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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatoid arthritis
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Accession:DOID:7148 term browser browse the term
Definition:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (DO)
Synonyms:exact_synonym: RA;   RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO;   atrophic arthritis;   rheumatic arthritis or polyarthritis
 narrow_synonym: RHEUMATOID ARTHRITIS, PROGRESSION OF
 primary_id: MESH:D001172
 alt_id: OMIM:180300
 xref: ICD10CM:M06.9;   ICD9CM:714.0;   NCI:C2884
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin IEA GAD PMID:15118671 RGD:1331525 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20080907, PMID:22104130 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACAN aggrecan disease_progression IEP
EXP
protein:increased degradation:cartilage
CTD Direct Evidence: marker/mechanism
CTD PMID:15292528, PMID:16507130 RGD:11570537 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G ACKR3 atypical chemokine receptor 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 2:236,537,131...236,582,358
Ensembl chr 2:236,567,787...236,582,354
JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 IEP mRNA:increased expression:synovium RGD PMID:11801682 RGD:10043106 NCBI chr 1:161,184,302...161,202,339
Ensembl chr 1:161,184,302...161,199,054
JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 IEP protein:alternative form:synovium RGD PMID:11801682 RGD:10043106 NCBI chr21:26,917,922...26,967,758
Ensembl chr21:26,917,922...26,967,088
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing IEP
EXP
protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12833524, PMID:21789720 RGD:5686424 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADORA2A adenosine A2a receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G ADRB3 adrenoceptor beta 3 IAGP DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:12739037 RGD:5684893 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G AFF3 AF4/FMR2 family member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 2:99,545,419...100,142,590
Ensembl chr 2:99,545,419...100,192,428
JBrowse link
G AGER advanced glycosylation end-product specific receptor IEP
EXP
protein:decreased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:16385501, PMID:20541603 RGD:7244141 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:18617548 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G ANG angiogenin IEP RGD PMID:12653852 RGD:6892721 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971
JBrowse link
G ANKRD55 ankyrin repeat domain 55 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 5:56,099,680...56,233,330
Ensembl chr 5:56,099,680...56,233,330
JBrowse link
G ANXA3 annexin A3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 4:78,551,761...78,610,447
Ensembl chr 4:78,551,747...78,610,451
JBrowse link
G AP4B1-AS1 AP4B1 antisense RNA 1 IAGP ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:15004560, PMID:15208781, PMID:15273934, PMID:15580548, PMID:15719322, PMID:15744042, PMID:16273109, PMID:16339849, PMID:16470599, PMID:17170052, PMID:17436241, PMID:17554300, PMID:17878369, PMID:18301444, PMID:18978792, PMID:19265110, PMID:19430480, PMID:19898480, PMID:21841778, PMID:28492532 NCBI chr 1:113,812,612...113,901,237
Ensembl chr 1:113,856,635...113,901,237
JBrowse link
G APOA4 apolipoprotein A4 IEP protein:increased expression:blood serum (human) RGD PMID:20367977 RGD:5685646 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G ARID5B AT-rich interaction domain 5B EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963, PMID:23143596 NCBI chr10:61,901,254...62,096,944
Ensembl chr10:61,901,684...62,096,944
JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19193698 NCBI chr 2:215,311,974...215,359,745
Ensembl chr 2:215,311,956...215,349,773
JBrowse link
G B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 2:62,196,115...62,224,731
Ensembl chr 2:62,196,115...62,224,731
JBrowse link
G B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr16:67,148,104...67,150,998
Ensembl chr16:67,148,104...67,150,998
JBrowse link
G BAIAP2L1 BAR/IMD domain containing adaptor protein 2 like 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 7:98,291,650...98,401,090
Ensembl chr 7:98,291,650...98,401,090
JBrowse link
G BCL2A1 BCL2 related protein A1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BDKRB2 bradykinin receptor B2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein IDA
IEP
protein:increased expression:serum RGD PMID:22447331, PMID:3488088 RGD:6483593, RGD:6483600 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BGN biglycan EXP CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr  X:153,494,980...153,509,546
Ensembl chr  X:153,494,980...153,509,546
JBrowse link
G BLK BLK proto-oncogene, Src family tyrosine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 8:11,493,991...11,564,599
Ensembl chr 8:11,486,894...11,564,599
JBrowse link
G BMP4 bone morphogenetic protein 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G BMP6 bone morphogenetic protein 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G BTNL2 butyrophilin like 2 susceptibility IAGP DNA:SNPs: : RGD PMID:23364395 RGD:9685033 NCBI chr 6:32,393,339...32,408,879
Ensembl chr 6:32,393,963...32,407,128
JBrowse link
G C3 complement C3 IEP RGD PMID:7561187 RGD:11040775 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G C4B complement C4B (Chido blood group) IAGP RGD PMID:22076784 RGD:5688263 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G CALD1 caldesmon 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 7:134,779,629...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CASP7 caspase 7 IEP RGD PMID:18785314 RGD:5684540 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CAST calpastatin IDA RGD PMID:7706496 RGD:5683620 NCBI chr 5:96,662,037...96,774,683
Ensembl chr 5:96,525,267...96,779,595
JBrowse link
G CAT catalase EXP CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV2 caveolin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 7:116,499,738...116,508,541
Ensembl chr 7:116,287,380...116,508,541
JBrowse link
G CCL2 C-C motif chemokine ligand 2 IEP protein:increased expression:serum RGD PMID:20056091 RGD:4891442 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL21 C-C motif chemokine ligand 21 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136
JBrowse link
G CCL22 C-C motif chemokine ligand 22 IEP protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chr16:57,358,783...57,366,189
Ensembl chr16:57,358,783...57,366,189
JBrowse link
G CCL8 C-C motif chemokine ligand 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr17:34,319,435...34,321,402
Ensembl chr17:34,319,435...34,321,402
JBrowse link
G CCN1 cellular communication network factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589
Ensembl chr 1:85,580,761...85,584,589
JBrowse link
G CCN2 cellular communication network factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CCR1 C-C motif chemokine receptor 1 IMP RGD PMID:12860725 RGD:5688170 NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313
JBrowse link
G CCR3 C-C motif chemokine receptor 3 IEP protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr 3:46,210,699...46,266,706
Ensembl chr 3:46,163,604...46,266,706
JBrowse link
G CCR4 C-C motif chemokine receptor 4 IEP protein:increased expression:synovial membrane:
mRNA:increased expression:synovium:
RGD PMID:19942450, PMID:25430645 RGD:10054497, RGD:10054499 NCBI chr 3:32,951,555...32,956,349
Ensembl chr 3:32,951,644...32,956,349
JBrowse link
G CCR5 C-C motif chemokine receptor 5 resistance
no_association
IAGP DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD PMID:16541097, PMID:17565662 RGD:1626290, RGD:1626283 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G CCR6 C-C motif chemokine receptor 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453841, PMID:20453842, PMID:23143596 NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,696
JBrowse link
G CD2 CD2 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:116,754,430...116,769,229
Ensembl chr 1:116,754,430...116,769,229
JBrowse link
G CD244 CD244 molecule susceptibility IAGP
EXP
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:18794858 NCBI chr 1:160,830,160...160,862,892
Ensembl chr 1:160,830,160...160,862,887
JBrowse link
G CD28 CD28 molecule IEP
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596, PMID:19075187 RGD:5131619 NCBI chr 2:203,706,509...203,739,756
Ensembl chr 2:203,706,475...203,738,912
JBrowse link
G CD3E CD3e molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr11:118,304,730...118,316,173
Ensembl chr11:118,304,730...118,316,175
Ensembl chr11:118,304,730...118,316,175
JBrowse link
G CD40 CD40 molecule IAGP
EXP
DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:18794853, PMID:20453842, PMID:23143596, PMID:20498205 RGD:5490972 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CD5 CD5 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr11:61,093,963...61,127,852
Ensembl chr11:61,102,489...61,127,852
JBrowse link
G CD80 CD80 molecule IEP protein:increased expression:serum RGD PMID:22917707 RGD:6893647 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G CD83 CD83 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918
JBrowse link
G CDK6 cyclin dependent kinase 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18794853 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CEBPB CCAAT enhancer binding protein beta IEP protein:increased expression:knee, articular cartilage (human) RGD PMID:19248099 RGD:10401213 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CHI3L1 chitinase 3 like 1 severity IEP protein:increased secretion:serum (human) RGD PMID:10461474 RGD:4892605 NCBI chr 1:203,178,931...203,186,704
Ensembl chr 1:203,178,931...203,186,704
