:5686905 NCBI chr 5:127,483,843...127,486,388
Ensembl chr 5:133,647,667...133,650,213
JBrowse link
G IL4R interleukin 4 receptor severity ISO DNA:SNP: :rs1805010 (human) RGD PMID:24782180 RGD:10402783 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G IL5 interleukin 5 ISO RGD PMID:22293286 RGD:5687156 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274, PMID:22450443 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16729287, PMID:23143596 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089
JBrowse link
G IL6ST interleukin 6 signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 5:58,023,704...58,081,895
Ensembl chr 5:59,669,606...59,708,817
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr  X:143,560,802...143,570,185
Ensembl chr  X:153,446,827...153,460,602
JBrowse link
G IRF5 interferon regulatory factor 5 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD
ClinVar
PMID:15657875, PMID:16642019, PMID:17599733, PMID:18063667, PMID:20453842, PMID:23143596 NCBI chr 7:120,889,752...120,902,096
Ensembl chr 7:133,415,170...133,426,356
JBrowse link
G IRF8 interferon regulatory factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073
JBrowse link
G ITGA6 integrin subunit alpha 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr2B:59,714,348...59,794,762
Ensembl chr2B:177,169,536...177,250,143
JBrowse link
G ITGB2 integrin subunit beta 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
JBrowse link
G ITPA inosine triphosphatase treatment ISO DNA:SNP: :94C>A(human) RGD PMID:29441893 RGD:14975307 NCBI chr20:3,295,075...3,309,546
Ensembl chr20:3,056,395...3,070,924
JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:21510883 RGD:6483024 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626
JBrowse link
G KIF5A kinesin family member 5A susceptibility ISO DNA:snps:intron, 3' utr:c.2756-43A>C, c.*776C>T (rs775246, rs775251) (human)
CTD Direct Evidence: marker/mechanism
DNA:snp:intron:c.1717-152C>G (rs1678542) (human)
RGD
CTD
PMID:21784728, PMID:23143596, PMID:23378462 RGD:12793072, RGD:12793073 NCBI chr12:31,340,201...31,376,849
Ensembl chr12:31,599,376...31,635,327
JBrowse link
G LCN2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7554268 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798
JBrowse link
G LHX2 LIM homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 9:95,132,445...95,154,130
Ensembl chr 9:123,655,845...123,676,796
JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain ISO DNA:polymorphism (human) RGD PMID:11454644 RGD:5147860 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
JBrowse link
G LOC100973583 HLA class II histocompatibility antigen, DQ alpha 2 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 6:32,314,091...32,319,909
Ensembl chr 6:33,429,832...33,435,363
JBrowse link
G LOC100975642 zinc finger protein Aiolos ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr17:17,459,438...17,498,452
Ensembl chr17:17,643,750...17,741,479
JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD
PMID:7706905, PMID:10637275, PMID:19192274, PMID:19447938 RGD:7174696, RGD:8549810 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G LOC100995226 HLA class II histocompatibility antigen, DP beta 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17956852, PMID:22286218 NCBI chr 6:32,648,780...32,659,613
Ensembl chr 6:33,763,566...33,774,387
JBrowse link
G LRRK2 leucine rich repeat kinase 2 ISO RGD PMID:17082220 RGD:5508419 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462
JBrowse link
G LY96 lymphocyte antigen 96 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 8:70,525,058...70,567,839
Ensembl chr 8:72,169,986...72,207,372
JBrowse link
G MAB21L2 mab-21 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 4:142,913,376...142,916,001
Ensembl chr 4:154,563,939...154,565,018
JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 6:111,647,847...111,653,821 JBrowse link
G MBD2 methyl-CpG binding domain protein 2 ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr18:47,534,356...47,609,481 JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase susceptibility
no_association
ISO DNA:snps:introns:IVS5-140A>G (rs3138355), IVS6-218C>T (rs2005618) (human)
DNA:snps:cds, intron:p.E346K, IVS6-218C>T (rs140693, rs2005618) (human)
RGD PMID:20676650, PMID:22505706 RGD:9588977, RGD:9588978 NCBI chr 3:126,489,125...126,498,034
Ensembl chr 3:133,839,643...133,851,450
JBrowse link
G MDK midkine ISO RGD PMID:15146411 RGD:1581200 NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254
JBrowse link
G MGARP mitochondria localized glutamic acid rich protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 4:131,629,272...131,643,996
Ensembl chr 4:142,936,873...142,952,601
JBrowse link
G MIF macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
G MMEL1 membrane metalloendopeptidase like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:1,323,914...1,362,178
Ensembl chr 1:2,462,621...2,504,213
JBrowse link
G MMP1 matrix metallopeptidase 1 ISO protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104
JBrowse link
G MMP10 matrix metallopeptidase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr11:97,710,819...97,721,263
Ensembl chr11:101,201,665...101,212,103
JBrowse link
G MMP12 matrix metallopeptidase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
JBrowse link
G MMP3 matrix metallopeptidase 3 disease_progression ISO protein:increased expression:serum (human) RGD PMID:7639798, PMID:11796404, PMID:22314025 RGD:7207128, RGD:7241254, RGD:8693673 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354
JBrowse link
G MMP8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G MPO myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:26001728 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO DNA:SNP: :677C>T(human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:22104130, PMID:23685257 RGD:7387222 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419
JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:28135245 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G NCF2 neutrophil cytosolic factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 1:159,085,923...159,121,259
Ensembl chr 1:163,243,636...163,278,420
JBrowse link
G NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr12:31,686,325...31,692,483
Ensembl chr12:31,940,681...31,944,813
JBrowse link
G NFKBIE NFKB inhibitor epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 6:43,853,921...43,861,686
Ensembl chr 6:45,138,209...45,144,680
JBrowse link
G NFKBIL1 NFKB inhibitor like 1 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
DNA:snp:promoter:c.-132T>A (rs2071592) (human)
OMIM
ClinVar
CTD
RGD
PMID:12509789 RGD:1331681 NCBI chr 6:31,207,927...31,219,916
Ensembl chr 6:32,098,554...32,109,944
JBrowse link
G NOTCH4 notch receptor 4 ISO mRNA : increased expression: : cd4+ cells RGD PMID:20132067 RGD:6480790 NCBI chr 6:31,842,233...31,871,412
Ensembl chr 6:32,722,112...32,750,978
JBrowse link
G NPSR1 neuropeptide S receptor 1 ISO RGD PMID:20179762 RGD:4891930 NCBI chr 7:35,274,102...35,494,389
Ensembl chr 7:35,663,335...35,883,988
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO mRNA:increased expression:paw RGD PMID:18448865 RGD:4892311 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 9:70,907,056...70,950,221 JBrowse link
G PADI2 peptidyl arginine deiminase 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chr 1:16,011,708...16,064,344
Ensembl chr 1:17,067,729...17,120,513
JBrowse link
G PADI4 peptidyl arginine deiminase 4 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:23143596 NCBI chr 1:16,255,680...16,311,256
Ensembl chr 1:17,311,436...17,365,426
JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:1708827 RGD:6482653 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883
JBrowse link
G PGF placental growth factor ISO RGD PMID:19180491 RGD:6483591 NCBI chr14:55,494,152...55,508,066 JBrowse link
G PLA2G7 phospholipase A2 group VII ISO RGD PMID:17326817 RGD:6482776 NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212
JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:22011479 RGD:6484117 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561
JBrowse link
G PLB1 phospholipase B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24520335 NCBI chr2A:28,502,449...28,650,348
Ensembl chr2A:28,584,636...28,730,640
JBrowse link
G PLD4 phospholipase D family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr14:85,574,724...85,587,176
Ensembl chr14:105,360,584...105,369,247
JBrowse link
G PLEK pleckstrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr2A:68,414,281...68,446,647
Ensembl chr2A:69,537,983...69,570,393
JBrowse link
G PON1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16055108 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
JBrowse link
G POU3F1 POU class 3 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:37,317,800...37,320,004 JBrowse link
G PRDM1 PR/SET domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815
JBrowse link
G PRKCQ protein kinase C theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr10:6,458,138...6,610,781
Ensembl chr10:6,440,316...6,593,900
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15167967 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11978490, PMID:19192274, PMID:21905970 RGD:5508313 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G PTK2 protein tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 8:137,330,777...137,677,306
Ensembl chr 8:140,412,773...140,684,898
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 susceptibility
no_association
ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
DNA:snp:cds:p.R620W (rs2476601) (human)
DNA:SNP::1858C>T (human)
DNA:snp:cds:p.R263Q (rs33996649) (human)
OMIM
ClinVar
CTD
RGD
PMID:15004560, PMID:15208781, PMID:15273934, PMID:15580548, PMID:15719322, PMID:15744042, PMID:16273109, PMID:16339849, PMID:16470599, PMID:17170052, PMID:17436241, PMID:17554300, PMID:17878369, PMID:18301444, PMID:18978792, PMID:19265110, PMID:19430480, PMID:19898480, PMID:20453842, PMID:21190368, PMID:21279993, PMID:21467606, PMID:21841778, PMID:23143596, PMID:28492532, PMID:30224649 RGD:6484535, RGD:6484595, RGD:7829746 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994
JBrowse link
G PXK PX domain containing serine/threonine kinase like ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 3:58,265,626...58,358,247
Ensembl chr 3:59,711,749...59,773,556
JBrowse link
G RAB8A RAB8A, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr19:15,598,029...15,619,988
Ensembl chr19:16,580,720...16,602,189
JBrowse link
G RAP2A RAP2A, member of RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr13:78,595,330...78,629,012
Ensembl chr13:97,751,799...97,785,194
JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr15:17,417,684...17,494,333
Ensembl chr15:35,675,348...35,750,315
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 4:20,719,548...20,835,439
Ensembl chr 4:25,995,263...26,107,683
JBrowse link
G RCAN1 regulator of calcineurin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr21:20,889,123...20,987,964
Ensembl chr21:34,258,355...34,267,025
JBrowse link
G REL REL proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19503088, PMID:20453842, PMID:23143596 NCBI chr2A:60,972,022...61,013,562
Ensembl chr2A:62,113,581...62,155,241
JBrowse link
G RGMB repulsive guidance molecule BMP co-receptor b ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 5:94,080,200...94,107,441
Ensembl chr 5:99,639,527...99,661,904
JBrowse link
G RUNX1 RUNX family transcription factor 1 no_association ISO DNA:SNP: :rs2268277 (human)
DNA:SNP:intron:24658G>C (human)
DNA:SNPs: :rs2242720, rs4816502 (human)
RGD PMID:16821265, PMID:18087673, PMID:18328148, PMID:20018071 RGD:6482836, RGD:6482837, RGD:6482839, RGD:6482840 NCBI chr21:21,159,586...21,423,946
Ensembl chr21:34,530,956...34,788,544
