Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:rheumatoid arthritis
go back to main search page
Accession:DOID:7148 term browser browse the term
Definition:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (DO)
Synonyms:exact_synonym: RA;   RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO;   atrophic arthritis;   rheumatic arthritis or polyarthritis
 narrow_synonym: RHEUMATOID ARTHRITIS, PROGRESSION OF
 primary_id: MESH:D001172
 alt_id: OMIM:180300
 xref: ICD10CM:M06.9;   ICD9CM:714.0;   NCI:C2884
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20080907, PMID:22104130 NCBI chrNW_004936763:1,225,355...1,308,257 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936636:292,631...341,999 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936490:11,039,968...11,086,670 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936472:14,396,986...14,624,597 JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936578:5,838,044...5,916,287 JBrowse link
G Acan aggrecan disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased degradation:cartilage
CTD
RGD
PMID:15292528, PMID:16507130 RGD:11570537 NCBI chrNW_004936483:14,811,152...14,846,305 JBrowse link
G Ackr3 atypical chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936525:1,559,575...1,570,679 JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 ISO mRNA:increased expression:synovium RGD PMID:11801682 RGD:10043106 NCBI chrNW_004936903:490,718...500,443 JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO protein:alternative form:synovium RGD PMID:11801682 RGD:10043106 NCBI chrNW_004936640:857,565...899,355 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:12833524, PMID:21789720 RGD:5686424 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936619:597,970...618,564 JBrowse link
G Adrb3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:12739037 RGD:5684893 NCBI chrNW_004936710:1,410,589...1,413,279 JBrowse link
G Aff3 AF4/FMR2 family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936661:771,265...1,264,456 JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO protein:decreased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16385501, PMID:20541603 RGD:7244141 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18617548 NCBI chrNW_004936546:3,737,908...3,783,492 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Ang angiogenin ISO RGD PMID:12653852 RGD:6892721 NCBI chrNW_004936880:39,372...40,070 JBrowse link
G Ankrd55 ankyrin repeat domain 55 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936480:11,672,300...11,769,183 JBrowse link
G Anxa3 annexin A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936676:2,153,752...2,216,498 JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:20367977 RGD:5685646 NCBI chrNW_004936542:2,098,683...2,101,127 JBrowse link
G Arid5b AT-rich interaction domain 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963, PMID:23143596 NCBI chrNW_004936614:1,072,263...1,252,573 JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19193698 NCBI chrNW_004936586:1,782,581...1,809,458 JBrowse link
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936491:7,482,226...7,511,419 JBrowse link
G B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936475:17,624,327...17,627,944 JBrowse link
G Baiap2l1 BAR/IMD domain containing adaptor protein 2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936750:829,188...918,316 JBrowse link
G Bcl2a1 BCL2 related protein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936471:37,981,851...37,993,097 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936604:548,844...551,031 JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:3488088, PMID:22447331 RGD:6483593, RGD:6483600 NCBI chrNW_004936580:5,480,023...5,482,288 JBrowse link
G Bgn biglycan ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chrNW_004936809:375,589...389,718 JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936675:3,228,982...3,246,617 JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936534:4,707,658...4,871,865 JBrowse link
G Btnl2 butyrophilin like 2 susceptibility ISO DNA:SNPs: : RGD PMID:23364395 RGD:9685033 NCBI chrNW_004936727:567,656...587,784 JBrowse link
G C3 complement C3 ISO RGD PMID:7561187 RGD:11040775 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chrNW_004936579:868,681...1,046,198 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:18785314 RGD:5684540 NCBI chrNW_004936486:4,082,664...4,114,942 JBrowse link
G Cast calpastatin ISO RGD PMID:7706496 RGD:5683620 NCBI chrNW_004936523:6,688,153...6,798,184 JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Cav2 caveolin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936589:2,553,932...2,561,186 JBrowse link
G Ccl21 C-C motif chemokine ligand 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chrNW_004936524:2,787,963...2,789,116 JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chrNW_004936475:9,432,505...9,436,240 JBrowse link
G Ccl8 C-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936538:805,273...806,715 JBrowse link
G Ccn1 cellular communication network factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936608:152,174...155,123 JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936560:42,561...45,748 JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chrNW_004936596:223,660...224,739 JBrowse link
G Ccr4 C-C motif chemokine receptor 4 ISO mRNA:increased expression:synovium:
protein:increased expression:synovial membrane:
RGD PMID:19942450, PMID:25430645 RGD:10054497, RGD:10054499 NCBI chrNW_004936473:23,321,167...23,323,075 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453841, PMID:20453842, PMID:23143596 NCBI chrNW_004936489:16,669,297...16,689,451 JBrowse link
G Cd2 CD2 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936627:1,902,120...1,915,257 JBrowse link
G Cd244 CD244 molecule susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:18794858 NCBI chrNW_004936903:146,108...162,410 JBrowse link
G Cd28 CD28 molecule ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:19075187, PMID:19898481, PMID:20453842, PMID:23143596 RGD:5131619 NCBI chrNW_004936631:335,411...363,407 JBrowse link
G Cd3e CD3e molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936542:3,379,361...3,390,677 JBrowse link
G Cd40 CD40 molecule ISO DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:18794853, PMID:20453842, PMID:20498205, PMID:23143596 RGD:5490972 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Cd5 CD5 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936581:1,854,166...1,866,843 JBrowse link
G Cd80 CD80 molecule ISO protein:increased expression:serum RGD PMID:22917707 RGD:6893647 NCBI chrNW_004936536:6,462,080...6,483,450 JBrowse link
G Cd83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936552:637,471...654,422 JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853 NCBI chrNW_004936803:1,025,047...1,229,396 JBrowse link