JBrowse link
G CIITA class II major histocompatibility complex transactivator susceptibility
no_association
IAGP
EXP
DNA:haplotype:promoter/CDS:rs3087456G/rs4774C
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
DNA:polymorphism:promoter:-168A>G
DNA:polymorphism:promoter:rs3087456, no association in a German cohort
CTD
OMIM
ClinVar
PMID:15821736, PMID:16849401, PMID:19221398, PMID:15821736, PMID:16426246 RGD:5491176, RGD:1358146, RGD:5491189 NCBI chr16:10,866,208...10,941,562
Ensembl chr16:10,866,222...10,943,021
JBrowse link
G CLEC12A C-type lectin domain family 12 member A EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr12:9,951,268...9,995,209
Ensembl chr12:9,951,316...9,995,694
JBrowse link
G CLEC16A C-type lectin domain containing 16A IAGP DNA:polymorphism:intron:rs6498169G RGD PMID:19221398 RGD:5491176 NCBI chr16:10,944,539...11,193,272
Ensembl chr16:10,944,564...11,182,186
JBrowse link
G COL2A1 collagen type II alpha 1 chain EXP CTD Direct Evidence: marker/mechanism CTD PMID:27028940, PMID:29935983 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CP ceruloplasmin EXP CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CRP C-reactive protein IEP
EXP
ISO
protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:1568518, PMID:22173958, PMID:22173958 RGD:6904209, RGD:6904209 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CSF2 colony stimulating factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,867,771...203,873,965
JBrowse link
G CTSD cathepsin D EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 IEP RGD PMID:11465708 RGD:4892002 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:19192274 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 IEP protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr  X:71,615,913...71,618,515
Ensembl chr  X:71,615,916...71,618,511
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G DDIT4 DNA damage inducible transcript 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
JBrowse link
G DDX6 DEAD-box helicase 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr11:118,747,763...118,791,696
Ensembl chr11:118,747,763...118,791,164
JBrowse link
G DHFR dihydrofolate reductase EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DNASE1L3 deoxyribonuclease 1 like 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr 3:58,192,257...58,210,972
Ensembl chr 3:58,192,257...58,214,697
JBrowse link
G DNASE2 deoxyribonuclease 2, lysosomal ISS OMIM:180300 MouseDO NCBI chr19:12,875,209...12,881,449
Ensembl chr19:12,875,209...12,881,466
JBrowse link
G DNMT1 DNA methyltransferase 1 severity IEP mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta disease_progression IAGP DNA:polymorphism:promoter:-283C>T(human) RGD PMID:19777235 RGD:9589110 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G EDN1 endothelin 1 treatment IDA RGD PMID:22249931 RGD:8661695 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G ELN elastin IDA RGD PMID:12643515 RGD:9585739 NCBI chr 7:74,027,772...74,069,907
Ensembl chr 7:74,027,789...74,069,907
JBrowse link
G ENO1 enolase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19898480 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G EPAS1 endothelial PAS domain protein 1 IEP protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G ESR2 estrogen receptor 2 severity IAGP DNA:SNP:exon:rs1256049(human) RGD PMID:21523342 RGD:5508794 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G F2 coagulation factor II, thrombin EXP CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FAS Fas cell surface death receptor susceptibility IAGP
IMP
IEP
DNA:snp:promoter:g.-670A>G (human)
protein:increased expression:serum (human)
RGD PMID:23053964, PMID:20875116, PMID:12148596 RGD:8662433, RGD:12903969, RGD:8662455 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand EXP CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia IEP protein:increased expression:synovial joint: RGD PMID:16670289 RGD:9685708 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,792,518
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa IAGP
EXP
IDA
DNA:polymorphism: :p.H131R (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:20453842, PMID:23143596, PMID:12508778, PMID:8254199 RGD:5147978, RGD:5147984 NCBI chr 1:161,505,430...161,524,048
Ensembl chr 1:161,505,430...161,524,013
JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa susceptibility IAGP
IEP
DNA:polymorphism:exon:p.F158V(rs396991)(human)
DNA:CNVs
protein:decreased expression:NK cell
RGD PMID:19019892, PMID:25154742, PMID:15334114 RGD:5508391, RGD:11344974, RGD:5508467 NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,737
JBrowse link
G FKBP5 FKBP prolyl isomerase 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
JBrowse link
G FOXO3 forkhead box O3 IEP mRNA,protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell,synovium: RGD PMID:19435720 RGD:10402186 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FOXP3 forkhead box P3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20476861 NCBI chr  X:49,250,436...49,264,932
Ensembl chr  X:49,250,438...49,270,477
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G FPGS folylpolyglutamate synthase EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 9:127,802,858...127,814,520
Ensembl chr 9:127,794,597...127,814,327
JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr21:33,503,931...33,542,892
Ensembl chr21:33,503,931...33,543,491
JBrowse link
G GATA3 GATA binding protein 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr10:8,045,420...8,075,198
Ensembl chr10:8,045,378...8,075,198
JBrowse link
G GC GC vitamin D binding protein IEP
EXP
protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD PMID:3874814, PMID:9548303 RGD:5509931 NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041
JBrowse link
G GDF5 growth differentiation factor 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18830904 NCBI chr20:35,433,347...35,454,749
Ensembl chr20:35,433,347...35,454,746
JBrowse link
G GGH gamma-glutamyl hydrolase EXP CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 8:63,015,079...63,038,806
Ensembl chr 8:63,015,079...63,038,806
JBrowse link
G GIN1 gypsy retrotransposon integrase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 5:103,086,000...103,120,149
Ensembl chr 5:103,086,000...103,120,138
JBrowse link
G GPRC5A G protein-coupled receptor class C group 5 member A EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr12:12,891,562...12,917,937
Ensembl chr12:12,890,782...12,917,937
Ensembl chr12:12,890,782...12,917,937
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO
EXP
IEP
DNA: deletion: : heterozygous
CTD Direct Evidence: marker/mechanism
protein: decreased expression: mononuclear leukocytes
CTD PMID:10094932, PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 no_association ISO
IEP
DNA: deletion::GRK2 and GRK6 deletions resulted in more severe arthritis
protein: : mononuclear blood cells
RGD PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO
EXP
IEP
DNA: deletion: : homozygous
CTD Direct Evidence: marker/mechanism
protein: decreased expression: mononuclear leukocytes
CTD PMID:10094932, PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr 5:177,426,496...177,442,891
Ensembl chr 5:177,403,204...177,442,901
JBrowse link
G GSDME gasdermin E EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 7:24,698,355...24,762,235
Ensembl chr 7:24,698,355...24,757,940
JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility IAGP DNA:deletion: :
DNA:deletion: :
RGD PMID:16887863, PMID:15940757, PMID:16870093 RGD:5490993, RGD:5490998, RGD:5490994 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTT1 glutathione S-transferase theta 1 severity
susceptibility
IAGP DNA:deletion: : RGD PMID:19473562, PMID:20401725, PMID:20597111 RGD:5490553, RGD:5490983, RGD:5490982
G HAPLN1 hyaluronan and proteoglycan link protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 5:83,637,805...83,721,210
Ensembl chr 5:83,637,805...83,720,855
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 3:121,631,399...121,660,903
Ensembl chr 3:121,631,399...121,660,927
JBrowse link
G HDAC1 histone deacetylase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:32289289 NCBI chr 1:32,292,083...32,333,628
Ensembl chr 1:32,292,083...32,333,635
JBrowse link
G HFE homeostatic iron regulator IAGP DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HGF hepatocyte growth factor disease_progression IEP protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HLA-DPB1 major histocompatibility complex, class II, DP beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17956852, PMID:22286218 NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,990...33,089,696
JBrowse link
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 IAGP DNA:polymorphisms (human)
DNA:polymorphism (human)
RGD PMID:11482129, PMID:11454644 RGD:5147859, RGD:5147860 NCBI chr 6:32,637,406...32,654,846
Ensembl chr 6:32,628,179...32,647,062
JBrowse link
G HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 6:32,741,391...32,747,198
Ensembl chr 6:32,741,391...32,747,198
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 IAGP DNA:polymorphism (human) RGD PMID:11454644 RGD:5147860 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP
EXP
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human)
DNA:polymorphisms (human)
DNA:polymorphisms: :multiple (human)
CTD PMID:19898480, PMID:20453842, PMID:22286218, PMID:18512783, PMID:11454644, PMID:19117368, PMID:21246357 RGD:4144826, RGD:5147860, RGD:5147616, RGD:5147567 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 severity ISO RGD PMID:18025202 RGD:9685481 NCBI chr 7:26,189,920...26,200,775
Ensembl chr 7:26,173,057...26,201,529
JBrowse link
G HOXD10 homeobox D10 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:176,116,778...176,119,937
Ensembl chr 2:176,108,790...176,119,942
