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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatoid arthritis
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Accession:DOID:7148 term browser browse the term
Definition:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (DO)
Synonyms:exact_synonym: RA;   RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO;   atrophic arthritis;   rheumatic arthritis or polyarthritis
 narrow_synonym: RHEUMATOID ARTHRITIS, PROGRESSION OF
 primary_id: MESH:D001172
 alt_id: OMIM:180300
 xref: ICD10CM:M06.9;   ICD9CM:714.0;   NCI:C2884
For additional species annotation, visit the Alliance of Genome Resources.


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rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO GAD PMID:15118671 RGD:1331525 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:20080907, PMID:22104130 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Acan aggrecan disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased degradation:cartilage
CTD PMID:15292528, PMID:16507130 RGD:11570537 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Ackr3 atypical chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:90,203,980...90,215,724
Ensembl chr 1:90,203,980...90,216,751
JBrowse link
G Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 ISO mRNA:increased expression:synovium RGD PMID:11801682 RGD:10043106 NCBI chr 1:171,250,129...171,262,267
Ensembl chr 1:171,250,421...171,260,637
JBrowse link
G Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) ISO protein:alternative form:synovium RGD PMID:11801682 RGD:10043106 NCBI chr16:85,858,157...85,901,125
Ensembl chr16:85,856,173...85,901,828
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12833524, PMID:21789720 RGD:5686424 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adrb3 adrenergic receptor, beta 3 ISO DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:12739037 RGD:5684893 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Aff3 AF4/FMR2 family, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:38,175,393...38,630,178
Ensembl chr 1:38,177,326...38,664,955
JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO protein:decreased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:16385501, PMID:20541603 RGD:7244141 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ahr aryl-hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18617548 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 ISO RGD PMID:12653852 RGD:6892721 NCBI chr14:51,091,077...51,102,009
Ensembl chr14:51,091,150...51,102,009
JBrowse link
G Ankrd55 ankyrin repeat domain 55 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr13:112,288,451...112,384,005
Ensembl chr13:112,288,451...112,384,002
JBrowse link
G Anxa3 annexin A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr 5:96,793,385...96,845,968
Ensembl chr 5:96,793,339...96,845,966
JBrowse link
G Apoa4 apolipoprotein A-IV ISO protein:increased expression:blood serum (human) RGD PMID:20367977 RGD:5685646 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Arid5b AT rich interactive domain 5B (MRF1-like) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963, PMID:23143596 NCBI chr10:68,092,523...68,279,355
Ensembl chr10:68,092,520...68,278,740
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19193698 NCBI chr 1:71,557,156...71,579,403
Ensembl chr 1:71,557,150...71,579,631
JBrowse link
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr11:22,834,739...22,860,336
Ensembl chr11:22,759,738...22,860,961
JBrowse link
G B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 8:105,252,638...105,255,250
Ensembl chr 8:105,252,638...105,255,153
JBrowse link
G Baiap2l1 BAI1-associated protein 2-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 5:144,264,525...144,358,112
Ensembl chr 5:144,264,526...144,358,112
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Bglap bone gamma carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:22447331, PMID:3488088 RGD:6483593, RGD:6483600 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bgn biglycan ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr  X:73,483,601...73,495,936
Ensembl chr  X:73,483,602...73,495,933
JBrowse link
G Blk B lymphoid kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr14:63,372,837...63,417,187
Ensembl chr14:63,372,836...63,417,037
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Btnl2 butyrophilin-like 2 susceptibility ISO DNA:SNPs: : RGD PMID:23364395 RGD:9685033 NCBI chr17:34,354,789...34,369,492
Ensembl chr17:34,354,822...34,369,495
JBrowse link
G C3 complement component 3 ISO RGD PMID:7561187 RGD:11040775 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G C4b complement component 4B (Chido blood group) ISO RGD PMID:22076784 RGD:5688263 NCBI chr17:34,728,139...34,743,902
Ensembl chr17:34,728,380...34,743,882
JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Casp7 caspase 7 ISO RGD PMID:18785314 RGD:5684540 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Cast calpastatin ISO RGD PMID:7706496 RGD:5683620 NCBI chr13:74,692,366...74,808,874
Ensembl chr13:74,692,368...74,808,810
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav2 caveolin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 6:17,281,185...17,289,130
Ensembl chr 6:17,281,185...17,289,115
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 ISO protein:increased expression:serum RGD PMID:20056091 RGD:4891442 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl21a chemokine (C-C motif) ligand 21A (serine) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
JBrowse link
G Ccl22 chemokine (C-C motif) ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chr 8:94,745,684...94,751,388
Ensembl chr 8:94,745,590...94,751,699
JBrowse link
G Ccl8 chemokine (C-C motif) ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr11:82,115,185...82,116,799
Ensembl chr11:82,115,185...82,116,799
JBrowse link
G Ccn1 cellular communication network factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 3:145,646,971...145,649,985
Ensembl chr 3:145,646,976...145,649,981
JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccr1 chemokine (C-C motif) receptor 1 ISO RGD PMID:12860725 RGD:5688170 NCBI chr 9:123,962,126...123,968,692
Ensembl chr 9:123,962,124...123,968,692
JBrowse link
G Ccr3 chemokine (C-C motif) receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr 9:124,017,825...124,031,692
Ensembl chr 9:124,021,972...124,031,689
JBrowse link
G Ccr4 chemokine (C-C motif) receptor 4 ISO protein:increased expression:synovial membrane:
mRNA:increased expression:synovium:
RGD PMID:19942450, PMID:25430645 RGD:10054497, RGD:10054499 NCBI chr 9:114,490,316...114,505,476
Ensembl chr 9:114,490,316...114,504,916
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 resistance
no_association
ISO DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD PMID:16541097, PMID:17565662 RGD:1626290, RGD:1626283 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Ccr6 chemokine (C-C motif) receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453841, PMID:20453842, PMID:23143596 NCBI chr17:8,236,041...8,258,519
Ensembl chr17:8,236,043...8,257,141
JBrowse link
G Cd2 CD2 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 3:101,275,908...101,287,939
Ensembl chr 3:101,275,899...101,287,939
JBrowse link
G Cd244a CD244 molecule A susceptibility ISO ClinVar Annotator: match by OMIM:180300
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:18794858 NCBI chr 1:171,558,718...171,585,316
Ensembl chr 1:171,559,193...171,609,746
JBrowse link
G Cd28 CD28 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596, PMID:19075187 RGD:5131619 NCBI chr 1:60,746,388...60,773,359
Ensembl chr 1:60,716,800...60,773,359
JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 9:44,998,735...45,009,663
Ensembl chr 9:44,998,740...45,009,627
JBrowse link
G Cd40 CD40 antigen ISO DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:18794853, PMID:20453842, PMID:23143596, PMID:20498205 RGD:5490972 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd5 CD5 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr19:10,718,107...10,739,026
Ensembl chr19:10,717,116...10,739,002
JBrowse link
G Cd80 CD80 antigen ISO protein:increased expression:serum RGD PMID:22917707 RGD:6893647 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd83 CD83 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr13:43,785,112...43,803,133
Ensembl chr13:43,784,775...43,803,132
JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta ISO protein:increased expression:knee, articular cartilage (human) RGD PMID:19248099 RGD:10401213 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Chil1 chitinase-like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:10461474 RGD:4892605 NCBI chr 1:134,182,156...134,190,031
Ensembl chr 1:134,182,176...134,190,181