G Chi3l1 chitinase 3 like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:10461474 RGD:4892605 NCBI chrNW_004936567:1,411,080...1,418,332 JBrowse link
G Ciita class II major histocompatibility complex transactivator susceptibility
no_association
ISO ClinVar Annotator: match by term: Rheumatoid arthritis
DNA:haplotype:promoter/CDS:rs3087456G/rs4774C
DNA:polymorphism:promoter:rs3087456, no association in a German cohort
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
RGD
CTD
PMID:15821736, PMID:16426246, PMID:16849401, PMID:19221398 RGD:5491176, RGD:5491189 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Clec12a C-type lectin domain family 12 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936902:542,981...556,142 JBrowse link
G Clec16a C-type lectin domain containing 16A ISO DNA:polymorphism:intron:rs6498169G RGD PMID:19221398 RGD:5491176 NCBI chrNW_004936530:9,089,478...9,264,563 JBrowse link
G Col2a1 collagen type II alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:27028940, PMID:29935983 NCBI chrNW_004936512:5,861,933...5,894,898 JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chrNW_004936519:6,431,156...6,473,183 JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:1568518, PMID:22173958 RGD:6904209 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Csf2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936647:3,081,896...3,083,864 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936816:680,798...690,959 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:11465708 RGD:4892002 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:19192274 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO protein:increased expression:synovial fluid, neutrophil RGD PMID:19017998 RGD:4145632 NCBI chrNW_004936762:66,636...69,694 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Ddit4 DNA damage inducible transcript 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936521:6,646,864...6,648,982 JBrowse link
G Ddx6 DEAD-box helicase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936542:3,748,599...3,781,405 JBrowse link
G Dhfr dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Dnase1l3 deoxyribonuclease 1 like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chrNW_004936473:8,430,235...8,495,170 JBrowse link
G Dnmt1 DNA methyltransferase 1 severity ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chrNW_004936659:520,181...565,496 JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO DNA:polymorphism:promoter:-283C>T(human) RGD PMID:19777235 RGD:9589110 NCBI chrNW_004936485:19,547,836...19,570,716 JBrowse link
G Edn1 endothelin 1 treatment ISO RGD PMID:22249931 RGD:8661695 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Eln elastin ISO RGD PMID:12643515 RGD:9585739 NCBI chrNW_004936543:3,135,169...3,165,023 JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898480 NCBI chrNW_004936623:3,115,357...3,130,289 JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Esr2 estrogen receptor 2 severity ISO DNA:SNP:exon:rs1256049(human) RGD PMID:21523342 RGD:5508794 NCBI chrNW_004936495:7,956,168...8,018,356 JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26001728 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO DNA:snp:promoter:g.-670A>G (human)
protein:increased expression:serum (human)
RGD PMID:12148596, PMID:20875116, PMID:23053964 RGD:12903969, RGD:8662433, RGD:8662455 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human)
DNA:CNVs
protein:decreased expression:NK cell
RGD PMID:15334114, PMID:19019892, PMID:25154742 RGD:11344974, RGD:5508391, RGD:5508467 NCBI chrNW_004937131:42,523...49,533 JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936476:23,611,166...23,702,283 JBrowse link
G Foxo3 forkhead box O3 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell,synovium: RGD PMID:19435720 RGD:10402186 NCBI chrNW_004936564:4,788,036...4,907,600 JBrowse link
G Foxp3 forkhead box P3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20476861 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
G Fpgs folylpolyglutamate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936487:15,453,010...15,466,591 JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936500:8,750,928...8,782,303 JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936484:6,780,692...6,800,883 JBrowse link
G Gc GC vitamin D binding protein ISO protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:3874814, PMID:9548303 RGD:5509931 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18830904 NCBI chrNW_004936561:5,343,038...5,347,721 JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23897011 NCBI chrNW_004936496:10,485,528...10,505,506 JBrowse link
G Gin1 gypsy retrotransposon integrase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936523:1,418,387...1,443,322 JBrowse link
G Gprc5a G protein-coupled receptor class C group 5 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936587:4,427,208...4,443,302 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO CTD Direct Evidence: marker/mechanism
DNA: deletion: : heterozygous
protein: decreased expression: mononuclear leukocytes
CTD
RGD
PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 no_association ISO protein: : mononuclear blood cells
DNA: deletion::GRK2 and GRK6 deletions resulted in more severe arthritis
RGD PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO DNA: deletion: : homozygous
protein: decreased expression: mononuclear leukocytes
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10094932, PMID:18662895 RGD:5688373, RGD:5688380 NCBI chrNW_004936597:1,706,671...1,722,370 JBrowse link
G Gsdme gasdermin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936478:1,655,487...1,720,996 JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936469:2,745,568...2,772,789 JBrowse link
G Hcls1 hematopoietic cell-specific Lyn substrate 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936536:8,065,489...8,084,777 JBrowse link
G Hdac1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289289 NCBI chrNW_004936474:15,320,635...15,351,418 JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Hgf hepatocyte growth factor disease_progression ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chrNW_004936734:354,798...428,356 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 RGD:10395366 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 severity ISO RGD PMID:18025202 RGD:9685481 NCBI chrNW_004936478:2,970,261...2,980,277 JBrowse link
G Hoxd10 homeobox D10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936509:5,603,661...5,606,850 JBrowse link