Ensembl chr 2:176,108,790...176,119,942
JBrowse link
G HOXD11 homeobox D11 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:176,107,280...176,109,754
Ensembl chr 2:176,104,216...176,109,754
JBrowse link
G HOXD13 homeobox D13 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:176,087,487...176,095,944
Ensembl chr 2:176,092,721...176,095,944
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 IEP mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 IEP protein:increased expression:peripheral blood lymphocyte (human) RGD PMID:22047640 RGD:5688784 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 IEP protein:increased expression:synovial joint RGD PMID:11315915 RGD:5685639 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 IEP protein:increased expression:synovial cell: RGD PMID:23739258 RGD:10402561 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,416
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 IEP protein:increased expression:serum: RGD PMID:21417552 RGD:10402843 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 IEP mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IFNG interferon gamma treatment IDA
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:1417133 RGD:8157623 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF2 insulin like growth factor 2 IAGP
IEP
DNA:loss of imprinting:synovial cell
protein:decreased expression:plasma
RGD PMID:19556211, PMID:11247331 RGD:5510001, RGD:5510014 NCBI chr11:2,129,112...2,149,603
Ensembl chr11:2,129,112...2,141,238
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IKZF3 IKAROS family zinc finger 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr17:39,757,715...39,864,312
Ensembl chr17:39,757,718...39,864,312
JBrowse link
G IL10 interleukin 10 susceptibility IAGP
EXP
ClinVar Annotator: match by term: Rheumatoid arthritis, progression of
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:12847677, PMID:22450443 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL13 interleukin 13 IEP protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL17A interleukin 17A treatment IMP RGD PMID:20926833 RGD:9068415 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16368150 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL19 interleukin 19 IAGP ClinVar Annotator: match by term: Rheumatoid arthritis, progression of ClinVar PMID:12847677 NCBI chr 1:206,770,773...206,842,981
Ensembl chr 1:206,770,764...206,842,981
JBrowse link
G IL1A interleukin 1 alpha severity IDA
IEP
associated with lung disease, interstitial
protein:increased expression:plasma, synovial fluid
RGD PMID:11192540, PMID:8162643 RGD:4142818, RGD:7794716 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta IEP
EXP
protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12566094, PMID:17379860, PMID:22450443, PMID:22414257 RGD:6482656 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist IDA
EXP
ISO
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:7706905, PMID:19192274, PMID:19447938, PMID:10637275 RGD:7174696, RGD:8549810 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G IL2 interleukin 2 IDA RGD PMID:6421522 RGD:8662948 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL20 interleukin 20 IEP RGD PMID:16947773 RGD:5147395 NCBI chr 1:206,863,565...206,869,223
Ensembl chr 1:206,865,354...206,869,223
JBrowse link
G IL21R interleukin 21 receptor ISO RGD PMID:19342640 RGD:6892964 NCBI chr16:27,402,162...27,452,043
Ensembl chr16:27,402,174...27,452,042
JBrowse link
G IL23A interleukin 23 subunit alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr12:56,334,159...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL23R interleukin 23 receptor susceptibility IAGP DNA:SNP::rs1343151(human) RGD PMID:18647855 RGD:8549596 NCBI chr 1:67,138,639...67,259,979
Ensembl chr 1:67,138,907...67,259,979
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:20476861, PMID:23143596 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL2RB interleukin 2 receptor subunit beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,125,843...37,175,054
JBrowse link
G IL3 interleukin 3 IAGP DNA: SNPs: Multiple: gene-gene interaction RGD PMID:20018070 RGD:5686905 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204
JBrowse link
G IL4R interleukin 4 receptor severity IAGP DNA:SNP: :rs1805010 (human) RGD PMID:24782180 RGD:10402783 NCBI chr16:27,313,668...27,364,778
Ensembl chr16:27,313,668...27,364,778
JBrowse link
G IL5 interleukin 5 IEP RGD PMID:22293286 RGD:5687156 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274, PMID:22450443 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6R interleukin 6 receptor EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16729287, PMID:23143596 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G IL6ST interleukin 6 signal transducer EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr  X:154,010,507...154,019,984
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRF5 interferon regulatory factor 5 IAGP
EXP
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:15657875, PMID:16642019, PMID:17599733, PMID:18063667, PMID:20453842, PMID:23143596 NCBI chr 7:128,937,032...128,950,038
Ensembl chr 7:128,937,457...128,950,038
JBrowse link
G IRF8 interferon regulatory factor 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,162...85,922,606
JBrowse link
G ITGA6 integrin subunit alpha 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,427,354...172,506,459
JBrowse link
G ITGB2 integrin subunit beta 2 IAGP ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr21:44,885,949...44,928,815
Ensembl chr21:44,885,953...44,931,989
JBrowse link
G ITPA inosine triphosphatase treatment IAGP DNA:SNP: :94C>A(human) RGD PMID:29441893 RGD:14975307 NCBI chr20:3,208,676...3,227,449
Ensembl chr20:3,208,868...3,223,870
JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:21510883 RGD:6483024 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,128,183
Ensembl chr 9:4,984,390...5,128,183
JBrowse link
G KIF5A kinesin family member 5A susceptibility IAGP
EXP
DNA:snp:intron:c.1717-152C>G (rs1678542) (human)
CTD Direct Evidence: marker/mechanism
DNA:snps:intron, 3' utr:c.2756-43A>C, c.*776C>T (rs775246, rs775251) (human)
CTD PMID:23143596, PMID:23378462, PMID:21784728 RGD:12793072, RGD:12793073 NCBI chr12:57,550,039...57,586,633
Ensembl chr12:57,546,026...57,586,633
Ensembl chr12:57,546,026...57,586,633
JBrowse link
G LCN2 lipocalin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:7554268 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
JBrowse link
G LHX2 LIM homeobox 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 9:124,011,759...124,033,301
Ensembl chr 9:124,001,670...124,033,301
JBrowse link
G LPA lipoprotein(a) IEP protein:increased expression:serum RGD PMID:21523363 RGD:5509910 NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,483...160,664,259
Ensembl chr 6:160,531,483...160,664,259
JBrowse link
G LRRK2 leucine rich repeat kinase 2 IEP RGD PMID:17082220 RGD:5508419 NCBI chr12:40,224,890...40,369,285
Ensembl chr12:40,196,744...40,369,285
JBrowse link
G LY96 lymphocyte antigen 96 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 8:73,991,275...74,099,807
Ensembl chr 8:73,991,392...74,029,079
JBrowse link
G MAB21L2 mab-21 like 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 4:150,582,151...150,584,693
Ensembl chr 4:150,582,151...150,584,693
JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 6:113,857,345...113,863,475
Ensembl chr 6:113,857,345...113,863,475
JBrowse link
G MBD2 methyl-CpG binding domain protein 2 IEP mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr18:54,151,606...54,224,669
Ensembl chr18:54,151,606...54,224,669
JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase susceptibility
no_association
IAGP DNA:snps:introns:IVS5-140A>G (rs3138355), IVS6-218C>T (rs2005618) (human)
DNA:snps:cds, intron:p.E346K, IVS6-218C>T (rs140693, rs2005618) (human)
RGD PMID:20676650, PMID:22505706 RGD:9588977, RGD:9588978 NCBI chr 3:129,430,947...129,440,029
Ensembl chr 3:129,430,944...129,440,179
JBrowse link
G MDK midkine ISO RGD PMID:15146411 RGD:1581200 NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837
JBrowse link
G MGARP mitochondria localized glutamic acid rich protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 4:139,266,165...139,280,225
Ensembl chr 4:139,266,165...139,280,225
JBrowse link
G MIF macrophage migration inhibitory factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MMEL1 membrane metalloendopeptidase like 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:2,590,639...2,633,042
Ensembl chr 1:2,590,639...2,633,016
JBrowse link
G MMP1 matrix metallopeptidase 1 IEP protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MMP10 matrix metallopeptidase 10 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628
JBrowse link
G MMP12 matrix metallopeptidase 12 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MMP14 matrix metallopeptidase 14 ISS OMIM:180300 MouseDO NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G MMP2 matrix metallopeptidase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 disease_progression IEP protein:increased expression:serum (human) RGD PMID:7639798, PMID:22314025, PMID:11796404 RGD:7207128, RGD:8693673, RGD:7241254 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MMP8 matrix metallopeptidase 8 IEP protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chr11:102,711,796...102,724,967
Ensembl chr11:102,711,796...102,727,050
JBrowse link
G MMP9 matrix metallopeptidase 9 IEP RGD PMID:16406300 RGD:1582623 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase EXP CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:26001728 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 IAGP DNA:missense mutations:cds:multiple (human) RGD PMID:15987486 RGD:5490238 NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262
JBrowse link