JBrowse link
G Ciita class II transactivator susceptibility
no_association
ISO DNA:haplotype:promoter/CDS:rs3087456G/rs4774C (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by OMIM:180300
DNA:polymorphism:promoter:-168A>G (human)
DNA:polymorphism:promoter:rs3087456, no association in a German cohort (Human)
CTD
OMIM
ClinVar
PMID:15821736, PMID:16849401, PMID:19221398, PMID:15821736, PMID:16426246 RGD:5491176, RGD:1358146, RGD:5491189 NCBI chr16:10,480,014...10,531,064
Ensembl chr16:10,480,059...10,528,418
JBrowse link
G Clec12a C-type lectin domain family 12, member a ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 6:129,349,783...129,365,303
Ensembl chr 6:129,342,691...129,365,303
JBrowse link
G Clec16a C-type lectin domain family 16, member A ISO DNA:polymorphism:intron:rs6498169G (human) RGD PMID:19221398 RGD:5491176 NCBI chr16:10,545,309...10,744,878
Ensembl chr16:10,545,339...10,744,878
JBrowse link
G Col2a1 collagen, type II, alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27028940, PMID:29935983 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:1568518, PMID:22173958, PMID:22173958 RGD:6904209, RGD:6904209 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Cx3cl1 chemokine (C-X3-C motif) ligand 1 ISO RGD PMID:11465708 RGD:4892002 NCBI chr 8:94,772,180...94,782,427
Ensembl chr 8:94,772,009...94,782,427
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:19192274 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chr 5:90,759,298...90,761,625
Ensembl chr 5:90,759,360...90,761,624
JBrowse link
G Cxcr3 chemokine (C-X-C motif) receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chr  X:101,731,535...101,734,147
Ensembl chr  X:101,731,535...101,734,269
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 9:44,602,983...44,640,731
Ensembl chr 9:44,604,892...44,640,731
JBrowse link
G Dhfr dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr13:92,354,783...92,389,053
Ensembl chr13:92,354,726...92,389,053
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr14:7,965,187...7,994,760
Ensembl chr14:7,964,533...7,994,573
JBrowse link
G Dnase2a deoxyribonuclease II alpha IEA OMIM:180300 MouseDO NCBI chr 8:84,908,755...84,911,703
Ensembl chr 8:84,908,560...84,922,915
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 severity ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3b DNA methyltransferase 3B disease_progression ISO DNA:polymorphism:promoter:-283C>T(human) RGD PMID:19777235 RGD:9589110 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Edn1 endothelin 1 treatment ISO RGD PMID:22249931 RGD:8661695 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Eln elastin ISO RGD PMID:12643515 RGD:9585739 NCBI chr 5:134,702,595...134,747,368
Ensembl chr 5:134,702,593...134,747,323
JBrowse link
G Eno1 enolase 1, alpha non-neuron ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898480 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Esr2 estrogen receptor 2 (beta) severity ISO DNA:SNP:exon:rs1256049(human) RGD PMID:21523342 RGD:5508794 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) susceptibility ISO DNA:snp:promoter:g.-670A>G (human)
protein:increased expression:serum (human)
RGD PMID:23053964, PMID:20875116, PMID:12148596 RGD:8662433, RGD:12903969, RGD:8662455 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I ISO protein:increased expression:synovial joint: RGD PMID:16670289 RGD:9685708 NCBI chr 3:96,282,909...96,293,969
Ensembl chr 3:96,282,909...96,293,969
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Fcgr4 Fc receptor, IgG, low affinity IV susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human)
DNA:CNVs
protein:decreased expression:NK cell
RGD PMID:19019892, PMID:25154742, PMID:15334114 RGD:5508391, RGD:11344974, RGD:5508467 NCBI chr 1:171,018,926...171,029,761
Ensembl chr 1:171,018,920...171,029,761
JBrowse link
G Fkbp5 FK506 binding protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr17:28,398,753...28,486,149
Ensembl chr17:28,399,094...28,517,527
JBrowse link
G Foxo3 forkhead box O3 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell,synovium: RGD PMID:19435720 RGD:10402186 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Foxp3 forkhead box P3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20476861 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Fpgs folylpolyglutamyl synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 2:32,682,609...32,704,196
Ensembl chr 2:32,682,609...32,704,145
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr16:91,621,395...91,646,972
Ensembl chr16:91,621,186...91,646,952
JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 2:9,857,078...9,887,953
Ensembl chr 2:9,857,078...9,890,034
JBrowse link
G Gc vitamin D binding protein ISO protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD PMID:3874814, PMID:9548303 RGD:5509931 NCBI chr 5:89,417,511...89,457,898
Ensembl chr 5:89,417,522...89,457,898
JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18830904 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367
JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chr 4:20,041,997...20,066,111
Ensembl chr 4:20,042,052...20,066,750
JBrowse link
G Gin1 gypsy retrotransposon integrase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 1:97,770,172...97,793,710
Ensembl chr 1:97,770,172...97,793,709
JBrowse link
G Gprc5a G protein-coupled receptor, family C, group 5, member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 6:135,065,662...135,084,709
Ensembl chr 6:135,065,651...135,084,709
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IAGP
ISO
DNA: deletion: : heterozygous
CTD Direct Evidence: marker/mechanism
protein: decreased expression: mononuclear cells
CTD PMID:10094932, PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 no_association IAGP
ISO
DNA: deletion::GRK2 and GRK6 deletions resulted in more severe arthritis
protein: decreased expression: mononuclear leukocytes
RGD PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr19:60,889,560...61,095,968
Ensembl chr19:60,889,749...61,095,968
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IAGP
ISO
DNA: deletion: : homozygous
CTD Direct Evidence: marker/mechanism
protein: decreased expression: mononuclear cells
CTD PMID:10094932, PMID:18662895, PMID:10094932 RGD:5688373, RGD:5688380 NCBI chr13:55,445,072...55,460,927
Ensembl chr13:55,445,072...55,460,927
JBrowse link
G Gsdme gasdermin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 6:50,207,401...50,263,857
Ensembl chr 6:50,188,888...50,263,862
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 susceptibility ISO DNA:deletion: :
DNA:deletion: :
RGD PMID:16887863, PMID:15940757, PMID:16870093 RGD:5490993, RGD:5490998, RGD:5490994 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 severity
susceptibility
ISO DNA:deletion: : RGD PMID:19473562, PMID:20401725, PMID:20597111 RGD:5490553, RGD:5490983, RGD:5490982 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphisms
DNA:polymorphism (human)
RGD PMID:11482129, PMID:11454644 RGD:5147859, RGD:5147860 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphism (human) RGD PMID:11454644 RGD:5147860 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphisms: :multiple (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human)
DNA:polymorphisms (human)
CTD PMID:19898480, PMID:20453842, PMID:22286218, PMID:21246357, PMID:11454644, PMID:19117368 RGD:5147567, RGD:5147860, RGD:5147616 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr13:89,540,529...89,611,832
Ensembl chr13:89,539,796...89,611,652
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr16:36,934,983...36,963,214
Ensembl chr16:36,934,983...36,963,212
JBrowse link
G Hdac1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289289 NCBI chr 4:129,516,104...129,542,646
Ensembl chr 4:129,516,104...129,542,713
JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hgf hepatocyte growth factor disease_progression ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 severity ISO RGD PMID:18025202 RGD:9685481 NCBI chr 6:51,460,434...51,470,048
Ensembl chr 6:51,460,932...51,469,894
JBrowse link
G Hoxd10 homeobox D10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:74,684,273...74,695,106
Ensembl chr 2:74,691,924...74,695,105
JBrowse link
G Hoxd11 homeobox D11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:74,679,558...74,687,016
Ensembl chr 2:74,679,557...74,687,016
JBrowse link
G Hoxd13 homeobox D13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:74,668,225...74,671,603
Ensembl chr 2:74,668,310...74,671,599
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 1:193,221,640...193,264,045
Ensembl chr 1:193,221,634...193,264,075
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hspa4 heat shock protein 4 ISO protein:increased expression:peripheral blood lymphocyte (human) RGD PMID:22047640 RGD:5688784 NCBI chr11:53,259,814...53,300,479