G Hoxd13 homeobox D13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936509:5,579,846...5,581,651 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936557:3,358,809...3,403,461 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chrNW_004936835:316,767...321,999 JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:peripheral blood lymphocyte (human) RGD PMID:22047640 RGD:5688784 NCBI chrNW_004936647:2,087,650...2,133,343 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO protein:increased expression:synovial joint RGD PMID:11315915 RGD:5685639 NCBI chrNW_004936487:13,348,465...13,352,717 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO protein:increased expression:synovial cell: RGD PMID:23739258 RGD:10402561 NCBI chrNW_004936531:7,702,186...7,716,428 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO protein:increased expression:serum: RGD PMID:21417552 RGD:10402843 NCBI chrNW_004936543:2,110,351...2,111,896 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO mRNA:increased expression:peripheral blood leukocyte: RGD PMID:21417552 RGD:10402843 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Ifng interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:1417133, PMID:22450443 RGD:8157623 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Igf2 insulin like growth factor 2 ISO DNA:loss of imprinting:synovial cell
protein:decreased expression:plasma
RGD PMID:11247331, PMID:19556211 RGD:5510001, RGD:5510014 NCBI chrNW_004936816:972,902...981,232 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Ikzf3 IKAROS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936490:14,939,693...15,025,728 JBrowse link
G Il10 interleukin 10 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:12847677, PMID:22450443 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:20926833 RGD:9068415 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16368150 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Rheumatoid arthritis, progression of ClinVar PMID:12847677 NCBI chrNW_004936557:5,765,093...5,769,853 JBrowse link
G Il1a interleukin 1 alpha severity ISO protein:increased expression:plasma, synovial fluid
associated with lung disease, interstitial
RGD PMID:8162643, PMID:11192540 RGD:4142818, RGD:7794716 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum
CTD
RGD
PMID:12566094, PMID:17379860, PMID:22414257, PMID:22450443 RGD:6482656 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:7706905, PMID:10637275, PMID:19192274, PMID:19447938 RGD:7174696, RGD:8549810 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il2 interleukin 2 ISO RGD PMID:6421522 RGD:8662948 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il20 interleukin 20 ISO RGD PMID:16947773 RGD:5147395 NCBI chrNW_004936557:5,749,419...5,751,776 JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:19342640 RGD:6892964 NCBI chrNW_004936501:11,100,170...11,112,112 JBrowse link
G Il23a interleukin 23 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936646:743,630...745,998 JBrowse link
G Il23r interleukin 23 receptor susceptibility ISO DNA:SNP::rs1343151(human) RGD PMID:18647855 RGD:8549596 NCBI chrNW_004936591:4,365,598...4,425,053 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:20476861, PMID:23143596 NCBI chrNW_004936484:8,514,333...8,555,392 JBrowse link
G Il2rb interleukin 2 receptor subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936492:3,795,940...3,805,822 JBrowse link
G Il3 interleukin 3 ISO DNA: SNPs: Multiple: gene-gene interaction RGD PMID:20018070 RGD:5686905 NCBI chrNW_004936647:3,102,922...3,104,758 JBrowse link
G Il4r interleukin 4 receptor severity ISO DNA:SNP: :rs1805010 (human) RGD PMID:24782180 RGD:10402783 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22293286 RGD:5687156 NCBI chrNW_004936647:2,647,982...2,651,477 JBrowse link
G Il6r interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16729287, PMID:23143596 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Il6st interleukin 6 signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936809:891,407...900,311 JBrowse link
G Irf5 interferon regulatory factor 5 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Rheumatoid arthritis
CTD
ClinVar
PMID:15657875, PMID:16642019, PMID:17599733, PMID:18063667, PMID:20453842, PMID:23143596 NCBI chrNW_004936579:6,138,372...6,149,531 JBrowse link
G Irf8 interferon regulatory factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936641:2,608,109...2,622,446 JBrowse link
G Itga6 integrin subunit alpha 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936509:2,508,446...2,587,643 JBrowse link
G Itgb2 integrin subunit beta 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G Itpa inosine triphosphatase treatment ISO DNA:SNP: :94C>A(human) RGD PMID:29441893 RGD:14975307 NCBI chrNW_004936485:15,499,688...15,511,992 JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:21510883 RGD:6483024 NCBI chrNW_004936503:111,722...243,627 JBrowse link
G Kif5a kinesin family member 5A susceptibility ISO DNA:snps:intron, 3' utr:c.2756-43A>C, c.*776C>T (rs775246, rs775251) (human)
CTD Direct Evidence: marker/mechanism
DNA:snp:intron:c.1717-152C>G (rs1678542) (human)
RGD
CTD
PMID:21784728, PMID:23143596, PMID:23378462 RGD:12793072, RGD:12793073 NCBI chrNW_004936646:1,697,531...1,730,376 JBrowse link
G Lcn2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7554268 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
G Lhx2 LIM homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936487:12,395,817...12,413,860 JBrowse link
G LOC101963197 HLA class II histocompatibility antigen, DP beta 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17956852, PMID:22286218 NCBI chrNW_004936476:25,730,800...25,741,089 JBrowse link
G LOC101964209 C-C chemokine receptor type 1 ISO RGD PMID:12860725 RGD:5688170 NCBI chrNW_004936596:177,774...183,186 JBrowse link
G LOC101968486 HLA class II histocompatibility antigen, DQ alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936727:373,464...378,784 JBrowse link
G Lrrk2 leucine rich repeat kinase 2 ISO RGD PMID:17082220 RGD:5508419 NCBI chrNW_004936607:628,469...761,117 JBrowse link
G Ly96 lymphocyte antigen 96 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860 NCBI chrNW_004936648:2,653,252...2,671,453 JBrowse link
G Mab21l2 mab-21 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936689:694,119...696,840 JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936679:2,373,104...2,379,230 JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 ISO mRNA:increased expression:mononuclear cell RGD PMID:20937307 RGD:9588623 NCBI chrNW_004936497:9,512,350...9,619,250 JBrowse link
G Mbd4 methyl-CpG binding domain 4, DNA glycosylase susceptibility
no_association
ISO DNA:snps:introns:IVS5-140A>G (rs3138355), IVS6-218C>T (rs2005618) (human)
DNA:snps:cds, intron:p.E346K, IVS6-218C>T (rs140693, rs2005618) (human)
RGD PMID:20676650, PMID:22505706 RGD:9588977, RGD:9588978 NCBI chrNW_004936602:956,829...964,653 JBrowse link
G Mdk midkine ISO RGD PMID:15146411 RGD:1581200 NCBI chrNW_004936562:2,687,825...2,690,292 JBrowse link
G Mgarp mitochondria localized glutamic acid rich protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936535:8,321,443...8,336,773 JBrowse link