JBrowse link
G RUNX2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 6:45,003,962...45,133,148
Ensembl chr 6:46,189,432...46,524,389
JBrowse link
G SEMA3C semaphorin 3C ISO protein:increased expression:knee, synovium (human) RGD PMID:15077297 RGD:1580084 NCBI chr 7:72,706,615...72,884,163
Ensembl chr 7:86,368,753...86,545,580
JBrowse link
G SLC11A1 solute carrier family 11 member 1 severity ISO DNA:polymorphisms, deletion: :823C>T, p.D543N (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter (human)
RGD
CTD
PMID:10719815, PMID:12135431, PMID:16597321 RGD:5684967, RGD:5684971 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SLC22A4 solute carrier family 22 member 4 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:14608356 NCBI chr 5:127,717,077...127,766,793
Ensembl chr 5:133,879,387...133,929,439
JBrowse link
G SLC25A12 solute carrier family 25 member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr2B:59,071,123...59,297,327
Ensembl chr2B:176,532,940...176,641,894
JBrowse link
G SMS spermine synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr  X:14,571,432...14,625,601 JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:15292528, PMID:24313545 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:15761492 RGD:1581382 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935
JBrowse link
G SPRED2 sprouty related EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr2A:65,380,608...65,503,139
Ensembl chr2A:66,503,260...66,624,840
JBrowse link
G ST6GALNAC5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:17568789 NCBI chr 1:76,080,706...76,284,836
Ensembl chr 1:78,167,280...78,366,180
JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO associated with T-cell large granular lymphocyte leukemia
ClinVar Annotator: match by term: Rheumatoid arthritis
RGD
ClinVar
PMID:22591296, PMID:28492532, PMID:30311386 RGD:6892936 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
JBrowse link
G STAT4 signal transducer and activator of transcription 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011
JBrowse link
G STS steroid sulfatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 Ensembl chr  X:7,047,017...7,207,540 JBrowse link
G SUPT20H SPT20 homolog, SAGA complex component ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chr13:18,217,142...18,268,937
Ensembl chr13:36,647,544...36,687,513
JBrowse link
G TAGAP T cell activation RhoGTPase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 6:156,923,859...156,934,714
Ensembl chr 6:161,938,457...161,949,158
JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:9645419 RGD:6482275 NCBI chr 6:32,394,586...32,408,297
Ensembl chr 6:33,507,332...33,523,750
JBrowse link
G TFPI2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:17379860 NCBI chr 7:85,835,141...85,839,515
Ensembl chr 7:99,426,006...99,431,099
JBrowse link
G THBD thrombomodulin ISO RGD PMID:15700117 RGD:5685020 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
JBrowse link
G TLE3 TLE family member 3, transcriptional corepressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr15:49,000,145...49,050,246
Ensembl chr15:67,770,176...67,817,320
JBrowse link
G TLR2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
JBrowse link
G TMPO thymopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr12:96,100,509...96,135,364
Ensembl chr12:99,514,803...99,546,535
JBrowse link
G TNF tumor necrosis factor treatment
no_association
ISO DNA:SNP:promoter:-857C>T (human)
DNA:SNP:promoter:-238G>A, -308G>A (human)
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:2001072, PMID:8391952, PMID:12563673, PMID:12566094, PMID:22450443, PMID:25311255 RGD:10450537, RGD:12904065 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFAIP2 TNF alpha induced protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr14:83,745,176...83,759,157
Ensembl chr14:103,561,181...103,570,309
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:21841782, PMID:23143596, PMID:30224649 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO CTD Direct Evidence: therapeutic CTD PMID:23333834 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422
JBrowse link
G TNFRSF14 TNF receptor superfamily member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 1:1,288,493...1,296,532
Ensembl chr 1:2,427,631...2,435,615
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A treatment ISO DNA:SNP:promoter:36G>A (human) RGD PMID:25311255 RGD:12904065 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
JBrowse link
G TNFSF14 TNF superfamily member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr19:5,691,648...5,700,935
Ensembl chr19:6,614,378...6,621,763
JBrowse link
G TRAF1 TNF receptor associated factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:23143596 NCBI chr 9:92,030,205...92,056,776
Ensembl chr 9:120,376,592...120,402,948
JBrowse link
G TRAF6 TNF receptor associated factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr11:36,457,633...36,483,616
Ensembl chr11:36,335,609...36,356,334
JBrowse link
G TRAPPC2 trafficking protein particle complex 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr  X:6,321,264...6,341,650
Ensembl chr  X:13,609,852...13,629,916
JBrowse link
G TXNDC5 thioredoxin domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326410 NCBI chr 6:7,720,141...7,749,672
Ensembl chr 6:8,001,831...8,027,408
JBrowse link
G TXNIP thioredoxin interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:121,763,312...121,767,468 JBrowse link
G TYK2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr19:9,901,612...9,932,623
Ensembl chr19:10,565,490...10,594,541
JBrowse link
G TYMS thymidylate synthetase treatment ISO DNA:polymorphism: : RGD PMID:22763757 RGD:11075093 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320
JBrowse link
G VDR vitamin D receptor no_association ISO DNA:SNP: :rs1544410 (human)
DNA:SNP:exon:rs2228570 (human)
RGD PMID:21820934 RGD:8158077 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192
JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:
CTD
RGD
PMID:16368150, PMID:24387171 RGD:8548659 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G VIM vimentin ISO RGD PMID:21792832 RGD:6480508 NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642
JBrowse link
adult-onset Still's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HGF hepatocyte growth factor ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
juvenile rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:129,392,396...129,465,962
Ensembl chr 3:136,713,816...136,764,655
JBrowse link
G ACRBP acrosin binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:6,768,971...6,778,613
Ensembl chr12:6,685,963...6,695,344
JBrowse link
G ADCY7 adenylate cyclase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:30,507,836...30,581,068
Ensembl chr16:49,410,143...49,462,278
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602
JBrowse link
G ANKRD9 ankyrin repeat domain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:83,122,024...83,128,173 JBrowse link
G AOPEP aminopeptidase O (putative) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:65,825,138...66,188,001
Ensembl chr 9:93,986,951...94,311,201
JBrowse link
G APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:19,866,522...19,872,836 JBrowse link
G AQP9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:37,107,061...37,154,887
Ensembl chr15:55,418,767...55,466,541
JBrowse link
G AREG amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:49,737,191...49,747,013 JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:126,688,608...127,080,662
Ensembl chr 8:129,418,796...130,021,261
JBrowse link
G AVL9 AVL9 cell migration associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:33,104,760...33,194,941 JBrowse link
G B4GALT5 beta-1,4-galactosyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr20:45,977,801...46,058,429
Ensembl chr20:47,041,469...47,123,214
JBrowse link
G BEND2 BEN domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:10,786,031...10,844,265
Ensembl chr  X:18,151,097...18,208,838
JBrowse link
G BTG1 BTG anti-proliferation factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:89,678,431...89,681,177
Ensembl chr12:92,992,584...92,994,038
JBrowse link
G BTG3 BTG anti-proliferation factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr21:4,327,813...4,347,053
Ensembl chr21:17,693,067...17,712,280
JBrowse link
G C2BH2orf88 chromosome 2B C2orf88 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:77,446,455...77,509,809
Ensembl chr2B:195,424,996...195,425,283
JBrowse link
G C8B complement C8 beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:7980680 NCBI chr 1:56,213,618...56,250,488
Ensembl chr 1:57,923,720...57,960,674
JBrowse link
G C9orf72 C9orf72-SMCR8 complex subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:27,395,054...27,422,282
Ensembl chr 9:28,001,813...28,022,066
JBrowse link
G CALD1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:126,743,466...126,935,412
Ensembl chr 7:139,337,692...139,440,643
JBrowse link
G CAMSAP1 calmodulin regulated spectrin associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:106,881,023...106,979,501
Ensembl chr 9:135,866,980...135,944,911
JBrowse link
G CCR5 C-C motif chemokine receptor 5 no_association ISO DNA:polymorphisms: :multiple (human)
DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
RGD PMID:16775617, PMID:17565662 RGD:1626283, RGD:1626284 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
JBrowse link
G CD14 CD14 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966
JBrowse link
G CD83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:13,961,342...13,980,686
Ensembl chr 6:14,330,752...14,349,946
JBrowse link
G CD8B CD8b molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2A:86,863,320...86,909,989 JBrowse link
G CIITA class II major histocompatibility complex transactivator no_association
susceptibility
ISO DNA:polymorphism:promoter:rs3087456, no association in a German cohort
DNA:polymorphism:exon:1614G>C (human)
RGD PMID:16426246, PMID:17661914 RGD:5491187, RGD:5491189 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485
JBrowse link
G CLU clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523
JBrowse link
G CMTM2 CKLF like MARVEL transmembrane domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:46,897,655...46,906,760
Ensembl chr16:65,999,285...66,007,739
JBrowse link
G CREM cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:35,247,426...35,335,545
Ensembl chr10:35,825,218...35,912,432
JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum RGD PMID:22885951 RGD:6906884 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
JBrowse link
G CTTN cortactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:65,500,074...65,539,158 JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504, PMID:26387944 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647
JBrowse link
G DAPK1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:58,628,872...58,836,205
Ensembl chr 9:86,681,953...86,887,958
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701
JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960
JBrowse link
G DUSP2 dual specificity phosphatase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2A:103,169,874...103,172,158 JBrowse link
G DUSP4 dual specificity phosphatase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:28,623,777...28,641,432
Ensembl chr 8:25,819,989...25,834,332
JBrowse link
G DYSF dysferlin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2A:71,495,573...71,730,073
Ensembl chr2A:72,994,888...73,228,846
JBrowse link
G EGF epidermal growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:102,410,724...102,509,691
Ensembl chr 4:112,977,565...113,076,460
JBrowse link
G EGR1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260
JBrowse link
G ELF2 E74 like ETS transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:131,420,985...131,540,691