Ensembl chr11:53,259,814...53,300,457
JBrowse link
G Hspa5 heat shock protein 5 ISO protein:increased expression:synovial joint RGD PMID:11315915 RGD:5685639 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa9 heat shock protein 9 ISO protein:increased expression:synovial cell: RGD PMID:23739258 RGD:10402561 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb1 heat shock protein 1 ISO protein:increased expression:serum: RGD PMID:21417552 RGD:10402843 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Ifng interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:1417133 RGD:8157623 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf2 insulin-like growth factor 2 ISO DNA:loss of imprinting:synovial cell
protein:decreased expression:plasma
RGD PMID:19556211, PMID:11247331 RGD:5510001, RGD:5510014 NCBI chr 7:142,650,768...142,666,816
Ensembl chr 7:142,650,766...142,666,816
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Ikzf3 IKAROS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr11:98,464,610...98,546,031
Ensembl chr11:98,464,902...98,546,031
JBrowse link
G Il10 interleukin 10 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:12847677, PMID:22450443 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:20926833 RGD:9068415 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16368150 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of ClinVar PMID:12847677 NCBI chr 1:130,932,656...130,945,457
Ensembl chr 1:130,932,656...130,940,115
JBrowse link
G Il1a interleukin 1 alpha severity ISO associated with lung disease, interstitial
protein:increased expression:plasma, synovial fluid
RGD PMID:11192540, PMID:8162643 RGD:4142818, RGD:7794716 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12566094, PMID:17379860, PMID:22450443, PMID:22414257 RGD:6482656 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO
IMP
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:7706905, PMID:19192274, PMID:19447938, PMID:10637275 RGD:7174696, RGD:8549810 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 ISO RGD PMID:6421522 RGD:8662948 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il20 interleukin 20 ISO RGD PMID:16947773 RGD:5147395 NCBI chr 1:130,906,985...130,911,296
Ensembl chr 1:130,906,985...130,911,451
JBrowse link
G Il21r interleukin 21 receptor IMP RGD PMID:19342640 RGD:6892964 NCBI chr 7:125,603,252...125,634,397
Ensembl chr 7:125,603,429...125,633,570
JBrowse link
G Il23a interleukin 23, alpha subunit p19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752
JBrowse link
G Il23r interleukin 23 receptor susceptibility ISO DNA:SNP::rs1343151(human) RGD PMID:18647855 RGD:8549596 NCBI chr 6:67,422,932...67,491,855
Ensembl chr 6:67,422,932...67,491,855
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:20476861, PMID:23143596 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Il2rb interleukin 2 receptor, beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr15:78,479,256...78,511,621
Ensembl chr15:78,479,256...78,495,271
JBrowse link
G Il3 interleukin 3 ISO DNA: SNPs: Multiple: gene-gene interaction RGD PMID:20018070 RGD:5686905 NCBI chr11:54,265,085...54,267,279
Ensembl chr11:54,265,303...54,267,277
JBrowse link
G Il4ra interleukin 4 receptor, alpha severity ISO DNA:SNP: :rs1805010 (human) RGD PMID:24782180 RGD:10402783 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22293286 RGD:5687156 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274, PMID:22450443 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il6ra interleukin 6 receptor, alpha ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16729287, PMID:23143596 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Il6st interleukin 6 signal transducer ISO
IEA
CTD Direct Evidence: marker/mechanism
OMIM:180300
CTD
MouseDO
PMID:20453842 NCBI chr13:112,464,070...112,506,860
Ensembl chr13:112,464,070...112,510,086
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Irf5 interferon regulatory factor 5 ISO ClinVar Annotator: match by synonym: RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:15657875, PMID:16642019, PMID:17599733, PMID:18063667, PMID:20453842, PMID:23143596 NCBI chr 6:29,526,130...29,541,869
Ensembl chr 6:29,526,625...29,541,871
JBrowse link
G Irf8 interferon regulatory factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 8:120,736,358...120,756,694
Ensembl chr 8:120,736,358...120,756,694
JBrowse link
G Itga6 integrin alpha 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 2:71,786,886...71,858,427
Ensembl chr 2:71,745,616...71,858,416
JBrowse link
G Itgb2 integrin beta 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Itpa inosine triphosphatase (nucleoside triphosphate pyrophosphatase) treatment ISO DNA:SNP: :94C>A(human) RGD PMID:29441893 RGD:14975307 NCBI chr 2:130,664,692...130,681,614
Ensembl chr 2:130,667,610...130,681,614
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:21510883 RGD:6483024 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Kif5a kinesin family member 5A susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:snps:intron, 3' utr:c.2756-43A>C, c.*776C>T (rs775246, rs775251) (human)
DNA:snp:intron:c.1717-152C>G (rs1678542) (human)
CTD PMID:23143596, PMID:21784728, PMID:23378462 RGD:12793073, RGD:12793072 NCBI chr10:127,225,695...127,266,348
Ensembl chr10:127,225,696...127,263,348
JBrowse link
G Lcn2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7554268 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Lhx2 LIM homeobox protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 2:38,339,271...38,369,737
Ensembl chr 2:38,339,281...38,369,733
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO RGD PMID:17082220 RGD:5508419 NCBI chr15:91,672,791...91,816,124
Ensembl chr15:91,673,175...91,816,120
JBrowse link
G Ly96 lymphocyte antigen 96 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chr 1:16,688,456...16,709,605
Ensembl chr 1:16,688,051...16,709,611
JBrowse link
G Mab21l2 mab-21-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 3:86,546,050...86,548,283
Ensembl chr 3:86,545,581...86,548,629
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:37,133,243...37,138,926
Ensembl chr10:37,133,375...37,138,920
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chr18:70,568,225...70,629,134
Ensembl chr18:70,568,189...70,626,131
JBrowse link
G Mbd4 methyl-CpG binding domain protein 4 susceptibility
no_association
ISO DNA:snps:introns:IVS5-140A>G (rs3138355), IVS6-218C>T (rs2005618) (human)
DNA:snps:cds, intron:p.E346K, IVS6-218C>T (rs140693, rs2005618) (human)
RGD PMID:20676650, PMID:22505706 RGD:9588977, RGD:9588978 NCBI chr 6:115,840,697...115,853,400
Ensembl chr 6:115,840,697...115,853,371
JBrowse link
G Mdk midkine IAGP RGD PMID:15146411 RGD:1581200 NCBI chr 2:91,929,805...91,932,297
Ensembl chr 2:91,929,805...91,932,297
JBrowse link
G Mgarp mitochondria localized glutamic acid rich protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr 3:51,388,412...51,396,547
Ensembl chr 3:51,388,412...51,396,738
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mmel1 membrane metallo-endopeptidase-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 4:154,869,585...154,895,530
Ensembl chr 4:154,869,585...154,895,528
JBrowse link
G Mmp10 matrix metallopeptidase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 9:7,502,342...7,510,242
Ensembl chr 9:7,502,352...7,510,240
JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) IEA OMIM:180300 MouseDO NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364
JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) ISO protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chr 9:7,464,141...7,476,869
Ensembl chr 9:7,464,141...7,476,869
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp3 matrix metallopeptidase 3 disease_progression ISO protein:increased expression:serum (human) RGD PMID:7639798, PMID:22314025, PMID:11796404 RGD:7207128, RGD:8693673, RGD:7241254 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chr 9:7,558,429...7,568,486
Ensembl chr 9:7,558,456...7,568,485
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:26001728 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial ISO DNA:missense mutations:cds:multiple (human) RGD PMID:15987486 RGD:5490238 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:SNP: :677C>T(human)
CTD Direct Evidence: marker/mechanism
CTD PMID:22104130, PMID:23685257 RGD:7387222 NCBI chr 4:148,039,077...148,059,562
Ensembl chr 4:148,039,077...148,059,551
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:28135245 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991
JBrowse link
G Ndufa4l2 Ndufa4, mitochondrial complex associated like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr10:127,509,274...127,517,154
Ensembl chr10:127,514,967...127,517,154
JBrowse link
G Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr17:45,555,700...45,563,169