G Mif macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Mmel1 membrane metalloendopeptidase like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936737:970,504...997,452 JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO protein:increased expression:plasma (human) RGD PMID:9972954 RGD:7207129 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Mmp10 matrix metallopeptidase 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936551:5,188,395...5,197,477 JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16872482 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004936551:5,228,950...5,238,948 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16406300 RGD:1582623 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443, PMID:26001728 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :677C>T(human)
CTD
RGD
PMID:22104130, PMID:23685257 RGD:7387222 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:28135245 NCBI chrNW_004936543:3,617,369...3,630,990 JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936481:6,300,894...6,325,878 JBrowse link
G Ndufa4l2 NDUFA4 mitochondrial complex associated like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936646:1,428,025...1,430,215 JBrowse link
G Nfkbie NFKB inhibitor epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936476:15,818,605...15,825,558 JBrowse link
G Nfkbil1 NFKB inhibitor like 1 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
DNA:snp:promoter:c.-132T>A (rs2071592) (human)
OMIM
ClinVar
CTD
RGD
PMID:12509789 RGD:1331681 NCBI chrNW_004936727:1,950,356...1,963,847 JBrowse link
G Notch4 notch receptor 4 ISO mRNA : increased expression: : cd4+ cells RGD PMID:20132067 RGD:6480790 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Npsr1 neuropeptide S receptor 1 ISO RGD PMID:20179762 RGD:4891930 NCBI chrNW_004936478:10,352,894...10,542,949 JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO mRNA:increased expression:paw RGD PMID:18448865 RGD:4892311 NCBI chrNW_004936504:10,960,069...11,056,834 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936524:8,252,321...8,290,747 JBrowse link
G Padi2 peptidyl arginine deiminase 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chrNW_004936474:4,033,703...4,066,468 JBrowse link
G Padi4 peptidyl arginine deiminase 4 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:23143596 NCBI chrNW_004936474:4,219,183...4,239,551 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:1708827 RGD:6482653 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pgf placental growth factor ISO RGD PMID:19180491 RGD:6483591 NCBI chrNW_004936488:4,098,187...4,111,108 JBrowse link
G Pla2g7 phospholipase A2 group VII ISO RGD PMID:17326817 RGD:6482776 NCBI chrNW_004936476:13,609,847...13,646,174 JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:22011479 RGD:6484117 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Plb1 phospholipase B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24520335 NCBI chrNW_004936493:4,112,632...4,210,882 JBrowse link
G Pld4 phospholipase D family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936621:515,710...523,317 JBrowse link
G Plek pleckstrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936491:12,762,421...12,818,249 JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16055108 NCBI chrNW_004936585:4,954,871...4,979,560 JBrowse link
G Prdm1 PR/SET domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898481, PMID:20453842, PMID:23143596 NCBI chrNW_004936564:2,594,362...2,690,680 JBrowse link
G Prkcq protein kinase C theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:23143596 NCBI chrNW_004936484:8,048,239...8,166,058 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15167967 NCBI chrNW_004936487:10,745,465...10,758,812 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11978490, PMID:19192274, PMID:21905970 RGD:5508313 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936470:10,379,855...10,578,531 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446963 NCBI chrNW_004936626:2,390,004...2,472,039 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 susceptibility
no_association
ISO ClinVar Annotator: match by term: Rheumatoid arthritis
DNA:SNP::1858C>T (human)
DNA:snp:cds:p.R263Q (rs33996649) (human)
CTD Direct Evidence: marker/mechanism
DNA:snp:cds:p.R620W (rs2476601) (human)
OMIM
ClinVar
RGD
CTD
PMID:15004560, PMID:15208781, PMID:15273934, PMID:15580548, PMID:15719322, PMID:15744042, PMID:16273109, PMID:16339849, PMID:16470599, PMID:17170052, PMID:17436241, PMID:17554300, PMID:17878369, PMID:18301444, PMID:18978792, PMID:19265110, PMID:19430480, PMID:19898480, PMID:20453842, PMID:21190368, PMID:21279993, PMID:21467606, PMID:21841778, PMID:23143596, PMID:28492532, PMID:30224649 RGD:6484535, RGD:6484595, RGD:7829746 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936567:5,266,653...5,378,464 JBrowse link
G Pxk PX domain containing serine/threonine kinase like ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chrNW_004936473:2,587,145...2,635,083 JBrowse link
G Rab8a RAB8A, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936596:4,385,788...4,403,393 JBrowse link
G Rap2a RAP2A, member of RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936472:12,634,563...12,671,656 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936471:2,152,231...2,222,260 JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
G Rcan1 regulator of calcineurin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936500:7,942,099...7,950,256 JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19503088, PMID:20453842, PMID:23143596 NCBI chrNW_004936491:6,405,493...6,435,096 JBrowse link
G Rgmb repulsive guidance molecule BMP co-receptor b ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004936523:5,050,765...5,078,777 JBrowse link
G Runx1 RUNX family transcription factor 1 no_association ISO DNA:SNPs: :rs2242720, rs4816502 (human)
DNA:SNP:intron:24658G>C (human)
DNA:SNP: :rs2268277 (human)
RGD PMID:16821265, PMID:18087673, PMID:18328148, PMID:20018071 RGD:6482836, RGD:6482837, RGD:6482839, RGD:6482840 NCBI chrNW_004936500:7,621,328...7,710,909 JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936476:14,695,965...14,818,246 JBrowse link
G Sema3c semaphorin 3C ISO protein:increased expression:knee, synovium (human) RGD PMID:15077297 RGD:1580084 NCBI chrNW_004936810:903,306...1,063,024 JBrowse link
G Slc11a1 solute carrier family 11 member 1 severity ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphisms, deletion: :823C>T, p.D543N (human)
DNA:polymorphism:promoter (human)
CTD
RGD
PMID:10719815, PMID:12135431, PMID:16597321 RGD:5684967, RGD:5684971 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Slc22a4 solute carrier family 22 member 4 susceptibility ISO ClinVar Annotator: match by term: Rheumatoid arthritis
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:14608356 NCBI chrNW_004936647:2,825,814...2,874,786 JBrowse link
G Slc25a12 solute carrier family 25 member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936509:1,994,082...2,077,731 JBrowse link