Ensembl chr 4:142,731,593...142,850,778
JBrowse link
G ETNK1 ethanolamine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:63,623,723...63,690,306
Ensembl chr12:66,237,566...66,297,223
JBrowse link
G ETV6 ETS variant transcription factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:11,675,955...11,920,913
Ensembl chr12:11,844,939...12,179,537
JBrowse link
G FAM20A FAM20A golgi associated secretory pathway pseudokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:62,474,317...62,537,800
Ensembl chr17:67,864,331...67,927,128
JBrowse link
G FAXDC2 fatty acid hydroxylase domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:150,222,289...150,255,055
Ensembl chr 5:156,217,594...156,249,567
JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220
JBrowse link
G FCHSD2 FCH and double SH3 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:67,915,796...68,219,482 JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:42,416,781...42,424,003
Ensembl chr19:51,013,350...51,020,570
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2A:28,392,328...28,416,838
Ensembl chr2A:28,485,613...28,498,397
JBrowse link
G FOXP1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:66,925,063...66,928,222
Ensembl chr 1:68,880,912...68,884,188
JBrowse link
G GMPR guanosine monophosphate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:16,094,994...16,151,499
Ensembl chr 6:16,460,651...16,515,796
JBrowse link
G GNG11 G protein subunit gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:85,870,321...85,875,309
Ensembl chr 7:99,461,797...99,466,632
JBrowse link
G GP1BB glycoprotein Ib platelet subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:2,485,350...2,486,688 JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:135,699,553...135,713,366
Ensembl chr 5:141,816,402...141,830,531
JBrowse link
G HERPUD2 HERPUD family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:36,259,315...36,321,705
Ensembl chr 7:36,494,153...36,556,481
JBrowse link
G HFE homeostatic iron regulator ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:16047841 RGD:8694357 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO protein:increased expression:serum,synovial fluid: RGD PMID:8255671 RGD:12910480 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974
JBrowse link
G IL1A interleukin 1 alpha ISO DNA:SNP:promoter:-889C>T (human) RGD PMID:8162643 RGD:7794716 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801
JBrowse link
G IL2 interleukin 2 ISO protein:increased expression:mononuclear cell RGD PMID:21859687 RGD:5147870 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:serum: RGD PMID:9489833 RGD:7829742 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ITGA2B integrin subunit alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:13,009,514...13,027,289
Ensembl chr17:13,176,843...13,193,269
JBrowse link
G ITGB5 integrin subunit beta 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:121,863,676...122,013,438
Ensembl chr 3:128,762,200...128,877,172
JBrowse link
G JMJD1C jumonji domain containing 1C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:59,674,227...60,028,763
Ensembl chr10:61,999,571...62,295,332
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:58,042,794...58,045,536 JBrowse link
G KAT6B lysine acetyltransferase 6B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:71,354,585...71,561,572
Ensembl chr10:74,035,496...74,223,975
JBrowse link
G KCNJ15 potassium inwardly rectifying channel subfamily J member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr21:24,615,779...24,668,267
Ensembl chr21:38,010,261...38,011,388
JBrowse link
G KLF4 Kruppel like factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:78,634,545...78,639,447
Ensembl chr 9:106,820,954...106,825,797
JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335
JBrowse link
G LACC1 laccase domain containing 1 ISO OMIM NCBI chr13:25,047,306...25,063,644
Ensembl chr 3:198,998,153...199,012,230
JBrowse link
G LILRA5 leukocyte immunoglobulin like receptor A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:51,265,665...51,272,519
Ensembl chr19:60,106,656...60,112,709
JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain ISO DNA:polymorphism (human) RGD PMID:10457895 RGD:5147863 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
JBrowse link
G LOC100980195 histone H2A type 1-B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:26,051,779...26,052,699 JBrowse link
G LOC100985450 histone H2B type 1-C/E/F/G/I ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:26,051,127...26,051,730
Ensembl chr 6:26,679,372...26,679,752
Ensembl chr 6:26,679,372...26,679,752
Ensembl chr 6:26,679,372...26,679,752
Ensembl chr 6:26,679,372...26,679,752
JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G LPP LIM domain containing preferred translocation partner in lipoma ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:185,179,432...185,916,477
Ensembl chr 3:193,991,530...194,462,641
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:2,070,299...2,502,471
Ensembl chr 7:2,187,104...2,601,328
JBrowse link
G MAFF MAF bZIP transcription factor F ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:19,114,929...19,129,901 JBrowse link
G MAML2 mastermind like transcriptional coactivator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:90,982,013...91,350,289
Ensembl chr11:94,511,873...94,873,977
JBrowse link
G MAP2 microtubule associated protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:96,681,268...96,991,650
Ensembl chr2B:215,314,857...215,391,728
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
JBrowse link
G MBL2 mannose binding lectin 2 ISO RGD PMID:18334024 RGD:12910845 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
JBrowse link
G MEX3C mex-3 RNA binding family member C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:44,546,129...44,569,580 JBrowse link