Ensembl chr17:45,555,703...45,563,169
JBrowse link
G Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 susceptibility ISO ClinVar Annotator: match by OMIM:180300
CTD Direct Evidence: marker/mechanism
DNA:snp:promoter:c.-132T>A (rs2071592) (human)
ClinVar
CTD
OMIM
PMID:12509789, PMID:12509789 RGD:1331681 NCBI chr17:35,220,175...35,236,481
Ensembl chr17:35,220,175...35,235,792
JBrowse link
G Notch4 notch 4 ISO mRNA : increased expression: : cd4+ cells RGD PMID:20132067 RGD:6480790 NCBI chr17:34,564,286...34,588,543
Ensembl chr17:34,564,268...34,588,503
JBrowse link
G Npsr1 neuropeptide S receptor 1 ISO RGD PMID:20179762 RGD:4891930 NCBI chr 9:24,097,912...24,317,590
Ensembl chr 9:24,097,996...24,316,398
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO mRNA:increased expression:paw RGD PMID:18448865 RGD:4892311 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 4:48,045,078...48,086,447
Ensembl chr 4:48,045,153...48,086,447
JBrowse link
G Padi2 peptidyl arginine deiminase, type II ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chr 4:140,906,336...140,952,586
Ensembl chr 4:140,906,344...140,952,586
JBrowse link
G Padi4 peptidyl arginine deiminase, type IV susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD
OMIM
ClinVar
PMID:23143596 NCBI chr 4:140,745,508...140,774,239
Ensembl chr 4:140,745,865...140,774,236
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide ISO RGD PMID:1708827 RGD:6482653 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pgf placental growth factor ISO RGD PMID:19180491 RGD:6483591 NCBI chr12:85,166,637...85,177,785
Ensembl chr12:85,166,635...85,177,790
JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) ISO RGD PMID:17326817 RGD:6482776 NCBI chr17:43,567,994...43,612,202
Ensembl chr17:43,568,098...43,612,201
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:22011479 RGD:6484117 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Plb1 phospholipase B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24520335 NCBI chr 5:32,232,691...32,364,356
Ensembl chr 5:32,232,708...32,366,520
JBrowse link
G Pld4 phospholipase D family, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr12:112,760,446...112,768,986
Ensembl chr12:112,760,655...112,768,990
JBrowse link
G Plek pleckstrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr11:16,971,206...17,008,718
Ensembl chr11:16,971,206...17,052,381
JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16055108 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Pou3f1 POU domain, class 3, transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 4:124,657,646...124,660,655
Ensembl chr 4:124,656,807...124,660,655
JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596 NCBI chr10:44,437,174...44,528,558
Ensembl chr10:44,437,177...44,528,501
JBrowse link
G Prkcq protein kinase C, theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chr 2:11,171,905...11,301,226
Ensembl chr 2:11,172,108...11,301,222
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15167967 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11978490, PMID:19192274, PMID:21905970 RGD:5508313 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chr18:67,665,501...67,724,632
Ensembl chr18:67,665,511...67,724,595
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) susceptibility
no_association
ISO DNA:snp:cds:p.R620W (rs2476601) (human)
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
DNA:SNP::1858C>T (human)
DNA:snp:cds:p.R263Q (rs33996649) (human)
ClinVar
OMIM
CTD
PMID:15004560, PMID:15208781, PMID:15273934, PMID:15580548, PMID:15719322, PMID:15744042, PMID:16273109, PMID:16339849, PMID:16470599, PMID:17170052, PMID:17436241, PMID:17554300, PMID:17878369, PMID:18301444, PMID:18978792, PMID:19265110, PMID:19430480, PMID:19898480, PMID:20453842, PMID:21190368, PMID:21841778, PMID:23143596, PMID:28492532, PMID:30224649, PMID:15208781, PMID:21467606, PMID:21279993 RGD:6484535, RGD:7829746, RGD:6484595 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:138,062,859...138,175,756
Ensembl chr 1:138,062,861...138,175,708
JBrowse link
G Pxk PX domain containing serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr14:8,098,180...8,165,117
Ensembl chr14:8,098,211...8,165,117
JBrowse link
G Rab8a RAB8A, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 8:72,161,200...72,181,366
Ensembl chr 8:72,161,200...72,183,904
JBrowse link
G Rap2a RAS related protein 2a ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr14:120,478,461...120,507,194
Ensembl chr14:120,478,444...120,507,194
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 2:117,279,983...117,342,877
Ensembl chr 2:117,279,993...117,343,001
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 5:53,555,779...53,657,445
Ensembl chr 5:53,466,152...53,657,362
JBrowse link
G Rcan1 regulator of calcineurin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr16:92,391,951...92,466,169
Ensembl chr16:92,391,953...92,470,867
JBrowse link
G Rel reticuloendotheliosis oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19503088, PMID:20453842, PMID:23143596 NCBI chr11:23,736,847...23,770,969
Ensembl chr11:23,736,847...23,770,970
JBrowse link
G Rgmb repulsive guidance molecule family member B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chr17:15,804,661...15,831,246
Ensembl chr17:15,803,188...15,831,039
JBrowse link
G Runx1 runt related transcription factor 1 no_association ISO DNA:SNPs: :rs2242720, rs4816502 (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs2268277 (human)
DNA:SNP:intron:24658G>C (human)
CTD PMID:23143596, PMID:20018071, PMID:18087673, PMID:18328148, PMID:16821265 RGD:6482836, RGD:6482840, RGD:6482839, RGD:6482837 NCBI chr16:92,601,466...92,826,074
Ensembl chr16:92,601,466...92,826,149
JBrowse link
G Runx2 runt related transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C ISO protein:increased expression:knee, synovium (human) RGD PMID:15077297 RGD:1580084 NCBI chr 5:17,574,816...17,730,268
Ensembl chr 5:17,574,281...17,730,268
JBrowse link
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 severity ISO DNA:polymorphism:promoter (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms, deletion: :823C>T, p.D543N (human)
CTD PMID:16597321, PMID:12135431, PMID:10719815 RGD:5684967, RGD:5684971 NCBI chr 1:74,375,014...74,386,057
Ensembl chr 1:74,375,195...74,386,062
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 susceptibility ISO ClinVar Annotator: match by OMIM:180300
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:14608356 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
JBrowse link
G Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 2:71,274,270...71,367,781
Ensembl chr 2:71,271,063...71,367,749
JBrowse link
G Sms spermine synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr  X:157,443,851...157,492,287
Ensembl chr  X:157,443,855...157,492,287
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:15292528, PMID:24313545 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15761492 RGD:1581382 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Spred2 sprouty-related EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr11:19,924,442...20,024,026
Ensembl chr11:19,924,375...20,024,026
JBrowse link
G St6galnac5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:17568789 NCBI chr 3:152,819,885...152,982,210
Ensembl chr 3:152,817,081...152,982,246
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO associated with T-cell large granular lymphocyte leukemia
ClinVar Annotator: match by term: Rheumatoid arthritis
ClinVar PMID:28492532, PMID:30311386, PMID:22591296 RGD:6892936 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189
JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274
G Supt20 SPT20 SAGA complex component ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chr 3:54,692,760...54,728,763
Ensembl chr 3:54,692,807...54,728,766
JBrowse link
G Tagap T cell activation Rho GTPase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr17:7,926,000...7,934,897
Ensembl chr17:7,926,000...7,934,897
JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) ISO RGD PMID:9645419 RGD:6482275 NCBI chr17:34,204,479...34,216,321
Ensembl chr17:34,203,527...34,216,321
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:17379860 NCBI chr 6:3,962,589...3,988,978
Ensembl chr 6:3,962,595...3,988,919
JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15700117 RGD:5685020 NCBI chr 2:148,404,471...148,408,188
Ensembl chr 2:148,404,466...148,408,188
JBrowse link
G Tle3 transducin-like enhancer of split 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chr 9:61,372,326...61,418,497
Ensembl chr 9:61,372,366...61,418,497
JBrowse link
G Tlr2 toll-like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tmpo thymopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chr10:91,147,571...91,181,752
Ensembl chr10:91,147,571...91,181,315