G Sms spermine synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936624:2,345,573...2,402,157 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524, PMID:15292528, PMID:24313545 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15761492 RGD:1581382 NCBI chrNW_004936905:148,956...156,023 JBrowse link
G Spred2 sprouty related EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936491:10,053,546...10,170,950 JBrowse link
G St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17379860, PMID:17568789 NCBI chrNW_004936571:3,815,867...3,971,219 JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936506:7,196,860...7,235,854 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO associated with T-cell large granular lymphocyte leukemia
ClinVar Annotator: match by term: Rheumatoid arthritis
RGD
ClinVar
PMID:22591296, PMID:28492532, PMID:30311386 RGD:6892936 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936644:1,328,327...1,395,856 JBrowse link
G Supt20h SPT20 homolog, SAGA complex component ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar NCBI chrNW_004936472:31,119,671...31,129,939 JBrowse link
G Tagap T cell activation RhoGTPase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936489:10,615,324...10,623,720 JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:9645419 RGD:6482275 NCBI chrNW_004936476:25,913,699...25,923,419 JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528, PMID:17379860 NCBI chrNW_004936803:69,296...90,270 JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15700117 RGD:5685020 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Tle3 TLE family member 3, transcriptional corepressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596 NCBI chrNW_004936471:29,682,313...29,730,229 JBrowse link
G Tlr2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tmpo thymopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12833524 NCBI chrNW_004936492:14,972,391...15,000,115 JBrowse link
G Tnf tumor necrosis factor treatment
no_association
ISO DNA:SNP:promoter:-857C>T (human)
DNA:SNP:promoter:-238G>A, -308G>A (human)
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:2001072, PMID:8391952, PMID:12563673, PMID:12566094, PMID:22450443, PMID:25311255 RGD:10450537, RGD:12904065 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfaip2 TNF alpha induced protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936621:1,891,326...1,903,504 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:20453842, PMID:21841782, PMID:23143596, PMID:30224649 NCBI chrNW_004936560:5,124,955...5,138,988 JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b ISO CTD Direct Evidence: therapeutic CTD PMID:23333834 NCBI chrNW_004936470:27,571,263...27,598,725 JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842 NCBI chrNW_004936737:1,008,228...1,013,575 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment ISO DNA:SNP:promoter:36G>A (human) RGD PMID:25311255 RGD:12904065 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Tnfsf14 TNF superfamily member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004936588:3,976,492...3,979,825 JBrowse link
G Traf1 TNF receptor associated factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794853, PMID:23143596 NCBI chrNW_004936487:9,349,883...9,368,946 JBrowse link
G Traf6 TNF receptor associated factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453842, PMID:23143596 NCBI chrNW_004936533:1,857,685...1,874,973 JBrowse link
G Trappc2 trafficking protein particle complex 2 ISO ClinVar Annotator: match by term: Rheumatoid arthritis ClinVar PMID:30311386 NCBI chrNW_004936470:3,278,415...3,292,905 JBrowse link
G Txndc5 thioredoxin domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326410 NCBI chrNW_004936534:4,679,636...4,706,682 JBrowse link
G Txnip thioredoxin interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19192274 NCBI chrNW_004936867:722,544...726,595 JBrowse link
G Tyk2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23143596, PMID:30224649 NCBI chrNW_004936659:681,463...704,484 JBrowse link
G Tyms thymidylate synthetase treatment ISO DNA:polymorphism: : RGD PMID:22763757 RGD:11075093 NCBI chrNW_004936550:33,797...42,233 JBrowse link
G Vdr vitamin D receptor no_association ISO DNA:SNP:exon:rs2228570 (human)
DNA:SNP: :rs1544410 (human)
RGD PMID:21820934 RGD:8158077 NCBI chrNW_004936512:5,741,836...5,800,999 JBrowse link
G Vegfa vascular endothelial growth factor A disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:
CTD
RGD
PMID:16368150, PMID:24387171 RGD:8548659 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Vim vimentin ISO RGD PMID:21792832 RGD:6480508 NCBI chrNW_004936520:10,051,692...10,059,324 JBrowse link
adult-onset Still's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hgf hepatocyte growth factor ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chrNW_004936734:354,798...428,356 JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:serum: RGD PMID:24387171 RGD:8548659 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
juvenile rheumatoid arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936529:5,661,772...5,723,108 JBrowse link
G Acrbp acrosin binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936709:1,148,454...1,158,069 JBrowse link
G Adcy7 adenylate cyclase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936475:3,368,069...3,393,306 JBrowse link
G Ankrd9 ankyrin repeat domain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936835:608,461...613,157 JBrowse link
G Aopep aminopeptidase O (putative) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936626:3,704,474...3,973,913 JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:19,321,366...19,361,227 JBrowse link
G Areg amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936470:18,340,120...18,640,396 JBrowse link
G Avl9 AVL9 cell migration associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936478:8,545,240...8,606,875 JBrowse link
G B4galt5 beta-1,4-galactosyltransferase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936514:4,719,198...4,736,638 JBrowse link
G Bend2 BEN domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936470:7,379,946...7,441,955 JBrowse link
G Btg1 BTG anti-proliferation factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936507:8,789,952...8,797,247 JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936505:10,032,333...10,046,008 JBrowse link
G C8b complement C8 beta chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:7980680 NCBI chrNW_004936522:4,638,111...4,673,388 JBrowse link
G C9orf72 C9orf72-SMCR8 complex subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936611:2,074,655...2,101,846 JBrowse link
G Cald1 caldesmon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936579:868,681...1,046,198 JBrowse link
G Camsap1 calmodulin regulated spectrin associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936669:1,785,229...1,831,876 JBrowse link
G Cd14 CD14 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936531:9,572,392...9,575,771 JBrowse link