G MS4A4A membrane spanning 4-domains A4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:55,512,315...55,540,758
Ensembl chr11:58,955,095...58,983,570
JBrowse link
G MSN moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:54,785,309...54,859,364
Ensembl chr  X:64,781,550...64,933,292
JBrowse link
G MTSS1 MTSS I-BAR domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:121,235,545...121,413,037
Ensembl chr 8:123,987,577...124,032,339
JBrowse link
G MYZAP myocardial zonula adherens protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:36,560,355...36,653,881 JBrowse link
G NDEL1 nudE neurodevelopment protein 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:43,186,255...43,218,436 JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:70,907,056...70,950,221 JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071
JBrowse link
G OSM oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:11,298,965...11,303,009
Ensembl chr22:29,101,085...29,105,081
JBrowse link
G PACSIN2 protein kinase C and casein kinase substrate in neurons 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:23,757,565...23,900,837
Ensembl chr22:41,908,922...41,999,692
JBrowse link
G PCYT1B phosphate cytidylyltransferase 1, choline, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:17,155,065...17,269,909
Ensembl chr  X:24,522,460...24,636,942
JBrowse link
G PER1 period circadian regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:43,502,080...43,518,098
Ensembl chr17:48,234,360...48,250,391
JBrowse link
G PGM5 phosphoglucomutase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:56,262,870...56,412,833 JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561
JBrowse link
G PLK2 polo like kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:55,543,828...55,550,116
Ensembl chr 5:57,177,836...57,184,793
JBrowse link
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:143,091,833...143,181,831
Ensembl chr 3:150,675,424...150,764,939
JBrowse link
G PROS1 protein S ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:90,934,641...91,039,059
Ensembl chr 3:97,615,734...97,718,756
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO DNA: snp : cds : rs2476601 RGD PMID:15934099 RGD:6484550 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G R3HDM2 R3H domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:31,494,789...31,672,343
Ensembl chr12:31,868,368...31,923,910
JBrowse link
G RASGEF1B RasGEF domain family member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:42,153,818...42,771,749
Ensembl chr 4:48,004,253...48,620,978
JBrowse link
G RBM47 RNA binding motif protein 47 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:34,744,484...34,951,402
Ensembl chr 4:40,597,366...40,640,599
JBrowse link
G RERE arginine-glutamic acid dipeptide repeats ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:7,111,594...7,576,667
Ensembl chr 1:8,351,367...8,648,973
JBrowse link
G RHOBTB1 Rho related BTB domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:57,410,347...57,541,038
Ensembl chr10:59,740,662...59,815,536
JBrowse link
G RNF103 ring finger protein 103 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2A:86,659,672...86,680,154 JBrowse link
G SELP selectin P severity ISO protein:increased expression:plasma RGD PMID:21124648 RGD:6219006 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G SH2D2A SH2 domain containing 2A ISO DNA:polymorphism:promoter RGD PMID:15129233 RGD:2298870 NCBI chr 1:132,149,450...132,160,280
Ensembl chr 1:135,972,824...135,981,754
JBrowse link
G SH3BGRL2 SH3 domain binding glutamate rich protein like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:77,303,334...77,584,938
Ensembl chr 6:80,782,103...80,850,087
JBrowse link
G SIK1 salt inducible kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr21:29,675,040...29,689,408 JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:51,909,444...52,328,719
Ensembl chr14:71,038,600...71,192,916
JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10857800, PMID:16597321 RGD:5684977 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SLC22A16 solute carrier family 22 member 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:108,232,950...108,332,469
Ensembl chr 6:112,302,265...112,354,829
JBrowse link
G SLC26A2 solute carrier family 26 member 2 susceptibility ISO DNA:SNPs: : RGD PMID:17393463 RGD:13208931 NCBI chr 5:145,385,433...145,412,180
Ensembl chr 5:151,391,842...151,412,676
JBrowse link
G SMAD3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185
JBrowse link
G STAB1 stabilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:52,437,378...52,466,143
Ensembl chr 3:53,665,386...53,694,139
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
JBrowse link
G STIM1 stromal interaction molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:3,726,501...3,954,951
Ensembl chr11:3,840,513...4,065,224
JBrowse link
G TCF7L2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281
JBrowse link
G TFDP1 transcription factor Dp-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:94,730,343...94,789,328
Ensembl chr13:113,789,280...113,840,825
JBrowse link
G TFPI tissue factor pathway inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384
JBrowse link
G THBD thrombomodulin ISO protein:increased expression:serum RGD PMID:15209962 RGD:5685023 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
JBrowse link
G THBS1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382
JBrowse link
G TNFAIP8 TNF alpha induced protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:114,657,140...114,784,819
Ensembl chr 5:120,442,500...120,569,877
JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:22,352,777...22,368,737
Ensembl chr 8:19,292,020...19,307,719
JBrowse link
G TNIK TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:168,067,839...168,466,290
Ensembl chr 3:176,255,547...176,650,795
JBrowse link