JBrowse link
G Tnf tumor necrosis factor treatment
no_association
ISO
IEA
OMIM:180300
DNA:SNP:promoter:-238G>A, -308G>A (human)
DNA:SNP:promoter:-857C>T (human)
CTD Direct Evidence: marker/mechanism|therapeutic
MouseDO
CTD
PMID:2001072, PMID:8391952, PMID:12566094, PMID:22450443, PMID:12563673, PMID:25311255, PMID:25311255 RGD:10450537, RGD:12904065, RGD:12904065 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip2 tumor necrosis factor, alpha-induced protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr12:111,442,450...111,455,018
Ensembl chr12:111,442,469...111,455,018
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:21841782, PMID:23143596, PMID:30224649 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) ISO CTD Direct Evidence: therapeutic CTD PMID:23333834 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484
JBrowse link
G Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chr 4:154,918,487...154,928,620
Ensembl chr 4:154,921,933...154,928,563
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a treatment ISO DNA:SNP:promoter:36G>A (human) RGD PMID:25311255 RGD:12904065 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chr17:57,189,474...57,194,181
Ensembl chr17:57,189,492...57,194,177
JBrowse link
G Traf1 TNF receptor-associated factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:23143596 NCBI chr 2:34,941,750...34,961,812
Ensembl chr 2:34,941,750...34,961,772
JBrowse link
G Traf6 TNF receptor-associated factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chr 2:101,678,420...101,701,668
Ensembl chr 2:101,678,429...101,701,669
JBrowse link
G Trappc2 trafficking protein particle complex 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chr  X:166,440,702...166,453,140
Ensembl chr  X:166,440,574...166,453,140
JBrowse link
G Txndc5 thioredoxin domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326410 NCBI chr13:38,500,266...38,528,824
Ensembl chr13:38,500,079...38,528,824
JBrowse link
G Txnip thioredoxin interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chr 3:96,557,957...96,561,857
Ensembl chr 3:96,557,957...96,561,883
JBrowse link
G Tyk2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chr 9:21,104,068...21,131,393
Ensembl chr 9:21,104,068...21,131,243
JBrowse link
G Tyms thymidylate synthase treatment ISO DNA:polymorphism: : RGD PMID:22763757 RGD:11075093 NCBI chr 5:30,038,546...30,073,645
Ensembl chr 5:30,058,202...30,073,617
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor no_association ISO DNA:SNP:exon:rs2228570 (human)
DNA:SNP: :rs1544410 (human)
RGD PMID:21820934, PMID:21820934 RGD:8158077, RGD:8158077 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Vegfa vascular endothelial growth factor A disease_progression ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism
CTD PMID:16368150, PMID:24387171 RGD:8548659 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vim vimentin ISO RGD PMID:21792832 RGD:6480508 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase IEA OMIM:180300 MouseDO NCBI chr 1:36,761,798...36,782,821
Ensembl chr 1:36,761,798...36,782,818
JBrowse link
G Zfp36 zinc finger protein 36 IEA OMIM:180300 MouseDO NCBI chr 7:28,376,784...28,379,228
Ensembl chr 7:28,376,784...28,380,253
JBrowse link
adult-onset Still's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hgf hepatocyte growth factor ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
Juvenile Pauciarticular Chronic Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism: :HLA-DRB1*1104, HLA-DRB1*080(human) RGD PMID:7955632 RGD:7365102 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
juvenile rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700019D03Rik RIKEN cDNA 1700019D03 gene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:52,922,324...52,992,657
Ensembl chr 1:52,922,324...53,020,179
JBrowse link
G Acpp acid phosphatase, prostate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:104,288,240...104,337,722
Ensembl chr 9:104,288,251...104,337,748
JBrowse link
G Acrbp proacrosin binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:125,049,927...125,063,265
Ensembl chr 6:125,049,689...125,063,267
JBrowse link
G Adcy7 adenylate cyclase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:88,272,190...88,329,965
Ensembl chr 8:88,272,403...88,329,962
JBrowse link
G Alox12 arachidonate 12-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:70,241,457...70,255,380
Ensembl chr11:70,241,457...70,255,353
JBrowse link
G Ankrd9 ankyrin repeat domain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:110,976,420...110,979,082
Ensembl chr12:110,975,353...110,979,040
JBrowse link
G Aopep aminopeptidase O ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:62,964,893...63,326,096
Ensembl chr13:62,964,893...63,326,096
JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:71,110,659...71,167,849
Ensembl chr 9:71,110,659...71,168,682
JBrowse link
G Areg amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:91,139,599...91,148,432
Ensembl chr 5:91,139,599...91,148,432
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:64,086,840...64,382,941
Ensembl chr15:64,086,857...64,382,919
JBrowse link
G Avl9 AVL9 cell migration associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:56,714,839...56,761,912
Ensembl chr 6:56,714,899...56,761,912
JBrowse link
G B4galt5 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:167,298,444...167,349,178
Ensembl chr 2:167,298,444...167,349,183
JBrowse link
G Btg1 BTG anti-proliferation factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:96,617,001...96,622,813
Ensembl chr10:96,617,006...96,622,809
JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:78,359,860...78,377,181
Ensembl chr16:78,332,637...78,377,192
JBrowse link
G C8b complement component 8, beta polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:7980680 NCBI chr 4:104,766,317...104,804,548
Ensembl chr 4:104,766,317...104,804,548
JBrowse link
G C9orf72 C9orf72, member of C9orf72-SMCR8 complex ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:35,191,285...35,226,153
Ensembl chr 4:35,191,285...35,226,175
JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Camsap1 calmodulin regulated spectrin-associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:25,926,838...25,983,562
Ensembl chr 2:25,926,838...25,983,282
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 no_association ISO DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
DNA:polymorphisms: :multiple (human)
RGD PMID:17565662, PMID:16775617 RGD:1626283, RGD:1626284 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Cd14 CD14 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd83 CD83 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:43,785,112...43,803,133
Ensembl chr13:43,784,775...43,803,132
JBrowse link
G Cd8b1 CD8 antigen, beta chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:71,322,788...71,337,492
Ensembl chr 6:71,322,788...71,337,494
JBrowse link
G Ciita class II transactivator susceptibility
no_association
ISO DNA:polymorphism:exon:1614G>C (human)
DNA:polymorphism:promoter:rs3087456, no association in a German cohort (Human)
RGD PMID:17661914, PMID:16426246 RGD:5491187, RGD:5491189 NCBI chr16:10,480,014...10,531,064
Ensembl chr16:10,480,059...10,528,418
JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:104,281,042...104,293,181
Ensembl chr 8:104,281,042...104,293,181
JBrowse link
G Crem cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum RGD PMID:22885951 RGD:6906884 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Cttn cortactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:144,435,724...144,471,560
Ensembl chr 7:144,435,733...144,471,009
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504, PMID:26387944 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:60,601,723...60,763,191
Ensembl chr13:60,601,947...60,763,191
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G Dusp2 dual specificity phosphatase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:127,336,159...127,338,377
Ensembl chr 2:127,336,159...127,338,376
JBrowse link
G Dusp4 dual specificity phosphatase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:34,807,610...34,819,894
Ensembl chr 8:34,807,297...34,819,894
JBrowse link
G Dysf dysferlin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:84,008,361...84,211,060
Ensembl chr 6:84,008,590...84,211,060
JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egr1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Elf2 E74-like factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:51,252,720...51,340,683
Ensembl chr 3:51,252,720...51,340,663
JBrowse link
G Etnk1 ethanolamine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:143,166,866...143,208,546
Ensembl chr 6:143,167,221...143,232,307
JBrowse link
G Etv6 ets variant 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:134,035,700...134,270,158