G Cd83 CD83 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936552:637,471...654,422 JBrowse link
G Cd8b CD8b molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936712:828,073...841,889 JBrowse link
G Ciita class II major histocompatibility complex transactivator no_association
susceptibility
ISO DNA:polymorphism:promoter:rs3087456, no association in a German cohort
DNA:polymorphism:exon:1614G>C (human)
RGD PMID:16426246, PMID:17661914 RGD:5491187, RGD:5491189 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Cmtm2 CKLF like MARVEL transmembrane domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936475:16,916,568...16,921,196 JBrowse link
G Crem cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936574:3,478,969...3,546,738 JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:22885951 RGD:6906884 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Cttn cortactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936599:481,234...503,857 JBrowse link
G CUNH2orf88 chromosome unknown C2orf88 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936506:7,883,823...7,903,949 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504, PMID:26387944 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936680:2,842,930...3,020,757 JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936609:2,688,170...2,691,057 JBrowse link
G Dusp2 dual specificity phosphatase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936744:271,619...273,272 JBrowse link
G Dusp4 dual specificity phosphatase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936573:765,954...778,524 JBrowse link
G Dysf dysferlin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936491:15,412,606...15,618,519 JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936563:1,058,803...1,181,393 JBrowse link
G Egr1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Elf2 E74 like ETS transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936535:8,426,550...8,496,129 JBrowse link
G Etnk1 ethanolamine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936548:4,340,632...4,405,880 JBrowse link
G Etv6 ETS variant transcription factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936587:5,328,467...5,457,260 JBrowse link
G Fam20a FAM20A golgi associated secretory pathway pseudokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936541:7,867,856...7,916,145 JBrowse link
G Faxdc2 fatty acid hydroxylase domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936515:8,004,569...8,038,794 JBrowse link
G Fchsd2 FCH and double SH3 domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936498:2,089,069...2,344,007 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936488:4,384,710...4,388,118 JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936706:1,900,954...1,907,567 JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936493:4,308,683...4,327,102 JBrowse link
G Foxp1 forkhead box P1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936603:2,631,781...3,146,104 JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936591:3,998,359...4,001,491 JBrowse link
G Gmpr guanosine monophosphate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936552:2,458,728...2,496,145 JBrowse link
G Gng11 G protein subunit gamma 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936803:57,659...62,005 JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936619:3,627,649...3,629,129 JBrowse link
G Hbegf heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936531:9,332,939...9,345,039 JBrowse link
G Herpud2 HERPUD family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936478:11,294,193...11,335,241 JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:16047841 RGD:8694357 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Hspa6 heat shock protein family A (Hsp70) member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004937131:25,603...28,458 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO protein:increased expression:serum,synovial fluid: RGD PMID:8255671 RGD:12910480 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Il1a interleukin 1 alpha ISO DNA:SNP:promoter:-889C>T (human) RGD PMID:8162643 RGD:7794716 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:mononuclear cell RGD PMID:21859687 RGD:5147870 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Itga2b integrin subunit alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936541:813,815...828,826 JBrowse link
G Itgb5 integrin subunit beta 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936725:417,824...530,993 JBrowse link
G Jmjd1c jumonji domain containing 1C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936753:1,413,935...1,645,974 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936522:3,034,364...3,037,632 JBrowse link
G Kat6b lysine acetyltransferase 6B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936521:4,309,699...4,497,755 JBrowse link
G Kcnj15 potassium inwardly rectifying channel subfamily J member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936500:4,685,832...4,690,338 JBrowse link
G Klf4 Kruppel like factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936559:5,105,456...5,109,970 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936548:2,078,568...2,113,877 JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936578:1,362,041...2,009,031 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Maff MAF bZIP transcription factor F ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936492:2,983,322...2,988,900 JBrowse link
G Map2 microtubule associated protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936845:475,406...752,600 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936619:1,889,841...1,932,646 JBrowse link
G Mex3c mex-3 RNA binding family member C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936497:12,178,350...12,201,795 JBrowse link
G Ms4a4a membrane spanning 4-domains A4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936581:2,550,229...2,572,638 JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936635:2,390,390...2,461,870 JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936470:22,963,498...23,117,923 JBrowse link
G Myzap myocardial zonula adherens protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:18,853,797...18,940,362 JBrowse link
G Ndel1 nudE neurodevelopment protein 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936595:1,656,956...1,692,775 JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936469:21,912,118...21,920,486 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936524:8,252,321...8,290,747 JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936766:1,104,841...1,306,368 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936902:405,536...416,393 JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936904:390,089...394,195 JBrowse link
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936718:739,133...850,775 JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936624:31,678...125,318 JBrowse link