G MTHFR methylenetetrahydrofolate reductase IAGP
EXP
DNA:SNP: :677C>T(human)
CTD Direct Evidence: marker/mechanism
CTD PMID:22104130, PMID:23685257 RGD:7387222 NCBI chr 1:11,785,723...11,806,103
Ensembl chr 1:11,785,723...11,806,455
Ensembl chr 1:11,785,723...11,806,455
JBrowse link
G NCF1 neutrophil cytosolic factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:28135245 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NCF2 neutrophil cytosolic factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 1:183,555,562...183,590,914
Ensembl chr 1:183,555,563...183,590,876
Ensembl chr 1:183,555,563...183,590,876
JBrowse link
G NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr12:57,234,903...57,240,762
Ensembl chr12:57,234,903...57,240,715
JBrowse link
G NFKBIE NFKB inhibitor epsilon EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 6:44,258,166...44,265,551
Ensembl chr 6:44,258,166...44,265,788
JBrowse link
G NFKBIL1 NFKB inhibitor like 1 susceptibility IAGP
EXP
DNA:snp:promoter:c.-132T>A (rs2071592) (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD
OMIM
ClinVar
PMID:12509789, PMID:12509789 RGD:1331681 NCBI chr 6:31,546,851...31,558,829
Ensembl chr 6:31,546,870...31,558,829
JBrowse link
G NOTCH4 notch receptor 4 IEP mRNA : increased expression: : cd4+ cells RGD PMID:20132067 RGD:6480790 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067
JBrowse link
G NPSR1 neuropeptide S receptor 1 IAGP RGD PMID:20179762 RGD:4891930 NCBI chr 7:34,658,218...34,878,332
Ensembl chr 7:34,658,218...34,878,332
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO mRNA:increased expression:paw RGD PMID:18448865 RGD:4892311 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 9:99,821,885...99,866,893
Ensembl chr 9:99,821,855...99,866,891
JBrowse link
G PADI2 peptidyl arginine deiminase 2 IAGP ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chr 1:17,066,761...17,119,453
Ensembl chr 1:17,066,761...17,119,451
JBrowse link
G PADI4 peptidyl arginine deiminase 4 susceptibility EXP
IAGP
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD
ClinVar
OMIM
PMID:23143596 NCBI chr 1:17,308,195...17,364,004
Ensembl chr 1:17,308,195...17,364,004
JBrowse link
G PDGFB platelet derived growth factor subunit B IEP RGD PMID:1708827 RGD:6482653 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PGF placental growth factor IEP RGD PMID:19180491 RGD:6483591 NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626
JBrowse link
G PLA2G7 phospholipase A2 group VII IEP RGD PMID:17326817 RGD:6482776 NCBI chr 6:46,700,558...46,735,836
Ensembl chr 6:46,704,201...46,735,693
JBrowse link
G PLAUR plasminogen activator, urokinase receptor IDA RGD PMID:22011479 RGD:6484117 NCBI chr19:43,646,095...43,670,197
Ensembl chr19:43,646,095...43,670,547
JBrowse link
G PLB1 phospholipase B1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24520335 NCBI chr 2:28,488,578...28,644,142
Ensembl chr 2:28,457,145...28,644,142
JBrowse link
G PLD4 phospholipase D family member 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr14:104,924,301...104,937,789
Ensembl chr14:104,924,713...104,937,790
Ensembl chr14:104,924,713...104,937,790
JBrowse link
G PLEK pleckstrin EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 2:68,365,282...68,397,453
Ensembl chr 2:68,365,282...68,397,453
JBrowse link
G PON1 paraoxonase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16055108 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G POU3F1 POU class 3 homeobox 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:38,043,829...38,046,793
Ensembl chr 1:38,043,829...38,046,793
JBrowse link
G PRDM1 PR/SET domain 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596 NCBI chr 6:106,046,729...106,109,938
Ensembl chr 6:105,993,463...106,109,939
JBrowse link
G PRKCQ protein kinase C theta EXP CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr10:6,393,038...6,580,646
Ensembl chr10:6,427,143...6,580,301
JBrowse link
G PSG5 pregnancy specific beta-1-glycoprotein 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr19:43,167,743...43,186,536
Ensembl chr19:43,166,256...43,186,536
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15167967 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 IMP
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:11978490, PMID:19192274, PMID:21905970 RGD:5508313 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTK2 protein tyrosine kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr18:12,785,478...12,884,351
Ensembl chr18:12,785,478...12,929,643
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 susceptibility
no_association
IAGP
EXP
DNA:snp:cds:p.R620W (rs2476601) (human)
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
DNA:SNP::1858C>T (human)
DNA:snp:cds:p.R263Q (rs33996649) (human)
ClinVar
OMIM
CTD
PMID:15004560, PMID:15208781, PMID:15273934, PMID:15580548, PMID:15719322, PMID:15744042, PMID:16273109, PMID:16339849, PMID:16470599, PMID:17170052, PMID:17436241, PMID:17554300, PMID:17878369, PMID:18301444, PMID:18978792, PMID:19265110, PMID:19430480, PMID:19898480, PMID:20453842, PMID:21190368, PMID:21841778, PMID:23143596, PMID:28492532, PMID:30224649, PMID:15208781, PMID:21467606, PMID:21279993 RGD:6484535, RGD:7829746, RGD:6484595 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:198,639,025...198,757,476
Ensembl chr 1:198,638,457...198,757,476
JBrowse link
G PXK PX domain containing serine/threonine kinase like EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 3:58,332,890...58,426,127
Ensembl chr 3:58,332,880...58,426,127
JBrowse link
G RAB8A RAB8A, member RAS oncogene family EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr19:16,111,889...16,134,234
Ensembl chr19:16,111,889...16,134,234
JBrowse link
G RAP2A RAP2A, member of RAS oncogene family EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr13:97,434,169...97,469,128
Ensembl chr13:97,434,169...97,469,128
JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr15:38,488,097...38,564,814
Ensembl chr15:38,488,103...38,565,575
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G RCAN1 regulator of calcineurin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr21:34,516,442...34,615,123
Ensembl chr21:34,513,142...34,615,113
JBrowse link
G REL REL proto-oncogene, NF-kB subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19503088, PMID:20453842, PMID:23143596 NCBI chr 2:60,881,521...60,931,612
Ensembl chr 2:60,881,521...60,931,610
Ensembl chr 2:60,881,521...60,931,610
JBrowse link
G RGMB repulsive guidance molecule BMP co-receptor b EXP CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 5:98,768,632...98,796,494
Ensembl chr 5:98,768,650...98,798,643
JBrowse link
G RUNX1 RUNX family transcription factor 1 no_association IAGP DNA:SNPs: :rs2242720, rs4816502 (human)
DNA:SNP: :rs2268277 (human)
DNA:SNP:intron:24658G>C (human)
RGD PMID:20018071, PMID:18087673, PMID:18328148, PMID:16821265 RGD:6482836, RGD:6482840, RGD:6482839, RGD:6482837 NCBI chr21:35,372,507...35,580,764
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G RUNX1 RUNX family transcription factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr21:34,787,801...35,049,334
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G RUNX2 RUNX family transcription factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SEMA3C semaphorin 3C IEP protein:increased expression:knee, synovium (human) RGD PMID:15077297 RGD:1580084 NCBI chr 7:80,742,538...80,922,389
Ensembl chr 7:80,742,538...80,922,359
JBrowse link
G SLC11A1 solute carrier family 11 member 1 severity IAGP
EXP
DNA:polymorphism:promoter (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms, deletion: :823C>T, p.D543N (human)
CTD PMID:16597321, PMID:12135431, PMID:10719815 RGD:5684967, RGD:5684971 NCBI chr 2:218,381,766...218,396,894
Ensembl chr 2:218,382,029...218,396,894
JBrowse link
G SLC22A4 solute carrier family 22 member 4 susceptibility IAGP
EXP
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:14608356 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G SLC25A12 solute carrier family 25 member 12 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859
JBrowse link
G SMS spermine synthase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837
JBrowse link
G SOD2 superoxide dismutase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:15292528, PMID:24313545 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPP1 secreted phosphoprotein 1 IDA RGD PMID:15761492 RGD:1581382 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G SPRED2 sprouty related EVH1 domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 2:65,307,425...65,432,599
Ensembl chr 2:65,310,851...65,432,637
JBrowse link
G ST6GALNAC5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:17568789 NCBI chr 1:76,867,449...77,069,167
Ensembl chr 1:76,867,480...77,067,546
JBrowse link
G STAT1 signal transducer and activator of transcription 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 IAGP associated with T-cell large granular lymphocyte leukemia
ClinVar Annotator: match by term: Rheumatoid arthritis
ClinVar PMID:28492532, PMID:30311386, PMID:22591296 RGD:6892936 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G STAT4 signal transducer and activator of transcription 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 2:191,029,576...191,172,684
Ensembl chr 2:191,029,576...191,151,596
JBrowse link
G STS steroid sulfatase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr  X:7,147,290...7,354,641
Ensembl chr  X:7,147,237...7,804,358
JBrowse link
G SUPT20H SPT20 homolog, SAGA complex component IAGP ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chr13:37,009,312...37,059,714
Ensembl chr13:37,009,312...37,059,713
JBrowse link
G TAGAP T cell activation RhoGTPase activating protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 6:159,034,481...159,044,991
Ensembl chr 6:159,034,468...159,045,152
JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member IAGP RGD PMID:9645419 RGD:6482275 NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,770
JBrowse link
G TFPI2 tissue factor pathway inhibitor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:17379860 NCBI chr 7:93,885,396...93,890,753
Ensembl chr 7:93,885,396...93,890,753
JBrowse link
G THBD thrombomodulin IDA RGD PMID:15700117 RGD:5685020 NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672
JBrowse link
G TLE3 TLE family member 3, transcriptional corepressor EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr15:70,047,790...70,098,171
Ensembl chr15:70,047,790...70,098,176
JBrowse link
G TLR2 toll like receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TMPO thymopoietin EXP CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr12:98,515,573...98,550,351
Ensembl chr12:98,515,579...98,550,351
Ensembl chr12:98,515,579...98,550,351
JBrowse link
G TNF tumor necrosis factor treatment
no_association
IMP
EXP
IAGP
CTD Direct Evidence: marker/mechanism|therapeutic
DNA:SNP:promoter:-238G>A, -308G>A (human)
DNA:SNP:promoter:-857C>T (human)
CTD PMID:2001072, PMID:8391952, PMID:12566094, PMID:22450443, PMID:12563673, PMID:25311255, PMID:25311255 RGD:10450537, RGD:12904065, RGD:12904065 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP2 TNF alpha induced protein 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr14:103,121,175...103,137,439
Ensembl chr14:103,121,476...103,137,439
Ensembl chr14:103,121,476...103,137,439
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:21841782, PMID:23143596, PMID:30224649 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b EXP CTD Direct Evidence: therapeutic CTD PMID:23333834 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
G TNFRSF14 TNF receptor superfamily member 14 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 1:2,556,371...2,563,829
Ensembl chr 1:2,555,639...2,565,382
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A treatment IAGP DNA:SNP:promoter:36G>A (human) RGD PMID:25311255 RGD:12904065 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFSF14 TNF superfamily member 14 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr19:6,658,126...6,670,595
Ensembl chr19:6,661,253...6,670,588
JBrowse link
G TRAF1 TNF receptor associated factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:23143596 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173
JBrowse link
G TRAF6 TNF receptor associated factor 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272
JBrowse link
G TRAPPC2 trafficking protein particle complex 2 IAGP ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr  X:13,712,243...13,734,633
Ensembl chr  X:13,712,244...13,734,635
JBrowse link
G TXNDC5 thioredoxin domain containing 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23326410 NCBI chr 6:7,881,517...7,910,788
Ensembl chr 6:7,881,517...7,910,788
JBrowse link
G TXNIP thioredoxin interacting protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G TYK2 tyrosine kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr19:10,350,528...10,380,572
Ensembl chr19:10,350,529...10,380,572
JBrowse link
G TYMS thymidylate synthetase treatment IAGP DNA:polymorphism: : RGD PMID:22763757 RGD:11075093 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
G VDR vitamin D receptor no_association IAGP DNA:SNP:exon:rs2228570 (human)
DNA:SNP: :rs1544410 (human)
RGD PMID:21820934, PMID:21820934 RGD:8158077, RGD:8158077 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression IEP
EXP
protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism
CTD PMID:16368150, PMID:24387171 RGD:8548659 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VIM vimentin IDA RGD PMID:21792832 RGD:6480508 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 ISS OMIM:180300 MouseDO NCBI chr 2:97,712,030...97,744,327
Ensembl chr 2:97,713,576...97,739,862
Ensembl chr 2:97,713,576...97,739,862
JBrowse link
G ZFP36 ZFP36 ring finger protein ISS OMIM:180300 MouseDO NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
JBrowse link
adult-onset Still's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HGF hepatocyte growth factor IEP protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G VEGFA vascular endothelial growth factor A IEP protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
Juvenile Pauciarticular Chronic Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP DNA:polymorphism: :HLA-DRB1*1104, HLA-DRB1*080(human) RGD PMID:7955632 RGD:7365102 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
juvenile rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:132,317,403...132,368,765
Ensembl chr 3:132,317,369...132,368,298
JBrowse link
G ACRBP acrosin binding protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:6,638,075...6,647,432
Ensembl chr12:6,638,075...6,647,433
JBrowse link
G ADCY7 adenylate cyclase 7 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:50,246,138...50,318,135
Ensembl chr16:50,246,137...50,318,135
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:6,993,791...7,010,754
Ensembl chr17:6,996,049...7,010,754
JBrowse link
G ANKRD9 ankyrin repeat domain 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:102,501,767...102,509,776
Ensembl chr14:102,501,767...102,509,799
JBrowse link
G AOPEP aminopeptidase O (putative) EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:94,726,669...95,148,264
Ensembl chr 9:94,726,701...95,087,218
JBrowse link
G APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:38,957,609...38,963,184
Ensembl chr22:38,952,741...38,992,778
JBrowse link
G AQP9 aquaporin 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911
JBrowse link
G AREG amphiregulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005
JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:130,052,104...130,443,848
Ensembl chr 8:130,052,104...130,443,674
JBrowse link
G AVL9 AVL9 cell migration associated EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:32,495,489...32,588,726
Ensembl chr 7:32,495,426...32,588,726
JBrowse link
G B4GALT5 beta-1,4-galactosyltransferase 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr20:49,632,945...49,713,878
Ensembl chr20:49,632,945...49,713,878
JBrowse link
G BEND2 BEN domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:18,162,931...18,220,886
Ensembl chr  X:18,162,931...18,220,886
JBrowse link
G BTG1 BTG anti-proliferation factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:92,140,278...92,145,846
Ensembl chr12:92,140,278...92,145,846
JBrowse link
G BTG3 BTG anti-proliferation factor 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr21:17,593,653...17,612,940
Ensembl chr21:17,593,653...17,612,947
Ensembl chr21:17,593,653...17,612,947
JBrowse link
G C2orf88 chromosome 2 open reading frame 88 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:189,879,479...190,203,484
Ensembl chr 2:189,879,609...190,203,484
JBrowse link
G C8B complement C8 beta chain EXP CTD Direct Evidence: marker/mechanism CTD PMID:7980680 NCBI chr 1:56,929,207...56,974,383
Ensembl chr 1:56,929,207...56,966,140
JBrowse link
G C9orf72 C9orf72-SMCR8 complex subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:27,546,546...27,573,866
Ensembl chr 9:27,535,640...27,573,866
JBrowse link
G CALD1 caldesmon 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:134,779,629...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CAMSAP1 calmodulin regulated spectrin associated protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:135,808,487...135,907,551
Ensembl chr 9:135,808,487...135,907,546
JBrowse link
G CCR5 C-C motif chemokine receptor 5 no_association IAGP DNA:polymorphisms: :multiple (human)
DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
RGD PMID:16775617, PMID:17565662 RGD:1626284, RGD:1626283 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G CD14 CD14 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CD83 CD83 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918
JBrowse link
G CD8B CD8b molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:86,815,369...86,861,886
Ensembl chr 2:86,815,339...86,861,924
JBrowse link
G CIITA class II major histocompatibility complex transactivator susceptibility
no_association
IAGP DNA:polymorphism:exon:1614G>C (human)
DNA:polymorphism:promoter:rs3087456, no association in a German cohort
RGD PMID:17661914, PMID:16426246 RGD:5491187, RGD:5491189 NCBI chr16:10,866,208...10,941,562
Ensembl chr16:10,866,222...10,943,021
JBrowse link
G CLU clusterin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G CMTM2 CKLF like MARVEL transmembrane domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:66,579,463...66,588,275
Ensembl chr16:66,579,448...66,588,275
JBrowse link
G CREM cAMP responsive element modulator EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:35,126,830...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CRP C-reactive protein IEP protein:increased expression:serum RGD PMID:22885951 RGD:6906884 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,867,771...203,873,965
JBrowse link
G CTTN cortactin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:70,398,529...70,436,579
Ensembl chr11:70,398,404...70,436,584
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504, PMID:26387944 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G DAPK1 death associated protein kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:87,497,228...87,708,634
Ensembl chr 9:87,497,228...87,708,634
JBrowse link
G DDIT3 DNA damage inducible transcript 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DUSP1 dual specificity phosphatase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G DUSP2 dual specificity phosphatase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:96,143,166...96,145,468
Ensembl chr 2:96,143,169...96,145,440
JBrowse link
G DUSP4 dual specificity phosphatase 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:29,333,064...29,350,684