Ensembl chr 6:134,035,700...134,270,158
JBrowse link
G Fam20a FAM20A, golgi associated secretory pathway pseudokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:109,669,746...109,723,163
Ensembl chr11:109,669,749...109,722,279
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:96,282,909...96,293,969
Ensembl chr 3:96,282,909...96,293,969
JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:101,108,499...101,284,405
Ensembl chr 7:101,092,863...101,284,405
JBrowse link
G Fos FBJ osteosarcoma oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosb FBJ osteosarcoma oncogene B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:19,302,696...19,310,118
Ensembl chr 7:19,302,696...19,310,051
JBrowse link
G Fosl2 fos-like antigen 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:32,136,472...32,157,840
Ensembl chr 5:32,135,801...32,157,842
JBrowse link
G Foxp1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:98,925,342...99,522,746
Ensembl chr 6:98,925,338...99,522,721
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gm12248 predicted gene 12248 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:58,063,682...58,093,196
Ensembl chr11:58,063,552...58,093,134
JBrowse link
G Gm15262 predicted gene 15262 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:161,297,856...161,334,722
Ensembl chr  X:161,287,456...161,366,252
JBrowse link
G Gmpr guanosine monophosphate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:45,507,428...45,546,386
Ensembl chr13:45,507,444...45,553,800
JBrowse link
G Gng11 guanine nucleotide binding protein (G protein), gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:4,003,987...4,008,445
Ensembl chr 6:4,003,904...4,008,445
JBrowse link
G Gp1bb glycoprotein Ib, beta polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:18,620,319...18,622,403
Ensembl chr16:18,620,317...18,622,403
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 susceptibility ISO DNA:deletion: : RGD PMID:18328165 RGD:5490992 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO DNA:polymorphism (human) RGD PMID:19811310, PMID:10457895 RGD:5147815, RGD:5147863 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO DNA:polymorphism (human) RGD PMID:10457895 RGD:5147863 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta ISO DNA:polymorphism (human) RGD PMID:19908388, PMID:10457895 RGD:5147587, RGD:5147863 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G H2ac8 H2A clustered histone 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:23,570,663...23,571,220
Ensembl chr13:23,570,517...23,571,220
JBrowse link
G Hbegf heparin-binding EGF-like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:36,504,927...36,515,805
Ensembl chr18:36,504,927...36,515,805
JBrowse link
G Herpud2 HERPUD family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:25,108,126...25,151,813
Ensembl chr 9:25,108,132...25,151,820
JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:16047841 RGD:8694357 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO protein:increased expression:serum,synovial fluid: RGD PMID:8255671 RGD:12910480 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Igf1r insulin-like growth factor I receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Il1a interleukin 1 alpha ISO DNA:SNP:promoter:-889C>T (human) RGD PMID:8162643 RGD:7794716 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:mononuclear cell RGD PMID:21859687 RGD:5147870 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 ISO
ISS
protein:increased expression:serum:
OMIM:604302
MouseDO PMID:9489833 RGD:7829742 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga2b integrin alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:102,453,297...102,469,883
Ensembl chr11:102,453,297...102,470,122
JBrowse link
G Itgb5 integrin beta 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:33,829,665...33,949,338
Ensembl chr16:33,829,665...33,949,338
JBrowse link
G Jmjd1c jumonji domain containing 1C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:67,096,351...67,256,326
Ensembl chr10:67,096,125...67,256,326
JBrowse link
G Jun jun proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kat6b K(lysine) acetyltransferase 6B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:21,499,216...21,672,478
Ensembl chr14:21,481,434...21,672,478
JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:95,257,558...95,300,260
Ensembl chr16:95,257,558...95,300,260
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:145,216,699...145,250,420
Ensembl chr 6:145,216,699...145,250,239
JBrowse link
G Lacc1 laccase domain containing 1 ISO ClinVar Annotator: match by term: JUVENILE ARTHRITIS OMIM
ClinVar
PMID:25147203, PMID:25220867, PMID:27881174, PMID:29717096, PMID:30872671 NCBI chr14:77,021,739...77,036,929
Ensembl chr14:77,024,200...77,036,904
JBrowse link
G Lilra5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:4,237,643...4,243,690
Ensembl chr 7:4,237,754...4,243,463
JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:24,393,350...24,992,578
Ensembl chr16:24,393,507...24,992,578
JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:140,008,689...140,321,608
Ensembl chr 5:140,008,689...140,321,552
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Maml2 mastermind like transcriptional coactivator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:13,296,561...13,709,533
Ensembl chr 9:13,297,957...13,709,388
JBrowse link
G Map2 microtubule-associated protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 ISO RGD PMID:18334024 RGD:12910845 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Mex3c mex3 RNA binding family member C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:73,572,637...73,592,578
Ensembl chr18:73,573,044...73,592,575
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISS OMIM:604302 MouseDO NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mir22hg Mir22 host gene (non-protein coding) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:75,461,539...75,466,690
Ensembl chr11:75,461,539...75,466,676
JBrowse link
G Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:11,404,717...11,427,246
Ensembl chr19:11,404,770...11,427,246
JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:96,096,045...96,168,553
Ensembl chr  X:96,096,042...96,168,552
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:58,941,234...59,083,956
Ensembl chr15:58,941,234...59,082,005
JBrowse link
G Myzap myocardial zonula adherens protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:71,504,347...71,592,360
Ensembl chr 9:71,504,347...71,592,360
JBrowse link
G Ndel1 nudE neurodevelopment protein 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:68,821,434...68,853,146
Ensembl chr11:68,821,434...68,871,858
JBrowse link
G Neat1 nuclear paraspeckle assembly transcript 1 (non-protein coding) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:5,824,708...5,845,480
Ensembl chr19:5,824,708...5,845,478
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:48,045,078...48,086,447
Ensembl chr 4:48,045,153...48,086,447
JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:31,807,452...32,891,609
Ensembl chr 8:31,814,551...32,884,797
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:129,479,150...129,507,350
Ensembl chr 6:129,485,244...129,507,165
JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:4,236,785...4,241,026
Ensembl chr11:4,236,420...4,241,026
JBrowse link
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr15:83,375,607...83,464,610
Ensembl chr15:83,375,607...83,464,606
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta isoform ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr  X:93,654,863...93,749,951
Ensembl chr  X:93,654,863...93,749,951
JBrowse link
G Per1 period circadian clock 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:69,095,108...69,109,965
Ensembl chr11:69,095,217...69,109,960
JBrowse link
G Pgm5 phosphoglucomutase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:24,678,261...24,861,842
Ensembl chr19:24,683,016...24,861,855
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Plk2 polo like kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:110,395,044...110,400,844
Ensembl chr13:110,395,046...110,400,844
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:92,539,636...92,608,428
Ensembl chr 9:92,542,223...92,608,428
JBrowse link
G Pros1 protein S (alpha) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr16:62,854,307...62,929,346
Ensembl chr16:62,854,307...62,929,346
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ISO DNA: snp : cds : rs2476601 RGD PMID:15934099 RGD:6484550 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G R3hdm2 R3H domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:127,380,332...127,499,384
Ensembl chr10:127,380,327...127,499,384
JBrowse link