G Per1 period circadian regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936595:1,366,883...1,382,138 JBrowse link
G Pgm5 phosphoglucomutase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936503:4,696,473...4,858,561 JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Plk2 polo like kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936480:9,680,461...9,686,593 JBrowse link
G Plod2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936519:9,053,192...9,139,221 JBrowse link
G Pros1 protein S ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936666:18,303...110,357 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO DNA: snp : cds : rs2476601 RGD PMID:15934099 RGD:6484550 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G R3hdm2 R3H domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936646:1,447,704...1,571,363 JBrowse link
G Rasgef1b RasGEF domain family member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936749:177,737...723,269 JBrowse link
G Rbm47 RNA binding motif protein 47 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936482:7,852,346...8,016,612 JBrowse link
G Rere arginine-glutamic acid dipeptide repeats ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936623:2,678,627...2,942,387 JBrowse link
G Rhobtb1 Rho related BTB domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936614:2,101,175...2,230,441 JBrowse link
G Rnf103 ring finger protein 103 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936712:977,650...997,623 JBrowse link
G Selp selectin P severity ISO protein:increased expression:plasma RGD PMID:21124648 RGD:6219006 NCBI chrNW_004936481:17,076,660...17,112,501 JBrowse link
G Sh2d2a SH2 domain containing 2A ISO DNA:polymorphism:promoter RGD PMID:15129233 RGD:2298870 NCBI chrNW_004936580:5,959,971...5,967,250 JBrowse link
G Sh3bgrl2 SH3 domain binding glutamate rich protein like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936510:10,488,055...10,516,114 JBrowse link
G Sik1 salt inducible kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936500:774,749...784,326 JBrowse link
G Sipa1l1 signal induced proliferation associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936488:819,503...1,175,043 JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO DNA:repeat:promoter (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10857800, PMID:16597321 RGD:5684977 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Slc22a16 solute carrier family 22 member 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936564:6,311,934...6,352,759 JBrowse link
G Slc26a2 solute carrier family 26 member 2 susceptibility ISO DNA:SNPs: : RGD PMID:17393463 RGD:13208931 NCBI chrNW_004936504:4,990,996...5,005,658 JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
G Stab1 stabilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936473:3,333,988...3,363,256 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Stim1 stromal interaction molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936498:849,775...1,063,552 JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
G Tfdp1 transcription factor Dp-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936472:184,808...214,628 JBrowse link
G Tfpi tissue factor pathway inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936506:10,103,120...10,172,800 JBrowse link
G Thbd thrombomodulin ISO protein:increased expression:serum RGD PMID:15209962 RGD:5685023 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936471:3,064,466...3,081,125 JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936469:26,129,339...26,145,464 JBrowse link
G Tnfaip8 TNF alpha induced protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936715:2,205,977...2,322,835 JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936593:1,166,995...1,546,253 JBrowse link
G Treml1 triggering receptor expressed on myeloid cells like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936476:18,668,809...18,673,183 JBrowse link
G Ttll5 tubulin tyrosine ligase like 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936488:4,723,314...4,983,926 JBrowse link
G Ube2e1 ubiquitin conjugating enzyme E2 E1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936473:15,487,341...15,557,516 JBrowse link
G Ube3c ubiquitin protein ligase E3C ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936797:452,597...529,631 JBrowse link
G Uhrf1bp1l UHRF1 binding protein 1 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936492:13,622,582...13,703,033 JBrowse link
G Wasf3 WASP family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936948:345,942...465,323 JBrowse link
G Wwox WW domain containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936475:26,342,245...27,209,563 JBrowse link
G Zfand3 zinc finger AN1-type containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936476:21,365,287...21,591,031 JBrowse link
G Zfc3h1 zinc finger C3H1-type containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:19565504 NCBI chrNW_004936568:681,802...730,918 JBrowse link
Sjogren's syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E onset ISO DNA:polymorphism:exon: RGD PMID:15328426 RGD:7495765 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Bdnf brain derived neurotrophic factor severity ISO protein:increased expression:serum: RGD PMID:18830907 RGD:8657019 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G C3 complement C3 ISO RGD PMID:17675493 RGD:7401265 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cast calpastatin ISO associated with Lupus Erythematosus, Systemic RGD PMID:15540513 RGD:5683622 NCBI chrNW_004936523:6,688,153...6,798,184 JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:salivary ductal epithelium (human) RGD PMID:12472667 RGD:11520791 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Crp C-reactive protein ISO associated with Arthritis, Rheumatoid;protein:increased expression:serum: RGD PMID:2353152, PMID:16013223 RGD:9491774, RGD:9491835 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO mRNA:increased expression:salivary gland:
DNA:SNPs,haplotype: :+49A/G (rs231775),(rs3087243)(human)
RGD PMID:12528117, PMID:16869018 RGD:7421506, RGD:7421519 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Dgkq diacylglycerol kinase theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:serum (human)
protein:decreased expression:lacrimal gland, lymphocyte (mouse)
RGD PMID:9870874, PMID:9890678, PMID:11157873 RGD:8662410, RGD:8662436, RGD:8662451 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO RGD PMID:9853108 RGD:6218983 NCBI chrNW_004936518:4,291,391...4,310,752 JBrowse link
G Gtf2i general transcription factor IIi ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066 NCBI chrNW_004936543:3,521,763...3,611,410 JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:24941846 RGD:10450595 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 ISO RGD PMID:19264855 RGD:10054311 NCBI chrNW_004936739:1,135,282...1,144,643 JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO protein:increased expression:plasma