Ensembl chr 8:29,333,064...29,350,684
JBrowse link
G DYSF dysferlin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:71,453,154...71,686,763
Ensembl chr 2:71,453,722...71,686,768
JBrowse link
G EGF epidermal growth factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGR1 early growth response 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ELF2 E74 like ETS transcription factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:139,057,220...139,177,218
Ensembl chr 4:139,028,112...139,177,218
JBrowse link
G ETNK1 ethanolamine kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:22,625,145...22,690,665
Ensembl chr12:22,625,075...22,690,665
JBrowse link
G ETV6 ETS variant transcription factor 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:11,649,601...11,895,386
Ensembl chr12:11,649,674...11,895,377
Ensembl chr12:11,649,674...11,895,377
JBrowse link
G FAM20A FAM20A golgi associated secretory pathway pseudokinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:68,530,276...68,601,367
Ensembl chr17:68,535,113...68,601,367
JBrowse link
G FAXDC2 fatty acid hydroxylase domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:154,817,018...154,850,683
Ensembl chr 5:154,818,492...154,859,252
JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,792,518
JBrowse link
G FCHSD2 FCH and double SH3 domains 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:72,836,743...73,142,682
Ensembl chr11:72,836,745...73,142,318
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:28,392,855...28,417,317
Ensembl chr 2:28,392,448...28,417,317
JBrowse link
G FOXP1 forkhead box P1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:70,954,708...71,583,983
Ensembl chr 3:70,952,817...71,583,993
Ensembl chr 3:70,952,817...71,583,993
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GMPR guanosine monophosphate reductase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:16,238,587...16,295,549
Ensembl chr 6:16,238,587...16,295,549
JBrowse link
G GNG11 G protein subunit gamma 11 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:93,921,735...93,928,610
Ensembl chr 7:93,921,735...93,928,610
JBrowse link
G GP1BB glycoprotein Ib platelet subunit beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:19,723,539...19,724,771
Ensembl chr22:19,723,539...19,724,771
Ensembl chr22:19,723,539...19,724,771
JBrowse link
G GSTT1 glutathione S-transferase theta 1 susceptibility IAGP DNA:deletion: : RGD PMID:18328165 RGD:5490992
G H2AC8 H2A clustered histone 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:26,216,921...26,217,483
Ensembl chr 6:26,216,975...26,217,483
JBrowse link
G H2BC8 H2B clustered histone 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:26,216,200...26,216,688
Ensembl chr 6:26,215,159...26,216,692
JBrowse link
G HBEGF heparin binding EGF like growth factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
JBrowse link
G HERPUD2 HERPUD family member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:35,632,659...35,695,811
Ensembl chr 7:35,632,659...35,697,459
Ensembl chr 7:35,632,659...35,697,459
JBrowse link
G HFE homeostatic iron regulator IAGP DNA:missense mutation:cds:p.C282Y (human) RGD PMID:16047841 RGD:8694357 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 IEP
IAGP
DNA:polymorphism (human) RGD PMID:19811310, PMID:10457895 RGD:5147815, RGD:5147863 NCBI chr 6:32,637,406...32,654,846
Ensembl chr 6:32,628,179...32,647,062
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 IAGP DNA:polymorphism (human) RGD PMID:10457895 RGD:5147863 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 IAGP DNA:polymorphism (human) RGD PMID:19908388, PMID:10457895 RGD:5147587, RGD:5147863 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 IEP protein:increased expression:serum,synovial fluid: RGD PMID:8255671 RGD:12910480 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IGF1R insulin like growth factor 1 receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IL1A interleukin 1 alpha IAGP DNA:SNP:promoter:-889C>T (human) RGD PMID:8162643 RGD:7794716 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1RN interleukin 1 receptor antagonist EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G IL2 interleukin 2 IEP protein:increased expression:mononuclear cell RGD PMID:21859687 RGD:5147870 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 IEP
IEA
protein:increased expression:serum:
OMIM:604302
MouseDO PMID:9489833 RGD:7829742 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGA2B integrin subunit alpha 2b EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649
JBrowse link
G ITGB5 integrin subunit beta 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:124,761,948...124,901,418
Ensembl chr 3:124,761,948...124,901,418
JBrowse link
G JMJD1C jumonji domain containing 1C EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:63,167,221...63,521,890
Ensembl chr10:63,167,221...63,521,850
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KAT6B lysine acetyltransferase 6B EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:74,824,927...75,032,624
Ensembl chr10:74,824,927...75,032,624
JBrowse link
G KCNJ15 potassium inwardly rectifying channel subfamily J member 15 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr21:38,229,926...38,307,357
Ensembl chr21:38,155,549...38,307,357
JBrowse link
G KLF4 Kruppel like factor 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
JBrowse link
G KRAS KRAS proto-oncogene, GTPase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G LACC1 laccase domain containing 1 IAGP ClinVar Annotator: match by term: JUVENILE ARTHRITIS OMIM
ClinVar
PMID:25147203, PMID:25220867, PMID:27881174, PMID:29717096, PMID:30872671 NCBI chr13:43,879,178...43,893,932
Ensembl chr13:43,879,284...43,893,932
JBrowse link
G LILRA5 leukocyte immunoglobulin like receptor A5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:54,307,070...54,313,166
Ensembl chr19:54,307,070...54,313,166
JBrowse link
G LPP LIM domain containing preferred translocation partner in lipoma EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:188,152,152...188,890,671
Ensembl chr 3:188,153,284...188,890,671
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243
JBrowse link
G MAFF MAF bZIP transcription factor F EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAML2 mastermind like transcriptional coactivator 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:95,976,598...96,343,308
Ensembl chr11:95,976,598...96,343,195
JBrowse link
G MAP2 microtubule associated protein 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,058...209,734,118
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MBL2 mannose binding lectin 2 IEP RGD PMID:18334024 RGD:12910845 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G MEX3C mex-3 RNA binding family member C EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:51,174,550...51,197,681
Ensembl chr18:51,174,550...51,218,333
Ensembl chr18:51,174,550...51,218,333
JBrowse link
G MIF macrophage migration inhibitory factor IEA OMIM:604302 MouseDO NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MIR22HG MIR22 host gene EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:1,711,504...1,716,272
Ensembl chr17:1,711,493...1,717,174
JBrowse link
G MS4A4A membrane spanning 4-domains A4A EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:60,280,666...60,308,970
Ensembl chr11:60,185,702...60,317,944
JBrowse link
G MSN moesin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:65,588,382...65,741,931
Ensembl chr  X:65,588,377...65,741,931
JBrowse link
G MTSS1 MTSS I-BAR domain containing 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:124,550,784...124,728,473
Ensembl chr 8:124,550,784...124,728,473
Ensembl chr 8:124,550,784...124,728,473
JBrowse link
G MYZAP myocardial zonula adherens protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:57,591,904...57,685,364
Ensembl chr15:57,591,904...57,685,364
JBrowse link
G NDEL1 nudE neurodevelopment protein 1 like 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:8,435,884...8,472,744
Ensembl chr17:8,413,131...8,490,411
JBrowse link
G NEAT1 nuclear paraspeckle assembly transcript 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:65,422,798...65,445,540
Ensembl chr11:65,422,774...65,445,540
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:99,821,885...99,866,893
Ensembl chr 9:99,821,855...99,866,891
JBrowse link
G NRG1 neuregulin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G OSM oncostatin M EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
JBrowse link
G PACSIN2 protein kinase C and casein kinase substrate in neurons 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr22:42,869,766...43,015,149
Ensembl chr22:42,835,412...43,015,149
JBrowse link
G PCYT1B phosphate cytidylyltransferase 1, choline, beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:24,558,087...24,672,887
Ensembl chr  X:24,558,087...24,672,677
JBrowse link
G PER1 period circadian regulator 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:8,140,470...8,156,360
Ensembl chr17:8,140,472...8,156,506
JBrowse link
G PGM5 phosphoglucomutase 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:68,356,584...68,531,061
Ensembl chr 9:68,328,308...68,531,061
JBrowse link
G PLAUR plasminogen activator, urokinase receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:43,646,095...43,670,197
Ensembl chr19:43,646,095...43,670,547
JBrowse link
G PLK2 polo like kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139
JBrowse link
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:146,069,437...146,161,184
Ensembl chr 3:146,069,440...146,163,653
JBrowse link
G PROS1 protein S EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:93,873,051...93,973,896
Ensembl chr 3:93,873,051...93,980,003
Ensembl chr 3:93,873,051...93,980,003