G Rasgef1b RasGEF domain family, member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:99,217,420...99,252,927
Ensembl chr 5:99,217,426...99,729,065
JBrowse link
G Rbm47 RNA binding motif protein 47 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:66,016,549...66,151,954
Ensembl chr 5:66,016,549...66,173,118
JBrowse link
G Rere arginine glutamic acid dipeptide (RE) repeats ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 4:150,281,511...150,621,966
Ensembl chr 4:150,281,646...150,621,966
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:69,151,058...69,291,791
Ensembl chr10:69,151,434...69,291,791
JBrowse link
G Rnf103 ring finger protein 103 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:71,493,844...71,510,880
Ensembl chr 6:71,493,894...71,510,881
JBrowse link
G Selp selectin, platelet severity ISO protein:increased expression:plasma RGD PMID:21124648 RGD:6219006 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Sh2d2a SH2 domain containing 2A ISO RGD PMID:15129233 RGD:2298870 NCBI chr 3:87,846,755...87,855,722
Ensembl chr 3:87,846,755...87,855,722
JBrowse link
G Sh3bgrl2 SH3 domain binding glutamic acid-rich protein like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:83,548,338...83,600,292
Ensembl chr 9:83,548,327...83,638,801
JBrowse link
G Sik1 salt inducible kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:31,844,248...31,855,804
Ensembl chr17:31,844,250...31,855,804
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:82,169,377...82,451,786
Ensembl chr12:82,169,320...82,451,786
JBrowse link
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 ISO DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:16597321, PMID:10857800 RGD:5684977 NCBI chr 1:74,375,014...74,386,057
Ensembl chr 1:74,375,195...74,386,062
JBrowse link
G Slc22a16 solute carrier family 22 (organic cation transporter), member 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:40,570,321...40,604,132
Ensembl chr10:40,570,336...40,604,132
JBrowse link
G Slc26a2 solute carrier family 26 (sulfate transporter), member 2 susceptibility ISO DNA:SNPs: : RGD PMID:17393463 RGD:13208931 NCBI chr18:61,196,854...61,211,596
Ensembl chr18:61,192,919...61,211,612
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Stab1 stabilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:31,139,017...31,168,651
Ensembl chr14:31,139,013...31,168,641
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Stim1 stromal interaction molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 7:102,261,514...102,437,319
Ensembl chr 7:102,267,806...102,437,319
JBrowse link
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr19:55,741,797...55,933,659
Ensembl chr19:55,741,820...55,933,654
JBrowse link
G Tfdp1 transcription factor Dp 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:13,338,725...13,378,448
Ensembl chr 8:13,338,751...13,378,448
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:84,432,855...84,476,775
Ensembl chr 2:84,432,855...84,476,775
JBrowse link
G Thbd thrombomodulin ISO protein:increased expression:serum RGD PMID:15209962 RGD:5685023 NCBI chr 2:148,404,471...148,408,188
Ensembl chr 2:148,404,466...148,408,188
JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 2:52,038,113...52,056,681
Ensembl chr 2:52,038,009...52,056,686
JBrowse link
G Tnfaip8 tumor necrosis factor, alpha-induced protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr18:49,979,427...50,093,229
Ensembl chr18:49,979,427...50,107,173
JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 3:28,261,901...28,670,585
Ensembl chr 3:28,263,214...28,675,858
JBrowse link
G Treml1 triggering receptor expressed on myeloid cells-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:48,359,916...48,367,176
Ensembl chr17:48,359,916...48,367,176
JBrowse link
G Ttll5 tubulin tyrosine ligase-like family, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr12:85,824,693...86,053,760
Ensembl chr12:85,824,659...86,061,893
JBrowse link
G Tubb2a tubulin, beta 2A class IIA ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr13:34,074,278...34,078,008
Ensembl chr13:34,074,274...34,078,007
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr14:18,282,726...18,332,004
Ensembl chr14:18,282,722...18,331,859
JBrowse link
G Ube3c ubiquitin protein ligase E3C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:29,569,242...29,676,077
Ensembl chr 5:29,569,242...29,676,092
JBrowse link
G Uhrf1bp1l UHRF1 (ICBP90) binding protein 1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:89,744,968...89,819,891
Ensembl chr10:89,744,991...89,819,871
JBrowse link
G Wasf3 WASP family, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 5:146,385,006...146,473,615
Ensembl chr 5:146,384,985...146,473,615
JBrowse link
G Wwox WW domain-containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr 8:114,439,635...115,352,712
Ensembl chr 8:114,439,655...115,352,708
JBrowse link
G Zfand3 zinc finger, AN1-type domain 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr17:30,005,039...30,210,823
Ensembl chr17:30,004,733...30,210,828
JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chr10:115,384,799...115,432,772
Ensembl chr10:115,384,959...115,432,772
JBrowse link
Sjogren's syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) IEA OMIM:270150 MouseDO NCBI chr10:78,030,022...78,043,610
Ensembl chr10:78,030,022...78,043,610
JBrowse link
G Apoe apolipoprotein E onset ISO DNA:polymorphism:exon: RGD PMID:15328426 RGD:7495765 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Bdnf brain derived neurotrophic factor severity ISO protein:increased expression:serum: RGD PMID:18830907 RGD:8657019 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 ISO mRNA, protein:increased expression: labial gland, CD19+ B cell, CD4-CD8-CD19-monocyte: RGD PMID:30249485 RGD:14398821 NCBI chr 8:71,534,255...71,537,472
Ensembl chr 8:71,534,255...71,537,456
JBrowse link
G C3 complement component 3 IMP RGD PMID:17675493 RGD:7401265 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G Cast calpastatin ISO associated with Lupus Erythematosus, Systemic RGD PMID:15540513 RGD:5683622 NCBI chr13:74,692,366...74,808,874
Ensembl chr13:74,692,368...74,808,810
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 no_association ISO DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD PMID:12412204, PMID:23773920 RGD:8551796, RGD:8551818 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 IEA OMIM:270150 MouseDO NCBI chr11:99,144,199...99,155,077
Ensembl chr11:99,144,196...99,155,077
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:salivary ductal epithelium (human) RGD PMID:12472667 RGD:11520791 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Crp C-reactive protein, pentraxin-related ISO associated with Arthritis, Rheumatoid;protein:increased expression:serum: RGD PMID:2353152, PMID:16013223 RGD:9491774, RGD:9491835 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility ISO DNA:SNPs,haplotype: :+49A/G (rs231775),(rs3087243)(human)
mRNA:increased expression:salivary gland:
RGD PMID:16869018, PMID:12528117 RGD:7421506, RGD:7421519 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEA OMIM:270150 MouseDO NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO associated with Arthritis, Rheumatoid;DNA:polymorphism: :4889A>G (human) RGD PMID:12590982 RGD:5147747 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Dgkq diacylglycerol kinase, theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 5:108,647,044...108,660,830
Ensembl chr 5:108,646,693...108,669,672
JBrowse link
G E2f1 E2F transcription factor 1 IEA OMIM:270150 MouseDO NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) ISO
IEA
IMP
IEP
protein:increased expression:serum (human)
OMIM:270150
protein:decreased expression:lacrimal gland, lymphocyte (mouse)
MouseDO PMID:9890678, PMID:9870874, PMID:11157873 RGD:8662410, RGD:8662451, RGD:8662436 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO RGD PMID:9853108 RGD:6218983 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575
JBrowse link
G Gtf2i general transcription factor II I ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066 NCBI chr 5:134,237,832...134,317,678
Ensembl chr 5:134,237,834...134,314,760
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO DNA:polymorphism:cds:HLA-DQA1*0101 (human)
DNA:polymorphisms::HLA-DQA1*0501,LA-DQA1*0301/2;
RGD PMID:11555411, PMID:21315052 RGD:5147809, RGD:7421543 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility ISO DNA:polymorphisms:cds:HLA-DQB1*0201 (human)
associated with Chronic Hepatitis C;DNA:polymorphism:cds:HLA-DQB1*02 (human)
DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0201, HLA-DQB1*0401, HLA-DQB1*0601 (human)
RGD PMID:21315052, PMID:17489060, PMID:8468491 RGD:7421543, RGD:36174022, RGD:7483566 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism:cds:HLA-DRB1*0301 (human) RGD PMID:11555411 RGD:5147809 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:24941846 RGD:10450595 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 ISO RGD PMID:19264855 RGD:10054311 NCBI chr11:50,375,257...50,386,528