G TREML1 triggering receptor expressed on myeloid cells like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:40,726,243...40,731,358
Ensembl chr 6:42,034,988...42,039,695
JBrowse link
G TTLL5 tubulin tyrosine ligase like 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:56,216,214...56,513,718
Ensembl chr14:75,058,897...75,356,494
JBrowse link
G TUBB2A tubulin beta 2A class IIa ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:2,993,653...2,997,570 JBrowse link
G UBE2E1 ubiquitin conjugating enzyme E2 E1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:23,719,632...23,803,302
Ensembl chr 3:24,045,747...24,127,820
JBrowse link
G UBE3C ubiquitin protein ligase E3C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:148,756,024...148,886,688
Ensembl chr 7:160,474,767...160,580,046
JBrowse link
G UHRF1BP1L UHRF1 binding protein 1 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:97,617,019...97,723,669
Ensembl chr12:101,026,575...101,131,811
JBrowse link
G WASF3 WASP family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:7,849,687...7,980,979
Ensembl chr13:26,250,171...26,328,553
JBrowse link
G WWOX WW domain containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:58,689,609...59,800,333
Ensembl chr16:78,125,302...79,231,546
JBrowse link
G ZFAND3 zinc finger AN1-type containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:37,383,659...37,743,202
Ensembl chr 6:38,683,961...38,906,806
JBrowse link
G ZFC3H1 zinc finger C3H1-type containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:69,133,048...69,187,291
Ensembl chr12:71,992,638...72,047,056
JBrowse link
Sjogren's syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E onset ISO DNA:polymorphism:exon: RGD PMID:15328426 RGD:7495765 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G BDNF brain derived neurotrophic factor severity ISO protein:increased expression:serum: RGD PMID:18830907 RGD:8657019 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
JBrowse link
G BST2 bone marrow stromal cell antigen 2 ISO mRNA, protein:increased expression: labial gland, CD19+ B cell, CD4-CD8-CD19-monocyte: RGD PMID:30249485 RGD:14398821 NCBI chr19:16,890,257...16,892,989
Ensembl chr19:17,863,991...17,866,728
JBrowse link
G C3 complement C3 ISO RGD PMID:17675493 RGD:7401265 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
JBrowse link
G CAST calpastatin ISO associated with Lupus Erythematosus, Systemic RGD PMID:15540513 RGD:5683622 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650
JBrowse link
G CCR5 C-C motif chemokine receptor 5 no_association ISO DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD PMID:12412204, PMID:23773920 RGD:8551796, RGD:8551818 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:salivary ductal epithelium (human) RGD PMID:12472667 RGD:11520791 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202
JBrowse link
G CRP C-reactive protein ISO associated with Arthritis, Rheumatoid;protein:increased expression:serum: RGD PMID:2353152, PMID:16013223 RGD:9491774, RGD:9491835 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO mRNA:increased expression:salivary gland:
DNA:SNPs,haplotype: :+49A/G (rs231775),(rs3087243)(human)
RGD PMID:12528117, PMID:16869018 RGD:7421506, RGD:7421519 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO associated with Arthritis, Rheumatoid;DNA:polymorphism: :4889A>G (human) RGD PMID:12590982 RGD:5147747 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636
JBrowse link
G DGKQ diacylglycerol kinase theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 4:1,075,133...1,090,081
Ensembl chr 4:994,985...1,007,724
JBrowse link
G FAS Fas cell surface death receptor ISO protein:decreased expression:lacrimal gland, lymphocyte (mouse)
protein:increased expression:serum (human)
RGD PMID:9870874, PMID:9890678, PMID:11157873 RGD:8662410, RGD:8662436, RGD:8662451 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G GDNF glial cell derived neurotrophic factor ISO RGD PMID:9853108 RGD:6218983 NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362
JBrowse link
G GTF2I general transcription factor IIi ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066 Ensembl chr 7:81,831,442...81,901,926 JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:24941846 RGD:10450595 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 ISO RGD PMID:19264855 RGD:10054311 NCBI chr 5:174,764,771...174,775,201 JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO protein:increased expression:salivary gland
protein:increased expression:plasma
RGD PMID:11359451, PMID:15037117, PMID:21589878 RGD:8158122, RGD:8547696, RGD:8547705 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G IFNG interferon gamma ISO RGD PMID:15584966, PMID:28421993 RGD:14975117, RGD:8142390 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IL10 interleukin 10 ISO RGD PMID:12233881 RGD:1580479 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL12A interleukin 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 3:157,011,675...157,019,897
Ensembl chr 3:165,061,505...165,068,666
JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
JBrowse link
G IL17A interleukin 17A ISO RGD PMID:21182786 RGD:8696035 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
JBrowse link
G IL18 interleukin 18 ISO protein:increased expression:saliva RGD PMID:23906036 RGD:8655918 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
JBrowse link
G IL23R interleukin 23 receptor ISO protein:increased expression:minor salivary gland: RGD PMID:22262980 RGD:8549566 NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
JBrowse link
G IL6 interleukin 6 severity ISO DNA:polymorphims:promoter:-174G>C(human)
protein:increased expression:plasma:
RGD PMID:11426023 RGD:7829718 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 6:76,717,234...76,751,725
Ensembl chr 6:79,989,745...80,059,221
JBrowse link
G ITSN2 intersectin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr2A:24,199,600...24,354,314
Ensembl chr2A:24,297,373...24,419,593
JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain susceptibility ISO DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0201, HLA-DQB1*0401, HLA-DQB1*0601 (human)
associated with Chronic Hepatitis C;DNA:polymorphism:cds:HLA-DQB1*02 (human)
DNA:polymorphisms:cds:HLA-DQB1*0201 (human)
RGD PMID:8468491, PMID:17489060, PMID:21315052 RGD:36174022, RGD:7421543, RGD:7483566 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
protein:increased expression:conjunctiva (human)
RGD PMID:9646842, PMID:11527941 RGD:8549786, RGD:8549807 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G LTA lymphotoxin alpha susceptibility
no_association
ISO protein:increased expression:saliva, serum
DNA:SNP, haplotype:intron: (rs909253) (human)
DNA:SNPs: :multiple (human)
RGD PMID:20952683, PMID:22294627 RGD:8548776, RGD:8548787 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375
JBrowse link
G MMP3 matrix metallopeptidase 3 ISO RGD PMID:19332626 RGD:8693671 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased activity:saliva RGD PMID:9923658, PMID:15316122 RGD:8547814, RGD:8547858 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G MUC16 mucin 16, cell surface associated ISO mRNA, protein:increased expression:conjunctival epithelial cell, tear RGD PMID:19122828 RGD:7364772 NCBI chr19:8,416,393...8,568,418 JBrowse link
G MUC19 mucin 19, oligomeric ISO mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18184611 RGD:7364736 NCBI chr12:48,135,613...48,319,443 JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18184611 RGD:7364736 NCBI chr11:1,191,223...1,234,373 JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28135245 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G PHIP pleckstrin homology domain interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 6:76,785,886...76,929,475
Ensembl chr 6:80,064,340...80,184,036
JBrowse link
G PON1 paraoxonase 1 ISO protein:decreased activity:serum (human) RGD PMID:20497955 RGD:8547550 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
JBrowse link
G PRDM1 PR/SET domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 no_association ISO DNA:snp:cds:c.1858C>T (human) RGD PMID:15933742, PMID:16163373 RGD:11534998, RGD:11534999 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G PTTG1 PTTG1 regulator of sister chromatid separation, securin ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 5:155,812,745...155,819,684
Ensembl chr 5:162,506,832...162,513,869
JBrowse link
G SELP selectin P ISO protein:increased expression:plasma RGD PMID:19832990 RGD:6478702 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility
no_association
ISO DNA:SNP:intron: (rs7582694) (human)
DNA:SNP:intron: (rs7574865) (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:18273036, PMID:20360187, PMID:20535138, PMID:24097066, PMID:24097067 RGD:8661690, RGD:8661708, RGD:8661709 NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011
JBrowse link
G TGFB1 transforming growth factor beta 1 severity ISO RGD PMID:7554451, PMID:9358754 RGD:7394829, RGD:7394845 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G TNF tumor necrosis factor treatment ISO DNA:polymorphism: :-1031T>C(human) RGD PMID:22703762, PMID:24941846 RGD:10450595, RGD:7394766 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066, PMID:24097067 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819
JBrowse link
G TNIP1 TNFAIP3 interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 5:146,457,347...146,514,515
Ensembl chr 5:152,459,868...152,510,540
JBrowse link
G VIM vimentin ISO RGD PMID:6352937 RGD:6480477 NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642
JBrowse link
G VIP vasoactive intestinal peptide ISO RGD PMID:22059987 RGD:5685375 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730
JBrowse link
Sjögren-Mikulicz Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTM1 glutathione S-transferase mu 1 susceptibility ISO DNA:deletion: : RGD PMID:10616008 RGD:5491001 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
Systemic Juvenile Rheumatoid Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:26914138 RGD:11529541 NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352
JBrowse link
G IL6 interleukin 6 ISO OMIM NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor treatment ISO RGD PMID:18358927 RGD:10402823 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089
JBrowse link
G MIF macrophage migration inhibitory factor ISO OMIM NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12770
    disease of anatomical entity 12302
      musculoskeletal system disease 5217
        autoimmune disease of musculoskeletal system 801
          rheumatic disease 628
            rheumatoid arthritis 404
              Caplan's syndrome 0
              Felty's syndrome 0
              Rheumatoid Nodule 0
              Rheumatoid Vasculitis 0
              Sjogren's syndrome + 50
              Sjögren-Mikulicz Syndrome 1
              adult-onset Still's disease 2
              juvenile rheumatoid arthritis + 146
              palindromic rheumatism 0
Path 2
Term Annotations click to browse term
  disease 12770
    disease of anatomical entity 12302
      Immune & Inflammatory Diseases 2912
        immune system disease 2474
          primary immunodeficiency disease 1945
            autoimmune disease 1329
              autoimmune disease of musculoskeletal system 801
                rheumatic disease 628
                  rheumatoid arthritis 404
                    Caplan's syndrome 0
                    Felty's syndrome 0
                    Rheumatoid Nodule 0
                    Rheumatoid Vasculitis 0
                    Sjogren's syndrome + 50
                    Sjögren-Mikulicz Syndrome 1
                    adult-onset Still's disease 2
                    juvenile rheumatoid arthritis + 146
                    palindromic rheumatism 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.