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 IAGP DNA: snp : cds : rs2476601 RGD PMID:15934099 RGD:6484550 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G R3HDM2 R3H domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:57,253,764...57,431,043
Ensembl chr12:57,253,762...57,431,005
JBrowse link
G RASGEF1B RasGEF domain family member 1B EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:81,426,393...81,471,907
Ensembl chr 4:81,426,393...82,044,244
JBrowse link
G RBM47 RNA binding motif protein 47 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:40,423,270...40,630,911
Ensembl chr 4:40,423,267...40,630,875
JBrowse link
G RERE arginine-glutamic acid dipeptide repeats EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:8,352,404...8,817,640
Ensembl chr 1:8,352,397...8,848,921
JBrowse link
G RHOBTB1 Rho related BTB domain containing 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:60,869,438...61,001,486
Ensembl chr10:60,869,438...61,001,440
JBrowse link
G RNF103 ring finger protein 103 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:86,603,393...86,623,877
Ensembl chr 2:86,603,398...86,623,866
JBrowse link
G SELP selectin P severity IEP protein:increased expression:plasma RGD PMID:21124648 RGD:6219006 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G SH2D2A SH2 domain containing 2A IAGP DNA:polymorphism:promoter RGD PMID:15129233 RGD:2298870 NCBI chr 1:156,806,238...156,816,853
Ensembl chr 1:156,806,243...156,816,848
Ensembl chr 1:156,806,243...156,816,848
JBrowse link
G SH3BGRL2 SH3 domain binding glutamate rich protein like 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:79,631,329...79,703,659
Ensembl chr 6:79,631,329...79,703,655
JBrowse link
G SIK1 salt inducible kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr21:43,414,483...43,427,131
Ensembl chr21:43,414,483...43,427,131
JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:71,320,418...71,741,209
Ensembl chr14:71,320,449...71,741,229
JBrowse link
G SLC11A1 solute carrier family 11 member 1 IAGP
EXP
DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:16597321, PMID:10857800 RGD:5684977 NCBI chr 2:218,381,766...218,396,894
Ensembl chr 2:218,382,029...218,396,894
JBrowse link
G SLC22A16 solute carrier family 22 member 16 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:110,424,587...110,476,674
Ensembl chr 6:110,424,687...110,476,641
JBrowse link
G SLC26A2 solute carrier family 26 member 2 susceptibility IAGP DNA:SNPs: : RGD PMID:17393463 RGD:13208931 NCBI chr 5:149,960,758...149,987,400
Ensembl chr 5:149,960,758...149,993,455
Ensembl chr 5:149,960,758...149,993,455
JBrowse link
G SLC2A3 solute carrier family 2 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G SMAD3 SMAD family member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G STAB1 stabilin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:52,495,338...52,524,496
Ensembl chr 3:52,495,338...52,524,495
JBrowse link
G STAT3 signal transducer and activator of transcription 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G STIM1 stromal interaction molecule 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:3,854,604...4,093,210
Ensembl chr11:3,854,527...4,093,210
JBrowse link
G TCF7L2 transcription factor 7 like 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:112,950,247...113,167,678
Ensembl chr10:112,950,247...113,167,678
JBrowse link
G TFDP1 transcription factor Dp-1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:113,584,688...113,641,473
Ensembl chr13:113,584,721...113,641,473
JBrowse link
G TFPI tissue factor pathway inhibitor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:187,464,230...187,554,501
Ensembl chr 2:187,464,230...187,565,760
JBrowse link
G THBD thrombomodulin IEP protein:increased expression:serum RGD PMID:15209962 RGD:5685023 NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672
JBrowse link
G THBS1 thrombospondin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:151,357,592...151,380,046
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G TNFAIP8 TNF alpha induced protein 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:119,268,759...119,399,688
Ensembl chr 5:119,268,692...119,399,688
JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,590...23,117,437
Ensembl chr 8:23,102,590...23,117,437
JBrowse link
G TNIK TRAF2 and NCK interacting kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:171,058,414...171,460,408
Ensembl chr 3:171,058,414...171,460,408
JBrowse link
G TREML1 triggering receptor expressed on myeloid cells like 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:41,149,097...41,158,450
Ensembl chr 6:41,149,342...41,154,337
JBrowse link
G TTLL5 tubulin tyrosine ligase like 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:75,661,246...75,955,079
Ensembl chr14:75,633,625...75,955,079
JBrowse link
G TUBB2A tubulin beta 2A class IIa EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:3,153,666...3,157,544
Ensembl chr 6:3,153,666...3,157,544
JBrowse link
G UBE2E1 ubiquitin conjugating enzyme E2 E1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:23,805,955...23,891,640
Ensembl chr 3:23,805,955...23,891,640
JBrowse link
G UBE3C ubiquitin protein ligase E3C EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:157,138,926...157,269,370
Ensembl chr 7:157,138,916...157,269,370
JBrowse link
G UHRF1BP1L UHRF1 binding protein 1 like EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:100,026,251...100,142,874
Ensembl chr12:100,028,455...100,142,874
JBrowse link
G WASF3 WASP family member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:26,539,139...26,688,948
Ensembl chr13:26,557,683...26,688,948
JBrowse link
G WWOX WW domain containing oxidoreductase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:78,099,654...79,212,667
Ensembl chr16:78,099,430...79,212,667
JBrowse link
G ZFAND3 zinc finger AN1-type containing 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:37,819,727...38,154,624
Ensembl chr 6:37,819,727...38,154,624
JBrowse link
G ZFC3H1 zinc finger C3H1-type containing EXP CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:71,609,599...71,663,848
Ensembl chr12:71,609,472...71,667,725
Ensembl chr12:71,609,472...71,667,725
JBrowse link
Sjogren's syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIRE autoimmune regulator ISS OMIM:270150 MouseDO NCBI chr21:44,285,876...44,298,648
Ensembl chr21:44,285,838...44,298,648
JBrowse link
G APOE apolipoprotein E onset IAGP DNA:polymorphism:exon: RGD PMID:15328426 RGD:7495765 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G BDNF brain derived neurotrophic factor severity IEP protein:increased expression:serum: RGD PMID:18830907 RGD:8657019 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BST2 bone marrow stromal cell antigen 2 IEP mRNA, protein:increased expression: labial gland, CD19+ B cell, CD4-CD8-CD19-monocyte: RGD PMID:30249485 RGD:14398821 NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630
JBrowse link
G C3 complement C3 ISO RGD PMID:17675493 RGD:7401265 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G CAST calpastatin IDA associated with Lupus Erythematosus, Systemic RGD PMID:15540513 RGD:5683622 NCBI chr 5:96,662,037...96,774,683
Ensembl chr 5:96,525,267...96,779,595
JBrowse link
G CCR5 C-C motif chemokine receptor 5 no_association IAGP DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD PMID:12412204, PMID:23773920 RGD:8551796, RGD:8551818 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G CCR7 C-C motif chemokine receptor 7 ISS OMIM:270150 MouseDO NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472
JBrowse link
G CD40LG CD40 ligand IEP protein:increased expression:salivary ductal epithelium (human) RGD PMID:12472667 RGD:11520791 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CRP C-reactive protein IEP associated with Arthritis, Rheumatoid;protein:increased expression:serum: RGD PMID:2353152, PMID:16013223 RGD:9491774, RGD:9491835 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 susceptibility IAGP
IEP
DNA:SNPs,haplotype: :+49A/G (rs231775),(rs3087243)(human)
mRNA:increased expression:salivary gland:
RGD PMID:16869018, PMID:12528117 RGD:7421506, RGD:7421519 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,867,771...203,873,965
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISS OMIM:270150 MouseDO NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 IAGP associated with Arthritis, Rheumatoid;DNA:polymorphism: :4889A>G (human) RGD PMID:12590982 RGD:5147747 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DGKQ diacylglycerol kinase theta EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 4:958,887...973,569
Ensembl chr 4:958,887...986,895
JBrowse link
G E2F1 E2F transcription factor 1 ISS OMIM:270150 MouseDO NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G FAS Fas cell surface death receptor IEP
ISS
ISO
protein:increased expression:serum (human)
OMIM:270150
protein:decreased expression:lacrimal gland, lymphocyte (mouse)
MouseDO PMID:9890678, PMID:9870874, PMID:11157873 RGD:8662410, RGD:8662451, RGD:8662436 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 1:161,505,430...161,524,048
Ensembl chr 1:161,505,430...161,524,013
JBrowse link
G GDNF glial cell derived neurotrophic factor IEP RGD PMID:9853108 RGD:6218983 NCBI chr 5:37,812,677...37,840,044
Ensembl chr 5:37,812,677...37,840,041
JBrowse link
G GTF2I general transcription factor IIi EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097066 NCBI chr 7:74,657,718...74,760,692
Ensembl chr 7:74,650,231...74,760,692
JBrowse link
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 susceptibility IAGP DNA:polymorphism:cds:HLA-DQA1*0101 (human)
DNA:polymorphisms::HLA-DQA1*0501,LA-DQA1*0301/2;
RGD PMID:11555411, PMID:21315052 RGD:5147809, RGD:7421543 NCBI chr 6:32,637,406...32,654,846
Ensembl chr 6:32,628,179...32,647,062
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP DNA:polymorphisms:cds:HLA-DQB1*0201 (human)