Ensembl chr11:50,376,990...50,386,528
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO
IMP
IEP
protein:increased expression:salivary gland
protein:increased expression:plasma
RGD PMID:11359451, PMID:21589878, PMID:15037117 RGD:8158122, RGD:8547705, RGD:8547696 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Id3 inhibitor of DNA binding 3 IEA OMIM:270150 MouseDO NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Ifng interferon gamma IMP
ISO
RGD PMID:15584966, PMID:28421993 RGD:8142390, RGD:14975117 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:12233881 RGD:1580479 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12a interleukin 12a ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il17a interleukin 17A IMP RGD PMID:21182786 RGD:8696035 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:saliva RGD PMID:23906036 RGD:8655918 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
protein:increased expression:conjunctiva (human)
RGD PMID:9646842, PMID:11527941 RGD:8549786, RGD:8549807 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 IEA OMIM:270150 MouseDO NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il23r interleukin 23 receptor ISO protein:increased expression:minor salivary gland: RGD PMID:22262980 RGD:8549566 NCBI chr 6:67,422,932...67,491,855
Ensembl chr 6:67,422,932...67,491,855
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain IEA OMIM:270150 MouseDO NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Il4 interleukin 4 IEA OMIM:270150 MouseDO NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 severity ISO protein:increased expression:plasma:
DNA:polymorphims:promoter:-174G>C(human)
RGD PMID:11426023, PMID:11426023 RGD:7829718, RGD:7829718 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 9:82,829,806...82,847,688
Ensembl chr 9:82,829,540...82,847,687
JBrowse link
G Itsn2 intersectin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr12:4,592,643...4,713,952
Ensembl chr12:4,592,638...4,713,962
JBrowse link
G Lta lymphotoxin A no_association
susceptibility
IMP
ISO
DNA:SNPs: :multiple (human)
DNA:SNP, haplotype:intron: (rs909253) (human)
protein:increased expression:saliva, serum
RGD PMID:20952683, PMID:22294627, PMID:22294627, PMID:20952683 RGD:8548776, RGD:8548787, RGD:8548787, RGD:8548776 NCBI chr17:35,203,165...35,205,578
Ensembl chr17:35,203,165...35,205,351
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 IEA OMIM:270150 MouseDO NCBI chr11:103,219,764...103,267,401
Ensembl chr11:103,219,762...103,267,472
JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:19332626 RGD:8693671 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased activity:saliva RGD PMID:15316122, PMID:9923658 RGD:8547814, RGD:8547858 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Muc16 mucin 16 ISO mRNA, protein:increased expression:conjunctival epithelial cell, tear RGD PMID:19122828 RGD:7364772 NCBI chr 9:18,495,445...18,674,821
Ensembl chr 9:18,495,455...18,674,530
JBrowse link
G Muc19 mucin 19 ISO
IEA
mRNA:decreased expression:conjunctival epithelial cell
OMIM:270150
MouseDO PMID:18184611 RGD:7364736 NCBI chr15:91,838,326...91,934,555
Ensembl chr15:91,838,326...91,934,555
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric ISO mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18184611 RGD:7364736 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28135245 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha IEA OMIM:270150 MouseDO NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Phip pleckstrin homology domain interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr 9:82,866,159...82,981,668
Ensembl chr 9:82,866,159...82,975,516
JBrowse link
G Pon1 paraoxonase 1 ISO protein:decreased activity:serum (human) RGD PMID:20497955 RGD:8547550 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr10:44,437,174...44,528,558
Ensembl chr10:44,437,177...44,528,501
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) no_association ISO DNA:snp:cds:c.1858C>T (human) RGD PMID:16163373, PMID:15933742 RGD:11534998, RGD:11534999 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G Pttg1 pituitary tumor-transforming gene 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr11:43,420,244...43,427,463
Ensembl chr11:43,420,250...43,426,251
JBrowse link
G Reg1 regenerating islet-derived 1 ISO protein:increased expression:minor salivary gland, salivary ductal epithelium (human) RGD PMID:19016805 RGD:9850137 NCBI chr 6:78,425,983...78,428,668
Ensembl chr 6:78,422,711...78,428,667
JBrowse link
G Rorc RAR-related orphan receptor gamma IEA OMIM:270150 MouseDO NCBI chr 3:94,372,794...94,398,276
Ensembl chr 3:94,372,794...94,398,276
JBrowse link
G Selp selectin, platelet ISO protein:increased expression:plasma RGD PMID:19832990 RGD:6478702 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G St14 suppression of tumorigenicity 14 (colon carcinoma) IEA OMIM:270150 MouseDO NCBI chr 9:31,088,590...31,131,811
Ensembl chr 9:31,089,402...31,131,853
JBrowse link
G Stat4 signal transducer and activator of transcription 4 susceptibility
no_association
ISO DNA:SNP:intron: (rs7582694) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs7574865) (human)
CTD PMID:24097066, PMID:24097067, PMID:20535138, PMID:20360187, PMID:18273036 RGD:8661690, RGD:8661709, RGD:8661708 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189
JBrowse link
G Tgfb1 transforming growth factor, beta 1 severity IMP
IEA
IEP
OMIM:270150 MouseDO PMID:9358754, PMID:7554451 RGD:7394829, RGD:7394845 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thbs1 thrombospondin 1 IEA OMIM:270150 MouseDO NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Tnf tumor necrosis factor treatment ISO DNA:polymorphism: :-1031T>C(human) RGD PMID:22703762, PMID:24941846 RGD:7394766, RGD:10450595 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066, PMID:24097067 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b IEA OMIM:270150 MouseDO NCBI chr 8:10,006,229...10,036,000
Ensembl chr 8:10,006,467...10,039,072
JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chr11:54,910,787...54,962,956
Ensembl chr11:54,910,785...54,962,917
JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 IEA OMIM:270150 MouseDO NCBI chr10:39,612,934...39,655,307
Ensembl chr10:39,612,934...39,655,307
JBrowse link
G Vim vimentin ISO RGD PMID:6352937 RGD:6480477 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Vip vasoactive intestinal polypeptide IDA RGD PMID:22059987 RGD:5685375 NCBI chr10:5,639,193...5,647,617
Ensembl chr10:5,639,218...5,647,617
JBrowse link
Sjögren-Mikulicz Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstm1 glutathione S-transferase, mu 1 susceptibility ISO DNA:deletion: : RGD PMID:10616008 RGD:5491001 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
Systemic Juvenile Rheumatoid Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 IMP RGD PMID:26914138 RGD:11529541 NCBI chr 8:24,584,133...24,596,952
Ensembl chr 8:24,584,136...24,597,009
JBrowse link
G Il6 interleukin 6 ISO OMIM NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il6ra interleukin 6 receptor, alpha treatment ISO RGD PMID:18358927 RGD:10402823 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO OMIM NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13427
    disease of anatomical entity 12903
      musculoskeletal system disease 5436
        autoimmune disease of musculoskeletal system 869
          rheumatic disease 665
            rheumatoid arthritis 428
              Caplan's syndrome 0
              Felty's syndrome 0
              Rheumatoid Nodule 0
              Rheumatoid Vasculitis 0
              Sjogren's syndrome + 68
              Sjögren-Mikulicz Syndrome 1
              adult-onset Still's disease 2
              juvenile rheumatoid arthritis + 150
              palindromic rheumatism 0
Path 2
Term Annotations click to browse term
  disease 13427
    disease of anatomical entity 12903
      Immune & Inflammatory Diseases 3153
        immune system disease 2636
          primary immunodeficiency disease 2067
            autoimmune disease 1422
              autoimmune disease of musculoskeletal system 869
                rheumatic disease 665
                  rheumatoid arthritis 428
                    Caplan's syndrome 0
                    Felty's syndrome 0
                    Rheumatoid Nodule 0
                    Rheumatoid Vasculitis 0
                    Sjogren's syndrome + 68
                    Sjögren-Mikulicz Syndrome 1
                    adult-onset Still's disease 2
                    juvenile rheumatoid arthritis + 150
                    palindromic rheumatism 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.