ONTOLOGY REPORT - ANNOTATIONS


Term:chronic myeloid leukemia
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Accession:DOID:8552 term browser browse the term
Definition:Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Synonyms:exact_synonym: CML;   CML - chronic myelogenous leukemia;   Chronic Myelogenous Leukemia;   Chronic Myelogenous Leukemias;   Chronic Myeloid Leukemias;   Leukemia, Myelogenous, Chronic, BCR-ABL Positive;   PH1-positive myeloid leukemia;   PH1-positive myeloid leukemias;   Ph1-Positive Myelogenous Leukemia;   Ph1-positive myelogenous leukemias;   Philadelphia-positive myeloid leukemia;   chronic granulocytic leukemia;   chronic granulocytic leukemias;   chronic myelocytic leukemia;   chronic myelocytic leukemias
 narrow_synonym: CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB;   Leukemia, Philadelphia chromosome-positive, resistant to imatinib
 primary_id: MESH:D015464
 alt_id: OMIM:608232;   RDO:0005019
 xref: GARD:6105
For additional species annotation, visit the Alliance of Genome Resources.


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chronic myeloid leukemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:11081178
RGD:11081180
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:11080961
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:11081178
RGD:11081181
RGD:11081180
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1598673
RGD:13674161
RGD:8554872
RGD:11554173
RGD:11038814
RGD:14392796
RGD:11038807
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1298615
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:11039056
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:11039056
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:13674160
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:11554173
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:11554173
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:11353850
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:1600510
RGD:13674161
RGD:11554173
RGD:14392796
RGD:11038783
RGD:11038776
RGD:11038775
RGD:7240710
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:11554173
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:8554872
G Ca9 carbonic anhydrase 9 JBrowse link 5 59,008,277 59,015,535 RGD:11554173
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:11041099
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:11520794
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:13673878
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:11251777
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 RGD:11251777
G Cdkn2a_v2 cyclin-dependent kinase inhibitor 2A, variant 2 RGD:11251777
G Chordc1 cysteine and histidine rich domain containing 1 JBrowse link 8 17,421,552 17,445,513 RGD:13592920
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:13674160
G Cry1 cryptochrome circadian regulator 1 JBrowse link 7 24,534,593 24,634,098 RGD:11554173
G Cry2 cryptochrome circadian regulator 2 JBrowse link 3 81,314,151 81,344,143 RGD:11554173
G Csf3r colony stimulating factor 3 receptor JBrowse link 5 144,031,353 144,051,966 RGD:8554872
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:11352729
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:11353798
RGD:11353810
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:9588667
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:9588667
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:9588667
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:13674165
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:11252188
RGD:11060463
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:13782088
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11049146
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:11049146
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:11344957
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:13699433
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:11352762
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:11554173
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:9685380
G Hmmr hyaluronan-mediated motility receptor JBrowse link 10 25,861,490 25,890,639 RGD:11554173
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10755566
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:11554173
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:11049154
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:10450889
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:10450889
G Insl6 insulin-like 6 JBrowse link 1 247,473,292 247,476,827 RGD:8554872
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:8554872
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:8554872
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:11554173
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:13703044
G Mir150 microRNA 150 JBrowse link 1 101,115,974 101,116,058 RGD:13782140
G Mlf1 myeloid leukemia factor 1 JBrowse link 2 164,549,423 164,582,645 RGD:1600902
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:10449408
G Ncstn nicastrin JBrowse link 13 90,451,046 90,467,256 RGD:13592920
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:1600902
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:10769357
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:8554872
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:11552593
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:11554173
G Per2 period circadian regulator 2 JBrowse link 9 98,555,154 98,597,362 RGD:11554173
G Per3 period circadian regulator 3 JBrowse link 5 168,088,126 168,123,482 RGD:11554173
G Prame preferentially expressed antigen in melanoma JBrowse link X 106,082,984 106,091,256 RGD:11535035
RGD:11554173
G Prtn3 proteinase 3 JBrowse link 7 12,643,712 12,646,951 RGD:11554173
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:11041777
RGD:11041781
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:11041777
G Setbp1 SET binding protein 1 JBrowse link 18 75,090,733 75,432,446 RGD:8554872
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:13592920
G Sipa1 signal-induced proliferation-associated 1 JBrowse link 1 221,006,305 221,018,820 RGD:13592920
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:13782079
G Srsf1 serine and arginine rich splicing factor 1 JBrowse link 10 75,334,200 75,341,197 RGD:11038774
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:11038663
RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:13782079
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:13432135
G Wt1 WT1 transcription factor JBrowse link 3 95,133,221 95,180,574 RGD:11554173
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:11081180
Blast Crisis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation-induced cytidine deaminase JBrowse link 4 155,359,909 155,371,104 RGD:11554173
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:11554173
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:734951
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10755566
G Mir150 microRNA 150 JBrowse link 1 101,115,974 101,116,058 RGD:13782140
G Tcn2 transcobalamin 2 JBrowse link 14 84,173,992 84,189,299 RGD:11060122
familial chronic myelocytic leukemia-like syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf8 interferon regulatory factor 8 JBrowse link 19 54,314,859 54,336,643 RGD:13592920
Myeloid Leukemia, Accelerated Phase term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 17 85,360,439 85,370,283 RGD:11554173
G Mir150 microRNA 150 JBrowse link 1 101,115,974 101,116,058 RGD:13782140
Myeloid Leukemia, Chronic-Phase term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:11038809
RGD:11038811
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:11038809
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:11353797
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:11252165
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:11040457
RGD:11040461
G Gfi1b growth factor independent 1B transcriptional repressor JBrowse link 3 7,190,721 7,203,444 RGD:11040460

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14919
    disease of cellular proliferation 5587
      Neoplasms by Histologic Type 3445
        leukemia 572
          myeloid leukemia 360
            chronic myeloid leukemia 85
              Blast Crisis 6
              Myeloid Leukemia, Accelerated Phase 2
              Myeloid Leukemia, Chronic-Phase 6
              familial chronic myelocytic leukemia-like syndrome 1
Path 2
Term Annotations click to browse term
  disease 14919
    disease of anatomical entity 14083
      Hemic and Lymphatic Diseases 1590
        hematopoietic system disease 1374
          Hematologic Neoplasms 784
            hematologic cancer 783
              bone marrow cancer 288
                myeloid neoplasm 228
                  chronic myeloid leukemia 85
                    Blast Crisis 6
                    Myeloid Leukemia, Accelerated Phase 2
                    Myeloid Leukemia, Chronic-Phase 6
                    familial chronic myelocytic leukemia-like syndrome 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.