associated with Chronic Hepatitis C;DNA:polymorphism:cds:HLA-DQB1*02 (human)
DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0201, HLA-DQB1*0401, HLA-DQB1*0601 (human)
RGD PMID:21315052, PMID:17489060, PMID:8468491 RGD:7421543, RGD:36174022, RGD:7483566 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP DNA:polymorphism:cds:HLA-DRB1*0301 (human) RGD PMID:11555411 RGD:5147809 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:24941846 RGD:10450595 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 IDA RGD PMID:19264855 RGD:10054311 NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784
JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment IEP
ISO
protein:increased expression:salivary gland
protein:increased expression:plasma
RGD PMID:11359451, PMID:21589878, PMID:15037117 RGD:8158122, RGD:8547705, RGD:8547696 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein ISS OMIM:270150 MouseDO NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G IFNG interferon gamma ISO
IEP
RGD PMID:15584966, PMID:28421993 RGD:8142390, RGD:14975117 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 IAGP RGD PMID:12233881 RGD:1580479 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12A interleukin 12A EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
JBrowse link
G IL13 interleukin 13 IEP protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL17A interleukin 17A ISO RGD PMID:21182786 RGD:8696035 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 IEP protein:increased expression:saliva RGD PMID:23906036 RGD:8655918 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1RN interleukin 1 receptor antagonist IAGP
IEP
DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
protein:increased expression:conjunctiva (human)
RGD PMID:9646842, PMID:11527941 RGD:8549786, RGD:8549807 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G IL2 interleukin 2 ISS OMIM:270150 MouseDO NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL23R interleukin 23 receptor IEP protein:increased expression:minor salivary gland: RGD PMID:22262980 RGD:8549566 NCBI chr 1:67,138,639...67,259,979
Ensembl chr 1:67,138,907...67,259,979
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISS OMIM:270150 MouseDO NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL4 interleukin 4 ISS OMIM:270150 MouseDO NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 severity IEP
IAGP
protein:increased expression:plasma:
DNA:polymorphims:promoter:-174G>C(human)
RGD PMID:11426023, PMID:11426023 RGD:7829718, RGD:7829718 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 6:78,867,486...78,979,411
Ensembl chr 6:78,867,551...78,946,440
JBrowse link
G ITSN2 intersectin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 2:24,202,864...24,360,538
Ensembl chr 2:24,202,864...24,360,714
JBrowse link
G LTA lymphotoxin alpha no_association
susceptibility
ISO
IAGP
IEP
DNA:SNPs: :multiple (human)
DNA:SNP, haplotype:intron: (rs909253) (human)
protein:increased expression:saliva, serum
RGD PMID:20952683, PMID:22294627, PMID:22294627, PMID:20952683 RGD:8548776, RGD:8548787, RGD:8548787, RGD:8548776 NCBI chr 6:31,560,550...31,574,324
Ensembl chr 6:31,572,054...31,574,324
JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 ISS OMIM:270150 MouseDO NCBI chr17:45,263,119...45,317,048
Ensembl chr17:45,263,119...45,317,029
JBrowse link
G MMP3 matrix metallopeptidase 3 IEP RGD PMID:19332626 RGD:8693671 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MMP9 matrix metallopeptidase 9 IEP
IDA
protein:increased activity:saliva RGD PMID:15316122, PMID:9923658 RGD:8547814, RGD:8547858 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MUC16 mucin 16, cell surface associated IEP mRNA, protein:increased expression:conjunctival epithelial cell, tear RGD PMID:19122828 RGD:7364772 NCBI chr19:8,848,840...9,010,390
Ensembl chr19:8,848,844...8,981,342
JBrowse link
G MUC19 mucin 19, oligomeric IEP
ISS
mRNA:decreased expression:conjunctival epithelial cell
OMIM:270150
MouseDO PMID:18184611 RGD:7364736 NCBI chr12:40,393,394...40,570,757
Ensembl chr12:40,393,395...40,570,832
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming IEP mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18184611 RGD:7364736 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NCF1 neutrophil cytosolic factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28135245 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NFKBIA NFKB inhibitor alpha ISS OMIM:270150 MouseDO NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PHIP pleckstrin homology domain interacting protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 6:78,934,419...79,078,294
Ensembl chr 6:78,934,419...79,078,254
JBrowse link
G PON1 paraoxonase 1 IEP protein:decreased activity:serum (human) RGD PMID:20497955 RGD:8547550 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PRDM1 PR/SET domain 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 6:106,046,729...106,109,938
Ensembl chr 6:105,993,463...106,109,939
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 no_association IAGP DNA:snp:cds:c.1858C>T (human) RGD PMID:16163373, PMID:15933742 RGD:11534998, RGD:11534999 NCBI chr 1:113,813,811...113,871,761
Ensembl chr 1:113,813,811...113,871,753
JBrowse link
G PTTG1 PTTG1 regulator of sister chromatid separation, securin EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739
JBrowse link
G REG1A regenerating family member 1 alpha IEP protein:increased expression:minor salivary gland, salivary ductal epithelium (human) RGD PMID:19016805 RGD:9850137 NCBI chr 2:79,120,488...79,123,409
Ensembl chr 2:79,120,362...79,123,409
JBrowse link
G RORC RAR related orphan receptor C ISS OMIM:270150 MouseDO NCBI chr 1:151,806,071...151,832,451
Ensembl chr 1:151,806,071...151,831,845
JBrowse link
G SELP selectin P IEP protein:increased expression:plasma RGD PMID:19832990 RGD:6478702 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G ST14 ST14 transmembrane serine protease matriptase ISS OMIM:270150 MouseDO NCBI chr11:130,159,782...130,210,362
Ensembl chr11:130,159,782...130,210,362
JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility
no_association
IAGP
EXP
DNA:SNP:intron: (rs7582694) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs7574865) (human)
CTD PMID:24097066, PMID:24097067, PMID:20535138, PMID:20360187, PMID:18273036 RGD:8661690, RGD:8661709, RGD:8661708 NCBI chr 2:191,029,576...191,172,684
Ensembl chr 2:191,029,576...191,151,596
JBrowse link
G TGFB1 transforming growth factor beta 1 severity ISO
ISS
OMIM:270150 MouseDO PMID:9358754, PMID:7554451 RGD:7394829, RGD:7394845 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THBS1 thrombospondin 1 ISS OMIM:270150 MouseDO NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TNF tumor necrosis factor treatment IAGP
ISO
DNA:polymorphism: :-1031T>C(human) RGD PMID:22703762, PMID:24941846 RGD:7394766, RGD:10450595 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097066, PMID:24097067 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TNFSF13B TNF superfamily member 13b ISS OMIM:270150 MouseDO NCBI chr13:108,268,240...108,308,484
Ensembl chr13:108,251,240...108,308,484
JBrowse link
G TNIP1 TNFAIP3 interacting protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 5:151,029,943...151,087,685
Ensembl chr 5:151,029,945...151,093,577
JBrowse link
G TRAF3IP2 TRAF3 interacting protein 2 ISS OMIM:270150 MouseDO NCBI chr 6:111,555,381...111,605,878
Ensembl chr 6:111,555,381...111,606,906
JBrowse link
G VIM vimentin IDA RGD PMID:6352937 RGD:6480477 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G VIP vasoactive intestinal peptide ISO RGD PMID:22059987 RGD:5685375 NCBI chr 6:152,750,797...152,759,765
Ensembl chr 6:152,750,797...152,759,765
JBrowse link
Sjögren-Mikulicz Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTM1 glutathione S-transferase mu 1 susceptibility IAGP DNA:deletion: : RGD PMID:10616008 RGD:5491001 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
Systemic Juvenile Rheumatoid Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:26914138 RGD:11529541 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G IL6 interleukin 6 IAGP OMIM NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6R interleukin 6 receptor treatment IMP RGD PMID:18358927 RGD:10402823 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G MIF macrophage migration inhibitory factor IAGP OMIM NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18864
    disease of anatomical entity 17349
      musculoskeletal system disease 6168
        autoimmune disease of musculoskeletal system 957
          rheumatic disease 742
            rheumatoid arthritis 468
              Caplan's syndrome 0
              Felty's syndrome 0
              Rheumatoid Nodule 0
              Rheumatoid Vasculitis 0
              Sjogren's syndrome + 68
              Sjögren-Mikulicz Syndrome 1
              adult-onset Still's disease 2
              juvenile rheumatoid arthritis + 153
              palindromic rheumatism 0
Path 2
Term Annotations click to browse term
  disease 18864
    disease of anatomical entity 17349
      Immune & Inflammatory Diseases 3472
        immune system disease 2928
          primary immunodeficiency disease 2265
            autoimmune disease 1578
              autoimmune disease of musculoskeletal system 957
                rheumatic disease 742
                  rheumatoid arthritis 468
                    Caplan's syndrome 0
                    Felty's syndrome 0
                    Rheumatoid Nodule 0
                    Rheumatoid Vasculitis 0
                    Sjogren's syndrome + 68
                    Sjögren-Mikulicz Syndrome 1
                    adult-onset Still's disease 2
                    juvenile rheumatoid arthritis + 153
                    palindromic rheumatism 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.