protein:increased expression:salivary gland
RGD PMID:11359451, PMID:15037117, PMID:21589878 RGD:8158122, RGD:8547696, RGD:8547705 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Ifng interferon gamma ISO RGD PMID:15584966, PMID:28421993 RGD:14975117, RGD:8142390 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 ISO RGD PMID:12233881 RGD:1580479 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il12a interleukin 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936519:6,166,060...6,180,652 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:12051401 RGD:8549582 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il17a interleukin 17A ISO RGD PMID:21182786 RGD:8696035 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:saliva RGD PMID:23906036 RGD:8655918 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:conjunctiva (human)
DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
RGD PMID:9646842, PMID:11527941 RGD:8549786, RGD:8549807 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il23r interleukin 23 receptor ISO protein:increased expression:minor salivary gland: RGD PMID:22262980 RGD:8549566 NCBI chrNW_004936591:4,365,598...4,425,053 JBrowse link
G Irak1bp1 interleukin 1 receptor associated kinase 1 binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936510:11,220,194...11,242,485 JBrowse link
G Itsn2 intersectin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936493:7,716,424...7,842,818 JBrowse link
G LOC101958024 submaxillary mucin-like protein ISO mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18184611 RGD:7364736 NCBI chrNW_004936607:418,290...443,988 JBrowse link
G LOC101967308 bone marrow stromal antigen 2 ISO mRNA, protein:increased expression: labial gland, CD19+ B cell, CD4-CD8-CD19-monocyte: RGD PMID:30249485 RGD:14398821 NCBI chrNW_004936596:3,492,733...3,501,347 JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO associated with Arthritis, Rheumatoid;DNA:polymorphism: :4889A>G (human) RGD PMID:12590982 RGD:5147747 NCBI chrNW_004936471:33,682,730...33,688,332 JBrowse link
G Lta lymphotoxin alpha no_association
susceptibility
ISO protein:increased expression:saliva, serum
DNA:SNPs: :multiple (human)
DNA:SNP, haplotype:intron: (rs909253) (human)
RGD PMID:20952683, PMID:22294627 RGD:8548776, RGD:8548787 NCBI chrNW_004936727:1,940,081...1,941,022 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased activity:saliva RGD PMID:9923658, PMID:15316122 RGD:8547814, RGD:8547858 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Muc16 mucin 16, cell surface associated ISO mRNA, protein:increased expression:conjunctival epithelial cell, tear RGD PMID:19122828 RGD:7364772 NCBI chrNW_004936588:5,506,683...5,586,450 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18184611 RGD:7364736 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28135245 NCBI chrNW_004936543:3,617,369...3,630,990 JBrowse link
G Phip pleckstrin homology domain interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936510:11,076,790...11,198,483 JBrowse link
G Pon1 paraoxonase 1 ISO protein:decreased activity:serum (human) RGD PMID:20497955 RGD:8547550 NCBI chrNW_004936585:4,954,871...4,979,560 JBrowse link
G Prdm1 PR/SET domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936564:2,594,362...2,690,680 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 no_association ISO DNA:snp:cds:c.1858C>T (human) RGD PMID:15933742, PMID:16163373 RGD:11534998, RGD:11534999 NCBI chrNW_004936690:2,180,804...2,232,869 JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936841:274,458...275,148 JBrowse link
G Reg1a regenerating family member 1 alpha ISO protein:increased expression:minor salivary gland, salivary ductal epithelium (human) RGD PMID:19016805 RGD:9850137 NCBI chrNW_004936556:4,873,331...4,875,608 JBrowse link
G Selp selectin P ISO protein:increased expression:plasma RGD PMID:19832990 RGD:6478702 NCBI chrNW_004936481:17,076,660...17,112,501 JBrowse link
G Stat4 signal transducer and activator of transcription 4 no_association
susceptibility
ISO DNA:SNP:intron: (rs7574865) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs7582694) (human)
RGD
CTD
PMID:18273036, PMID:20360187, PMID:20535138, PMID:24097066, PMID:24097067 RGD:8661690, RGD:8661708, RGD:8661709 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Tgfb1 transforming growth factor beta 1 severity ISO RGD PMID:7554451, PMID:9358754 RGD:7394829, RGD:7394845 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tnf tumor necrosis factor treatment ISO DNA:polymorphism: :-1031T>C(human) RGD PMID:22703762, PMID:24941846 RGD:10450595, RGD:7394766 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097066, PMID:24097067 NCBI chrNW_004936560:5,124,955...5,138,988 JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097067 NCBI chrNW_004936647:3,914,887...3,959,698 JBrowse link
G Vim vimentin ISO RGD PMID:6352937 RGD:6480477 NCBI chrNW_004936520:10,051,692...10,059,324 JBrowse link
G Vip vasoactive intestinal peptide ISO RGD PMID:22059987 RGD:5685375 NCBI chrNW_004936489:5,425,778...5,434,483 JBrowse link
Systemic Juvenile Rheumatoid Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:26914138 RGD:11529541 NCBI chrNW_004936843:658,058...672,662 JBrowse link
G Il6r interleukin 6 receptor treatment ISO RGD PMID:18358927 RGD:10402823 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Mif macrophage migration inhibitory factor ISO OMIM NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11962
    disease of anatomical entity 11526
      musculoskeletal system disease 4998
        autoimmune disease of musculoskeletal system 759
          rheumatic disease 595
            rheumatoid arthritis 382
              Caplan's syndrome 0
              Felty's syndrome 0
              Rheumatoid Nodule 0
              Rheumatoid Vasculitis 0
              Sjogren's syndrome + 46
              Sjögren-Mikulicz Syndrome 0
              adult-onset Still's disease 2
              juvenile rheumatoid arthritis + 131
              palindromic rheumatism 0
Path 2
Term Annotations click to browse term
  disease 11962
    disease of anatomical entity 11526
      Immune & Inflammatory Diseases 2756
        immune system disease 2345
          primary immunodeficiency disease 1838
            autoimmune disease 1247
              autoimmune disease of musculoskeletal system 759
                rheumatic disease 595
                  rheumatoid arthritis 382
                    Caplan's syndrome 0
                    Felty's syndrome 0
                    Rheumatoid Nodule 0
                    Rheumatoid Vasculitis 0
                    Sjogren's syndrome + 46
                    Sjögren-Mikulicz Syndrome 0
                    adult-onset Still's disease 2
                    juvenile rheumatoid arthritis + 131
                    palindromic rheumatism 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.